Motif ID: ATF2.p2

Z-value: 0.832


Transcription factors associated with ATF2.p2:

Gene SymbolEntrez IDGene Name
ATF2 1386 activating transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ATF2chr2_-_1757410960.401.2e-01Click!


Activity profile for motif ATF2.p2.

activity profile for motif ATF2.p2


Sorted Z-values histogram for motif ATF2.p2

Sorted Z-values for motif ATF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_187884721 1.904


chr1_-_16355013 1.710 NM_004431
EPHA2
EPH receptor A2
chr16_-_4528739 1.598 NM_001199055
NM_001199056
NM_013399
C16orf5


chromosome 16 open reading frame 5


chr12_-_123568781 1.508


chr16_-_78192111 1.485 NM_001031804
NM_005360
MAF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

chr7_+_28415495 1.475 LOC401317
hypothetical LOC401317
chr10_-_95350949 1.435 NM_006744
RBP4
retinol binding protein 4, plasma
chr4_-_23500706 1.415 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr12_+_70119785 1.392 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr11_+_116575249 1.380 NM_001001522
NM_003186
TAGLN

transgelin

chr3_+_189354167 1.310 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr4_-_186693574 1.279 NM_001114107
NM_014476
PDLIM3

PDZ and LIM domain 3

chr6_+_39868116 1.268


chr2_+_5750229 1.266 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chrX_-_83644054 1.251 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr22_+_40286957 1.236 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chr6_+_39868126 1.173 DAAM2
dishevelled associated activator of morphogenesis 2
chr8_+_40130143 1.164 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr14_+_100362204 1.083 MEG3
maternally expressed 3 (non-protein coding)
chr2_+_10969513 0.966 NM_002236
KCNF1
potassium voltage-gated channel, subfamily F, member 1
chr14_+_100362236 0.954 MEG3
maternally expressed 3 (non-protein coding)
chr5_+_14493905 0.934 TRIO
triple functional domain (PTPRF interacting)
chr11_+_61204392 0.908 NM_006133
DAGLA
diacylglycerol lipase, alpha
chr21_-_34820916 0.872 NM_203418
RCAN1
regulator of calcineurin 1
chr20_-_14266200 0.863 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr4_+_74488947 0.849 ALB
albumin
chr9_-_128924819 0.845 NM_012098
ANGPTL2
angiopoietin-like 2
chr3_+_62279707 0.824 C3orf14
chromosome 3 open reading frame 14
chr3_-_21767819 0.821 NM_024697
ZNF385D
zinc finger protein 385D
chr9_-_128924782 0.818 ANGPTL2
angiopoietin-like 2
chr1_+_99502655 0.808 LPPR4
lipid phosphate phosphatase-related protein type 4
chr7_-_41709191 0.805 NM_002192
INHBA
inhibin, beta A
chr4_-_142273881 0.804 NM_020724
RNF150
ring finger protein 150
chr5_-_111119846 0.802 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr6_-_127822227 0.792 NM_014702
KIAA0408
KIAA0408
chr4_+_74488910 0.790 ALB
albumin
chr11_-_8849485 0.787 ST5
suppression of tumorigenicity 5
chr4_-_111777651 0.786 PITX2
paired-like homeodomain 2
chr8_+_70567634 0.784 SULF1
sulfatase 1
chr6_+_148705421 0.781 NM_015278
SASH1
SAM and SH3 domain containing 1
chr8_+_134272463 0.779 NM_003882
NM_080838
WISP1

WNT1 inducible signaling pathway protein 1

chr6_-_46566969 0.776 RCAN2
regulator of calcineurin 2
chr12_+_55201854 0.770 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr1_+_182040837 0.764 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr4_-_111777584 0.755 PITX2
paired-like homeodomain 2
chr1_-_177106702 0.750 NM_004673
ANGPTL1
angiopoietin-like 1
chr14_+_62740878 0.733 NM_020663
RHOJ
ras homolog gene family, member J
chr3_-_102194938 0.732 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr14_+_95740916 0.720 BDKRB2
bradykinin receptor B2
chr17_-_13445942 0.715 NM_006042
HS3ST3A1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
chr9_-_128924706 0.713 ANGPTL2
angiopoietin-like 2
chr8_+_70567581 0.708 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr13_-_47885018 0.707 LPAR6
lysophosphatidic acid receptor 6
chr6_+_136214495 0.707 NM_018945
PDE7B
phosphodiesterase 7B
chr2_-_134042500 0.677 NM_207363
NM_207481
NCKAP5

