Motif ID: GLI1..3.p2

Z-value: 0.531


Transcription factors associated with GLI1..3.p2:

Gene SymbolEntrez IDGene Name
GLI1 2735 glioma-associated oncogene homolog 1 (zinc finger protein)
GLI2 2736 GLI-Kruppel family member GLI2
GLI3 2737 GLI-Kruppel family member GLI3



Activity profile for motif GLI1..3.p2.

activity profile for motif GLI1..3.p2


Sorted Z-values histogram for motif GLI1..3.p2

Sorted Z-values for motif GLI1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GLI1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_149699185 1.245 NM_014374
REPIN1
replication initiator 1
chr1_-_75854281 1.118 SLC44A5
solute carrier family 44, member 5
chr12_-_3732614 1.077 NM_001144958
NM_001144959
NM_032680
EFCAB4B


EF-hand calcium binding domain 4B


chr16_-_3049336 1.076


chr19_-_10900086 1.048 NM_024029
YIPF2
Yip1 domain family, member 2
chr20_-_48686832 0.986 NM_080829
FAM65C
family with sequence similarity 65, member C
chr1_-_11909042 0.974 NM_138346
KIAA2013
KIAA2013
chr4_+_1764802 0.964 NM_000142
NM_001163213
NM_022965
FGFR3


fibroblast growth factor receptor 3


chr16_+_66153810 0.961 NM_001191022
NM_006565
CTCF

CCCTC-binding factor (zinc finger protein)

chr14_+_104218487 0.941


chr19_+_10900419 0.937 NM_138358
C19orf52
chromosome 19 open reading frame 52
chr2_-_192767844 0.933 NM_016192
TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr1_-_209818675 0.920 NM_021194
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr11_+_58980986 0.909 NM_001004708
OR4D6
olfactory receptor, family 4, subfamily D, member 6
chr12_-_3732478 0.890 EFCAB4B
EF-hand calcium binding domain 4B
chr6_+_44076281 0.879 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chr1_-_38285033 0.879 NM_002699
POU3F1
POU class 3 homeobox 1
chr1_+_148090804 0.877 NM_021059
NM_001005464
HIST2H3C
HIST2H3A
histone cluster 2, H3c
histone cluster 2, H3a
chr4_+_72271218 0.866 NM_001098484
NM_001134742
SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr11_-_404975 0.849 NM_001135054
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr19_+_10900502 0.833 C19orf52
chromosome 19 open reading frame 52
chr11_-_118055564 0.827 NM_007180
TREH
trehalase (brush-border membrane glycoprotein)
chr13_-_40138607 0.802 NM_002015
FOXO1
forkhead box O1
chr1_-_209818576 0.789 SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr19_+_38485583 0.778 LOC80054
hypothetical LOC80054
chr7_+_68702252 0.773 AUTS2
autism susceptibility candidate 2
chr16_-_82778071 0.772 NM_005679
NM_139353
TAF1C

TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa

chr22_-_49317408 0.759 ODF3B
outer dense fiber of sperm tails 3B
chr2_-_154043403 0.759 NM_019845
RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
chr3_+_49566901 0.757 NM_003458
BSN
bassoon (presynaptic cytomatrix protein)
chr2_-_26058831 0.753 KIF3C
kinesin family member 3C
chr11_-_3035172 0.748 NM_001014437
NM_001194997
NM_001751
NM_139273
CARS



cysteinyl-tRNA synthetase



chr1_-_151784889 0.746 NM_002961
NM_019554
S100A4

S100 calcium binding protein A4

chr1_-_16411690 0.737 NM_153213
ARHGEF19
Rho guanine nucleotide exchange factor (GEF) 19
chr1_-_45081190 0.732 NM_001166292
NM_003738
PTCH2

patched 2

chr1_-_6343306 0.722 NM_181865
ACOT7
acyl-CoA thioesterase 7
chr16_+_1979959 0.698 NM_004209
SYNGR3
synaptogyrin 3
chr7_+_72883128 0.697 NM_001305
CLDN4
claudin 4
chr19_-_63565890 0.691 NM_198458
ZNF497
zinc finger protein 497
chr4_+_4912272 0.680 NM_002448
MSX1
msh homeobox 1
chr2_-_242096673 0.677 NM_006374
STK25
serine/threonine kinase 25
chr9_-_97318760 0.668 PTCH1
patched 1
chr8_+_21972804 0.668 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr11_+_9736408 0.660 LOC283104
hypothetical LOC283104
chr17_-_39632845 0.659 ATXN7L3
ataxin 7-like 3
chr17_+_35751796 0.652 NM_001024809
RARA
retinoic acid receptor, alpha
chr6_+_33280396 0.651 NM_014234
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr4_-_140696740 0.643 NM_030648
SETD7
SET domain containing (lysine methyltransferase) 7
chr1_-_39877928 0.642 NM_014571
HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr9_+_8848130 0.639


