Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 2.227


Transcription factors associated with POU5F1_SOX2{dimer}.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1
SOX2 6657 SRY (sex determining region Y)-box 2



Activity profile for motif POU5F1_SOX2{dimer}.p2.

activity profile for motif POU5F1_SOX2{dimer}.p2


Sorted Z-values histogram for motif POU5F1_SOX2{dimer}.p2

Sorted Z-values for motif POU5F1_SOX2{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1_SOX2{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_27508139 3.849 LOC643401
hypothetical protein LOC643401
chr4_+_100714995 3.409 MTTP
microsomal triglyceride transfer protein
chr1_-_1701313 2.521 NM_001198994
NADK
NAD kinase
chr2_+_169367345 2.421 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr6_+_132000134 2.404 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr4_+_74493918 2.374 ALB
albumin
chr13_+_96592051 2.364 MBNL2
muscleblind-like 2 (Drosophila)
chr1_+_165564904 2.295 NM_001198783
POU2F1
POU class 2 homeobox 1
chr1_+_165565006 2.251 POU2F1
POU class 2 homeobox 1
chr17_+_24394281 2.227 PIPOX
pipecolic acid oxidase
chr6_-_138862273 2.156


chr16_-_54424517 2.118 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr9_+_134843918 2.098 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr4_+_74493174 2.043 ALB
albumin
chr17_+_24394043 1.976 NM_016518
PIPOX
pipecolic acid oxidase
chr6_+_24465109 1.960 NM_181337
KAAG1
kidney associated antigen 1
chr12_+_102859354 1.950 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr21_+_41663853 1.922 MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr3_+_186529376 1.875 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr12_-_14887648 1.798 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr7_+_129057152 1.773 NM_001040110
NRF1
nuclear respiratory factor 1
chr6_-_43384507 1.768 NM_206922
CRIP3
cysteine-rich protein 3
chr14_+_38772870 1.763 NM_054024
MIA2
melanoma inhibitory activity 2
chr4_+_74493331 1.729 ALB
albumin
chr1_+_559129 1.664


chr1_-_100003936 1.657 NM_001013660
FRRS1
ferric-chelate reductase 1
chr1_+_61315516 1.655 NM_001145511
NFIA
nuclear factor I/A
chr1_+_61315378 1.614


chrX_-_55037235 1.508 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr11_-_16380967 1.503 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr10_+_4995685 1.462 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr4_+_74493266 1.417 ALB
albumin
chr2_+_233443237 1.415 NM_206895
C2orf82
chromosome 2 open reading frame 82
chr17_-_76720342 1.411 AATK
apoptosis-associated tyrosine kinase
chr6_+_88021644 1.408 ZNF292
zinc finger protein 292
chr6_+_26264531 1.369 HIST1H1E
histone cluster 1, H1e
chr19_-_5789740 1.366 FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr4_+_74493218 1.350 ALB
albumin
chr2_-_215998181 1.342 FN1
fibronectin 1
chr22_+_16423147 1.342 NM_031481
SLC25A18
solute carrier family 25 (mitochondrial carrier), member 18
chr10_-_69267774 1.339 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr10_-_5035967 1.322 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr18_-_73834670 1.312


chr16_-_21221872 1.298 NM_001014444
NM_001888
CRYM

crystallin, mu

chr6_+_64344307 1.297 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr6_+_26264537 1.290 NM_005321
HIST1H1E
histone cluster 1, H1e
chr10_+_7785235 1.275 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr16_+_70646008 1.272 NM_001126102
NM_005143
HP

haptoglobin

chr13_-_27441143 1.257 CDX2
caudal type homeobox 2
chr1_+_43063817 1.254 NM_018538
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr14_+_22859236 1.254 NM_004643
PABPN1
poly(A) binding protein, nuclear 1
chr10_+_7785290 1.203 ITIH2
inter-alpha (globulin) inhibitor H2
chr16_-_45339605 1.199 NM_182493
MYLK3
myosin light chain kinase 3
chr6_+_26212082 1.192 NM_003542
HIST1H4C
histone cluster 1, H4c
chr1_-_41398126 1.182 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr4_+_74493301 1.157 ALB
albumin
chr10_+_4995597 1.154 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr10_-_5436781 1.150 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3