NCK-associated protein 5

chr19_+_18584666 0.662 NM_012109
TMEM59L
transmembrane protein 59-like
chr1_-_1283770 0.645 NM_032348
MXRA8
matrix-remodelling associated 8
chr5_+_32747194 0.644 NM_000908
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr13_+_31503436 0.631 NM_023037
FRY
furry homolog (Drosophila)
chr20_-_33489383 0.629 NM_000557
GDF5
growth differentiation factor 5
chr2_-_216009015 0.615 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr18_-_35634247 0.615 LOC647946
hypothetical LOC647946
chr1_+_29435534 0.614 NM_001195001
NM_005704
NM_133177
NM_133178
PTPRU



protein tyrosine phosphatase, receptor type, U



chr4_+_74488835 0.601 NM_000477
ALB
albumin
chr14_-_79748273 0.587 NM_000793
NM_013989
DIO2

deiodinase, iodothyronine, type II

chr20_-_17897384 0.587 NM_152227
SNX5
sorting nexin 5
chr10_-_90957028 0.585 NM_003956
CH25H
cholesterol 25-hydroxylase
chr13_-_47885248 0.577 LPAR6
lysophosphatidic acid receptor 6
chr7_-_45095017 0.574 NM_001146334
NACAD
NAC alpha domain containing
chr3_-_8518327 0.573 LOC100288428
hypothetical LOC100288428
chr13_+_75232797 0.565 NM_015842
LMO7
LIM domain 7
chr2_-_224611568 0.563 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr9_+_17568952 0.561 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr4_-_96689373 0.559 NM_003728
UNC5C
unc-5 homolog C (C. elegans)
chr8_-_42184194 0.553 PLAT
plasminogen activator, tissue
chr22_-_42589543 0.552 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr15_-_61461127 0.551 NM_001218
NM_206925
CA12

carbonic anhydrase XII

chr6_+_148705646 0.544 SASH1
SAM and SH3 domain containing 1
chr13_-_19008884 0.539 NM_001141968
NM_130785
NM_199254
TPTE2


transmembrane phosphoinositide 3-phosphatase and tensin homolog 2


chr2_-_237987509 0.539 COL6A3
collagen, type VI, alpha 3
chrX_-_131918905 0.538 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr12_+_12935619 0.536 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr16_-_71639670 0.536 NM_006885
ZFHX3
zinc finger homeobox 3
chr12_-_90029328 0.533 LUM
lumican
chr10_+_63803921 0.530 NM_014951
NM_199450
NM_199451
ZNF365


zinc finger protein 365


chr8_-_42184350 0.526 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr1_+_165330710 0.526 NM_001080426
DUSP27
dual specificity phosphatase 27 (putative)
chr15_+_66658626 0.524 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr10_-_73953699 0.524 NM_001195519
CBARA1
calcium binding atopy-related autoantigen 1
chrX_+_49718954 0.521 NM_000084
CLCN5
chloride channel 5
chr2_-_216008689 0.521 FN1
fibronectin 1
chr11_-_8788765 0.515 NM_213618
ST5
suppression of tumorigenicity 5
chr2_-_237987545 0.513 COL6A3
collagen, type VI, alpha 3
chr15_-_61460967 0.512 CA12
carbonic anhydrase XII
chr2_-_237987554 0.505 COL6A3
collagen, type VI, alpha 3
chr8_-_72436832 0.504 EYA1
eyes absent homolog 1 (Drosophila)
chr2_+_154436670 0.503 NM_052917
GALNT13
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)
chr11_-_62213577 0.501 LRRN4CL
LRRN4 C-terminal like
chr2_-_237987553 0.500 COL6A3
collagen, type VI, alpha 3
chr4_+_145786622 0.497 NM_022475
HHIP
hedgehog interacting protein
chr10_+_123913094 0.497 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr4_+_3341521 0.492 NM_198227
RGS12
regulator of G-protein signaling 12
chr2_-_237987579 0.484 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr11_-_85107569 0.481 NM_206929
SYTL2
synaptotagmin-like 2
chr12_-_90029672 0.481 NM_002345
LUM
lumican
chr7_-_37923040 0.480 NM_003014
SFRP4
secreted frizzled-related protein 4
chr8_-_67253234 0.475 NM_000756
CRH
corticotropin releasing hormone
chr3_-_64186151 0.474 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr2_-_142605010 0.470 LRP1B
low density lipoprotein receptor-related protein 1B
chr1_+_99502435 0.469 NM_001166252
NM_014839
LPPR4

