Motif ID: HNF4A_NR2F1,2.p2

Z-value: 7.788


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
HNF4A 3172 hepatocyte nuclear factor 4, alpha
NR2F1 7025 nuclear receptor subfamily 2, group F, member 1
NR2F2 7026 nuclear receptor subfamily 2, group F, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HNF4Achr20_+_424632790.931.7e-07Click!
NR2F2chr15_+_94670160-0.485.7e-02Click!
NR2F1chr5_+_92944680-0.292.8e-01Click!


Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_241193492 16.140 NM_001195381
NM_001195382
GPR35

G protein-coupled receptor 35

chr10_-_101831579 15.596 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr17_+_24394281 14.717 PIPOX
pipecolic acid oxidase
chr9_-_126309510 14.551 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr12_+_51783540 14.542 NM_003578
SOAT2
sterol O-acyltransferase 2
chr12_+_51783554 14.195 SOAT2
sterol O-acyltransferase 2
chr10_+_102722275 13.548 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr3_-_52454082 13.263 NM_020163
SEMA3G
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr1_+_15941503 12.890 NM_001013641
TMEM82
transmembrane protein 82
chr6_+_131190237 12.685 NM_001195597
LOC285733
hypothetical LOC285733
chr9_-_14858974 12.645 FREM1
FRAS1 related extracellular matrix 1
chr1_-_167822248 11.880 F5
coagulation factor V (proaccelerin, labile factor)
chr13_+_112825113 11.690 NM_000504
F10
coagulation factor X
chr17_+_69950782 11.294 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr6_+_31731667 11.255 APOM
apolipoprotein M
chr2_-_74606819 11.222 NM_133637
DQX1
DEAQ box RNA-dependent ATPase 1
chr14_-_23847000 11.136 CIDEB
cell death-inducing DFFA-like effector b
chr6_+_31731647 11.095 NM_019101
APOM
apolipoprotein M
chr17_-_31353196 10.782 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr8_+_21972631 10.695 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr16_-_86527608 10.676 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr8_+_21972804 10.512 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr14_-_23847024 10.428 CIDEB
cell death-inducing DFFA-like effector b
chr9_-_129752687 10.418 NM_203305
FAM102A
family with sequence similarity 102, member A
chr14_-_23846993 10.414 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_23846904 10.274 CIDEB
cell death-inducing DFFA-like effector b
chr2_-_238164042 10.065 RAB17
RAB17, member RAS oncogene family
chr16_+_21152516 10.006 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr1_-_110108048 9.669 NM_024526
NM_133181
NM_139053
EPS8L3