chr19_+_16296632 0.631 NM_016270
KLF2
Kruppel-like factor 2 (lung)
chr7_-_23476156 0.629


chr17_-_17340219 0.625 NM_016084
RASD1
RAS, dexamethasone-induced 1
chr16_+_56259657 0.625 NM_170776
GPR97
G protein-coupled receptor 97
chr1_-_1300680 0.624 NM_017900
AURKAIP1
aurora kinase A interacting protein 1
chr8_+_21937533 0.621 NPM2
nucleophosmin/nucleoplasmin 2
chr17_+_71141108 0.618 NM_001162995
LOC643008
hypothetical protein LOC643008
chr12_+_110328126 0.613 NM_005475
SH2B3
SH2B adaptor protein 3
chr1_-_39877883 0.606 HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr22_+_46406115 0.603 LOC284930
hypothetical protein LOC284930
chr8_+_21972631 0.602 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr9_+_139292094 0.602 NM_017723
C9orf167
chromosome 9 open reading frame 167
chr1_-_24307514 0.601 MYOM3
myomesin family, member 3
chr7_-_99871981 0.599 NM_145030
C7orf47
chromosome 7 open reading frame 47
chr19_-_11477689 0.598 NM_138783
ZNF653
zinc finger protein 653
chr2_+_109112428 0.596 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr5_+_122452739 0.595 NM_001136239
PRDM6
PR domain containing 6
chr20_+_41576459 0.584 NM_015478
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr19_-_60573552 0.582 NM_000641
IL11
interleukin 11
chr2_+_172658453 0.580 NM_001038493
NM_178120
DLX1

distal-less homeobox 1

chr11_-_32413486 0.580 WT1
Wilms tumor 1
chr16_+_30952350 0.578 STX4
syntaxin 4
chr14_+_106009489 0.577 NCRNA00221
non-protein coding RNA 221
chr6_+_19946591 0.575


chr22_+_18090118 0.572 SEPT5-GP1BB
SEPT5-GP1BB read-through transcript
chr19_+_16296734 0.570 KLF2
Kruppel-like factor 2 (lung)
chr11_+_65236261 0.567 KAT5
K(lysine) acetyltransferase 5
chr17_+_4795128 0.565 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr22_+_45401321 0.563 NM_015124
GRAMD4
GRAM domain containing 4
chr12_-_111304138 0.562 NM_001109662
C12orf51
chromosome 12 open reading frame 51
chr7_+_68701704 0.557 NM_001127231
NM_001127232
NM_015570
AUTS2


autism susceptibility candidate 2


chr7_-_102044374 0.556 RASA4
RAS p21 protein activator 4
chr17_-_60401967 0.555 AMZ2P1
archaelysin family metallopeptidase 2 pseudogene 1
chr19_+_63670148 0.553 NM_014347
ZNF324
zinc finger protein 324
chr17_-_71272811 0.553 NM_000154
GALK1
galactokinase 1
chr18_-_17434811 0.552 ESCO1
establishment of cohesion 1 homolog 1 (S. cerevisiae)
chr16_-_73842884 0.547 NM_001170717
NM_014567
BCAR1

breast cancer anti-estrogen resistance 1

chr2_-_200030944 0.545 NM_001172509
SATB2
SATB homeobox 2
chr1_+_22224571 0.543 HSPC157
hypothetical LOC29092
chr1_+_32251988 0.543 NM_006559
KHDRBS1
KH domain containing, RNA binding, signal transduction associated 1
chr7_-_27180398 0.539 NM_018951
HOXA10
homeobox A10
chr2_+_96845704 0.536 NM_017623
NM_199078
CNNM3

cyclin M3

chr12_-_55696542 0.535 NM_001178054
NM_013251
TAC3

tachykinin 3

chr17_+_14145051 0.533 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr16_-_16224791 0.531 NM_001079528
NM_001171
ABCC6

