Motif ID: IKZF1.p2

Z-value: 1.406


Transcription factors associated with IKZF1.p2:

Gene SymbolEntrez IDGene Name
IKZF1 10320 IKAROS family zinc finger 1 (Ikaros)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IKZF1chr7_+_50318801-0.523.9e-02Click!


Activity profile for motif IKZF1.p2.

activity profile for motif IKZF1.p2


Sorted Z-values histogram for motif IKZF1.p2

Sorted Z-values for motif IKZF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_20001130 2.078 NM_001111019
NAV2
neuron navigator 2
chr11_+_20000938 2.040 NAV2
neuron navigator 2
chr1_+_31814709 1.974 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr1_+_31814672 1.968 NM_022164
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr8_-_95720870 1.687 LOC100288748
hypothetical LOC100288748
chr1_+_31814712 1.559 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr2_-_108972048 1.533 EDAR
ectodysplasin A receptor
chr20_+_55569542 1.413 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr3_-_185578621 1.409 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr2_-_238164042 1.333 RAB17
RAB17, member RAS oncogene family
chr3_+_197427779 1.323 NM_152672
OSTalpha
organic solute transporter alpha
chr1_-_151855413 1.280 NM_020672
S100A14
S100 calcium binding protein A14
chr2_-_108972100 1.276 NM_022336
EDAR
ectodysplasin A receptor
chr7_-_75876830 1.241 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr1_+_26728846 1.237 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr19_-_10558906 1.193 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr1_-_228916486 1.179 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr2_-_21120398 1.168 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_-_228916470 1.158 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr2_-_238164452 1.147 NM_022449
RAB17
RAB17, member RAS oncogene family
chr20_-_3097070 1.114 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr3_+_42176662 1.098 NM_014965
TRAK1
trafficking protein, kinesin binding 1
chr14_+_23527866 1.096 NM_198083
DHRS4
DHRS4L2
dehydrogenase/reductase (SDR family) member 4
dehydrogenase/reductase (SDR family) member 4 like 2
chr1_+_26728839 1.094 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr15_-_40236061 1.088 NM_213600
PLA2G4F
phospholipase A2, group IVF
chr1_-_28392966 1.082 NM_001164722
NM_001164721
PTAFR

platelet-activating factor receptor

chr1_+_26728827 1.056 NM_002953
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr12_-_51585004 1.018 NM_002273
KRT8
keratin 8
chr11_+_111294868 1.007 C11orf52
chromosome 11 open reading frame 52
chr4_-_155753249 0.995 FGG
fibrinogen gamma chain
chr14_-_23106779 0.992 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr4_-_155753207 0.992 FGG
fibrinogen gamma chain
chr4_-_155753272 0.973 FGG
fibrinogen gamma chain
chr7_+_147667461 0.973 CNTNAP2
contactin associated protein-like 2
chr22_+_36531246 0.958 H1F0
H1 histone family, member 0
chr4_-_155753287 0.948 FGG
fibrinogen gamma chain
chr17_+_35718948 0.943 NM_000964
RARA
retinoic acid receptor, alpha
chr14_-_34168911 0.943 SNX6
sorting nexin 6
chr13_+_112808102 0.943 NM_000131
NM_019616
F7

coagulation factor VII (serum prothrombin conversion accelerator)

chr2_+_17585462 0.942 VSNL1
visinin-like 1
chr2_-_152538694 0.941 NM_001005747
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr2_+_17585287 0.938 NM_003385
VSNL1
visinin-like 1
chr2_-_21120314 0.927 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_-_228916559 0.927 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr14_+_102636233 0.896 NM_001077594
EXOC3L4
exocyst complex component 3-like 4
chr4_-_155753332 0.896 NM_000509
NM_021870
FGG

fibrinogen gamma chain

chr9_+_129951552 0.894 NM_005564
LCN2
lipocalin 2
chr4_+_17125885 0.880 NM_001079827
CLRN2
clarin 2
chr19_+_50004134 0.872 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr22_+_36531059 0.870 NM_005318
H1F0
H1 histone family, member 0
chr10_-_74384485 0.867 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr10_-_74384569 0.861 PLA2G12B
phospholipase A2, group XIIB
chr19_+_59062982 0.851 MYADM
myeloid-associated differentiation marker
chr1_-_199635057 0.847 LAD1
ladinin 1
chr16_-_11587647 0.830 NM_004862
LITAF
lipopolysaccharide-induced TNF factor
chr19_+_59062937 0.828 NM_001020819
NM_138373
MYADM

