Motif ID: NKX3-2.p2

Z-value: 2.066


Transcription factors associated with NKX3-2.p2:

Gene SymbolEntrez IDGene Name
NKX3-2 579 NK3 homeobox 2



Activity profile for motif NKX3-2.p2.

activity profile for motif NKX3-2.p2


Sorted Z-values histogram for motif NKX3-2.p2

Sorted Z-values for motif NKX3-2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_17585462 3.948 VSNL1
visinin-like 1
chr2_-_70634129 2.738 NM_001099691
NM_003236
TGFA

transforming growth factor, alpha

chr1_+_107484151 2.539 NM_001113226
NM_001113228
NM_014917
NTNG1


netrin G1


chr10_+_24795446 2.505 KIAA1217
KIAA1217
chr2_+_17585287 2.298 NM_003385
VSNL1
visinin-like 1
chr10_+_24795465 2.290 KIAA1217
KIAA1217
chr10_-_105604942 2.160 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chr18_+_40514772 1.855 NM_015559
SETBP1
SET binding protein 1
chr5_+_52812236 1.803 NM_006350
NM_013409
FST

follistatin

chr20_+_51023159 1.788 TSHZ2
teashirt zinc finger homeobox 2
chr2_+_228386800 1.719 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr8_+_32905027 1.653


chrX_-_107568211 1.633 NM_033641
COL4A6
collagen, type IV, alpha 6
chr11_-_119513429 1.610 TRIM29
tripartite motif containing 29
chr16_+_55963883 1.607 CX3CL1
chemokine (C-X3-C motif) ligand 1
chr16_+_55963899 1.577 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr7_+_29200636 1.574 NM_004067
CHN2
chimerin (chimaerin) 2
chr2_-_109728958 1.549 NM_144710
NM_178584
SEPT10

septin 10

chr5_+_52812165 1.544 FST
follistatin
chr12_+_94861201 1.452 NM_152435
AMDHD1
amidohydrolase domain containing 1
chr8_+_123863075 1.423 NM_014943
ZHX2
zinc fingers and homeoboxes 2
chr8_-_122722674 1.422 NM_005328
HAS2
hyaluronan synthase 2
chr8_+_123863169 1.418 ZHX2
zinc fingers and homeoboxes 2
chr2_-_139254273 1.415 NM_007226
NXPH2
neurexophilin 2
chr8_+_120289735 1.411 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr1_+_107485071 1.410 NTNG1
netrin G1
chr11_+_66580861 1.391 NM_014578
RHOD
ras homolog gene family, member D
chr1_-_94779727 1.362 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr11_+_129823667 1.354 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr13_+_75232797 1.293 NM_015842
LMO7
LIM domain 7
chr11_-_119513948 1.273 TRIM29
tripartite motif containing 29
chr2_+_109729176 1.264 NM_023016
ANKRD57
ankyrin repeat domain 57
chr20_-_42249631 1.262 NM_020433
NM_175913
JPH2

junctophilin 2

chr12_+_32578513 1.231 FGD4
FYVE, RhoGEF and PH domain containing 4
chr10_-_98021144 1.220 NM_001114094
NM_013314
BLNK

B-cell linker

chr5_+_68746694 1.215 NM_001038603
MARVELD2
MARVEL domain containing 2
chr1_+_86662356 1.183 NM_006536
CLCA2
chloride channel accessory 2
chr6_+_54819527 1.170 NM_001010872
FAM83B
family with sequence similarity 83, member B
chr11_-_119514058 1.162 NM_012101
TRIM29
tripartite motif containing 29
chr1_-_24342158 1.149 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr10_+_59942874 1.147 NM_001080512
BICC1
bicaudal C homolog 1 (Drosophila)
chr10_-_116276651 1.128 NM_006720
ABLIM1
actin binding LIM protein 1
chr1_+_35020425 1.106 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr2_-_191723978 1.099 STAT4
signal transducer and activator of transcription 4
chr16_-_71650034 1.093 NM_001164766
ZFHX3
zinc finger homeobox 3
chr11_-_77411933 1.092 NM_023930
KCTD14
potassium channel tetramerisation domain containing 14
chr9_+_2612052 1.090 VLDLR
very low density lipoprotein receptor
chr20_+_19903778 1.079 RIN2
Ras and Rab interactor 2
chr12_-_51200347 1.075 NM_000424
KRT5
keratin 5
chr11_-_119514011 1.055 TRIM29
tripartite motif containing 29
chr3_-_191522886 1.053 NM_021101
CLDN1
claudin 1
chr3_+_61522922 1.046 PTPRG
protein tyrosine phosphatase, receptor type, G
chr1_+_199519202 1.032 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr5_+_96023926 1.026 CAST
calpastatin
chr9_+_111582317 1.002 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr3_+_106568430 0.971 ALCAM
activated leukocyte cell adhesion molecule
chr10_-_123343761 0.964 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr10_-_116276560 0.956 ABLIM1
actin binding LIM protein 1
chr3_+_106568243 0.941 ALCAM
activated leukocyte cell adhesion molecule
chr5_+_96023479 0.936 NM_001190442
CAST
calpastatin
chr4_+_169789327 0.932 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chr14_-_53491019 0.926 NM_130851
BMP4
bone morphogenetic protein 4
chr1_+_208178160 0.916 NM_001146261
NM_001146262
NM_001146264
NM_153262
SYT14