ATP-binding cassette, sub-family C (CFTR/MRP), member 6

chr19_+_2240996 0.530


chr8_-_41774296 0.529 NM_000037
NM_020475
NM_020476
NM_020477
ANK1



ankyrin 1, erythrocytic



chr22_-_17545872 0.529 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr9_-_85761472 0.527 NM_032307
C9orf64
chromosome 9 open reading frame 64
chr19_+_811615 0.522 CFD
complement factor D (adipsin)
chr19_+_482737 0.522 CDC34
cell division cycle 34 homolog (S. cerevisiae)
chr19_-_53832381 0.521 NM_001352
DBP
D site of albumin promoter (albumin D-box) binding protein
chr9_-_98368913 0.519 NM_001077181
CDC14B
CDC14 cell division cycle 14 homolog B (S. cerevisiae)
chr2_+_19932101 0.517 FLJ12334
hypothetical LOC400946
chr6_+_3009120 0.516 RIPK1
receptor (TNFRSF)-interacting serine-threonine kinase 1
chr12_-_55316350 0.514 NM_013449
BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr18_+_13208777 0.511 NM_181481
NM_181482
C18orf1

chromosome 18 open reading frame 1

chr16_+_30952382 0.510 NM_004604
STX4
syntaxin 4
chr15_+_38520594 0.509 NM_014952
BAHD1
bromo adjacent homology domain containing 1
chr2_+_220200530 0.508 NM_005070
NM_201574
SLC4A3

solute carrier family 4, anion exchanger, member 3

chr17_-_8474733 0.507 NM_005964
MYH10
myosin, heavy chain 10, non-muscle
chr5_-_177950161 0.506 NM_173465
COL23A1
collagen, type XXIII, alpha 1
chr14_-_73296387 0.504 C14orf43
chromosome 14 open reading frame 43
chr17_+_45008473 0.503 NXPH3
neurexophilin 3
chr16_+_67778441 0.501 NM_006750
SNTB2
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
chr16_-_2521359 0.497 NM_001048212
CEMP1
cementum protein 1
chr16_+_705080 0.494 NM_024042
METRN
meteorin, glial cell differentiation regulator
chr7_-_1034453 0.493 C7orf50
chromosome 7 open reading frame 50
chr2_-_242096592 0.486 STK25
serine/threonine kinase 25
chr7_-_102044419 0.486 NM_001079877
NM_006989
RASA4

RAS p21 protein activator 4

chr19_-_54618410 0.485 NM_178449
PTH2
parathyroid hormone 2
chr21_-_32906729 0.484 NM_021254
C21orf59
chromosome 21 open reading frame 59
chr11_-_18913121 0.481 NM_147199
MRGPRX1
MAS-related GPR, member X1
chr14_-_103058568 0.480 CKB
creatine kinase, brain
chr2_+_178685396 0.478 NM_152945
RBM45
RNA binding motif protein 45
chr17_-_37181626 0.478


chr16_+_85169615 0.476 NM_005250
FOXL1
forkhead box L1
chr18_-_42798364 0.474 NM_001100817
TCEB3C
TCEB3CL
transcription elongation factor B polypeptide 3C (elongin A3)
transcription elongation factor B polypeptide 3C-like
chr17_+_37693090 0.473 NM_003152
STAT5A
signal transducer and activator of transcription 5A
chr8_+_31616809 0.473 NM_013962
NRG1
neuregulin 1
chr1_+_11646735 0.472 NM_018438
FBXO6
F-box protein 6
chr22_-_17546276 0.472 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr11_-_65871592 0.471 NM_006876
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr22_+_18388656 0.470 C22orf25
chromosome 22 open reading frame 25
chr22_-_17546234 0.469 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr16_-_2258067 0.467 RNPS1
RNA binding protein S1, serine-rich domain
chr17_-_34811377 0.466 NM_001184906
NM_032875
FBXL20

