Motif ID: GATA6.p2

Z-value: 5.182


Transcription factors associated with GATA6.p2:

Gene SymbolEntrez IDGene Name
GATA6 2627 GATA binding protein 6

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GATA6chr18_+_18003401-0.292.8e-01Click!


Activity profile for motif GATA6.p2.

activity profile for motif GATA6.p2


Sorted Z-values histogram for motif GATA6.p2

Sorted Z-values for motif GATA6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GATA6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_100077072 28.790 NM_003227
TFR2
transferrin receptor 2
chr10_+_70745615 28.068 NM_033496
HK1
hexokinase 1
chr7_-_142369534 26.478 NM_000420
KEL
Kell blood group, metallo-endopeptidase
chr7_-_142369519 26.366 KEL
Kell blood group, metallo-endopeptidase
chr12_-_52975777 24.190 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr12_-_52975823 23.558 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr9_-_99740243 16.183 NM_197978
HEMGN
hemogen
chr6_-_49712483 15.869 NM_000324
RHAG
Rh-associated glycoprotein
chr11_+_118463906 14.681 NM_001024382
HMBS
hydroxymethylbilane synthase
chr6_+_31782618 14.635 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr12_+_52105131 14.401 AMHR2
anti-Mullerian hormone receptor, type II
chr1_+_181028016 14.096 NM_030769
NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr16_+_142853 14.061 NM_005332
HBZ
hemoglobin, zeta
chr1_+_43063817 13.460 NM_018538
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr1_-_156923111 13.399 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr1_-_27113018 12.896 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr17_-_59437782 12.847 NM_000873
ICAM2
intercellular adhesion molecule 2
chr16_-_87570716 12.467 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr10_-_48036698 11.796 NM_016204
GDF2
growth differentiation factor 2
chr19_+_13999959 11.613 NM_080864
RLN3
relaxin 3
chr19_-_12858956 10.951 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chrX_+_65152004 10.240


chr21_+_42697058 10.045 NM_001001895
NM_018961
UBASH3A

ubiquitin associated and SH3 domain containing A

chr17_-_53764867 10.036


chr10_-_99521701 9.775 NM_003015
SFRP5
secreted frizzled-related protein 5
chr1_-_153537810 9.585 NM_000298
PKLR
pyruvate kinase, liver and RBC
chr1_+_152560179 9.543 NM_080429
AQP10
aquaporin 10
chrX_+_44588192 9.419 NM_022076
DUSP21
dual specificity phosphatase 21
chr7_+_129807467 9.090 NM_001868
CPA1
carboxypeptidase A1 (pancreatic)
chr16_-_45339605 9.053 NM_182493
MYLK3
myosin light chain kinase 3
chr16_+_557011 9.046 NM_176677
NHLRC4
PIGQ
NHL repeat containing 4
phosphatidylinositol glycan anchor biosynthesis, class Q
chr19_-_11355882 9.008 NM_000121
EPOR
erythropoietin receptor
chr8_-_38127489 8.828 NM_000349
STAR
steroidogenic acute regulatory protein
chr19_+_10258642 8.788 NM_001039132
NM_001544
NM_022377
ICAM4


intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)


chr2_+_27573206 8.505 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr1_+_200698493 8.382 NM_032103
NM_032104
PPP1R12B

protein phosphatase 1, regulatory (inhibitor) subunit 12B

chr19_-_60241424 8.332 NM_001083899
NM_016363
GP6

glycoprotein VI (platelet)

chr8_-_86477585 8.277 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr8_+_124263932 8.255 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr2_+_108571336 8.045 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chrX_-_55074125 7.668 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr17_-_39822366 7.647 NM_000419
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr11_+_63730766 7.576 FERMT3
fermitin family member 3
chr16_+_31446703 7.537 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chr8_+_124264054 7.216 FAM83A
family with sequence similarity 83, member A
chr17_-_3766708 7.120 NM_002558
P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr1_-_153537362 7.077 NM_181871
PKLR
pyruvate kinase, liver and RBC
chr2_-_68952006 6.963 NM_014482
BMP10
bone morphogenetic protein 10
chr19_-_13074513 6.764 LYL1
lymphoblastic leukemia derived sequence 1
chr19_-_60360768 6.730 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr17_-_3766441 6.716 P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr1_-_25619863 6.650 NM_020485
NM_138616
NM_138617
NM_138618
RHCE



RHD
Rh blood group, CcEe antigens



Rh blood group, D antigen
chr2_+_220145197 6.611 NM_002191
INHA
inhibin, alpha
chr19_+_16860807 6.495 NM_003950
F2RL3
coagulation factor II (thrombin) receptor-like 3
chr2_-_43919392 6.488 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr9_-_113977285 6.451 NM_022486
SUSD1
sushi domain containing 1
chr1_-_206125877 6.362


chr2_+_43919606 6.301 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr1_+_25471470 6.284 NM_001127691
NM_016124
RHD

