Motif ID: RXRA_VDR{dimer}.p2

Z-value: 1.463


Transcription factors associated with RXRA_VDR{dimer}.p2:

Gene SymbolEntrez IDGene Name
VDR 7421 vitamin D (1,25- dihydroxyvitamin D3) receptor



Activity profile for motif RXRA_VDR{dimer}.p2.

activity profile for motif RXRA_VDR{dimer}.p2


Sorted Z-values histogram for motif RXRA_VDR{dimer}.p2

Sorted Z-values for motif RXRA_VDR{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RXRA_VDR{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_102722275 2.851 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr13_+_23742846 2.829 SPATA13
spermatogenesis associated 13
chr21_-_46399900 2.791 NM_006657
NM_206965
FTCD

formiminotransferase cyclodeaminase

chr18_-_6404900 2.560 NM_173464
L3MBTL4
l(3)mbt-like 4 (Drosophila)
chr5_-_178984192 2.132 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr22_+_16973556 2.088 TUBA8
tubulin, alpha 8
chr3_+_32834513 2.062 NM_001039111
TRIM71
tripartite motif containing 71
chr22_+_16973399 2.032 NM_001193414
NM_018943
TUBA8

tubulin, alpha 8

chr7_+_94374862 1.945 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr8_+_76482661 1.895 HNF4G
hepatocyte nuclear factor 4, gamma
chr9_+_139245029 1.772 NM_001177316
NM_001177317
SLC34A3

solute carrier family 34 (sodium phosphate), member 3

chr17_+_18320822 1.771 NM_001040078
LGALS9B
LGALS9C
lectin, galactoside-binding, soluble, 9B
lectin, galactoside-binding, soluble, 9C
chr8_-_8276598 1.694 NM_001080826
SGK223
homolog of rat pragma of Rnd2
chr15_+_89229275 1.651 NM_001143783
NM_001143784
FES

feline sarcoma oncogene

chr19_-_56582997 1.617 NM_001161748
NM_030657
LIM2

lens intrinsic membrane protein 2, 19kDa

chr14_+_94117483 1.538 NM_000624
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr7_+_128365226 1.534 NM_001098629
NM_001098630
IRF5

interferon regulatory factor 5

chrX_+_153423652 1.445 NM_001099856
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr17_-_20311411 1.419 NM_001042685
LGALS9B
lectin, galactoside-binding, soluble, 9B
chr14_-_33489708 1.336 NM_022073
EGLN3
egl nine homolog 3 (C. elegans)
chr1_+_93830106 1.318 LOC100129046
hypothetical LOC100129046
chr19_-_7244876 1.308 NM_000208
NM_001079817
INSR

insulin receptor

chr2_+_74594093 1.280 TLX2
T-cell leukemia homeobox 2
chr1_+_93830169 1.276 LOC100129046
hypothetical LOC100129046
chr12_+_56284867 1.271 NM_178502
DTX3
deltex homolog 3 (Drosophila)
chr1_-_1840564 1.245 NM_178545
TMEM52
transmembrane protein 52
chr11_-_124311512 1.140 NM_152722
HEPACAM
hepatic and glial cell adhesion molecule
chr11_+_76516957 1.101 NM_000260
NM_001127179
NM_001127180
MYO7A


myosin VIIA


chr2_+_108271526 1.098 NM_001056
NM_176825
SULT1C2

sulfotransferase family, cytosolic, 1C, member 2

chr20_-_52223918 1.070 NM_000782
NM_001128915
CYP24A1

cytochrome P450, family 24, subfamily A, polypeptide 1

chr7_-_44547382 1.069 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr22_+_48966394 1.038 TRABD
TraB domain containing
chr2_+_238432925 1.031 NM_005855
RAMP1
receptor (G protein-coupled) activity modifying protein 1
chrX_-_130250715 1.014 NM_001170963
IGSF1
immunoglobulin superfamily, member 1
chr2_+_222997456 0.998 SGPP2
sphingosine-1-phosphate phosphatase 2
chr11_+_72765318 0.997 NM_032871
RELT
RELT tumor necrosis factor receptor
chr16_+_31027231 0.980 BCKDK
branched chain ketoacid dehydrogenase kinase
chr17_+_2646481 0.969 NM_001100398
NM_015085
RAP1GAP2