F-box and leucine-rich repeat protein 20

chr10_+_52420936 0.464 NM_001098512
PRKG1
protein kinase, cGMP-dependent, type I
chr17_-_1342700 0.464 NM_001080779
MYO1C
myosin IC
chr8_-_10550026 0.463 NM_178857
RP1L1
retinitis pigmentosa 1-like 1
chr5_-_179712920 0.463 NM_005110
GFPT2
glutamine-fructose-6-phosphate transaminase 2
chr1_-_152202574 0.463 SLC39A1
solute carrier family 39 (zinc transporter), member 1
chr20_-_48741481 0.461


chr3_+_50272648 0.460


chr19_+_63654766 0.459 NM_207395
ZNF324B
zinc finger protein 324B
chr17_+_7283412 0.457 NM_004112
FGF11
fibroblast growth factor 11
chr22_-_17546296 0.456 NM_005984
SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr2_+_96355661 0.455 NM_178495
NM_001163524
ITPRIPL1

inositol 1,4,5-triphosphate receptor interacting protein-like 1

chr20_-_34102250 0.455 LOC647979
hypothetical LOC647979
chr2_-_6923215 0.454 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr5_+_176449156 0.453 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr16_+_29581783 0.452 NM_001030288
SPN
sialophorin
chr9_-_85761451 0.452 C9orf64
chromosome 9 open reading frame 64
chr17_+_45703765 0.451 NM_001168215
TMEM92
transmembrane protein 92
chr7_-_126819953 0.450 NM_176814
ZNF800
zinc finger protein 800
chr14_+_76297885 0.445 NM_014909
VASH1
vasohibin 1
chr22_-_49050847 0.445 NM_002751
MAPK11
mitogen-activated protein kinase 11
chr1_-_16812274 0.445 NM_017940
NBPF1
neuroblastoma breakpoint family, member 1
chr22_+_18388633 0.444 C22orf25
chromosome 22 open reading frame 25
chr17_-_7238546 0.444 NM_020360
PLSCR3
phospholipid scramblase 3
chr7_-_23476497 0.444 NM_006547
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr5_+_71438796 0.442 NM_005909
MAP1B
microtubule-associated protein 1B
chr8_-_142080169 0.440 NM_005607
NM_153831
PTK2

PTK2 protein tyrosine kinase 2

chr1_-_32574185 0.439 NM_023009
MARCKSL1
MARCKS-like 1
chr10_+_52421120 0.438 PRKG1
protein kinase, cGMP-dependent, type I
chr11_+_122806196 0.438 LOC100128242
hypothetical LOC100128242
chr11_+_10434056 0.438 NM_001025390
AMPD3
adenosine monophosphate deaminase 3
chr19_-_48700824 0.438 NM_198850
PHLDB3
pleckstrin homology-like domain, family B, member 3
chr2_+_149119029 0.434 NM_015630
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr1_-_39929654 0.433 NM_016257
HPCAL4
hippocalcin like 4
chr5_-_1397941 0.432 NM_030782
CLPTM1L
CLPTM1-like
chr14_+_103165244 0.432 NM_001130107
NM_005552
NM_182923
KLC1


kinesin light chain 1


chr2_+_173927783 0.431 NM_031942
NM_145810
CDCA7

cell division cycle associated 7

chr10_+_129237602 0.430 NM_001030013
NPS
neuropeptide S
chr7_+_119700924 0.429 NM_012281
KCND2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr19_+_935316 0.429 NM_024100
WDR18
WD repeat domain 18
chr16_-_29818334 0.425 SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr1_-_1300385 0.425 AURKAIP1
aurora kinase A interacting protein 1
chr3_+_3816079 0.424 NM_020873
LRRN1
leucine rich repeat neuronal 1
chr15_-_38834740 0.424 NM_018145
FAM82A2
family with sequence similarity 82, member A2
chr11_-_64268126 0.423 NM_001098671
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr20_+_61655934 0.420


chr1_-_1300416 0.417 NM_001127230
NM_001127229
AURKAIP1

aurora kinase A interacting protein 1

chr6_-_3697244 0.417 NM_183373
C6orf145
chromosome 6 open reading frame 145
chr12_-_6680053 0.417 NM_153685
C12orf53
chromosome 12 open reading frame 53
chr17_-_3740785 0.416 NM_172206
CAMKK1
calcium/calmodulin-dependent protein kinase kinase 1, alpha
chr1_+_26986996 0.416 NM_017837
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr19_+_60851207 0.415 CCDC106
coiled-coil domain containing 106
chr16_+_48865521 0.415 ADCY7
adenylate cyclase 7
chr14_+_99181232 0.414 NM_001127258
NM_032425
HHIPL1