myeloid-associated differentiation marker

chr2_-_113310796 0.815 NM_000576
IL1B
interleukin 1, beta
chr22_+_36531178 0.810 H1F0
H1 histone family, member 0
chr18_-_26935883 0.810 NM_004949
NM_024422
DSC2

desmocollin 2

chr14_+_64240902 0.804 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr14_-_23107106 0.802 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr19_+_59062962 0.797 MYADM
myeloid-associated differentiation marker
chr14_+_38772870 0.795 NM_054024
MIA2
melanoma inhibitory activity 2
chr17_-_76720342 0.780 AATK
apoptosis-associated tyrosine kinase
chr1_+_1971762 0.759 NM_002744
PRKCZ
protein kinase C, zeta
chr18_+_53865455 0.758 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr17_+_4621924 0.749 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr1_+_153366559 0.746 EFNA1
ephrin-A1
chr8_-_81246215 0.740 NM_001025253
NM_005079
TPD52

tumor protein D52

chr1_-_26553168 0.734 NM_001039775
AIM1L
absent in melanoma 1-like
chr5_+_175231144 0.723 CPLX2
complexin 2
chr12_-_56445653 0.720 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr20_+_41621119 0.715 SGK2
serum/glucocorticoid regulated kinase 2
chr4_-_35922288 0.711 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr12_-_57599571 0.703 NM_001136051
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr12_-_32940931 0.699 NM_001005242
NM_004572
PKP2

plakophilin 2

chr5_+_175231210 0.698 CPLX2
complexin 2
chr17_+_71154240 0.694 NM_001162997
LOC100130933
hypothetical protein LOC100130933
chr5_+_175231170 0.694


chr11_+_46697335 0.692 F2
coagulation factor II (thrombin)
chr20_+_41621079 0.692 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr17_+_46067114 0.686 NM_001144070
NM_003786
ABCC3

ATP-binding cassette, sub-family C (CFTR/MRP), member 3

chr1_-_158306570 0.679 NM_002241
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chr14_+_64240996 0.671 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr11_+_111294810 0.671 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr4_-_159311959 0.659 FAM198B
family with sequence similarity 198, member B
chr15_+_61123327 0.654 TPM1
tropomyosin 1 (alpha)
chr1_-_207892420 0.653 NM_000228
LAMB3
laminin, beta 3
chr21_-_36774257 0.653 NM_001146079
NM_144492
CLDN14

claudin 14

chr2_+_47449790 0.648 NM_002354
EPCAM
epithelial cell adhesion molecule
chr8_-_125809831 0.647 NM_014751
MTSS1
metastasis suppressor 1
chr14_+_23575460 0.642 NM_001082488
DHRS4L1
dehydrogenase/reductase (SDR family) member 4 like 1
chr1_-_109651140 0.640 NM_001010985
MYBPHL
myosin binding protein H-like
chrX_-_55037235 0.638 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr12_+_64504408 0.633 NM_003483
NM_003484
HMGA2