RAP1 GTPase activating protein 2

chr1_+_199259664 0.965


chr19_-_12305435 0.941 NM_145276
ZNF563
zinc finger protein 563
chr16_+_30952350 0.940 STX4
syntaxin 4
chr17_-_8006979 0.938 NM_014232
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr19_-_48700824 0.923 NM_198850
PHLDB3
pleckstrin homology-like domain, family B, member 3
chr7_+_39956633 0.897 CDK13
cyclin-dependent kinase 13
chr7_+_128365482 0.895 NM_032643
IRF5
interferon regulatory factor 5
chr11_-_124311106 0.881 HEPACAM
hepatic and glial cell adhesion molecule
chr12_+_55896844 0.867 NM_007224
NXPH4
neurexophilin 4
chr5_-_92982927 0.850


chr20_+_3749164 0.850 NM_018347
C20orf29
chromosome 20 open reading frame 29
chr16_+_30952382 0.845 NM_004604
STX4
syntaxin 4
chr16_-_4232053 0.826 NM_001098814
SRL
sarcalumenin
chr14_+_94117511 0.791 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr6_+_31538934 0.784 NM_006674
HCP5
HLA complex P5
chr11_-_66945190 0.764 PPP1CA
protein phosphatase 1, catalytic subunit, alpha isozyme
chr20_+_18516541 0.753 NM_080820
DTD1
D-tyrosyl-tRNA deacylase 1 homolog (S. cerevisiae)
chr16_+_31027115 0.749 NM_001122957
NM_005881
BCKDK

branched chain ketoacid dehydrogenase kinase

chr19_+_50100843 0.744 NM_000041
APOE
apolipoprotein E
chr21_-_34908614 0.741 NM_203417
RCAN1
regulator of calcineurin 1
chr12_+_119900677 0.735 HNF1A
HNF1 homeobox A
chr2_+_222997529 0.735 NM_152386
SGPP2
sphingosine-1-phosphate phosphatase 2
chr1_-_55103938 0.732 DHCR24
24-dehydrocholesterol reductase
chr19_+_12036513 0.722 NM_001136501
ZNF844
zinc finger protein 844
chr12_-_109611277 0.722 NM_032369
HVCN1
hydrogen voltage-gated channel 1
chr16_-_88295595 0.721 NM_152339
SPATA2L
spermatogenesis associated 2-like
chr2_+_128175413 0.718 SFT2D3
SFT2 domain containing 3
chr17_-_40843530 0.716 ARHGAP27
Rho GTPase activating protein 27
chr3_-_27739201 0.716 EOMES
eomesodermin
chr7_+_39956480 0.711 NM_003718
NM_031267
CDK13

cyclin-dependent kinase 13

chr19_-_1601246 0.709 NM_001136139
TCF3
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
chr19_-_12456544 0.708 ZNF709
zinc finger protein 709
chr7_+_97679501 0.706 NM_177455
BHLHA15
basic helix-loop-helix family, member a15
chr17_-_7023378 0.703 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr11_-_780103 0.702 NM_016564
CEND1
cell cycle exit and neuronal differentiation 1
chr3_-_49117169 0.702 NM_005051
QARS
glutaminyl-tRNA synthetase
chr20_-_39379533 0.698 ZHX3
zinc fingers and homeoboxes 3
chrX_-_39921525 0.697 NM_001123383
NM_001123384
BCOR

BCL6 corepressor

chr17_-_61655915 0.690 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr17_+_4434024 0.686 NM_198501
SMTNL2
smoothelin-like 2
chr16_+_14634324 0.685 BFAR
bifunctional apoptosis regulator
chr10_-_101831579 0.662 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr2_+_104837004 0.659


chr11_+_2378559 0.658 TSSC4
tumor suppressing subtransferable candidate 4
chr12_+_56299959 0.644 NM_133489
SLC26A10
solute carrier family 26, member 10
chr21_-_45165249 0.642 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr16_+_18986721 0.638 NM_001190983
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr20_-_33658823 0.629 FER1L4
fer-1-like 4 (C. elegans) pseudogene
chr17_-_6557375 0.621 NM_001143838
NM_177550
SLC13A5

solute carrier family 13 (sodium-dependent citrate transporter), member 5

chr3_+_48239865 0.588 NM_004345
CAMP
cathelicidin antimicrobial peptide
chr16_+_31027249 0.580 BCKDK
branched chain ketoacid dehydrogenase kinase
chr17_-_36469869 0.575 NM_001165252
LOC730755
keratin associated protein 2-4-like
chr17_-_59451662 0.575 NM_001099786
NM_001099787
NM_001099788
NM_001099789
ICAM2



intercellular adhesion molecule 2



chr20_+_29931257 0.571 TTLL9
tubulin tyrosine ligase-like family, member 9
chr2_-_230494862 0.570 NM_004238
TRIP12
thyroid hormone receptor interactor 12
chr1_+_224803226 0.565 C1orf95
chromosome 1 open reading frame 95
chr16_-_65742323 0.565 NM_033309
B3GNT9
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
chr14_-_106352471 0.563


chr9_-_135593265 0.560 NM_001134707
SARDH
sarcosine dehydrogenase
chr16_+_18986417 0.552 NM_016138
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr13_+_49658016 0.552


