Motif ID: JUN.p2

Z-value: 1.978


Transcription factors associated with JUN.p2:

Gene SymbolEntrez IDGene Name
JUN 3725 jun oncogene
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
JUNchr1_-_590222750.533.5e-02Click!
JUNBchr19_+_127632950.401.3e-01Click!
JUNDchr19_-_182530480.322.3e-01Click!


Activity profile for motif JUN.p2.

activity profile for motif JUN.p2


Sorted Z-values histogram for motif JUN.p2

Sorted Z-values for motif JUN.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of JUN.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_13445942 3.073 NM_006042
HS3ST3A1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
chr2_+_74635354 3.072 DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr11_-_118740069 2.816 NM_171997
USP2
ubiquitin specific peptidase 2
chr1_-_1283770 2.602 NM_032348
MXRA8
matrix-remodelling associated 8
chr19_-_53941835 2.560 NM_182575
IZUMO1
izumo sperm-egg fusion 1
chr6_+_139497933 2.558 NM_016217
HECA
headcase homolog (Drosophila)
chr11_-_118739838 2.394 USP2
ubiquitin specific peptidase 2
chr2_-_74634569 2.341 NM_032603
LOXL3
lysyl oxidase-like 3
chr2_+_74635019 2.337 NM_001381
DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr1_+_26368969 2.334 NM_015871
ZNF593
zinc finger protein 593
chr15_+_74416129 2.330 ISL2
ISL LIM homeobox 2
chr11_-_1549719 2.317 NM_004420
DUSP8
dual specificity phosphatase 8
chr16_+_30903963 2.306 NM_001142777
NM_001142778
NM_025193
HSD3B7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr15_+_74416156 2.245 NM_145805
ISL2
ISL LIM homeobox 2
chr22_-_42589543 2.229 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr2_+_219991342 2.090 NM_001927
DES
desmin
chr19_-_56919032 2.024 NM_001523
HAS1
hyaluronan synthase 1
chr9_+_133154896 1.996 NM_032728
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr3_+_158026769 1.965 NM_001004316
NM_001193283
LEKR1

leucine, glutamate and lysine rich 1

chr4_-_111777651 1.940 PITX2
paired-like homeodomain 2
chr19_-_55671273 1.893 FAM71E1
family with sequence similarity 71, member E1
chr22_+_40286957 1.873 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chr4_-_111777584 1.832 PITX2
paired-like homeodomain 2
chr6_+_39868116 1.759


chr6_+_39868126 1.735 DAAM2
dishevelled associated activator of morphogenesis 2
chr2_-_96899396 1.660 NM_017789
SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr11_-_68537243 1.635 NM_001098515
NM_145015
MRGPRF

MAS-related GPR, member F

chr6_-_29703725 1.625 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr3_+_129690735 1.554


chr21_-_42303517 1.544 NM_001098402
NM_001098403
NM_020727
ZNF295


zinc finger protein 295


chr11_-_111287657 1.470 NM_001885
CRYAB
crystallin, alpha B
chr9_+_131291224 1.459 LOC100506190
hypothetical LOC100506190
chr7_-_45095017 1.452 NM_001146334
NACAD
NAC alpha domain containing
chr9_-_19023183 1.448 NM_153707
FAM154A
family with sequence similarity 154, member A
chr22_+_20101661 1.415 NM_015094
HIC2
hypermethylated in cancer 2
chr12_+_52665196 1.381 NM_017409
HOXC10
homeobox C10
chr2_-_156897286 1.379 NM_006186
NR4A2
nuclear receptor subfamily 4, group A, member 2
chrX_+_151991474 1.351 NM_001170944
NM_032882
LOC100287428
PNMA6A
paraneoplastic antigen-like protein 6A related gene
paraneoplastic antigen like 6A
chr7_-_158314945 1.350 ESYT2
extended synaptotagmin-like protein 2
chr9_+_131291144 1.329


chr19_-_5291700 1.324 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr16_-_3008162 1.291 NM_021195
CLDN6
claudin 6
chr2_+_5750229 1.276 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr19_-_10202947 1.271 NM_004230
S1PR2
sphingosine-1-phosphate receptor 2
chr9_-_139473606 1.250 NM_001130969
NM_001130970
NM_001130971
NM_001178064
NM_015537
NELF




nasal embryonic LHRH factor




chr1_-_152394215 1.222 NM_001159484
NM_207308
NUP210L

nucleoporin 210kDa-like

chr7_-_112515068 1.217 NM_001146265
NM_018970
GPR85

G protein-coupled receptor 85

chr22_-_18807805 1.214 PI4KAP2
PI4KAP1
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 2
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 1
chr8_+_134272463 1.197 NM_003882
NM_080838
WISP1

