Motif ID: EN1,2.p2

Z-value: 3.561


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EN2chr7_+_154943466-0.439.7e-02Click!
EN1chr2_-_119322228-0.029.4e-01Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_40211324 10.024 RBM47
RNA binding motif protein 47
chr7_+_50318801 9.255 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr12_-_7172641 7.774 NM_031491
RBP5
retinol binding protein 5, cellular
chr2_+_102401580 5.908 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr4_-_80466177 5.362 NM_032693
NAA11
N(alpha)-acetyltransferase 11, NatA catalytic subunit
chr1_+_173111306 5.348 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr3_+_188197029 5.278


chr22_+_38627031 5.048 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr20_-_45410033 4.833 ZMYND8
zinc finger, MYND-type containing 8
chr2_+_68855436 4.468 NM_001166276
NM_014882
ARHGAP25

Rho GTPase activating protein 25

chr4_+_39874921 4.394 NM_004310
RHOH
ras homolog gene family, member H
chr2_-_158008763 3.962 NM_004288
CYTIP
cytohesin 1 interacting protein
chr2_+_96355661 3.937 NM_178495
NM_001163524
ITPRIPL1

inositol 1,4,5-triphosphate receptor interacting protein-like 1

chrX_-_48212683 3.887 SLC38A5
solute carrier family 38, member 5
chr1_-_180822686 3.844 NM_021133
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr22_+_38627129 3.796 GRAP2
GRB2-related adaptor protein 2
chr11_+_123600553 3.644 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr11_+_59979857 3.546 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr10_-_98021144 3.332 NM_001114094
NM_013314
BLNK

B-cell linker

chr6_-_32121784 3.317 NM_032470
TNXB
tenascin XB
chr5_-_86739683 3.308 CCNH
cyclin H
chr11_-_47356650 3.257 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr6_-_30188845 3.235 NM_007028
TRIM31
tripartite motif containing 31
chr4_-_54152480 3.200 NM_001126328
LNX1
ligand of numb-protein X 1
chrX_+_65152004 3.175


chr3_-_184756101 3.159 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr4_-_38710376 3.139 NM_024943
TMEM156
transmembrane protein 156
chr11_-_47356562 3.133 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr6_+_28601767 3.123 NM_001509
NM_003996
GPX5

glutathione peroxidase 5 (epididymal androgen-related protein)

chr3_-_185578621 3.070 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr10_-_104169458 3.039 PSD
pleckstrin and Sec7 domain containing
chr11_-_47356642 3.028 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr17_-_74361620 3.017 TIMP2
TIMP metallopeptidase inhibitor 2
chr6_-_43703024 2.977 GTPBP2
GTP binding protein 2
chr16_+_56567839 2.974 NM_199046
NM_199456
TEPP

testis, prostate and placenta expressed

chr11_-_47356672 2.970 NM_001080547
NM_003120
SPI1

spleen focus forming virus (SFFV) proviral integration oncogene spi1

chr3_+_99733432 2.895 NM_005290
GPR15
G protein-coupled receptor 15
chr1_+_111217244 2.890 NM_000560
CD53
CD53 molecule
chr6_-_43703057 2.853 GTPBP2
GTP binding protein 2
chr11_-_116605761 2.800 PCSK7
proprotein convertase subtilisin/kexin type 7
chr2_+_183290912 2.719 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr16_-_79811475 2.663 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr1_+_159032551 2.619 NM_001033667
NM_002348
LY9

lymphocyte antigen 9

chrX_-_130792297 2.518 LOC286467
hypothetical LOC286467
chr19_+_39402167 2.491 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr1_+_159943385 2.478 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr12_-_101036407 2.471 NM_024057
NUP37
nucleoporin 37kDa
chr17_+_43165608 2.445 NM_013351
TBX21
T-box 21
chr20_+_54420574 2.437 NM_001164116
NM_001164114
NM_001164115
NM_020356
CASS4