Rh blood group, D antigen

chr9_+_263025 6.262 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr1_+_157441133 6.225 NM_002036
DARC
Duffy blood group, chemokine receptor
chrX_+_152684150 6.128 PLXNB3
plexin B3
chr19_+_16860871 6.048 F2RL3
coagulation factor II (thrombin) receptor-like 3
chr15_-_41300316 6.010 EPB42
erythrocyte membrane protein band 4.2
chr12_+_25096472 5.963 NM_006152
LRMP
lymphoid-restricted membrane protein
chr5_-_34020445 5.893 NM_001012509
NM_016180
SLC45A2

solute carrier family 45, member 2

chr7_+_150321771 5.853 NM_001160109
NM_001160110
NM_001160111
NOS3


nitric oxide synthase 3 (endothelial cell)


chr11_-_116213511 5.706 NM_000039
APOA1
apolipoprotein A-I
chr9_+_33230165 5.663 NM_014471
SPINK4
serine peptidase inhibitor, Kazal type 4
chr17_+_53761293 5.594 LOC100506779
hypothetical LOC100506779
chr3_-_52839727 5.479 NM_001166449
NM_002218
ITIH4

inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)

chr7_+_106293112 5.396 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr19_-_13074669 5.360 LYL1
lymphoblastic leukemia derived sequence 1
chr6_-_49820030 5.323 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chr2_+_220087135 5.276 NM_018674
NM_182847
ACCN4

amiloride-sensitive cation channel 4, pituitary

chr19_+_40824486 5.254 NM_014209
ETV2
ets variant 2
chr21_+_36458708 5.226 NM_005128
DOPEY2
dopey family member 2
chr17_-_71352090 5.071 UNC13D
unc-13 homolog D (C. elegans)
chr12_-_68291208 5.033 NM_201550
LRRC10
leucine rich repeat containing 10
chr9_+_138677197 5.027 NM_201446
NM_016215
EGFL7

EGF-like-domain, multiple 7

chr11_-_56914668 4.996 NM_002728
PRG2
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
chr11_+_63730720 4.903 NM_031471
NM_178443
FERMT3

fermitin family member 3

chr1_-_30969016 4.867 NM_002379
MATN1
matrilin 1, cartilage matrix protein
chr21_+_37714470 4.833 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr14_+_19681734 4.730 NM_001004724
OR4N5
olfactory receptor, family 4, subfamily N, member 5
chr15_-_48626193 4.695 NM_203494
USP50
ubiquitin specific peptidase 50
chr3_-_10309600 4.639 NM_001134944
NM_001134945
NM_001134946
GHRL


ghrelin/obestatin prepropeptide


chr4_-_40212670 4.567 NM_019027
RBM47
RNA binding motif protein 47
chr9_+_124177421 4.559 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr5_-_176868483 4.538 DOK3
docking protein 3
chr11_-_123816190 4.443 NM_012378
OR8B8
olfactory receptor, family 8, subfamily B, member 8
chr7_-_112515068 4.442 NM_001146265
NM_018970
GPR85

G protein-coupled receptor 85

chr17_-_71352017 4.219 UNC13D
unc-13 homolog D (C. elegans)
chr20_+_42463387 4.155 HNF4A
hepatocyte nuclear factor 4, alpha
chrX_+_65299352 4.142 HEPH
hephaestin
chr6_-_11887265 4.125 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr1_+_198263352 4.105 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr2_+_108571209 4.089 LIMS1
LIM and senescent cell antigen-like domains 1
chrX_+_65299157 4.088 NM_138737
HEPH
hephaestin
chr6_-_50025115 4.080 NM_001166478
DEFB133
defensin, beta 133
chr20_-_45410033 3.987 ZMYND8
zinc finger, MYND-type containing 8
chr3_-_3127057 3.956 NM_000564
NM_175724
NM_175725
NM_175726
NM_175727
NM_175728
IL5RA





interleukin 5 receptor, alpha





chr7_-_107667728 3.943 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr16_+_80086454 3.939 NM_030629
CMIP
c-Maf-inducing protein
chr12_-_14887648 3.931 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr2_-_175207521 3.855 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr4_-_54152385 3.854 LNX1
ligand of numb-protein X 1
chr10_+_11246934 3.809 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr3_-_57209319 3.805 NM_003865
HESX1
HESX homeobox 1
chr16_+_24765052 3.788 NM_052944
SLC5A11
solute carrier family 5 (sodium/glucose cotransporter), member 11
chr8_-_41774296 3.755 NM_000037
NM_020475
NM_020476
NM_020477
ANK1



