Motif ID: HMX1.p2

Z-value: 1.319


Transcription factors associated with HMX1.p2:

Gene SymbolEntrez IDGene Name
HMX1 3166 H6 family homeobox 1



Activity profile for motif HMX1.p2.

activity profile for motif HMX1.p2


Sorted Z-values histogram for motif HMX1.p2

Sorted Z-values for motif HMX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_58750305 3.295 NM_001079907
ZNF331
zinc finger protein 331
chr11_+_131286513 3.289 NTM
neurotrimin
chr4_-_11039600 2.328 NM_005114
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr12_-_47604930 2.120 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr3_-_112796855 1.831 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr4_+_91267706 1.789 NM_001145065
FAM190A
family with sequence similarity 190, member A
chr8_+_32525269 1.733 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr1_-_58815415 1.677 TACSTD2
tumor-associated calcium signal transducer 2
chrX_+_48915127 1.658 NM_002668
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr19_+_43447078 1.575 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr19_+_43446937 1.565 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr21_-_31853160 1.550 NM_003253
TIAM1
T-cell lymphoma invasion and metastasis 1
chr19_-_11352850 1.506 EPOR
erythropoietin receptor
chr13_+_42046182 1.487 NM_003701
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr1_-_86394695 1.430 NM_152890
COL24A1
collagen, type XXIV, alpha 1
chr17_-_40695216 1.386 NM_152343
C17orf46
chromosome 17 open reading frame 46
chr1_-_231498081 1.384 NM_014801
PCNXL2
pecanex-like 2 (Drosophila)
chr19_+_43447262 1.315 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr1_-_197173159 1.314 LOC100131234
familial acute myelogenous leukemia related factor
chr1_+_234372454 1.289 NM_003272
GPR137B
G protein-coupled receptor 137B
chr8_-_29263714 1.268 NM_001394
DUSP4
dual specificity phosphatase 4
chr11_+_69602055 1.267 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr13_+_24152548 1.267 NM_001185085
NM_001676
ATP12A

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

chr9_-_109290107 1.247 KLF4
Kruppel-like factor 4 (gut)
chr19_-_63643400 1.196 NM_003433
ZNF132
zinc finger protein 132
chr19_+_58733144 1.168 NM_001079906
ZNF331
zinc finger protein 331
chr7_+_143683365 1.161 NM_005435
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr12_+_120840829 1.150 NM_001178003
NM_144668
WDR66

WD repeat domain 66

chr10_-_113933457 1.138 NM_020918
GPAM
glycerol-3-phosphate acyltransferase, mitochondrial
chr22_-_35970230 1.132 NM_002872
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr22_-_35970133 1.118 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr7_-_143523582 1.094 NM_001003702
ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35
chr7_-_143622233 1.074 ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35
chr21_-_38954433 1.073 ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr11_-_407324 1.043 NM_001135053
NM_021805
SIGIRR

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

chr17_+_77582774 1.035 NM_005052
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr3_-_11736946 1.027 NM_014667
VGLL4
vestigial like 4 (Drosophila)
chr4_-_177950658 1.026 NM_005429
VEGFC
vascular endothelial growth factor C
chr9_+_123501186 1.025 DAB2IP
DAB2 interacting protein
chr4_+_81325447 1.014 NM_020226
PRDM8
PR domain containing 8
chr16_-_85099941 1.013 LOC400550
hypothetical LOC400550
chr7_-_143622188 0.999 ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr17_-_6887965 0.995 NM_153357
SLC16A11
solute carrier family 16, member 11 (monocarboxylic acid transporter 11)
chr5_-_139992621 0.990 NM_000591
CD14
CD14 molecule
chr19_-_62912347 0.977 NM_001085384
ZNF154
zinc finger protein 154
chr6_+_41714171 0.969 NM_005586
MDFI
MyoD family inhibitor
chr5_-_9599157 0.964 NM_003966
SEMA5A
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr8_+_120497732 0.963 NM_002514
NOV
nephroblastoma overexpressed gene
chr5_+_148186348 0.962 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr17_-_7106497 0.958 CLDN7
claudin 7
chr5_+_96024434 0.941 CAST
calpastatin
chr6_-_56824371 0.930 DST
dystonin
chr18_-_44189625 0.928 ZBTB7C
zinc finger and BTB domain containing 7C
chr9_-_129656413 0.926 ENG
endoglin
chr15_-_80123935 0.903 MEX3B
mex-3 homolog B (C. elegans)
chr19_-_10558906 0.897 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr1_+_45565126 0.895 NM_032756
HPDL
4-hydroxyphenylpyruvate dioxygenase-like
chr2_-_133144094 0.890 LYPD1
LY6/PLAUR domain containing 1
chr1_+_155130146 0.886 NM_001080471
PEAR1
platelet endothelial aggregation receptor 1
chr12_-_29827952 0.871 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr1_-_55039458 0.868 NM_001114108
NM_017904
TTC22