synaptotagmin XIV



chr12_+_79995927 0.915 NM_024560
ACSS3
acyl-CoA synthetase short-chain family member 3
chr11_-_101906640 0.901 NM_002423
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr3_+_106568334 0.900 NM_001627
ALCAM
activated leukocyte cell adhesion molecule
chr12_-_6355165 0.898 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr3_-_55490401 0.897 WNT5A
wingless-type MMTV integration site family, member 5A
chr8_+_102573837 0.891 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr2_+_149895274 0.885 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr5_+_96023627 0.878 NM_001042440
CAST
calpastatin
chr2_-_109728693 0.872 SEPT10
septin 10
chr8_+_102574012 0.871 GRHL2
grainyhead-like 2 (Drosophila)
chr19_+_40322231 0.865 NM_005031
FXYD1
FXYD domain containing ion transport regulator 1
chr2_-_191723996 0.860 STAT4
signal transducer and activator of transcription 4
chr2_-_191724169 0.858 NM_003151
STAT4
signal transducer and activator of transcription 4
chr5_+_174084137 0.857 NM_002449
MSX2
msh homeobox 2
chr9_+_77695334 0.857 NM_001190482
NM_006200
PCSK5

proprotein convertase subtilisin/kexin type 5

chr3_+_185762233 0.854 NM_004443
EPHB3
EPH receptor B3
chr14_+_105024576 0.846 CRIP1
cysteine-rich protein 1 (intestinal)
chr2_-_160627366 0.845 NM_001007267
NM_001195641
NM_007366
PLA2R1


phospholipase A2 receptor 1, 180kDa


chr12_+_32546243 0.838 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr1_-_197173159 0.834 LOC100131234
familial acute myelogenous leukemia related factor
chr11_+_101488380 0.832 NM_001195045
YAP1
Yes-associated protein 1
chr3_-_55490442 0.812 WNT5A
wingless-type MMTV integration site family, member 5A
chr6_+_139055244 0.803 FLJ46906
hypothetical LOC441172
chr1_-_94475504 0.802 ARHGAP29
Rho GTPase activating protein 29
chr4_-_23500706 0.800 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr6_+_131190237 0.799 NM_001195597
LOC285733
hypothetical LOC285733
chr3_+_113061218 0.793 NM_001134439
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr20_+_43531806 0.789 NM_006103
WFDC2
WAP four-disulfide core domain 2
chr14_-_64479198 0.787 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr2_-_160764819 0.786 NM_000888
ITGB6
integrin, beta 6
chr3_-_188936941 0.777 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr8_-_99375739 0.772 NM_024759
NIPAL2
NIPA-like domain containing 2
chrX_+_105823723 0.769 NM_024539
RNF128
ring finger protein 128
chr14_+_30098079 0.769 NM_017769
G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chr12_+_51979721 0.768 NM_021640
C12orf10
chromosome 12 open reading frame 10
chr3_+_113061330 0.767 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr20_-_21442663 0.765 NM_002509
NKX2-2
NK2 homeobox 2
chr15_-_38420414 0.763 NM_207380
C15orf52
chromosome 15 open reading frame 52
chr10_-_95350949 0.755 NM_006744
RBP4
retinol binding protein 4, plasma
chr9_-_21984329 0.753 CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr8_+_123863224 0.752 ZHX2
zinc fingers and homeoboxes 2
chr3_+_113061296 0.746 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr9_-_126309510 0.742 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr16_+_639278 0.739 NM_145294
WDR90
WD repeat domain 90
chr4_-_78038025 0.732 NM_001029870
ANKRD56
ankyrin repeat domain 56
chr2_-_75641535 0.731 FAM176A
family with sequence similarity 176, member A
chr11_+_34599227 0.730 EHF
ets homologous factor
chr15_-_57452361 0.728 NM_004998
MYO1E
myosin IE
chr20_-_42249146 0.725 JPH2
junctophilin 2
chr10_-_7748811 0.725 NM_001001851
NM_030569
ITIH5