ankyrin 1, erythrocytic



chr7_-_112515035 3.715 GPR85
G protein-coupled receptor 85
chr1_-_109651140 3.670 NM_001010985
MYBPHL
myosin binding protein H-like
chr1_-_26266571 3.652 NM_032588
TRIM63
tripartite motif containing 63
chr5_+_1254709 3.561 NM_001003841
SLC6A19
solute carrier family 6 (neutral amino acid transporter), member 19
chr22_+_21543671 3.556 IGLV4-3
immunoglobulin lambda variable 4-3
chr6_-_30236667 3.532 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr17_-_53761119 3.499 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr7_-_112514990 3.412 GPR85
G protein-coupled receptor 85
chr15_-_41300526 3.406 NM_000119
NM_001114134
EPB42

erythrocyte membrane protein band 4.2

chr19_-_53081383 3.404 NM_003167
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr15_-_41300488 3.395 EPB42
erythrocyte membrane protein band 4.2
chrX_-_10761729 3.358 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr2_+_169465995 3.327 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr2_+_138438277 3.298 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr11_+_60858611 3.273 DAK
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chr1_-_154665807 3.272 NM_006365
C1orf61
chromosome 1 open reading frame 61
chr2_+_102294393 3.262 NM_016232
IL18R1
IL1RL1
interleukin 18 receptor 1
interleukin 1 receptor-like 1
chr19_-_53081326 3.261 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr22_-_25205376 3.255 NM_152841
HPS4
Hermansky-Pudlak syndrome 4
chr11_-_47330797 3.180 NM_000256
MYBPC3
myosin binding protein C, cardiac
chr13_-_45654296 3.167 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr12_+_25096755 3.130 LRMP
lymphoid-restricted membrane protein
chr16_-_69876262 3.114 FTSJD1
FtsJ methyltransferase domain containing 1
chr1_-_111848265 3.112 NM_000677
NM_020683
ADORA3

adenosine A3 receptor

chr16_-_66535457 3.105 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr12_-_69434330 3.099 PTPRR
protein tyrosine phosphatase, receptor type, R
chr12_-_119249938 3.091 NM_000928
PLA2G1B
phospholipase A2, group IB (pancreas)
chr16_+_24709922 3.062 TNRC6A
trinucleotide repeat containing 6A
chr17_-_74361620 3.044 TIMP2
TIMP metallopeptidase inhibitor 2
chr19_+_15612706 3.036 NM_000896
CYP4F3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr12_-_55696542 3.029 NM_001178054
NM_013251
TAC3

tachykinin 3

chr11_-_16387001 3.027 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr1_-_100416358 2.997 NM_144620
LRRC39
leucine rich repeat containing 39
chr22_+_33792125 2.961 NM_001008494
ISX
intestine-specific homeobox
chr1_+_196874867 2.956 PTPRC
protein tyrosine phosphatase, receptor type, C
chr11_+_93940121 2.952 NM_152431
PIWIL4
piwi-like 4 (Drosophila)
chr7_+_139175420 2.936 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr20_+_42463279 2.928 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr1_-_43509187 2.915 EBNA1BP2
EBNA1 binding protein 2
chr8_-_145672525 2.895 NM_003923
FOXH1
forkhead box H1
chr13_-_45654327 2.889 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr4_-_68678181 2.865 NM_207407
TMPRSS11F
transmembrane protease, serine 11F
chr2_-_121875610 2.856 CLASP1
cytoplasmic linker associated protein 1
chr9_+_71009746 2.834 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr7_+_129634935 2.808 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr2_-_39310176 2.807 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr13_-_48873735 2.785 NM_030925
CAB39L
calcium binding protein 39-like
chr9_+_96561750 2.779 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr15_-_74091817 2.756 NM_138573
NRG4
neuregulin 4
chr15_-_32398220 2.755 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chrX_-_24600661 2.743 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr4_+_151722526 2.722 NM_006439
MAB21L2
mab-21-like 2 (C. elegans)
chr12_+_48784057 2.711 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr13_-_45654292 2.710 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr21_+_37377116 2.687 NM_003316
TTC3
tetratricopeptide repeat domain 3
chr6_+_167624792 2.662 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr1_-_114231519 2.632 BCL2L15
BCL2-like 15
chr11_-_64520964 2.625 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr17_-_71352182 2.622 NM_199242
UNC13D
unc-13 homolog D (C. elegans)
chr1_-_114231691 2.607 NM_001010922
BCL2L15
BCL2-like 15
chr22_-_41685827 2.595 NM_001184971
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr8_-_38324809 2.590 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr1_-_180636373 2.572 NM_172000
TEDDM1
transmembrane epididymal protein 1
chr6_+_135558572 2.565