high mobility group AT-hook 2

chr7_-_22363036 0.629 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr11_-_18214891 0.623 NM_006512
SAA4
serum amyloid A4, constitutive
chr11_+_46697345 0.614 F2
coagulation factor II (thrombin)
chr14_-_23847024 0.602 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_47213906 0.594 NM_001113498
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr3_-_189354510 0.593 LOC339929
hypothetical LOC339929
chr2_-_220144254 0.590 OBSL1
obscurin-like 1
chr11_+_22652957 0.586 GAS2
growth arrest-specific 2
chr19_-_40693176 0.581 NM_001126059
DMKN
dermokine
chr2_+_27225362 0.578 NM_175769
TCF23
transcription factor 23
chr2_-_142605739 0.574 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr5_+_175231098 0.572 NM_001008220
CPLX2
complexin 2
chr15_+_38923470 0.569 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr20_-_23808313 0.568 NM_001900
CST5
cystatin D
chr2_-_180135559 0.566 NM_001113398
ZNF385B
zinc finger protein 385B
chr12_-_49708279 0.565 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr1_-_207892296 0.557 NM_001127641
LAMB3
laminin, beta 3
chr19_-_41191423 0.555 NM_001039876
C19orf46
chromosome 19 open reading frame 46
chr1_+_35020425 0.548 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr16_+_4654710 0.545 MGRN1
mahogunin, ring finger 1
chr3_+_143925904 0.534 NM_003304
TRPC1
transient receptor potential cation channel, subfamily C, member 1
chr3_+_32255215 0.529 CMTM8
CKLF-like MARVEL transmembrane domain containing 8
chr1_+_203740391 0.524 CDK18
cyclin-dependent kinase 18
chr19_+_51493486 0.523 NM_022462
HIF3A
hypoxia inducible factor 3, alpha subunit
chr15_-_38908197 0.517 NM_001130143
NM_017726
PPP1R14D

protein phosphatase 1, regulatory (inhibitor) subunit 14D

chr19_-_56147971 0.517 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr19_+_447453 0.516 NM_130760
NM_130762
MADCAM1

mucosal vascular addressin cell adhesion molecule 1

chr1_+_3378030 0.516 ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr15_-_88256922 0.514 NM_001199058
NM_182616
C15orf38-AP3S2
C15orf38
C15orf38-AP3S2 readthrough
chromosome 15 open reading frame 38
chr19_-_19245022 0.510 NM_001001524
TM6SF2
transmembrane 6 superfamily member 2
chr17_+_70244945 0.509 NM_001006638
NM_001163990
RAB37

RAB37, member RAS oncogene family

chr20_+_34206070 0.500 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr11_+_61276576 0.497 NM_001127392
C11orf9
chromosome 11 open reading frame 9
chr16_-_65510230 0.495 NM_004062
CDH16
cadherin 16, KSP-cadherin
chr11_-_16992524 0.495 NM_175058
PLEKHA7
pleckstrin homology domain containing, family A member 7
chr2_+_201158824 0.494 AOX1
aldehyde oxidase 1
chr1_-_6468108 0.493 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr7_-_96471544 0.492 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr20_-_24986501 0.492 ACSS1
acyl-CoA synthetase short-chain family member 1
chr1_+_1207351 0.491 NM_001130413
NM_002978
SCNN1D

sodium channel, nonvoltage-gated 1, delta

chr1_-_110108048 0.489 NM_024526
NM_133181
NM_139053
EPS8L3


EPS8-like 3


chr1_-_199635339 0.488 LAD1
ladinin 1
chr17_-_64108331 0.487 FAM20A
family with sequence similarity 20, member A
chr1_+_117253882 0.486 NM_020440
PTGFRN
prostaglandin F2 receptor negative regulator
chr14_+_23492780 0.484 NM_021004
DHRS4
dehydrogenase/reductase (SDR family) member 4
chrX_+_115481848 0.482 SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr12_-_55168168 0.482 NM_013267
GLS2
glutaminase 2 (liver, mitochondrial)
chr12_-_192990 0.480 NM_001122847
SLC6A12
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr3_+_32834513 0.480 NM_001039111
TRIM71
tripartite motif containing 71
chr3_+_52504410 0.479 STAB1
stabilin 1
chr1_+_218930542 0.479 C1orf115
chromosome 1 open reading frame 115
chr1_+_27062215 0.478 NM_006142
SFN
stratifin
chr20_-_1113116 0.478 NM_018354
C20orf46
chromosome 20 open reading frame 46
chr4_+_108965167 0.471 NM_001136258
SGMS2
sphingomyelin synthase 2
chr20_+_43895802 0.471 NM_001042632
NM_001042633
NM_033421
NM_152897
SNX21