Cas scaffolding protein family member 4



chr17_-_40843530 2.435 ARHGAP27
Rho GTPase activating protein 27
chr12_+_6424293 2.431 NM_001242
CD27
CD27 molecule
chr12_+_91620749 2.404 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr10_-_104168890 2.381 NM_002779
PSD
pleckstrin and Sec7 domain containing
chr1_-_164402575 2.368 NM_001017961
FAM78B
family with sequence similarity 78, member B
chr12_+_55018925 2.357 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr16_-_28425632 2.332 NM_145659
IL27
interleukin 27
chr3_+_120375053 2.322 NM_006952
UPK1B
uroplakin 1B
chr19_-_53515143 2.316 NM_144577
CCDC114
coiled-coil domain containing 114
chr17_-_53764867 2.290


chr4_+_71235259 2.290 NM_033122
CABS1
calcium-binding protein, spermatid-specific 1
chr20_+_61838479 2.288 LIME1
Lck interacting transmembrane adaptor 1
chrX_+_9391314 2.274 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr1_+_144124547 2.272 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr11_-_47356479 2.252 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr5_+_68703036 2.229 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr6_-_25834733 2.218 NM_170745
HIST1H2AA
histone cluster 1, H2aa
chr4_-_17415918 2.196 DCAF16
DDB1 and CUL4 associated factor 16
chr6_+_32515596 2.152 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr8_-_107023 2.130 NM_001005504
OR4F21
olfactory receptor, family 4, subfamily F, member 21
chr20_-_29751755 2.125


chr12_-_101396459 2.117 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr10_+_104169560 2.114 NM_024326
FBXL15
F-box and leucine-rich repeat protein 15
chr12_-_51585004 2.093 NM_002273
KRT8
keratin 8
chr2_-_152299229 2.075 NM_001164507
NM_001164508
NM_004543
NEB


nebulin


chr6_+_160247962 2.069 NM_002377
MAS1
MAS1 oncogene
chr3_+_171022403 2.069 NM_001080460
LRRIQ4
leucine-rich repeats and IQ motif containing 4
chr22_+_19248733 2.040 MED15
mediator complex subunit 15
chr14_+_87541220 2.024 NM_003608
GPR65
G protein-coupled receptor 65
chr16_-_88358946 1.992 FANCA
Fanconi anemia, complementation group A
chr19_+_47073029 1.973 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr4_-_54152385 1.972 LNX1
ligand of numb-protein X 1
chr12_-_69434330 1.965 PTPRR
protein tyrosine phosphatase, receptor type, R
chrX_+_134803450 1.949 NM_018666
SAGE1
sarcoma antigen 1
chr1_+_25471470 1.946 NM_001127691
NM_016124
RHD

Rh blood group, D antigen

chr11_-_56761250 1.940 NM_005161
APLNR
apelin receptor
chr1_+_43063817 1.909 NM_018538
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr7_+_106897737 1.886 NM_005295
GPR22
G protein-coupled receptor 22
chr20_+_61838389 1.866 NM_017806
LIME1
Lck interacting transmembrane adaptor 1
chr15_-_78050515 1.851 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr9_+_124072947 1.839 NM_199177
MRRF
mitochondrial ribosome recycling factor
chrX_-_47374647 1.838 NM_002621
CFP
complement factor properdin
chr8_-_66863841 1.830 NM_002603
PDE7A
phosphodiesterase 7A
chr19_-_44518465 1.821 GMFG
glia maturation factor, gamma
chr1_-_159306037 1.813 ARHGAP30
Rho GTPase activating protein 30
chr17_-_74361975 1.790 TIMP2
TIMP metallopeptidase inhibitor 2
chr14_-_20340377 1.782 NM_198232
RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr12_-_101115677 1.778 NM_002674
PMCH
pro-melanin-concentrating hormone
chr11_-_64403712 1.778 EHD1
EH-domain containing 1
chr6_-_33085290 1.773 HLA-DOA
major histocompatibility complex, class II, DO alpha
chr7_-_25234582 1.759 NM_022150
NPVF
neuropeptide VF precursor
chr11_-_123918759 1.733 NM_001005195
OR8B12
olfactory receptor, family 8, subfamily B, member 12
chr11_-_123758448 1.723 NM_001005468
OR8B2
olfactory receptor, family 8, subfamily B, member 2
chrX_-_7855400 1.714 NM_004650
PNPLA4
patatin-like phospholipase domain containing 4
chr19_-_40925151 1.708 NM_024660
TMEM149
transmembrane protein 149
chr11_+_123625632 1.707 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr2_-_144994038 1.699 ZEB2
zinc finger E-box binding homeobox 2
chr2_+_68445936 1.698 PLEK
pleckstrin
chr15_+_42815851 1.696 NM_080745
NM_182985
TRIM69