chr9_-_70780574 2.552


chr20_+_43368904 2.516 NM_014276
RBPJL
recombination signal binding protein for immunoglobulin kappa J region-like
chr11_-_64267037 2.513 RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr3_+_69895651 2.506 NM_006722
MITF
microphthalmia-associated transcription factor
chr20_+_55569542 2.503 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr2_-_96924582 2.500 NM_001172667
FAM178B
family with sequence similarity 178, member B
chr14_+_75058591 2.478 BATF
basic leucine zipper transcription factor, ATF-like
chr16_-_66535923 2.476 SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr18_+_3437607 2.467 NM_173207
TGIF1
TGFB-induced factor homeobox 1
chr11_+_10434056 2.463 NM_001025390
AMPD3
adenosine monophosphate deaminase 3
chr17_+_54188205 2.453 PPM1E
protein phosphatase, Mg2+/Mn2+ dependent, 1E
chr22_+_24468168 2.450 MYO18B
myosin XVIIIB
chr11_-_5523328 2.436 NM_001005289
OR52H1
olfactory receptor, family 52, subfamily H, member 1
chr2_-_188127294 2.416 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr2_-_144711375 2.406 NM_024659
GTDC1
glycosyltransferase-like domain containing 1
chr9_+_138810610 2.402 NM_001039374
KIAA1984
KIAA1984
chr22_+_24468110 2.384 NM_032608
MYO18B
myosin XVIIIB
chr8_-_30121741 2.354 NM_001100916
MBOAT4
membrane bound O-acyltransferase domain containing 4
chr1_+_158603480 2.334 NM_005598
NHLH1
nescient helix loop helix 1
chr11_+_59612712 2.330 NM_000139
MS4A2
membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
chr6_+_135558744 2.319 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr4_+_39084936 2.318 KLB
klotho beta
chr22_+_21559959 2.297 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr16_-_4778317 2.289 NM_001154458
NM_144605
SEPT12

septin 12

chr17_+_70431964 2.288 NM_178160
OTOP2
otopetrin 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.48 1.53e-13 GO:0032501 multicellular organismal process
5.52 8.23e-09 GO:0007586 digestion
1.83 8.28e-09 GO:0003008 system process
1.67 1.79e-07 GO:0065008 regulation of biological quality
2.71 3.94e-07 GO:0007608 sensory perception of smell
2.53 2.12e-06 GO:0007606 sensory perception of chemical stimulus
2.08 3.96e-06 GO:0007600 sensory perception
1.29 1.17e-05 GO:0050896 response to stimulus
1.76 2.56e-05 GO:0050877 neurological system process
2.09 4.67e-04 GO:0048878 chemical homeostasis
12.62 5.24e-04 GO:0044241 lipid digestion
2.85 6.82e-04 GO:0008202 steroid metabolic process
3.42 1.45e-03 GO:0006805 xenobiotic metabolic process
3.42 1.45e-03 GO:0071466 cellular response to xenobiotic stimulus
1.84 1.48e-03 GO:0042592 homeostatic process
3.39 1.65e-03 GO:0009410 response to xenobiotic stimulus
1.76 4.76e-03 GO:0006629 lipid metabolic process
3.99 1.61e-02 GO:0002576 platelet degranulation
2.55 2.23e-02 GO:0030168 platelet activation
5.73 3.15e-02 GO:0022600 digestive system process
1.93 3.18e-02 GO:0050878 regulation of body fluid levels

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.47 3.89e-10 GO:0071944 cell periphery
1.47 7.08e-10 GO:0005886 plasma membrane
1.25 8.14e-05 GO:0044425 membrane part
1.52 8.45e-05 GO:0005576 extracellular region
1.27 2.26e-04 GO:0031224 intrinsic to membrane
1.26 7.45e-04 GO:0016021 integral to membrane
1.66 3.00e-03 GO:0044421 extracellular region part
1.18 4.38e-03 GO:0016020 membrane
1.75 4.42e-03 GO:0005615 extracellular space
2.58 3.05e-02 GO:0016324 apical plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.75 9.53e-08 GO:0004872 receptor activity
2.73 1.99e-07 GO:0004984 olfactory receptor activity
1.83 8.28e-07 GO:0004888 transmembrane receptor activity
2.04 2.10e-06 GO:0004930 G-protein coupled receptor activity
1.59 5.99e-06 GO:0004871 signal transducer activity
1.59 5.99e-06 GO:0060089 molecular transducer activity
2.97 1.60e-02 GO:0046906 tetrapyrrole binding