EPS8-like 3


chr14_-_93924873 9.598 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr20_-_3097070 9.569 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr22_+_43451600 9.429 PRR5
proline rich 5 (renal)
chr19_+_4104593 9.426 NM_032607
CREB3L3
cAMP responsive element binding protein 3-like 3
chr1_-_172153024 9.372 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr1_-_172153087 9.333 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr6_+_30238961 9.210 NM_033229
TRIM15
tripartite motif containing 15
chr16_-_51138306 9.181 NM_001080430
TOX3
TOX high mobility group box family member 3
chr1_-_167822334 9.113 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr19_-_63715135 8.985 NM_012254
SLC27A5
solute carrier family 27 (fatty acid transporter), member 5
chr17_-_31352720 8.973 CCL14-CCL15
CCL14-CCL15 read-through transcript
chr17_-_31352643 8.882 CCL14-CCL15
CCL15
CCL14-CCL15 read-through transcript
chemokine (C-C motif) ligand 15
chr6_+_32090516 8.785 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr2_+_218992053 8.744 NM_007127
VIL1
villin 1
chr1_-_153537810 8.492 NM_000298
PKLR
pyruvate kinase, liver and RBC
chr17_+_35147697 8.433 NM_005310
GRB7
growth factor receptor-bound protein 7
chr11_-_116213511 8.156 NM_000039
APOA1
apolipoprotein A-I
chr20_+_55569542 8.121 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr20_+_35406497 8.118 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr19_+_46640902 8.085 NM_001130514
C19orf69
chromosome 19 open reading frame 69
chr20_+_34937928 8.082 NM_080628
C20orf118
chromosome 20 open reading frame 118
chr5_-_42847716 8.068 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr7_+_101704145 8.016 CUX1
cut-like homeobox 1
chr2_-_238164452 7.963 NM_022449
RAB17
RAB17, member RAS oncogene family
chr16_+_464844 7.815 NM_001142272
RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr1_-_176205970 7.725 SEC16B
SEC16 homolog B (S. cerevisiae)
chr6_+_32021793 7.723 CFB
complement factor B
chr1_-_176205672 7.553 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr17_+_24394043 7.495 NM_016518
PIPOX
pipecolic acid oxidase
chr11_+_60858611 7.422 DAK
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chr12_+_119900931 7.365 NM_000545
HNF1A
HNF1 homeobox A
chr1_-_159459814 7.328 APOA2
apolipoprotein A-II
chr19_-_55708936 7.312 NM_001114598
ASPDH
aspartate dehydrogenase domain containing
chr20_-_52120421 7.271 BCAS1
breast carcinoma amplified sequence 1
chr2_+_242398954 7.238 NEU4
sialidase 4
chr17_+_38259620 7.188 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr17_-_33179118 7.185 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr1_+_1351370 7.162 NM_001146685
TMEM88B
transmembrane protein 88B
chr2_+_11597530 7.117 NM_148903
GREB1
growth regulation by estrogen in breast cancer 1
chr19_+_40321584 7.071 FXYD1
FXYD domain containing ion transport regulator 1
chr2_+_27573206 7.056 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr20_-_52120710 7.035 NM_003657
BCAS1
breast carcinoma amplified sequence 1
chr17_-_33178987 7.013 HNF1B
HNF1 homeobox B
chr3_-_195553297 6.989 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr6_-_31953425 6.929 NM_001178045
SLC44A4
solute carrier family 44, member 4
chr10_-_76529253 6.908 NM_016364
DUSP13
dual specificity phosphatase 13
chr15_+_83228895 6.865 NM_004213
NM_201651
SLC28A1

solute carrier family 28 (sodium-coupled nucleoside transporter), member 1

chr17_-_7023378 6.833 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr1_-_24307514 6.788 MYOM3
myomesin family, member 3
chr16_-_45339605 6.764 NM_182493
MYLK3
myosin light chain kinase 3
chr10_-_74384485 6.759 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr3_-_58497913 6.748 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr1_+_226404037 6.622 NM_020435
GJC2
gap junction protein, gamma 2, 47kDa
chr5_+_133870175 6.575


chr7_-_100630912 6.568 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr19_-_18196302 6.551 NM_001098819
PDE4C
phosphodiesterase 4C, cAMP-specific
chr19_+_40321567 6.506 NM_021902
FXYD1
FXYD domain containing ion transport regulator 1
chr1_-_228916559 6.505 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr15_+_41672543 6.476 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr12_+_119900677 6.471 HNF1A
HNF1 homeobox A
chr10_-_74384569 6.453 PLA2G12B
phospholipase A2, group XIIB
chr17_+_4621924 6.401 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr6_+_32003380 6.355 C2
complement component 2
chr19_-_15906669 6.347 NM_001128932
NM_021187
CYP4F11

cytochrome P450, family 4, subfamily F, polypeptide 11

chr8_-_82769761 6.280 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr13_+_112808102 6.265 NM_000131
NM_019616
F7

coagulation factor VII (serum prothrombin conversion accelerator)

chr10_+_114123828 6.113 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr6_+_32021742 6.056 CFB
complement factor B
chr8_-_110773195 6.041 NM_001099743
NM_001099744
SYBU

syntabulin (syntaxin-interacting)