lipid phosphate phosphatase-related protein type 4

chr16_-_4528380 0.468 NM_001199054
C16orf5
chromosome 16 open reading frame 5
chr12_+_70120028 0.466 NM_003667
LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr12_+_79625538 0.465 NM_002469
MYF6
myogenic factor 6 (herculin)
chr14_+_95740768 0.455 NM_000623
BDKRB2
bradykinin receptor B2
chr22_-_27787793 0.453 NM_015370
C22orf31
chromosome 22 open reading frame 31
chr1_+_16203317 0.448 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr19_-_62043867 0.447 NM_001146326
NM_001146327
NM_015363
NM_001146184
NM_001146185
NM_001146187
NM_006210
ZIM2


PEG3



zinc finger, imprinted 2


paternally expressed 3



chr5_+_159276317 0.446 NM_000679
ADRA1B
adrenergic, alpha-1B-, receptor
chr4_+_120167264 0.442 SYNPO2
synaptopodin 2
chr8_-_72437020 0.439 NM_000503
EYA1
eyes absent homolog 1 (Drosophila)
chr5_+_66160359 0.435 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chrX_+_102471769 0.433 NM_152278
TCEAL7
transcription elongation factor A (SII)-like 7
chr4_+_54790190 0.431 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr11_+_76516957 0.428 NM_000260
NM_001127179
NM_001127180
MYO7A


myosin VIIA


chr12_-_7935010 0.425 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr10_+_95838801 0.423 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr19_-_56919032 0.420 NM_001523
HAS1
hyaluronan synthase 1
chr5_+_36642213 0.419 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr2_+_37425240 0.418 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr5_-_127901376 0.410 FBN2
fibrillin 2
chr17_-_39340414 0.410 MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr6_-_46401174 0.407 RCAN2
regulator of calcineurin 2
chr6_+_148705817 0.406 SASH1
SAM and SH3 domain containing 1
chr4_+_158361185 0.406 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr3_+_89239494 0.405 EPHA3
EPH receptor A3
chr3_-_9786583 0.404 CAMK1
calcium/calmodulin-dependent protein kinase I
chr4_-_156517423 0.398 MAP9
microtubule-associated protein 9
chr11_-_62213946 0.397 NM_203422
LRRN4CL
LRRN4 C-terminal like
chr8_-_93181091 0.395 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr15_-_80123935 0.391 MEX3B
mex-3 homolog B (C. elegans)
chr5_+_36642424 0.390 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr3_+_141136691 0.388 NM_022131
CLSTN2
calsyntenin 2
chr16_+_70654625 0.384 NM_020995
HPR
haptoglobin-related protein
chr4_+_120276386 0.379 NM_016599
MYOZ2
myozenin 2
chr2_+_219991342 0.377 NM_001927
DES
desmin
chr2_-_238861830 0.376 NM_022817
PER2
period homolog 2 (Drosophila)
chr19_+_50041400 0.376 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr17_-_19592178 0.375 NM_000691
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr16_-_54424473 0.375 CES1
carboxylesterase 1
chr12_+_12935759 0.374 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chrX_-_128485134 0.373 NM_003069
NM_139035
SMARCA1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

chr14_+_95792299 0.372 NM_000710
BDKRB1
bradykinin receptor B1
chr3_+_25444753 0.370 NM_016152
RARB
retinoic acid receptor, beta
chr16_-_54424517 0.370 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr5_+_54491702 0.368 NM_001008397
GPX8
glutathione peroxidase 8 (putative)
chr15_-_81037554 0.361 NM_001079533
NM_001079534
NM_001079535
CPEB1


cytoplasmic polyadenylation element binding protein 1


chr5_-_54317102 0.355 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr7_-_37922902 0.354 SFRP4
secreted frizzled-related protein 4
chr2_+_206847658 0.353 NM_020923
ZDBF2
zinc finger, DBF-type containing 2
chr3_-_9786623 0.352 CAMK1
calcium/calmodulin-dependent protein kinase I
chr4_-_156517544 0.351 NM_001039580
MAP9
microtubule-associated protein 9
chrX_+_110226030 0.351 NM_002578
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3
chr5_-_139993469 0.350 NM_001040021
NM_001174104
NM_001174105
CD14