WNT1 inducible signaling pathway protein 1

chr2_+_30307900 1.179 NM_030915
LBH
limb bud and heart development homolog (mouse)
chr10_+_50177192 1.150 NM_001135196
NM_199459
C10orf71

chromosome 10 open reading frame 71

chr21_-_38210531 1.148 NM_002240
KCNJ6
potassium inwardly-rectifying channel, subfamily J, member 6
chr7_-_112515035 1.144 GPR85
G protein-coupled receptor 85
chrX_-_151996613 1.124 NM_032882
PNMA6A
paraneoplastic antigen like 6A
chr19_+_11510578 1.119 NM_001299
CNN1
calponin 1, basic, smooth muscle
chr12_+_131194962 1.116


chr9_-_139473433 1.113 NELF
nasal embryonic LHRH factor
chr3_+_142569988 1.106 ZBTB38
zinc finger and BTB domain containing 38
chrX_+_153325684 1.103 FAM50A
family with sequence similarity 50, member A
chr17_+_35751796 1.103 NM_001024809
RARA
retinoic acid receptor, alpha
chr7_+_134483305 1.101 NM_018295
TMEM140
transmembrane protein 140
chr1_+_99502655 1.101 LPPR4
lipid phosphate phosphatase-related protein type 4
chr2_-_96899326 1.086 SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr19_+_55671600 1.084 C19orf63
chromosome 19 open reading frame 63
chr9_-_139473569 1.082 NELF
nasal embryonic LHRH factor
chr19_+_55671468 1.077 NM_175063
NM_206538
C19orf63

chromosome 19 open reading frame 63

chr11_+_116575249 1.076 NM_001001522
NM_003186
TAGLN

transgelin

chr12_+_131194967 1.074 NOC4L
nucleolar complex associated 4 homolog (S. cerevisiae)
chr8_-_142446546 1.070 NM_005293
GPR20
G protein-coupled receptor 20
chr10_-_131652364 1.064 EBF3
early B-cell factor 3
chr5_+_71438796 1.060 NM_005909
MAP1B
microtubule-associated protein 1B
chr12_-_121946561 1.059


chr11_-_5487728 1.052 NM_017481
UBQLN3
ubiquilin 3
chr7_-_112514990 1.042 GPR85
G protein-coupled receptor 85
chrX_+_153325643 1.039 NM_004699
FAM50A
family with sequence similarity 50, member A
chr7_-_100595552 1.039 NM_003378
VGF
VGF nerve growth factor inducible
chr1_+_99502435 1.037 NM_001166252
NM_014839
LPPR4

lipid phosphate phosphatase-related protein type 4

chr15_-_81037554 1.031 NM_001079533
NM_001079534
NM_001079535
CPEB1


cytoplasmic polyadenylation element binding protein 1


chr19_+_54226941 1.022 NM_033378
CGB1
CGB2
chorionic gonadotropin, beta polypeptide 1
chorionic gonadotropin, beta polypeptide 2
chr9_+_138341752 1.019 NM_001145638
NM_015597
GPSM1

G-protein signaling modulator 1

chr6_-_91063301 1.018 NM_001170794
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr9_-_98421894 1.008 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chr8_-_102033444 1.002 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr12_-_121946635 1.001 NM_024667
VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr8_-_102033409 1.000 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr8_-_102033424 0.991 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr1_+_1994943 0.988 NM_001033581
PRKCZ
protein kinase C, zeta
chr21_-_43671355 0.984 NM_173354
SIK1
salt-inducible kinase 1
chr8_-_102033434 0.979 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr12_+_118515646 0.970 NM_001136534
TMEM233
transmembrane protein 233
chr6_-_127822227 0.968 NM_014702
KIAA0408
KIAA0408
chr4_-_111763356 0.962 PITX2
paired-like homeodomain 2
chr8_-_102033423 0.946 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr8_-_41641881 0.946 NM_001142445
NM_020478
NM_020480
ANK1