chr10_+_7785360 1.144 ITIH2
inter-alpha (globulin) inhibitor H2
chr17_+_3324096 1.142 NM_001128085
ASPA
aspartoacylase
chr3_-_150422474 1.140 NM_000096
CP
ceruloplasmin (ferroxidase)
chr10_+_7785331 1.108 ITIH2
inter-alpha (globulin) inhibitor H2
chr1_+_57093030 1.101 NM_000562
C8A
complement component 8, alpha polypeptide
chr21_-_38415273 1.074 NM_005867
DSCR4
Down syndrome critical region gene 4
chr12_-_88573949 1.070 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr2_+_113601616 1.060 IL1RN
interleukin 1 receptor antagonist
chr1_+_559618 1.054


chr13_+_108079570 1.051 NM_001198950
MYO16
myosin XVI
chr18_-_3835295 1.022 NM_001003809
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr3_-_173723754 1.018 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr19_-_53081326 1.015 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr13_-_27441290 1.004 NM_001265
CDX2
caudal type homeobox 2
chr2_+_128644510 0.998 UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr5_+_140709907 0.994 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr4_-_110942783 0.983 NM_000204
CFI
complement factor I
chr4_+_88076418 0.981


chr10_-_11614279 0.978 NM_001080491
USP6NL
USP6 N-terminal like
chrX_+_7147471 0.952 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr2_+_113601608 0.944 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr3_+_45902999 0.942 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr4_+_17125885 0.937 NM_001079827
CLRN2
clarin 2
chr1_-_177106702 0.910 NM_004673
ANGPTL1
angiopoietin-like 1
chr8_-_17797127 0.902 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr12_+_25096472 0.897 NM_006152
LRMP
lymphoid-restricted membrane protein
chr7_+_29486010 0.889 NM_001039936
CHN2
chimerin (chimaerin) 2
chr17_-_64649608 0.872 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr10_+_4995453 0.868 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr1_-_229071957 0.866 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr5_-_43448174 0.845 NM_148672
CCL28
chemokine (C-C motif) ligand 28
chr12_-_121767272 0.832 NM_006018
GPR109B
G protein-coupled receptor 109B
chr6_+_32515596 0.831 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr4_-_88076328 0.815


chr12_-_6354650 0.811 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr5_+_68703036 0.810 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr1_+_50347176 0.796 NM_001144774
NM_021952
ELAVL4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chrX_-_131181141 0.794 RAP2C
RAP2C, member of RAS oncogene family
chr1_-_24112345 0.791 NM_001841
CNR2
cannabinoid receptor 2 (macrophage)
chr2_-_233349469 0.788 NM_001172416
NM_001172417
NM_002242
KCNJ13


potassium inwardly-rectifying channel, subfamily J, member 13


chr6_+_38798529 0.785 NM_001371
DNAH8
dynein, axonemal, heavy chain 8
chr3_+_63928459 0.785 NM_001128149
ATXN7
ataxin 7
chr15_+_38296920 0.784 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr10_+_114123765 0.780 ACSL5
acyl-CoA synthetase long-chain family member 5
chr20_+_16312 0.775 NM_153325
DEFB125
defensin, beta 125
chr3_-_156904690 0.773 NM_014996
PLCH1
phospholipase C, eta 1
chr4_+_170817787 0.760 CLCN3
chloride channel 3
chr3_-_87408301 0.749 NM_000306
NM_001122757
POU1F1