tetratricopeptide repeat domain 22

chr15_+_39032927 0.855 NM_001142776
NM_024111
CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr5_+_176717553 0.853


chr17_+_1906262 0.850 NM_001098202
HIC1
hypermethylated in cancer 1
chr5_-_168660293 0.827 NM_003062
SLIT3
slit homolog 3 (Drosophila)
chr4_+_177223978 0.824 NM_170710
NM_181265
WDR17

WD repeat domain 17

chr8_+_102574012 0.810 GRHL2
grainyhead-like 2 (Drosophila)
chr1_+_151917674 0.808 NM_000906
NPR1
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
chr6_-_56824672 0.803 DST
dystonin
chr4_+_177224142 0.799 WDR17
WD repeat domain 17
chr5_-_115938305 0.797 NM_020796
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr17_-_72045218 0.788 NM_134268
CYGB
cytoglobin
chr11_+_66580861 0.783 NM_014578
RHOD
ras homolog gene family, member D
chr1_+_154297588 0.783 NM_020387
RAB25
RAB25, member RAS oncogene family
chr8_-_75396016 0.782 NM_020647
JPH1
junctophilin 1
chr12_-_57599571 0.779 NM_001136051
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr5_+_68746694 0.775 NM_001038603
MARVELD2
MARVEL domain containing 2
chr19_+_39860398 0.774 NM_001012320
NM_018443
ZNF302

zinc finger protein 302

chr2_-_73350103 0.774 NM_001080410
FBXO41
F-box protein 41
chr7_+_838663 0.769 NM_001130965
SUN1
Sad1 and UNC84 domain containing 1
chr3_+_120496180 0.764 ARHGAP31
Rho GTPase activating protein 31
chr1_+_63831479 0.762 NM_002633
PGM1
phosphoglucomutase 1
chr4_-_90977149 0.755 NM_001146054
NM_007308
NM_000345
SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr3_+_11171213 0.744 NM_001098212
HRH1
histamine receptor H1
chr16_+_65754788 0.743 NM_001040667
NM_001538
HSF4

heat shock transcription factor 4

chr21_+_25856311 0.739 MIR155HG
MIR155 host gene (non-protein coding)
chr19_-_49644470 0.734 NM_014518
ZNF229
zinc finger protein 229
chr8_+_102573837 0.730 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr1_+_35020425 0.716 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr9_-_23811477 0.709 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr8_-_119703361 0.697 NM_001101676
NM_207506
SAMD12

sterile alpha motif domain containing 12

chr9_-_129656581 0.694 ENG
endoglin
chr8_-_119703297 0.693 SAMD12
sterile alpha motif domain containing 12
chr12_+_4253143 0.692 NM_001759
CCND2
cyclin D2
chr1_-_115682374 0.692 NM_002506
NGF
nerve growth factor (beta polypeptide)
chr4_+_156900053 0.691 GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr18_-_20231709 0.676 OSBPL1A
oxysterol binding protein-like 1A
chr18_-_20231783 0.671 NM_080597
OSBPL1A
oxysterol binding protein-like 1A
chr15_-_66511488 0.665 NM_001004439
ITGA11
integrin, alpha 11
chr3_-_126414252 0.663 NM_024628
SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr16_-_17472238 0.663 NM_022166
XYLT1
xylosyltransferase I
chr10_-_105604942 0.660 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chr9_+_81376666 0.654 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr17_+_71229191 0.651 ITGB4
integrin, beta 4
chrX_-_100801472 0.649 NM_014782
NM_177949
ARMCX2