tripartite motif containing 69

chr6_-_159386007 1.692 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr14_-_22658078 1.678 NM_001805
CEBPE
CCAAT/enhancer binding protein (C/EBP), epsilon
chrX_+_65300803 1.673 NM_001130860
NM_014799
HEPH

hephaestin

chr16_+_49288550 1.671 NM_022162
NOD2
nucleotide-binding oligomerization domain containing 2
chr1_+_47674275 1.633 NM_004474
FOXD2
forkhead box D2
chr9_+_95886558 1.629 NM_152422
PTPDC1
protein tyrosine phosphatase domain containing 1
chr6_-_123999640 1.621 NM_006073
TRDN
triadin
chr18_+_27210737 1.612 NM_001134453
NM_177986
DSG4

desmoglein 4

chr6_-_33085329 1.608 NM_002119
HLA-DOA
major histocompatibility complex, class II, DO alpha
chr7_-_38355949 1.598


chr7_+_106293112 1.583 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr3_+_46423682 1.581 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr1_+_32447281 1.571 NM_001099434
DCDC2B
doublecortin domain containing 2B
chr3_-_122862391 1.568 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr12_+_63510481 1.561


chr16_+_28850760 1.561 NM_001178098
NM_001770
CD19

CD19 molecule

chrX_-_48655978 1.551 PIM2
pim-2 oncogene
chr17_-_31441390 1.526 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr6_+_30212488 1.516 NM_138700
TRIM40
tripartite motif containing 40
chr22_+_49333327 1.515 NM_138433
KLHDC7B
kelch domain containing 7B
chr7_-_26202626 1.515 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr6_+_35373632 1.494 DEF6
differentially expressed in FDCP 6 homolog (mouse)
chr14_+_99601498 1.489 NM_016337
EVL
Enah/Vasp-like
chr12_+_6926014 1.489 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr3_-_113334657 1.489 NM_001190259
NM_001190260
NM_152785
GCET2


germinal center expressed transcript 2


chr16_+_29728932 1.488 MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr1_+_154390939 1.486 SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr12_+_119617060 1.481


chr15_-_32416336 1.470 NM_001042497
NM_133647
SLC12A6

solute carrier family 12 (potassium/chloride transporters), member 6

chr19_-_4491024 1.469 NM_052972
LRG1
leucine-rich alpha-2-glycoprotein 1
chrX_+_49480643 1.454 NM_007003
PAGE4
P antigen family, member 4 (prostate associated)
chr1_+_160618143 1.452 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr6_+_6533932 1.447 NM_004271
LY86
lymphocyte antigen 86
chr7_-_20223467 1.438 NM_182762
MACC1
metastasis associated in colon cancer 1
chr20_-_34807882 1.437 NM_022477
NM_032013
NDRG3

NDRG family member 3

chr10_+_5976354 1.436 NM_032807
FBXO18
F-box protein, helicase, 18
chr19_+_13999959 1.429 NM_080864
RLN3
relaxin 3
chr1_+_157526127 1.426 NM_002001
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr22_-_48865797 1.422 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr1_-_229627412 1.420 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr1_-_42574116 1.407 NM_001198850
FOXJ3
forkhead box J3
chr12_+_6925997 1.400 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr1_-_114215768 1.396 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr6_+_14032655 1.395 NM_001165034
RNF182
ring finger protein 182
chr14_+_59782222 1.395 NM_177952
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr7_+_117651947 1.386 NM_019644
ANKRD7
ankyrin repeat domain 7
chr1_+_152206969 1.386 NM_130898
CREB3L4
cAMP responsive element binding protein 3-like 4
chr16_+_557011 1.376 NM_176677
NHLRC4
PIGQ
NHL repeat containing 4
phosphatidylinositol glycan anchor biosynthesis, class Q
chr2_-_224974954 1.373 NM_001122779
NM_024785
FAM124B

family with sequence similarity 124B

chr22_+_19660361 1.372 AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr11_+_22652957 1.370 GAS2
growth arrest-specific 2
chr6_+_41411505 1.364 NM_004828
NCR2
natural cytotoxicity triggering receptor 2
chr11_+_5367182 1.355 NM_001004756
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr21_-_33805490 1.354 GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
chr6_-_116973465 1.353 NM_001139444
BET3L
BET3 like (S. cerevisiae)
chr1_-_220788048 1.349 NM_024746
HHIPL2
HHIP-like 2
chr17_-_24491521 1.342 MYO18A
myosin XVIIIA
chr17_-_36928604 1.341 NM_002275
KRT15
keratin 15
chr1_-_47468029 1.326 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr2_-_65013070 1.317 LOC400958
hypothetical LOC400958
chr14_+_22845851 1.316 NM_004050
BCL2L2-PABPN1
BCL2L2
BCL2L2-PABPN1 read-through transcript
BCL2-like 2
chr8_+_37714524 1.315


