Motif ID: GTF2A1,2.p2

Z-value: 2.323


Transcription factors associated with GTF2A1,2.p2:

Gene SymbolEntrez IDGene Name
GTF2A1 2957 general transcription factor IIA, 1, 19/37kDa
GTF2A2 2958 general transcription factor IIA, 2, 12kDa



Activity profile for motif GTF2A1,2.p2.

activity profile for motif GTF2A1,2.p2


Sorted Z-values histogram for motif GTF2A1,2.p2

Sorted Z-values for motif GTF2A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2A1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_27155197 2.309 EMILIN1
elastin microfibril interfacer 1
chr2_+_27154938 2.303 NM_007046
EMILIN1
elastin microfibril interfacer 1
chr2_-_218516950 2.048 NM_022648
TNS1
tensin 1
chr3_+_50279993 1.731 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chr17_+_42641712 1.709 NM_002476
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr16_+_56259657 1.680 NM_170776
GPR97
G protein-coupled receptor 97
chr20_-_34635091 1.636


chr1_+_6537924 1.581 NM_138697
NM_177540
TAS1R1

taste receptor, type 1, member 1

chr17_-_45633986 1.559 NM_000088
COL1A1
collagen, type I, alpha 1
chr20_+_34635362 1.485 NM_021809
TGIF2
TGFB-induced factor homeobox 2
chr17_+_4795128 1.479 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr1_+_984935 1.468 LOC100288175
hypothetical LOC100288175
chr1_+_148496792 1.459 NM_012113
CA14
carbonic anhydrase XIV
chr17_-_45633873 1.452 COL1A1
collagen, type I, alpha 1
chr2_-_238813365 1.444 NM_001142853
NM_018645
HES6

hairy and enhancer of split 6 (Drosophila)

chr2_-_238813284 1.437 HES6
hairy and enhancer of split 6 (Drosophila)
chrX_+_49718954 1.392 NM_000084
CLCN5
chloride channel 5
chr17_+_38259620 1.330 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr20_-_42457717 1.321


chr22_+_22445035 1.317 NM_005940
MMP11
matrix metallopeptidase 11 (stromelysin 3)
chr12_+_50342814 1.315 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr12_+_79634820 1.297 NM_005593
MYF5
myogenic factor 5
chr20_-_43889339 1.293 NM_003279
TNNC2
troponin C type 2 (fast)
chr11_-_85074848 1.286 NM_152723
CCDC89
coiled-coil domain containing 89
chr11_-_64582568 1.198 NM_005468
NAALADL1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr6_+_30238961 1.179 NM_033229
TRIM15
tripartite motif containing 15
chr19_-_56549853 1.170 NM_001014763
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr15_-_73792234 1.156 NM_001897
CSPG4
chondroitin sulfate proteoglycan 4
chr11_-_111287657 1.136 NM_001885
CRYAB
crystallin, alpha B
chr21_-_32879617 1.112 NM_144659
TCP10L
t-complex 10 (mouse)-like
chr5_-_134397470 1.111 PITX1
paired-like homeodomain 1
chr17_-_23721468 1.106 VTN
vitronectin
chr2_+_218929822 1.090 NM_198559
C2orf62
chromosome 2 open reading frame 62
chr15_-_73792150 1.083 CSPG4
chondroitin sulfate proteoglycan 4
chr17_-_68769613 1.072 NM_001129885
CPSF4L
cleavage and polyadenylation specific factor 4-like
chr1_+_200246370 1.068 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr17_-_39340638 1.053 NM_005374
MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr17_+_71141108 1.051 NM_001162995
LOC643008
hypothetical protein LOC643008
chr12_+_54910086 1.049 NM_173596
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr17_+_1611983 1.047 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr6_-_49712483 1.040 NM_000324
RHAG
Rh-associated glycoprotein
chr16_+_68765428 0.998 NM_173619
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chr1_+_984972 0.989 LOC100288175
hypothetical LOC100288175
chr17_-_60988077 0.982 NM_004655
AXIN2
axin 2
chr11_-_102001259 0.980 NM_004771
MMP20
matrix metallopeptidase 20
chr4_+_24406283 0.973 SOD3
superoxide dismutase 3, extracellular
chr14_+_99859427 0.970 NM_207117
SLC25A47
solute carrier family 25, member 47
chr16_+_48857962 0.968 ADCY7
adenylate cyclase 7
chr17_-_77602493 0.960 RFNG
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr17_+_1612092 0.959 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr8_-_145119627 0.958 NM_201378
PLEC
plectin
chr14_-_22358752 0.929 NM_001126106
SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr16_+_56616970 0.911 MMP15
matrix metallopeptidase 15 (membrane-inserted)
chr19_+_40465249 0.898 NM_021175
HAMP
hepcidin antimicrobial peptide
chr20_+_31334601 0.890 NM_033197
C20orf114
chromosome 20 open reading frame 114
chr16_+_82544327 0.887 NM_182981
OSGIN1
oxidative stress induced growth inhibitor 1
chr17_-_23721420 0.883 VTN
vitronectin
chr6_-_46401174 0.880 RCAN2
regulator of calcineurin 2
chr3_+_50217692 0.862 NM_006841
SLC38A3
solute carrier family 38, member 3
chr17_-_35774467 0.862 NM_152219
GJD3
gap junction protein, delta 3, 31.9kDa
chr17_-_23721485 0.860 NM_000638
VTN
vitronectin
chr17_-_23721430 0.834 VTN
vitronectin
chr17_-_23721351 0.833 VTN
vitronectin
chr11_-_1549719 0.832 NM_004420
DUSP8
dual specificity phosphatase 8
chr7_+_68701704 0.822 NM_001127231
NM_001127232
NM_015570
AUTS2