POU class 1 homeobox 1

chr3_-_102522093 0.743 NM_016247
IMPG2
interphotoreceptor matrix proteoglycan 2
chr16_+_52081836 0.738 RBL2
retinoblastoma-like 2 (p130)
chr6_+_131190237 0.737 NM_001195597
LOC285733
hypothetical LOC285733
chr7_-_16811131 0.735 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr7_+_1092968 0.735 NM_001039966
NM_001505
GPER

G protein-coupled estrogen receptor 1

chr6_-_138862271 0.724 NM_001144060
NHSL1
NHS-like 1
chr2_-_188086612 0.721 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr14_+_38720085 0.718 PNN
pinin, desmosome associated protein
chr9_+_111927601 0.707 NM_001136562
AKAP2
A kinase (PRKA) anchor protein 2
chr5_+_140751666 0.692 NM_014004
NM_032088
PCDHGA8

protocadherin gamma subfamily A, 8

chr6_-_108252200 0.690 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr1_+_93072947 0.687 RPL5
ribosomal protein L5
chr2_-_152392935 0.683 ARL5A
ADP-ribosylation factor-like 5A
chr10_+_91127792 0.675 NM_001010987
IFIT1B
interferon-induced protein with tetratricopeptide repeats 1B
chr6_+_26510443 0.669 NM_001145008
NM_001145009
NM_007048
NM_194441
BTN3A1



butyrophilin, subfamily 3, member A1



chr9_-_103185621 0.668 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr11_+_20001130 0.664 NM_001111019
NAV2
neuron navigator 2
chr4_-_186970366 0.662 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr18_+_9092618 0.658 NM_021074
NDUFV2
NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
chr4_-_123761615 0.658 NM_021803
IL21
interleukin 21
chr16_+_31105579 0.655


chr10_+_114123828 0.655 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr5_+_40877053 0.652 NM_032587
CARD6
caspase recruitment domain family, member 6
chr7_-_16471817 0.642 NM_015464
SOSTDC1
sclerostin domain containing 1
chr10_-_52315436 0.639 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr14_+_87560646 0.626 LOC283587
hypothetical protein LOC283587
chr3_-_52839727 0.613 NM_001166449
NM_002218
ITIH4

inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)

chr1_+_111217244 0.613 NM_000560
CD53
CD53 molecule
chr4_-_68093668 0.607


chr9_-_14900992 0.602 NM_144966
FREM1
FRAS1 related extracellular matrix 1
chrX_+_70255128 0.600 NM_005120
MED12
mediator complex subunit 12
chr13_-_102209422 0.599 NM_001146197
C13orf40
chromosome 13 open reading frame 40
chr5_+_76150637 0.593 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr2_-_20390601 0.589 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr12_+_61645361 0.588 RPL14
ribosomal protein L14
chr6_+_126282078 0.584 NCOA7
nuclear receptor coactivator 7
chr2_+_165858586 0.582 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr2_+_143351695 0.580 KYNU
kynureninase
chr12_-_9123126 0.571 A2M
alpha-2-macroglobulin
chr10_-_73518772 0.564 NM_001134434
NM_014767
SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr4_-_68093784 0.560 CENPC1
centromere protein C 1
chr19_-_62370667 0.552 NM_001012729
DUXA
double homeobox A
chr15_-_32398220 0.547 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr4_+_140806536 0.545 MGST2
microsomal glutathione S-transferase 2
chr13_-_27441423 0.542 CDX2
caudal type homeobox 2
chr5_+_176449156 0.539 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr14_-_106154332 0.538 LOC100126583
IGHG1
hypothetical LOC100126583
immunoglobulin heavy constant gamma 1 (G1m marker)
chr12_+_54172413 0.537 NM_001005519
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chr4_-_41445479 0.537 PHOX2B
paired-like homeobox 2b
chr1_+_111217314 0.536 CD53
CD53 molecule
chr1_+_190552744 0.532 NM_001039152
RGS21
regulator of G-protein signaling 21
chr15_+_63124760 0.531 NM_178859
OSTBETA
organic solute transporter beta
chr4_+_39874921 0.530 NM_004310
RHOH
ras homolog gene family, member H
chr6_+_64414389 0.530 NM_015153
PHF3
PHD finger protein 3
chr6_-_116707778 0.526 TSPYL1
TSPY-like 1
chr9_+_130485926 0.523 SET
SET nuclear oncogene
chr9_-_99740243 0.521 NM_197978
HEMGN
hemogen
chr2_-_37397669 0.520 NM_005813
PRKD3
protein kinase D3
chr15_-_74941339 0.520 NM_001145923
SCAPER
S-phase cyclin A-associated protein in the ER
chr9_-_85773899 0.519 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chrX_-_153698930 0.515 HMGN1P37
high-mobility group nucleosome binding domain 1 pseudogene 37
chr8_+_67096344 0.514 NM_033105
DNAJC5B
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr14_+_59934178 0.512