HHIP-like 1

chr9_+_130620540 0.414 NM_004435
ENDOG
endonuclease G
chr11_+_63766163 0.413 NM_057092
FKBP2
FK506 binding protein 2, 13kDa
chr20_+_31783426 0.411 NM_032819
ZNF341
zinc finger protein 341
chr5_+_175725050 0.408 NM_173664
ARL10
ADP-ribosylation factor-like 10
chr1_+_28568643 0.408 NM_001048183
PHACTR4
phosphatase and actin regulator 4
chr11_+_76455574 0.408 NM_004055
CAPN5
calpain 5
chr3_-_193609531 0.407 NM_021032
FGF12
fibroblast growth factor 12
chr20_-_36095236 0.407 NM_014657
TTI1
Tel2 interacting protein 1 homolog (S. pombe)
chr3_-_50580066 0.406 NM_001171740
NM_001171743
NM_016210
C3orf18


chromosome 3 open reading frame 18


chr4_-_5071996 0.406 NM_018659
CYTL1
cytokine-like 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.13 1.91e-06 GO:0065007 biological regulation
1.39 3.09e-06 GO:0007399 nervous system development
1.31 1.56e-05 GO:0030154 cell differentiation
1.31 1.59e-05 GO:0048869 cellular developmental process
1.35 2.04e-05 GO:0023051 regulation of signaling
1.38 2.06e-05 GO:0009966 regulation of signal transduction
1.14 2.21e-05 GO:0050794 regulation of cellular process
1.26 3.43e-05 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.13 6.29e-05 GO:0050789 regulation of biological process
1.31 8.56e-05 GO:0048583 regulation of response to stimulus
1.35 1.29e-04 GO:0009653 anatomical structure morphogenesis
1.24 1.45e-04 GO:0051171 regulation of nitrogen compound metabolic process
1.21 1.70e-04 GO:0031323 regulation of cellular metabolic process
1.24 2.20e-04 GO:0048731 system development
1.45 2.97e-04 GO:0022008 neurogenesis
1.24 3.33e-04 GO:0031326 regulation of cellular biosynthetic process
1.46 3.41e-04 GO:0048699 generation of neurons
1.27 4.39e-04 GO:0006355 regulation of transcription, DNA-dependent
1.20 4.84e-04 GO:0080090 regulation of primary metabolic process
1.24 5.41e-04 GO:0009889 regulation of biosynthetic process
1.26 8.52e-04 GO:0051252 regulation of RNA metabolic process
1.21 9.68e-04 GO:0048856 anatomical structure development
1.18 1.01e-03 GO:0019222 regulation of metabolic process
1.24 1.30e-03 GO:0010556 regulation of macromolecule biosynthetic process
1.24 1.37e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.19 1.71e-03 GO:0007275 multicellular organismal development
1.62 2.75e-03 GO:0007409 axonogenesis
1.60 2.99e-03 GO:0048812 neuron projection morphogenesis
1.18 3.40e-03 GO:0032502 developmental process
1.46 6.18e-03 GO:0030182 neuron differentiation
1.37 7.66e-03 GO:0009605 response to external stimulus
1.58 8.04e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.53 1.06e-02 GO:0031175 neuron projection development
1.37 1.09e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.65 1.38e-02 GO:0007411 axon guidance
1.46 1.43e-02 GO:0030030 cell projection organization
1.21 1.54e-02 GO:0010468 regulation of gene expression
1.52 1.58e-02 GO:0048858 cell projection morphogenesis
1.23 1.77e-02 GO:0048523 negative regulation of cellular process
1.46 1.84e-02 GO:0032989 cellular component morphogenesis
1.18 2.05e-02 GO:0060255 regulation of macromolecule metabolic process
1.20 2.07e-02 GO:0048518 positive regulation of biological process
1.51 2.39e-02 GO:0032990 cell part morphogenesis
1.59 2.80e-02 GO:0051056 regulation of small GTPase mediated signal transduction
1.21 3.83e-02 GO:0048519 negative regulation of biological process
1.48 4.38e-02 GO:0045892 negative regulation of transcription, DNA-dependent
1.71 4.96e-02 GO:0046578 regulation of Ras protein signal transduction

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.55 6.54e-06 GO:0043565 sequence-specific DNA binding
1.39 3.30e-04 GO:0030528 transcription regulator activity
1.10 2.11e-03 GO:0005515 protein binding
1.35 3.73e-03 GO:0001071 nucleic acid binding transcription factor activity
1.35 3.73e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.62 1.01e-02 GO:0016564 transcription repressor activity
1.59 1.84e-02 GO:0016563 transcription activator activity
1.62 1.94e-02 GO:0005083 small GTPase regulator activity
1.77 2.20e-02 GO:0003682 chromatin binding
1.20 2.91e-02 GO:0003677 DNA binding