chr18_+_46340400 0.542 NM_002747
MAPK4
mitogen-activated protein kinase 4
chr8_-_23596346 0.539 NM_006167
NKX3-1
NK3 homeobox 1
chr2_-_230494956 0.536 TRIP12
thyroid hormone receptor interactor 12
chr21_-_45165204 0.533 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr16_+_11978002 0.531 NM_032167
RUNDC2A
RUN domain containing 2A
chr14_-_63076155 0.530 PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr11_+_76561471 0.529 MYO7A
myosin VIIA
chr19_+_47509274 0.526 NM_173633
TMEM145
transmembrane protein 145
chr12_-_56422120 0.523 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr17_+_35751796 0.522 NM_001024809
RARA
retinoic acid receptor, alpha
chr10_-_21825879 0.518 C10orf114
chromosome 10 open reading frame 114
chr17_+_22823151 0.517 NM_014238
KSR1
kinase suppressor of ras 1
chr22_+_48966480 0.514 NM_025204
TRABD
TraB domain containing
chr8_-_39814860 0.512 NM_001464
ADAM2
ADAM metallopeptidase domain 2
chr16_+_18986459 0.512 COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr2_+_25118417 0.496 NM_014971
EFR3B
EFR3 homolog B (S. cerevisiae)
chr16_+_31027255 0.494 BCKDK
branched chain ketoacid dehydrogenase kinase
chr19_-_12028126 0.491 NM_001080404
ZNF878
zinc finger protein 878
chrX_+_46825179 0.486 RGN
regucalcin (senescence marker protein-30)
chr7_+_143331954 0.485 NM_001005281
OR6B1
olfactory receptor, family 6, subfamily B, member 1
chr2_+_74595073 0.481 NM_016170
TLX2
T-cell leukemia homeobox 2
chr21_+_44699796 0.476 NM_030891
LRRC3
leucine rich repeat containing 3
chr4_-_123092358 0.476 NM_001130698
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr11_+_63883192 0.476 NM_001006944
NM_003942
RPS6KA4

ribosomal protein S6 kinase, 90kDa, polypeptide 4

chr17_-_74289901 0.475 NM_004762
NM_017456
CYTH1

cytohesin 1

chr6_-_132314004 0.474 NM_001901
CTGF
connective tissue growth factor
chr9_+_130838720 0.464 FAM73B
family with sequence similarity 73, member B
chr1_-_39929654 0.463 NM_016257
HPCAL4
hippocalcin like 4
chr16_+_14634168 0.462 NM_016561
BFAR
bifunctional apoptosis regulator
chr4_-_2727548 0.458 NM_001161527
TNIP2
TNFAIP3 interacting protein 2
chr20_+_42463419 0.454 HNF4A
hepatocyte nuclear factor 4, alpha
chr11_+_65164167 0.454 NM_153253
SIPA1
signal-induced proliferation-associated 1
chr17_+_72958920 0.454 SEPT9
septin 9
chr16_+_55950195 0.450 NM_002990
CCL22
chemokine (C-C motif) ligand 22
chr2_+_220170804 0.449 NM_052902
STK11IP
serine/threonine kinase 11 interacting protein
chr1_-_23623713 0.442 NM_003196
TCEA3
transcription elongation factor A (SII), 3
chr14_+_23508922 0.441 NM_001193636
NM_001193637
NM_001193635
DHRS4L2


DHRS4L1
dehydrogenase/reductase (SDR family) member 4 like 2


dehydrogenase/reductase (SDR family) member 4 like 1
chr17_-_70367479 0.440 NM_000835
GRIN2C
glutamate receptor, ionotropic, N-methyl D-aspartate 2C
chr2_+_230495439 0.437 NM_174899
FBXO36
F-box protein 36
chr10_+_11087259 0.434 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chr2_+_20510312 0.432 NM_004040
RHOB
ras homolog gene family, member B
chr20_+_46971618 0.431 NM_006420
ARFGEF2
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr19_-_12456625 0.430 NM_152601
ZNF709
zinc finger protein 709
chr2_+_111206620 0.428 NM_001142807
ACOXL
acyl-CoA oxidase-like
chr17_+_4434582 0.427 NM_001114974
SMTNL2
smoothelin-like 2
chr11_-_65841077 0.424 NM_020404
CD248
CD248 molecule, endosialin
chr18_+_44319365 0.420 NM_001142397
NM_014772
CTIF