chr19_+_56420131 0.496 NM_001082618
NM_001177608
NM_001772
CD33


CD33 molecule


chr1_-_158759606 0.495 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr12_+_38306238 0.494 NM_001031748
C12orf40
chromosome 12 open reading frame 40
chr16_+_83349816 0.493 USP10
ubiquitin specific peptidase 10
chr3_+_122794859 0.489 NM_016298
FBXO40
F-box protein 40
chrX_+_65152004 0.485


chr18_-_3001944 0.484 NM_014646
LPIN2
lipin 2
chr4_+_74500748 0.483 ALB
albumin
chr6_+_31623370 0.481 NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr1_+_156842852 0.474 NM_001004478
OR10Z1
olfactory receptor, family 10, subfamily Z, member 1
chr4_+_88939725 0.473 NM_004967
IBSP
integrin-binding sialoprotein
chr4_-_149577404 0.471


chr1_-_180627934 0.469 NM_001033044
NM_002065
GLUL

glutamate-ammonia ligase

chr3_-_186752952 0.462 NM_139248
LIPH
lipase, member H
chr14_-_106240998 0.461 IGHV1-69
IGHG1
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant gamma 1 (G1m marker)
chr9_-_115877104 0.459 AMBP
alpha-1-microglobulin/bikunin precursor
chr10_-_61570665 0.456 NM_001149
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr6_+_27400518 0.454 NM_032030
FKSG83
FKSG83
chr4_+_140806371 0.453 NM_002413
MGST2
microsomal glutathione S-transferase 2
chr16_+_82540172 0.448 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr6_-_31668476 0.447 NM_001145466
NM_001145467
NM_147130
NCR3


natural cytotoxicity triggering receptor 3


chr1_-_149214063 0.438 NM_022075
NM_181746
LASS2

LAG1 homolog, ceramide synthase 2

chr14_-_20128721 0.436 NM_001024822
RNASE12
ribonuclease, RNase A family, 12 (non-active)
chr8_+_39890484 0.433 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr1_+_78243181 0.430 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr4_-_17415918 0.429 DCAF16
DDB1 and CUL4 associated factor 16
chr4_-_39199527 0.429 UGDH
UDP-glucose 6-dehydrogenase
chr2_+_135312655 0.426 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr10_-_32707549 0.425 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr2_+_228386800 0.421 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr20_+_39402834 0.421 NM_022896
LPIN3
lipin 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.79 9.78e-03 GO:0072376 protein activation cascade
1.87 1.38e-02 GO:0006955 immune response
2.43 3.42e-02 GO:0050778 positive regulation of immune response
1.62 3.48e-02 GO:0002376 immune system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.27 1.78e-02 GO:0005886 plasma membrane
1.40 3.25e-02 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.72 2.67e-04 GO:0004888 transmembrane receptor activity
1.80 4.41e-03 GO:0004930 G-protein coupled receptor activity
1.45 1.02e-02 GO:0004871 signal transducer activity
1.45 1.02e-02 GO:0060089 molecular transducer activity
2.09 2.84e-02 GO:0004984 olfactory receptor activity
1.46 4.01e-02 GO:0004872 receptor activity