armadillo repeat containing, X-linked 2

chr8_+_24828359 0.645 NM_001105541
NEFM
neurofilament, medium polypeptide
chr12_-_15265490 0.645 NM_001190726
NM_032918
RERG

RAS-like, estrogen-regulated, growth inhibitor

chr9_-_129656778 0.643 ENG
endoglin
chr21_-_27261276 0.642 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr4_-_78038025 0.637 NM_001029870
ANKRD56
ankyrin repeat domain 56
chr6_+_86216457 0.634 NT5E
5'-nucleotidase, ecto (CD73)
chr18_+_54682261 0.633 ZNF532
zinc finger protein 532
chr12_+_84198015 0.632 NM_006982
ALX1
ALX homeobox 1
chr6_+_3794620 0.630 NM_012135
FAM50B
family with sequence similarity 50, member B
chr17_-_7106987 0.629 NM_001185023
NM_001307
CLDN7

claudin 7

chr17_-_8809656 0.626 NM_001142633
PIK3R5
phosphoinositide-3-kinase, regulatory subunit 5
chr9_-_84867604 0.625 RASEF
RAS and EF-hand domain containing
chr20_+_56701224 0.625 NM_024663
NPEPL1
aminopeptidase-like 1
chr5_+_88221013 0.613 RPS6
ribosomal protein S6
chr10_+_8137356 0.610 GATA3
GATA binding protein 3
chr11_-_127897271 0.606 NM_001162422
NM_005238
ETS1

v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

chr8_-_24828134 0.600 NEFM
neurofilament, medium polypeptide
chr3_+_57517013 0.600 NM_177966
PDE12
phosphodiesterase 12
chrX_-_131918905 0.596 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr3_+_128874458 0.590 NM_172027
ABTB1
ankyrin repeat and BTB (POZ) domain containing 1
chr6_-_128883125 0.590 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chrX_-_34585287 0.589 NM_031442
TMEM47
transmembrane protein 47
chr7_+_5609416 0.589 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr7_+_129919330 0.588 MEST
mesoderm specific transcript homolog (mouse)
chr14_-_88328848 0.587 NM_183387
EML5
echinoderm microtubule associated protein like 5
chr11_+_66381451 0.587 NM_024036
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr2_+_109729176 0.586 NM_023016
ANKRD57
ankyrin repeat domain 57
chr10_+_83625049 0.584 NM_001010848
NM_001165972
NRG3

neuregulin 3

chr14_+_62740878 0.583 NM_020663
RHOJ
ras homolog gene family, member J
chr5_+_176717449 0.581 NM_006480
RGS14
regulator of G-protein signaling 14
chr5_+_178419938 0.579 NM_014594
ZNF354C
zinc finger protein 354C
chr13_+_57105859 0.575 PCDH17
protocadherin 17
chr8_+_121206478 0.574 NM_021110
COL14A1
collagen, type XIV, alpha 1
chr3_-_18441763 0.572 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr8_+_31616809 0.570 NM_013962
NRG1
neuregulin 1
chr4_+_148621694 0.570 EDNRA
endothelin receptor type A
chr9_-_129656830 0.570 NM_000118
NM_001114753
ENG

endoglin

chr3_-_150858274 0.568 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr12_+_4300607 0.565 NM_020375
C12orf5
chromosome 12 open reading frame 5
chr4_-_142273881 0.564 NM_020724
RNF150
ring finger protein 150
chr12_+_52634950 0.562 NM_173860
HOXC12
homeobox C12
chr17_-_45427565 0.560 NM_005220
DLX3
distal-less homeobox 3
chr8_+_95722448 0.557 ESRP1
epithelial splicing regulatory protein 1
chrX_+_101887562 0.554 NM_001142529
NM_001142530
BHLHB9