inter-alpha (globulin) inhibitor H5

chr10_-_29963906 0.724 NM_021738
SVIL
supervillin
chr15_-_57452345 0.722 MYO1E
myosin IE
chr10_-_116154212 0.720 AFAP1L2
actin filament associated protein 1-like 2
chr10_+_24537725 0.718 NM_001098501
NM_019590
KIAA1217

KIAA1217

chr1_+_148137778 0.717 NM_016074
BOLA1
bolA homolog 1 (E. coli)
chr9_+_2612134 0.713 VLDLR
very low density lipoprotein receptor
chr2_-_160627181 0.713 PLA2R1
phospholipase A2 receptor 1, 180kDa
chr17_-_6958282 0.711 NM_080914
ASGR2
asialoglycoprotein receptor 2
chr12_+_52806103 0.710 LOC400043
hypothetical LOC400043
chr11_+_34599163 0.710 NM_012153
EHF
ets homologous factor
chr4_+_148621518 0.709 NM_001166055
NM_001957
EDNRA

endothelin receptor type A

chr15_-_57452357 0.708 MYO1E
myosin IE
chr16_+_65790514 0.707 NM_024712
ELMO3
engulfment and cell motility 3
chr16_-_49742008 0.703 NM_001127892
SALL1
sal-like 1 (Drosophila)
chr12_+_99391870 0.701 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr12_-_47604930 0.699 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr3_-_48607596 0.698 NM_000094
COL7A1
collagen, type VII, alpha 1
chr5_+_135392482 0.695 NM_000358
TGFBI
transforming growth factor, beta-induced, 68kDa
chr10_+_123862430 0.694 TACC2
transforming, acidic coiled-coil containing protein 2
chr8_-_17702991 0.687


chr16_-_14695930 0.686 NM_003561
PLA2G10
phospholipase A2, group X
chr5_+_131437383 0.686 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr2_-_191723951 0.685 STAT4
signal transducer and activator of transcription 4
chr14_+_92049396 0.685 NM_024832
RIN3
Ras and Rab interactor 3
chrX_+_110226030 0.683 NM_002578
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3
chrX_-_114703273 0.683


chr9_-_21984379 0.680 CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr11_+_12355600 0.679 NM_018222
PARVA
parvin, alpha
chr1_-_94475840 0.678 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr19_+_10597167 0.672 NM_020428
SLC44A2
solute carrier family 44, member 2
chr12_+_56406296 0.672 LOC100130776
hypothetical LOC100130776
chr9_-_4289574 0.668 GLIS3
GLIS family zinc finger 3
chr4_+_74498042 0.667 ALB
albumin
chr18_+_59405513 0.666 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr1_-_233879617 0.664 NM_001098722
GNG4
guanine nucleotide binding protein (G protein), gamma 4
chr1_-_238842011 0.663 GREM2
gremlin 2
chr20_-_22512893 0.659 FOXA2
forkhead box A2
chr9_+_2612099 0.658 VLDLR
very low density lipoprotein receptor
chr3_+_112273352 0.656 PVRL3
poliovirus receptor-related 3
chr1_-_31942142 0.655 COL16A1
collagen, type XVI, alpha 1
chr6_-_128883125 0.654 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr2_-_75641587 0.653 NM_001135032
FAM176A
family with sequence similarity 176, member A
chr14_+_51397134 0.652 GNG2
guanine nucleotide binding protein (G protein), gamma 2
chr2_-_237080830 0.649 NM_024726
IQCA1
IQ motif containing with AAA domain 1
chr2_-_164300758 0.646 NM_018086
FIGN
fidgetin
chr10_+_20145350 0.645 NM_032812
PLXDC2
plexin domain containing 2
chr6_+_32003380 0.644 C2
complement component 2
chr14_+_51397166 0.644 GNG2
guanine nucleotide binding protein (G protein), gamma 2
chrX_-_64112993 0.643 NM_001178033
NM_018684
ZC4H2