sorting nexin family member 21



chr10_-_52315390 0.466 A1CF
APOBEC1 complementation factor
chr7_+_89621624 0.465 NM_012449
STEAP1
six transmembrane epithelial antigen of the prostate 1
chr5_-_125958503 0.464 NM_001182
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr14_+_22845851 0.461 NM_004050
BCL2L2-PABPN1
BCL2L2
BCL2L2-PABPN1 read-through transcript
BCL2-like 2
chr2_-_165406173 0.460 NM_014900
COBLL1
COBL-like 1
chr16_+_55217180 0.460 MT1E
metallothionein 1E
chr14_-_23493169 0.457 C14orf167
chromosome 14 open reading frame 167
chr2_+_27163114 0.451 NM_000221
NM_006488
KHK

ketohexokinase (fructokinase)

chr4_-_100359353 0.451 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr11_-_64582568 0.451 NM_005468
NAALADL1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr20_-_44370537 0.450 CDH22
cadherin 22, type 2
chr22_+_27609889 0.449 NM_032173
ZNRF3
zinc and ring finger 3
chr8_-_145881968 0.448 ARHGAP39
Rho GTPase activating protein 39
chr2_-_165133239 0.447 GRB14
growth factor receptor-bound protein 14
chr16_+_55217085 0.446 NM_175617
MT1E
metallothionein 1E
chr1_+_15955719 0.445 FBLIM1
filamin binding LIM protein 1
chr5_+_76150588 0.445 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr2_-_165406098 0.445 COBLL1
COBL-like 1
chr3_+_125586241 0.444 KALRN
kalirin, RhoGEF kinase
chr11_+_22652894 0.443 NM_005256
GAS2
growth arrest-specific 2
chr1_-_200879203 0.442 NM_001136504
SYT2
synaptotagmin II
chr8_+_95722516 0.441 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr17_-_64108843 0.441 FAM20A
family with sequence similarity 20, member A
chr16_-_69277194 0.440 MTSS1L
metastasis suppressor 1-like
chr10_-_92670764 0.438 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr19_+_40431122 0.436 LSR
lipolysis stimulated lipoprotein receptor
chr19_+_43447262 0.435 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr5_+_178255521 0.435 NM_030613
ZFP2
zinc finger protein 2 homolog (mouse)
chr17_+_24394043 0.435 NM_016518
PIPOX
pipecolic acid oxidase
chr6_-_47117951 0.434 NM_025048
NM_153840
GPR110

G protein-coupled receptor 110

chr17_-_7434113 0.433 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr16_-_2848106 0.432 NM_022119
PRSS22
protease, serine, 22
chr10_-_52315436 0.427 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr12_+_39372456 0.426 NM_001843
NM_175038
CNTN1

contactin 1

chr20_+_43896178 0.425 SNX21
sorting nexin family member 21
chr12_-_51153788 0.423 NM_173086
KRT6C
keratin 6C
chr8_+_95722575 0.423 ESRP1
epithelial splicing regulatory protein 1
chr15_-_64644758 0.422 NM_207338
LCTL
lactase-like
chr7_-_16811131 0.421 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr14_-_34169047 0.420 NM_021249
NM_152233
SNX6

sorting nexin 6

chr18_-_6404900 0.419 NM_173464
L3MBTL4
l(3)mbt-like 4 (Drosophila)
chr11_+_47236072 0.415 NM_001130101
NM_005693
NR1H3

nuclear receptor subfamily 1, group H, member 3

chr9_+_102830851 0.414 NM_207299
LPPR1
lipid phosphate phosphatase-related protein type 1
chr1_+_93830106 0.414 LOC100129046
hypothetical LOC100129046
chr3_-_12561962 0.413 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr12_-_192752 0.410 NM_003044
SLC6A12
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr2_-_74522534 0.409 RTKN
rhotekin
chr11_+_66580861 0.408 NM_014578
RHOD
ras homolog gene family, member D
chr19_+_4104593 0.407 NM_032607
CREB3L3
cAMP responsive element binding protein 3-like 3
chr11_+_384199 0.406 NM_007183
PKP3
plakophilin 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.08 4.34e-03 GO:0009987 cellular process
1.20 3.62e-02 GO:0016043 cellular component organization
1.20 3.84e-02 GO:0071840 cellular component organization or biogenesis

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 8.71e-03 GO:0005515 protein binding