basic helix-loop-helix domain containing, class B, 9

chr5_-_41906459 0.547 NM_000436
OXCT1
3-oxoacid CoA transferase 1
chr12_-_51887318 0.543 ITGB7
integrin, beta 7
chr12_-_26166485 0.542 BHLHE41
basic helix-loop-helix family, member e41
chr13_+_40929679 0.542 C13orf15
chromosome 13 open reading frame 15
chr5_+_60663842 0.541 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr13_+_40929690 0.540 C13orf15
chromosome 13 open reading frame 15
chr2_+_36436873 0.537 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr14_-_50631407 0.534 TRIM9
tripartite motif containing 9
chr17_+_21220260 0.532 NM_021012
KCNJ12
potassium inwardly-rectifying channel, subfamily J, member 12
chr11_-_605649 0.531 NM_004031
IRF7
interferon regulatory factor 7
chr1_-_215377718 0.530 NM_001134285
ESRRG
estrogen-related receptor gamma
chr13_-_37341859 0.524 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr13_-_113651815 0.520 NM_182614
FAM70B
family with sequence similarity 70, member B
chr17_-_1566223 0.519 C17orf91
chromosome 17 open reading frame 91
chr1_+_15446354 0.515 NM_052929
FHAD1
forkhead-associated (FHA) phosphopeptide binding domain 1
chr8_+_26427378 0.514 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr5_-_107034484 0.514 NM_001962
EFNA5
ephrin-A5
chr5_+_174084137 0.513 NM_002449
MSX2
msh homeobox 2
chr6_-_136913235 0.512 MAP7
microtubule-associated protein 7
chr5_-_136862130 0.511 SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr15_+_45263517 0.507 NM_001198999
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr8_-_72918697 0.502 MSC
musculin
chr2_-_175170674 0.501 WIPF1
WAS/WASL interacting protein family, member 1
chr18_-_20105644 0.500 OSBPL1A
oxysterol binding protein-like 1A
chr11_+_63463009 0.498 NM_024771
NAA40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr6_-_136913649 0.497 NM_001198616
NM_001198617
NM_003980
MAP7


microtubule-associated protein 7


chr12_-_78608873 0.496 NM_002583
PAWR
PRKC, apoptosis, WT1, regulator
chr17_-_25587079 0.494 NM_001045
SLC6A4
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
chr22_-_16020076 0.493 CECR5
cat eye syndrome chromosome region, candidate 5
chr4_+_102930856 0.490 BANK1
B-cell scaffold protein with ankyrin repeats 1
chr1_+_12149637 0.490 NM_001066
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr15_+_67009892 0.489 NM_145658
NM_001184780
SPESP1
NOX5
sperm equatorial segment protein 1
NADPH oxidase, EF-hand calcium binding domain 5
chr12_-_51887266 0.488 NM_000889
ITGB7
integrin, beta 7
chr15_+_81567327 0.484 NM_001144903
NM_023003
TM6SF1

transmembrane 6 superfamily member 1

chr5_-_41906216 0.483 OXCT1
3-oxoacid CoA transferase 1
chr7_-_37454933 0.482 NM_014800
ELMO1
engulfment and cell motility 1
chrX_-_134013644 0.482 NM_001078172
NM_001134321
FAM127B

family with sequence similarity 127, member B

chr18_+_12244317 0.480 NM_001279
CIDEA
cell death-inducing DFFA-like effector a
chr6_+_30002084 0.478


chr4_-_17392232 0.477 NM_015688
FAM184B
family with sequence similarity 184, member B
chr14_-_102593384 0.471 NM_006035
CDC42BPB
CDC42 binding protein kinase beta (DMPK-like)
chr4_+_102930786 0.470 NM_001127507
NM_017935
BANK1