autism susceptibility candidate 2


chr16_-_73012740 0.819 NM_001011880
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chr17_-_39340414 0.819 MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr22_+_20067662 0.816 NM_001128633
RIMBP3C
RIMS binding protein 3C
chr1_+_2975590 0.815 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr4_+_24406336 0.814 SOD3
superoxide dismutase 3, extracellular
chr17_+_1612056 0.807 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr10_+_74323344 0.796 NM_152635
OIT3
oncoprotein induced transcript 3
chr2_+_28469275 0.792 NM_005253
FOSL2
FOS-like antigen 2
chr12_-_7136189 0.772 C1R
complement component 1, r subcomponent
chr6_-_46401363 0.758 NM_005822
RCAN2
regulator of calcineurin 2
chr22_+_21852699 0.756 BCR
breakpoint cluster region
chrX_-_130250880 0.749 IGSF1
immunoglobulin superfamily, member 1
chr7_+_1094248 0.746 NM_001098201
GPER
G protein-coupled estrogen receptor 1
chr22_-_40856821 0.736 NM_000106
NM_001025161
CYP2D6

cytochrome P450, family 2, subfamily D, polypeptide 6

chr7_+_72720256 0.734 VPS37D
vacuolar protein sorting 37 homolog D (S. cerevisiae)
chr19_+_52214885 0.732 NPAS1
neuronal PAS domain protein 1
chrX_-_130250715 0.731 NM_001170963
IGSF1
immunoglobulin superfamily, member 1
chr11_+_7463175 0.730 NM_198474
OLFML1
olfactomedin-like 1
chr2_-_144994038 0.726 ZEB2
zinc finger E-box binding homeobox 2
chr1_-_154205675 0.721 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr17_+_53769659 0.716 LOC100506779
hypothetical LOC100506779
chr5_-_134397740 0.714 NM_002653
PITX1
paired-like homeodomain 1
chr16_+_56616782 0.713 NM_002428
MMP15
matrix metallopeptidase 15 (membrane-inserted)
chr13_+_99432258 0.708 NM_007129
ZIC2
Zic family member 2 (odd-paired homolog, Drosophila)
chr11_-_118722575 0.707 NM_015645
NM_031433
C1QTNF5
MFRP
C1q and tumor necrosis factor related protein 5
membrane frizzled-related protein
chr2_-_190635566 0.702 NM_005259
MSTN
myostatin
chr12_+_54700955 0.694 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr1_-_205186330 0.694 NM_002644
PIGR
polymeric immunoglobulin receptor
chr6_+_31976754 0.690 NM_001178063
C2
complement component 2
chr6_+_26212082 0.690 NM_003542
HIST1H4C
histone cluster 1, H4c
chrX_-_153290697 0.686 NM_006730
DNASE1L1
deoxyribonuclease I-like 1
chr17_-_60988226 0.668 AXIN2
axin 2
chr7_+_129807467 0.665 NM_001868
CPA1
carboxypeptidase A1 (pancreatic)
chr10_+_101532450 0.663 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr3_+_44601457 0.658 NM_173658
ZNF660
zinc finger protein 660
chr12_+_6768934 0.650 NM_001195014
NM_001195015
NM_001195016
NM_001195017
CD4