chr6_+_32057779 6.039 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr20_-_32363268 6.021 NM_001161766
AHCY
adenosylhomocysteinase
chr2_+_219354692 5.961 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr4_-_9632192 5.948 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr17_+_35147738 5.890 GRB7
growth factor receptor-bound protein 7
chr11_+_46697345 5.884 F2
coagulation factor II (thrombin)
chr19_-_19142053 5.809 MEF2B
myocyte enhancer factor 2B
chr1_-_153537362 5.794 NM_181871
PKLR
pyruvate kinase, liver and RBC
chr17_-_71352090 5.787 UNC13D
unc-13 homolog D (C. elegans)
chr17_-_68769613 5.748 NM_001129885
CPSF4L
cleavage and polyadenylation specific factor 4-like
chr11_+_46697312 5.704 NM_000506
F2
coagulation factor II (thrombin)
chr17_-_71352017 5.703 UNC13D
unc-13 homolog D (C. elegans)
chr11_+_46697335 5.699 F2
coagulation factor II (thrombin)
chr2_-_88208650 5.658 NM_001443
FABP1
fatty acid binding protein 1, liver
chr1_-_159459999 5.584 NM_001643
APOA2
apolipoprotein A-II
chr6_+_32021831 5.559 CFB
complement factor B
chr2_+_113648036 5.501 PSD4
pleckstrin and Sec7 domain containing 4
chr22_+_43451351 5.473 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr17_-_71352182 5.434 NM_199242
UNC13D
unc-13 homolog D (C. elegans)
chr1_-_1346465 5.430 NM_001145210
LOC441869
hypothetical protein LOC441869
chr7_-_50600536 5.430 NM_001082971
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr16_+_29597965 5.407 QPRT
quinolinate phosphoribosyltransferase
chr19_-_38052481 5.386 NM_001126335
NM_014270
SLC7A9

solute carrier family 7 (cationic amino acid transporter, y+ system), member 9

chr1_-_149611768 5.370 NM_003944
SELENBP1
selenium binding protein 1
chr2_-_233586145 5.352 NGEF
neuronal guanine nucleotide exchange factor
chrX_+_152565849 5.346 DUSP9
dual specificity phosphatase 9
chr10_+_114123765 5.317 ACSL5
acyl-CoA synthetase long-chain family member 5
chr12_-_55637648 5.310 NM_003708
RDH16
retinol dehydrogenase 16 (all-trans)
chr20_+_31059038 5.271 NM_025227
BPIL1
bactericidal/permeability-increasing protein-like 1
chr12_+_56114724 5.259 NM_005538
INHBC
inhibin, beta C
chr6_+_32003180 5.221 NM_000063
NM_001145903
C2

complement component 2

chr11_-_116168316 5.220 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr14_-_93924663 5.212 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr7_+_142692165 5.181 NM_153345
TMEM139
transmembrane protein 139
chr2_-_233586164 5.139 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr6_-_29635456 5.136 UBD
ubiquitin D
chr11_-_64520964 5.104 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr13_+_49658016 5.049


chr17_-_33982580 5.014 SRCIN1
SRC kinase signaling inhibitor 1
chr17_+_38306339 5.007 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr16_+_55963883 4.981 CX3CL1
chemokine (C-X3-C motif) ligand 1
chr12_-_53065758 4.955 ZNF385A
zinc finger protein 385A
chr2_+_218929822 4.954 NM_198559
C2orf62
chromosome 2 open reading frame 62
chr12_-_1791146 4.945 CACNA2D4
calcium channel, voltage-dependent, alpha 2/delta subunit 4
chr16_+_2954217 4.944 NM_024507
NM_172229
KREMEN2

kringle containing transmembrane protein 2

chr8_-_142307854 4.923 NM_001080431
SLC45A4
solute carrier family 45, member 4
chr11_+_73036241 4.904 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr19_-_63556632 4.885 NM_130786
A1BG
alpha-1-B glycoprotein
chr6_-_31853027 4.855 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr3_-_42892195 4.842 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr12_+_107797985 4.798 NM_001917
DAO
D-amino-acid oxidase
chr3_-_121883647 4.797 HGD
homogentisate 1,2-dioxygenase
chr1_-_11029882 4.789 MASP2
mannan-binding lectin serine peptidase 2
chr20_+_42417502 4.769 HNF4A
hepatocyte nuclear factor 4, alpha
chr2_+_10009242 4.731 NM_198182
GRHL1
grainyhead-like 1 (Drosophila)
chr1_-_228916958 4.713 NM_000029
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr5_-_16791346 4.692 MYO10
myosin X
chr10_+_60607232 4.668 NM_001143774
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr17_-_6958773 4.659 NM_001181
NM_080912
NM_080913
ASGR2