B-cell scaffold protein with ankyrin repeats 1

chr19_-_47619992 0.470 LIPE
lipase, hormone-sensitive
chr3_-_16529996 0.470 RFTN1
raftlin, lipid raft linker 1
chr4_-_57216816 0.467 HOPX
HOP homeobox
chr14_+_61653827 0.465 FLJ43390
hypothetical LOC646113
chr19_-_2378581 0.465 TIMM13
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr1_-_207891264 0.463 NM_001017402
LAMB3
laminin, beta 3
chr9_-_135029096 0.461 NM_021996
GBGT1
RALGDS
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
ral guanine nucleotide dissociation stimulator
chr19_-_43570503 0.458 NM_152657
GGN
gametogenetin
chr19_+_40299058 0.458 FXYD3
FXYD domain containing ion transport regulator 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.50 4.21e-07 GO:0023051 regulation of signaling
1.18 4.22e-06 GO:0050794 regulation of cellular process
1.41 6.88e-06 GO:0030154 cell differentiation
1.41 2.30e-05 GO:0048583 regulation of response to stimulus
1.16 2.50e-05 GO:0050789 regulation of biological process
1.48 3.67e-05 GO:0009966 regulation of signal transduction
1.60 9.10e-05 GO:0022008 neurogenesis
1.88 9.70e-05 GO:0051094 positive regulation of developmental process
1.37 9.83e-05 GO:0048869 cellular developmental process
1.59 9.94e-05 GO:0048468 cell development
1.15 1.09e-04 GO:0065007 biological regulation
1.25 1.79e-04 GO:0023052 signaling
1.59 2.88e-04 GO:0048699 generation of neurons
1.87 3.40e-04 GO:0007409 axonogenesis
1.63 4.22e-04 GO:2000026 regulation of multicellular organismal development
1.78 5.76e-04 GO:0031175 neuron projection development
1.26 6.60e-04 GO:0007165 signal transduction
1.82 6.80e-04 GO:0048812 neuron projection morphogenesis
1.83 6.96e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.69 1.64e-03 GO:0048666 neuron development
1.74 1.85e-03 GO:0000904 cell morphogenesis involved in differentiation
1.40 1.97e-03 GO:0007399 nervous system development
1.48 2.35e-03 GO:0010646 regulation of cell communication
1.30 2.69e-03 GO:0048522 positive regulation of cellular process
3.10 2.73e-03 GO:0048762 mesenchymal cell differentiation
1.51 4.54e-03 GO:0050793 regulation of developmental process
1.62 4.77e-03 GO:0030030 cell projection organization
1.27 5.57e-03 GO:0048518 positive regulation of biological process
1.86 8.43e-03 GO:0045597 positive regulation of cell differentiation
2.83 8.76e-03 GO:0060485 mesenchyme development
1.68 9.85e-03 GO:0048858 cell projection morphogenesis
1.41 1.04e-02 GO:0051239 regulation of multicellular organismal process
1.57 1.08e-02 GO:0030182 neuron differentiation
3.03 1.22e-02 GO:0014031 mesenchymal cell development
1.67 1.38e-02 GO:0032990 cell part morphogenesis
1.87 1.52e-02 GO:0022603 regulation of anatomical structure morphogenesis
1.83 1.61e-02 GO:0007411 axon guidance
1.84 1.85e-02 GO:0060284 regulation of cell development
1.38 2.06e-02 GO:0035556 intracellular signal transduction
1.25 2.61e-02 GO:0048731 system development
3.63 3.40e-02 GO:0014033 neural crest cell differentiation
1.22 3.88e-02 GO:0048856 anatomical structure development
3.77 4.37e-02 GO:0014032 neural crest cell development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.20 6.58e-04 GO:0071944 cell periphery
1.20 1.13e-03 GO:0005886 plasma membrane
2.12 2.81e-03 GO:0030424 axon
1.27 5.47e-03 GO:0044459 plasma membrane part
1.69 6.13e-03 GO:0043005 neuron projection
2.77 1.99e-02 GO:0030426 growth cone
2.69 3.10e-02 GO:0030427 site of polarized growth
2.96 3.75e-02 GO:0044309 neuron spine

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.07 2.06e-02 GO:0005488 binding