CD4 molecule



chr18_-_71268576 0.649 NM_001037331
C18orf62
chromosome 18 open reading frame 62
chr21_-_42608531 0.649 TFF3
trefoil factor 3 (intestinal)
chr2_-_198248828 0.648 NM_144629
RFTN2
raftlin family member 2
chr10_+_101532544 0.646 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr12_+_130004404 0.646 NM_198827
GPR133
G protein-coupled receptor 133
chr12_-_7136147 0.644 NM_001733
C1R
complement component 1, r subcomponent
chr3_+_197427779 0.641 NM_152672
OSTalpha
organic solute transporter alpha
chr2_-_144994349 0.636 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr9_-_135594715 0.628 NM_007101
SARDH
sarcosine dehydrogenase
chr17_-_31352720 0.628 CCL14-CCL15
CCL14-CCL15 read-through transcript
chr6_-_35804337 0.628 NM_001145775
FKBP5
FK506 binding protein 5
chr19_+_54160468 0.626 FTL
ferritin, light polypeptide
chr19_+_54160399 0.625 FTL
ferritin, light polypeptide
chr6_+_43247179 0.625 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr12_-_120781002 0.625 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr17_-_37599953 0.622 NM_001142622
NM_001142623
NM_032484
GHDC


GH3 domain containing


chr16_+_751050 0.621 NM_013404
MSLN
mesothelin
chr15_+_57696200 0.617 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr12_+_6768960 0.616 CD4
CD4 molecule
chr16_-_2970474 0.615 NM_004203
NM_182687
PKMYT1

protein kinase, membrane associated tyrosine/threonine 1

chr2_+_242146791 0.615 NM_032515
BOK
BCL2-related ovarian killer
chr1_+_95355415 0.614 NM_152487
TMEM56
transmembrane protein 56
chr11_-_67032125 0.611 CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr9_+_135233047 0.610 NM_153710
C9orf96
chromosome 9 open reading frame 96
chr19_+_54160369 0.604 NM_000146
FTL
ferritin, light polypeptide
chr22_-_22970850 0.603 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chrX_+_70438352 0.600 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr2_+_171280182 0.600


chr1_-_228916470 0.598 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr10_+_70745615 0.598 NM_033496
HK1
hexokinase 1
chr19_+_2818332 0.595 NM_024967
ZNF556
zinc finger protein 556
chr11_-_118799452 0.595 NM_006288
THY1
Thy-1 cell surface antigen
chr1_-_228916486 0.594 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr16_-_2970390 0.589 PKMYT1
protein kinase, membrane associated tyrosine/threonine 1
chr11_-_62213577 0.588 LRRN4CL
LRRN4 C-terminal like
chr5_-_114965959 0.586 NM_021649
TICAM2
toll-like receptor adaptor molecule 2
chr9_-_139084833 0.585 NM_178448
C9orf140
chromosome 9 open reading frame 140
chr1_-_56817823 0.584 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr2_+_28469199 0.583 FOSL2
FOS-like antigen 2
chr22_-_40856736 0.579 CYP2D6
cytochrome P450, family 2, subfamily D, polypeptide 6
chr1_+_1812769 0.576 LOC100132093
hypothetical protein LOC100132093
chr12_+_108038774 0.576 ACACB
acetyl-CoA carboxylase beta
chr6_-_32259974 0.573 NM_001136
NM_172197
AGER

advanced glycosylation end product-specific receptor

chr12_+_6768966 0.569 CD4
CD4 molecule
chr12_-_23993830 0.565 NM_006940
SOX5
SRY (sex determining region Y)-box 5
chr10_-_105410840 0.565


chr22_+_21116283 0.562


chr1_-_26105954 0.560 NM_203399
STMN1
stathmin 1
chr11_+_113280727 0.559 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr7_+_72720093 0.558 NM_001077621
VPS37D
vacuolar protein sorting 37 homolog D (S. cerevisiae)
chr11_+_117982422 0.553 NM_015157
PHLDB1
pleckstrin homology-like domain, family B, member 1
chr19_-_54093749 0.553 NM_003323
TULP2
tubby like protein 2
chr5_-_142057692 0.550 NM_001144934
NM_001144935
FGF1