asialoglycoprotein receptor 2


chr8_+_22909305 4.657 NM_001160037
RHOBTB2
Rho-related BTB domain containing 2
chr19_-_4491078 4.641 LRG1
leucine-rich alpha-2-glycoprotein 1
chr4_-_1156959 4.628 NM_001128325
SPON2
spondin 2, extracellular matrix protein
chr4_+_100714995 4.596 MTTP
microsomal triglyceride transfer protein
chr19_+_6415259 4.591 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr17_+_73638430 4.566 NM_152468
TMC8
transmembrane channel-like 8
chr12_-_7935010 4.563 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr22_-_31784328 4.548 NM_001135774
SYN3
synapsin III
chr1_+_38033666 4.536 NM_152496
MANEAL
mannosidase, endo-alpha-like
chr19_-_15451203 4.533 NM_052890
PGLYRP2
peptidoglycan recognition protein 2
chr16_-_16224791 4.526 NM_001079528
NM_001171
ABCC6

ATP-binding cassette, sub-family C (CFTR/MRP), member 6

chr12_-_120781002 4.502 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr10_+_103976132 4.417 NM_152310
ELOVL3
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3
chr17_-_23721351 4.385 VTN
vitronectin
chr17_-_71535076 4.370 NM_001988
EVPL
envoplakin
chr17_-_6958695 4.352 ASGR2
asialoglycoprotein receptor 2
chr19_-_19142090 4.351 NM_001145785
MEF2B
myocyte enhancer factor 2B
chr3_-_197422653 4.350 NM_001039617
ZDHHC19
zinc finger, DHHC-type containing 19
chr10_+_51246290 4.331 NM_001145262
NCOA4
nuclear receptor coactivator 4
chr10_+_101532544 4.326 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr6_+_33280396 4.278 NM_014234
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr8_+_144192011 4.277 NM_173687
C8orf31
chromosome 8 open reading frame 31
chr17_+_72958207 4.267 NM_001113496
SEPT9
septin 9
chr2_+_242398832 4.258 NM_001167600
NM_001167601
NEU4

sialidase 4

chr17_+_69939130 4.218 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr17_+_1593040 4.214 NM_001165920
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr17_+_45405128 4.210 NM_001934
DLX4
distal-less homeobox 4
chr3_-_10522340 4.195 ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr16_+_56211410 4.178 NM_001145770
NM_005682
GPR56

G protein-coupled receptor 56

chr16_+_68542126 4.177 NM_001136214
CLEC18A
C-type lectin domain family 18, member A
chr1_+_144439069 4.176 NM_002614
PDZK1
PDZ domain containing 1
chr19_-_4491024 4.175 NM_052972
LRG1
leucine-rich alpha-2-glycoprotein 1
chr16_-_54424517 4.137 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr1_-_6343306 4.124 NM_181865
ACOT7
acyl-CoA thioesterase 7
chr1_+_26220852 4.116 NM_004455
EXTL1
exostoses (multiple)-like 1
chr20_+_42417752 4.098 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha


chr1_+_203740391 4.094 CDK18
cyclin-dependent kinase 18
chr16_-_30032330 4.057 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr21_+_41616590 4.049 FAM3B
family with sequence similarity 3, member B
chr3_-_49434874 4.042 AMT
aminomethyltransferase
chr17_+_4795128 4.030 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr3_-_198784590 3.976 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr17_+_71582486 3.970 NM_003857
GALR2
galanin receptor 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.27 2.14e-04 GO:0042221 response to chemical stimulus
1.30 4.33e-04 GO:0044281 small molecule metabolic process
1.47 3.87e-03 GO:0006082 organic acid metabolic process
1.61 5.38e-03 GO:0071702 organic substance transport
1.45 1.24e-02 GO:0019752 carboxylic acid metabolic process
1.45 1.24e-02 GO:0043436 oxoacid metabolic process
1.79 1.51e-02 GO:0008202 steroid metabolic process
1.43 2.50e-02 GO:0042180 cellular ketone metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.48 1.91e-05 GO:0005626 insoluble fraction
1.48 2.52e-05 GO:0005624 membrane fraction
1.40 3.90e-05 GO:0000267 cell fraction
1.37 9.31e-03 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.41 1.01e-02 GO:0016491 oxidoreductase activity