CBP80/20-dependent translation initiation factor

chr5_-_176868483 0.419 DOK3
docking protein 3
chr17_-_53964386 0.416 NM_080415
NM_080416
SEPT4

septin 4

chr10_+_115929008 0.412 NM_198795
TDRD1
tudor domain containing 1
chr17_+_45008473 0.410 NXPH3
neurexophilin 3
chr11_-_64283945 0.406 PYGM
phosphorylase, glycogen, muscle
chr1_-_181826292 0.405 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr17_+_77528782 0.403 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr16_+_1974182 0.403 GFER
growth factor, augmenter of liver regeneration
chr21_+_45649429 0.400 NM_130445
COL18A1
collagen, type XVIII, alpha 1
chr14_+_69021149 0.394 NM_001161498
UPF0639
UPF0639 protein
chr16_+_27320983 0.390 NM_181078
NM_181079
IL21R

interleukin 21 receptor

chr16_-_31135895 0.390 NM_152901
PYDC1
PYD (pyrin domain) containing 1
chr17_+_77528699 0.389 NM_024083
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr13_-_52211925 0.389 NM_001011705
NM_007015
LECT1

leukocyte cell derived chemotaxin 1

chr1_-_3806683 0.388 NM_207356
C1orf174
chromosome 1 open reading frame 174
chr1_+_224803123 0.379 NM_001003665
C1orf95
chromosome 1 open reading frame 95
chr7_+_100792841 0.378 NM_133457
EMID2
EMI domain containing 2
chr16_+_28211123 0.377 NM_001024401
SBK1
SH3-binding domain kinase 1
chr18_+_32021418 0.375 NM_017947
MOCOS
molybdenum cofactor sulfurase
chr18_-_72973698 0.370 MBP
myelin basic protein
chr11_+_55884266 0.369 NM_001005205
OR8J1
olfactory receptor, family 8, subfamily J, member 1
chr15_+_57691272 0.366 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr4_-_35922288 0.362 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr8_-_37576515 0.360 LOC157860
hypothetical protein LOC157860
chr18_-_45975163 0.358 NM_001080467
MYO5B
myosin VB
chr16_-_3707450 0.357 NM_016292
TRAP1
TNF receptor-associated protein 1
chr14_-_34661387 0.356 PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr16_+_620932 0.353 NM_053284
WFIKKN1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr2_-_25047988 0.351 DNAJC27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr5_-_180169720 0.350 NM_001114617
MGAT1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr12_+_48784057 0.346 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr14_+_100262943 0.346 NM_003836
DLK1
delta-like 1 homolog (Drosophila)
chr12_+_27740694 0.345 NM_001029874
REP15
RAB15 effector protein
chr6_+_30960305 0.345 NM_013993
DDR1
discoidin domain receptor tyrosine kinase 1
chr12_+_52181643 0.339 NM_134324
TARBP2
TAR (HIV-1) RNA binding protein 2
chr20_+_337346 0.339 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr1_+_26220895 0.334 EXTL1
exostoses (multiple)-like 1
chr17_+_62803824 0.332 PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr17_+_69974375 0.327 CD300A
CD300a molecule
chr16_+_76313909 0.327 NM_001105663
NUDT7
nudix (nucleoside diphosphate linked moiety X)-type motif 7
chr13_+_23723831 0.326 SPATA13
spermatogenesis associated 13
chr13_-_52211836 0.321 LECT1
leukocyte cell derived chemotaxin 1
chr11_+_7491789 0.319 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr1_+_42619014 0.319 NM_173642
RIMKLA
ribosomal modification protein rimK-like family member A
chr11_-_116168316 0.317 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr11_+_17254854 0.315 NM_005013
NUCB2
nucleobindin 2
chr22_+_39404940 0.314 NM_005297
MCHR1
melanin-concentrating hormone receptor 1
chr3_-_13032130 0.312


chr4_+_2764510 0.310 NM_001122681
SH3BP2
SH3-domain binding protein 2
chr17_+_62804036 0.303 PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr3_-_27738788 0.302 NM_005442
EOMES
eomesodermin
chr1_-_40555959 0.302 COL9A2
collagen, type IX, alpha 2
chr12_+_131577229 0.295 NM_001142641
FBRSL1
fibrosin-like 1
chr20_+_39199263 0.290 PLCG1
phospholipase C, gamma 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.96 5.24e-03 GO:0051056 regulation of small GTPase mediated signal transduction
7.06 1.98e-02 GO:0032313 regulation of Rab GTPase activity
7.06 1.98e-02 GO:0032483 regulation of Rab protein signal transduction
1.26 2.04e-02 GO:0065007 biological regulation
3.23 3.10e-02 GO:0046578 regulation of Ras protein signal transduction
1.26 3.82e-02 GO:0050789 regulation of biological process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
6.92 5.80e-03 GO:0005097 Rab GTPase activator activity
4.50 2.51e-02 GO:0005099 Ras GTPase activator activity
2.79 3.17e-02 GO:0005083 small GTPase regulator activity