fibroblast growth factor 1 (acidic)

chr2_+_233099113 0.550 NM_000751
CHRND
cholinergic receptor, nicotinic, delta
chr8_+_17478214 0.544 NM_006207
PDGFRL
platelet-derived growth factor receptor-like
chr9_-_103185621 0.542 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr8_+_40130143 0.541 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr6_+_33495824 0.540 NM_006772
SYNGAP1
synaptic Ras GTPase activating protein 1
chr16_+_51690564 0.539 CHD9
chromodomain helicase DNA binding protein 9
chrX_+_152562013 0.538 DUSP9
dual specificity phosphatase 9
chr1_+_228949752 0.538 NM_006615
NM_016452
CAPN9

calpain 9

chr9_-_115880494 0.533 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr7_-_6490375 0.532 KDELR2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr5_+_60969392 0.532 NM_173667
FLJ37543
hypothetical protein FLJ37543
chr18_-_3001944 0.531 NM_014646
LPIN2
lipin 2
chr2_-_96145614 0.528 NM_000682
ADRA2B
adrenergic, alpha-2B-, receptor
chr8_-_145672525 0.527 NM_003923
FOXH1
forkhead box H1
chr11_+_57547928 0.524 NM_001005212
OR9Q1
olfactory receptor, family 9, subfamily Q, member 1
chr6_+_43246897 0.520 NM_003131
SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr5_+_140690387 0.520 NM_018912
NM_031993
PCDHGA1

protocadherin gamma subfamily A, 1

chr12_+_56290229 0.516 NM_001111270
ARHGEF25
Rho guanine nucleotide exchange factor (GEF) 25
chr4_+_41309482 0.516 LIMCH1
LIM and calponin homology domains 1
chr6_-_85529031 0.513 TBX18
T-box 18
chr1_-_20179495 0.512 NM_000300
NM_001161727
NM_001161728
PLA2G2A


phospholipase A2, group IIA (platelets, synovial fluid)


chr2_+_11600287 0.509 NM_033090
GREB1
growth regulation by estrogen in breast cancer 1
chr11_+_63864263 0.508 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr6_+_167504070 0.507 NM_001145121
TCP10L2
TCP10
t-complex 10-like 2 (mouse)
t-complex 10 homolog (mouse)
chr2_+_73973640 0.505 ACTG2
actin, gamma 2, smooth muscle, enteric
chr17_-_40344203 0.505 GFAP
glial fibrillary acidic protein
chr6_+_43247168 0.502 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr2_+_30523586 0.501 NM_182551
NM_001002257
LCLAT1

lysocardiolipin acyltransferase 1

chr1_+_238321794 0.496 NM_020066
FMN2
formin 2
chr7_-_150605112 0.492 NM_003078
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr21_+_46342440 0.487 NM_001849
NM_058174
NM_058175
COL6A2


collagen, type VI, alpha 2


chr22_+_20068039 0.487 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr1_+_179164195 0.484


chr6_+_30212488 0.484 NM_138700
TRIM40
tripartite motif containing 40
chr21_-_42608774 0.479 NM_003226
TFF3
trefoil factor 3 (intestinal)
chr1_+_31655607 0.476 NM_001199037
SERINC2
serine incorporator 2
chr11_+_46255737 0.476 NM_052854
CREB3L1
cAMP responsive element binding protein 3-like 1
chr19_+_810658 0.475 NM_001928
CFD
complement factor D (adipsin)
chr20_-_3610635 0.473 NM_025220
NM_153202
ADAM33

ADAM metallopeptidase domain 33

chr16_+_631828 0.472 NM_138418
FAM195A
family with sequence similarity 195, member A
chr2_+_170074457 0.469 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr4_+_41309690 0.469 LIMCH1
LIM and calponin homology domains 1
chr15_+_78858763 0.468 NM_018689
KIAA1199
KIAA1199
chr19_-_51081147 0.467 NM_015649
IRF2BP1
interferon regulatory factor 2 binding protein 1
chr4_-_23500706 0.465 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr2_+_113709553 0.464 LOC654433
hypothetical LOC654433

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.90 2.35e-02 GO:0042044 fluid transport

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.24 3.40e-02 GO:0005576 extracellular region

Nothing significant found in function category.