CD14 molecule


chr10_+_93673485 0.349 BTAF1
BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)
chr4_-_156517394 0.348 MAP9
microtubule-associated protein 9
chr9_+_138341752 0.346 NM_001145638
NM_015597
GPSM1

G-protein signaling modulator 1

chr6_-_75972473 0.343 COL12A1
collagen, type XII, alpha 1
chr5_-_121441866 0.343 LOX
lysyl oxidase
chr21_-_42060334 0.336 RIPK4
receptor-interacting serine-threonine kinase 4
chr3_-_9786628 0.334 NM_003656
CAMK1
calcium/calmodulin-dependent protein kinase I
chr4_+_119174947 0.333 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chrX_-_128485121 0.332 SMARCA1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr21_-_42060266 0.331 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr2_-_206790871 0.330 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chr7_+_89681069 0.327 NM_001040666
STEAP2
six transmembrane epithelial antigen of the prostate 2
chr6_-_46401363 0.321 NM_005822
RCAN2
regulator of calcineurin 2
chr3_+_89239363 0.320 NM_005233
NM_182644
EPHA3

EPH receptor A3

chr20_+_19863716 0.319 RIN2
Ras and Rab interactor 2
chr3_+_8518508 0.319 NM_014583
LMCD1
LIM and cysteine-rich domains 1
chr11_-_85108030 0.317 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr2_+_3683660 0.315 NM_018436
ALLC
allantoicase
chr9_+_129900590 0.314 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr3_+_8518539 0.313 LMCD1
LIM and cysteine-rich domains 1
chr17_+_12510030 0.312 MYOCD
myocardin
chr17_-_77824849 0.312 NM_001893
NM_139062
CSNK1D

casein kinase 1, delta

chr9_+_102987137 0.312 NM_017753
LPPR1
lipid phosphate phosphatase-related protein type 1
chr8_-_120033240 0.312 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr16_+_88517187 0.311 NM_006086
TUBB3
tubulin, beta 3
chr3_+_25444837 0.309 NM_000965
RARB
retinoic acid receptor, beta
chr1_+_57093030 0.309 NM_000562
C8A
complement component 8, alpha polypeptide
chr22_+_39404940 0.308 NM_005297
MCHR1
melanin-concentrating hormone receptor 1
chr4_-_54119159 0.307 NM_032622
LNX1
ligand of numb-protein X 1
chr4_-_54119102 0.306 LNX1
ligand of numb-protein X 1
chr4_-_54119123 0.306 LNX1
ligand of numb-protein X 1
chr11_+_24475091 0.304 NM_001009909
LUZP2
leucine zipper protein 2
chr20_-_5539487 0.301 NM_019593
GPCPD1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr2_-_224175293 0.300 SCG2
secretogranin II
chr2_-_224175339 0.296 SCG2
secretogranin II
chr17_+_38831874 0.292 NM_001661
ARL4D
ADP-ribosylation factor-like 4D
chr8_+_69026895 0.292 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.33 1.21e-03 GO:0032502 developmental process
1.36 2.13e-03 GO:0048856 anatomical structure development
1.37 5.92e-03 GO:0048731 system development
1.24 1.07e-02 GO:0032501 multicellular organismal process
1.51 2.44e-02 GO:0007399 nervous system development
1.30 3.79e-02 GO:0007275 multicellular organismal development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.22 2.84e-03 GO:0031091 platelet alpha granule
1.53 3.70e-02 GO:0044421 extracellular region part
4.01 4.98e-02 GO:0031093 platelet alpha granule lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.05 1.81e-02 GO:0042578 phosphoric ester hydrolase activity
1.16 1.92e-02 GO:0005515 protein binding