zinc finger, C4H2 domain containing

chr7_+_96473225 0.642 NM_005222
DLX6
distal-less homeobox 6
chr21_-_42060334 0.641 RIPK4
receptor-interacting serine-threonine kinase 4
chr6_+_29799182 0.639 HLA-F
major histocompatibility complex, class I, F
chr3_-_121884091 0.637 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr11_-_8849485 0.633 ST5
suppression of tumorigenicity 5
chr16_-_80602546 0.632 NM_145168
SDR42E1
short chain dehydrogenase/reductase family 42E, member 1
chr19_-_6671585 0.631 NM_000064
C3
complement component 3
chr1_-_6368324 0.631 NM_181864
ACOT7
acyl-CoA thioesterase 7
chr4_+_74497998 0.630 ALB
albumin
chr2_+_201099093 0.629 NM_001160033
NM_001160046
NM_152524
SGOL2


shugoshin-like 2 (S. pombe)


chr5_+_135392624 0.629 TGFBI
transforming growth factor, beta-induced, 68kDa
chr6_+_30018287 0.627 NM_002116
HLA-A
major histocompatibility complex, class I, A
chr20_-_22513050 0.625 NM_021784
FOXA2
forkhead box A2
chr2_+_238200922 0.622 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr6_+_32003180 0.619 NM_000063
NM_001145903
C2

complement component 2

chr2_+_101981888 0.616 NM_173343
IL1R2
interleukin 1 receptor, type II
chrX_-_83644054 0.616 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr10_-_30065760 0.610 SVIL
supervillin
chr1_+_64709063 0.607 NM_020925
CACHD1
cache domain containing 1
chr15_-_42274760 0.606 FRMD5
FERM domain containing 5
chr12_-_15757114 0.602 EPS8
epidermal growth factor receptor pathway substrate 8
chr9_+_123101926 0.601 GSN
gelsolin
chr10_+_7785331 0.601 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785290 0.601 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_73393998 0.601 NM_004273
CHST3
carbohydrate (chondroitin 6) sulfotransferase 3
chr6_+_41712907 0.597 MDFI
MyoD family inhibitor
chr2_-_19421852 0.597 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr18_-_26996742 0.593 NM_004948
NM_024421
DSC1

desmocollin 1

chr2_-_197499584 0.592 NM_024989
PGAP1
post-GPI attachment to proteins 1
chrX_-_50573759 0.591 NM_020717
SHROOM4
shroom family member 4
chr2_-_45090025 0.591 NM_016932
SIX2
SIX homeobox 2
chr10_-_33663305 0.588 NRP1
neuropilin 1
chr1_+_212228482 0.587 NM_002763
PROX1
prospero homeobox 1
chr1_-_152845399 0.587 NM_001193495
ADAR
adenosine deaminase, RNA-specific
chr3_-_192063158 0.586 NM_001146686
GEMC1
geminin coiled-coil domain-containing protein 1
chr6_-_138935359 0.585 NM_020464
NHSL1
NHS-like 1
chr6_+_30018265 0.584 HLA-A
major histocompatibility complex, class I, A
chr8_+_104379836 0.583 NM_001164615
FZD6
frizzled homolog 6 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.08 7.92e-06 GO:0009987 cellular process
1.23 2.16e-04 GO:0048518 positive regulation of biological process
1.26 1.30e-03 GO:0030154 cell differentiation
1.24 1.57e-03 GO:0048519 negative regulation of biological process
1.25 1.58e-03 GO:0048869 cellular developmental process
1.26 2.46e-03 GO:0048583 regulation of response to stimulus
1.30 4.17e-03 GO:0007399 nervous system development
1.22 4.68e-03 GO:0048522 positive regulation of cellular process
1.44 7.76e-03 GO:0045595 regulation of cell differentiation
1.22 2.03e-02 GO:0048523 negative regulation of cellular process
1.90 3.17e-02 GO:0045165 cell fate commitment
1.17 4.11e-02 GO:0048856 anatomical structure development
1.47 4.25e-02 GO:0048585 negative regulation of response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.11 2.45e-06 GO:0005737 cytoplasm
1.06 3.63e-03 GO:0044424 intracellular part
1.06 5.02e-03 GO:0005622 intracellular
1.51 1.32e-02 GO:0009986 cell surface
1.10 2.83e-02 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 2.75e-05 GO:0005515 protein binding
1.05 1.49e-02 GO:0005488 binding
1.46 3.35e-02 GO:0008289 lipid binding