chr17_+_22996461 1.312 LGALS9
lectin, galactoside-binding, soluble, 9
chr12_-_69434598 1.308 NM_130846
PTPRR
protein tyrosine phosphatase, receptor type, R
chr14_-_20340830 1.303 NM_002933
NM_198234
NM_198235
RNASE1


ribonuclease, RNase A family, 1 (pancreatic)


chr11_-_31789360 1.297 PAX6
paired box 6
chr19_-_44518516 1.296 NM_004877
GMFG
glia maturation factor, gamma
chr16_+_29581783 1.293 NM_001030288
SPN
sialophorin
chr12_+_119562737 1.284 NM_001033677
CABP1
calcium binding protein 1
chr19_-_14030970 1.279 NM_001145028
PALM3
paralemmin 3
chr12_-_69434650 1.275 PTPRR
protein tyrosine phosphatase, receptor type, R
chr17_-_60439764 1.274 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr19_-_4491078 1.268 LRG1
leucine-rich alpha-2-glycoprotein 1
chr1_-_202726068 1.265 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr1_+_149877955 1.252 SNX27
sorting nexin family member 27
chr3_-_122862447 1.250 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr15_-_74091817 1.230 NM_138573
NRG4
neuregulin 4
chr12_+_54316910 1.226 NM_206899
OR10P1
olfactory receptor, family 10, subfamily P, member 1
chr2_+_68726457 1.225 NM_138964
PROKR1
prokineticin receptor 1
chr13_+_110637173 1.221 NM_001113513
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr11_-_5247948 1.212 NM_005330
HBE1
hemoglobin, epsilon 1
chr3_+_38238080 1.210 OXSR1
oxidative-stress responsive 1
chr12_-_94469357 1.203 NM_032147
USP44
ubiquitin specific peptidase 44
chr12_+_49922592 1.201 DAZAP2
DAZ associated protein 2
chr7_-_100077072 1.198 NM_003227
TFR2
transferrin receptor 2
chr21_+_37713076 1.196 NM_130436
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr6_+_106653429 1.189 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr22_-_48865907 1.187 NM_139202
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr11_-_31789431 1.177 NM_000280
NM_001604
PAX6

paired box 6

chr10_-_48036698 1.174 NM_016204
GDF2
growth differentiation factor 2
chrX_+_36163971 1.170 NM_001098843
CXorf30
chromosome X open reading frame 30
chr12_+_6915698 1.170



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.66 2.24e-11 GO:0007608 sensory perception of smell
2.54 3.38e-11 GO:0007606 sensory perception of chemical stimulus
1.28 5.85e-09 GO:0050896 response to stimulus
1.93 1.34e-07 GO:0007600 sensory perception
1.88 7.56e-06 GO:0006955 immune response
1.52 5.04e-05 GO:0003008 system process
1.54 5.89e-04 GO:0050877 neurological system process
1.52 5.34e-03 GO:0002376 immune system process
1.63 1.25e-02 GO:0006952 defense response
3.20 2.04e-02 GO:0006959 humoral immune response
2.49 4.81e-02 GO:0002252 immune effector process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.35 8.35e-09 GO:0071944 cell periphery
1.35 1.75e-08 GO:0005886 plasma membrane
1.35 3.73e-03 GO:0005576 extracellular region
1.18 5.61e-03 GO:0031224 intrinsic to membrane
1.17 2.06e-02 GO:0016021 integral to membrane
1.53 2.78e-02 GO:0005615 extracellular space
1.46 2.81e-02 GO:0044421 extracellular region part
2.22 3.81e-02 GO:0005882 intermediate filament
1.14 4.75e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.75 1.39e-12 GO:0004984 olfactory receptor activity
2.02 1.94e-10 GO:0004930 G-protein coupled receptor activity
1.77 1.72e-09 GO:0004888 transmembrane receptor activity
1.53 3.64e-08 GO:0004871 signal transducer activity
1.53 3.64e-08 GO:0060089 molecular transducer activity
1.56 5.33e-07 GO:0004872 receptor activity