ankyrin 1, erythrocytic


chr16_+_415630 0.946 NM_014700
RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr10_+_18669619 0.939 NM_201590
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr19_+_55671594 0.924 C19orf63
chromosome 19 open reading frame 63
chr6_-_166321516 0.912 C6orf176
chromosome 6 open reading frame 176
chr8_-_102033510 0.911 NM_145690
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr1_-_180822686 0.906 NM_021133
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr16_+_415606 0.905 RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr12_+_131194931 0.900 NM_024078
NOC4L
nucleolar complex associated 4 homolog (S. cerevisiae)
chr1_-_149955870 0.894 NM_007185
CELF3
CUGBP, Elav-like family member 3
chr17_-_44058612 0.887 NM_024017
HOXB9
homeobox B9
chr2_+_10101822 0.886 NM_001177718
KLF11
Kruppel-like factor 11
chr7_-_158314963 0.884 NM_020728
ESYT2
extended synaptotagmin-like protein 2
chr19_+_55671584 0.883 C19orf63
chromosome 19 open reading frame 63
chr8_-_102033372 0.883 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr7_-_44992729 0.883 C7orf40
chromosome 7 open reading frame 40
chr11_-_118693021 0.877 NM_006500
MCAM
melanoma cell adhesion molecule
chr21_-_35343448 0.873 RUNX1
runt-related transcription factor 1
chr16_-_45339605 0.873 NM_182493
MYLK3
myosin light chain kinase 3
chr8_+_23442331 0.872 SLC25A37
solute carrier family 25, member 37
chr1_-_240228987 0.872 NM_001004343
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma
chr6_-_166321393 0.868 C6orf176
chromosome 6 open reading frame 176
chr21_-_35343428 0.867 RUNX1
runt-related transcription factor 1
chr6_+_45404031 0.866 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr3_+_148593911 0.861


chr6_+_105511615 0.859 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr19_+_47593137 0.857


chr2_-_74455161 0.855 NM_001135041
NM_023019
DCTN1

dynactin 1

chr11_-_61341011 0.855 NM_013402
FADS1
fatty acid desaturase 1
chr7_+_5598979 0.845 NM_003088
FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr7_+_128099581 0.845 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr7_+_65596078 0.844


chr6_-_91063181 0.842 NM_021813
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr19_-_54231884 0.840 NM_033377
CGB1
CGB2
chorionic gonadotropin, beta polypeptide 1
chorionic gonadotropin, beta polypeptide 2
chr8_-_67253234 0.839 NM_000756
CRH
corticotropin releasing hormone
chr10_+_104525877 0.828 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr21_-_35343456 0.828 NM_001754
RUNX1
runt-related transcription factor 1
chr2_-_237987509 0.826 COL6A3
collagen, type VI, alpha 3
chr7_+_116447499 0.820 ST7
suppression of tumorigenicity 7
chr19_+_10388448 0.817 PDE4A
phosphodiesterase 4A, cAMP-specific
chr12_-_121946581 0.807 VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr21_-_35343065 0.805 RUNX1
runt-related transcription factor 1
chr4_-_186693574 0.805 NM_001114107
NM_014476
PDLIM3

PDZ and LIM domain 3

chr19_+_16048266 0.803 TPM4
tropomyosin 4
chr17_+_1580504 0.801 WDR81
WD repeat domain 81
chr20_+_32610161 0.800 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr2_-_237987553 0.797 COL6A3
collagen, type VI, alpha 3
chr16_+_54782802 0.797 GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr7_+_100302885 0.795 NM_003302
TRIP6
thyroid hormone receptor interactor 6
chrX_+_148671394 0.792 NM_005365
NM_001080790
MAGEA9
MAGEA9B
melanoma antigen family A, 9
melanoma antigen family A, 9B
chr6_-_29703913 0.791 NM_021903
GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr19_+_18584666 0.790 NM_012109
TMEM59L
transmembrane protein 59-like
chr8_-_145983457 0.790 NM_030580
ZNF34
zinc finger protein 34
chr21_-_35343331 0.787 RUNX1
runt-related transcription factor 1
chr14_+_100362204 0.785 MEG3
maternally expressed 3 (non-protein coding)
chr14_+_100362236 0.785 MEG3
maternally expressed 3 (non-protein coding)
chr1_-_703848 0.779 LOC100288069
hypothetical LOC100288069
chr3_+_50272648 0.778


chrX_-_138114817 0.778 FGF13
fibroblast growth factor 13
chr8_-_66916830 0.778 PDE7A
phosphodiesterase 7A
chr2_-_237987545 0.774 COL6A3
collagen, type VI, alpha 3
chr7_+_100037817 0.773 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr2_-_237987579 0.770 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr5_+_118993152 0.770 NM_001163991
NM_182761
FAM170A

family with sequence similarity 170, member A

chr21_-_35343500 0.768 RUNX1
runt-related transcription factor 1
chr19_+_10404110 0.768 NM_001111309
PDE4A
phosphodiesterase 4A, cAMP-specific
chr2_-_219882302 0.767 NM_002846
PTPRN
protein tyrosine phosphatase, receptor type, N
chr18_+_22060383 0.766 NM_005640
TAF4B
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr4_-_111763655 0.765 NM_000325
PITX2
paired-like homeodomain 2
chr7_+_120378052 0.764 NM_019071
NM_198267
ING3

inhibitor of growth family, member 3

chr2_-_237987554 0.759 COL6A3
collagen, type VI, alpha 3
chr7_+_5598964 0.754 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr1_+_27591738 0.746 NM_005281
GPR3
G protein-coupled receptor 3
chrX_-_47364039 0.746


chr11_-_61340804 0.736 FADS1
fatty acid desaturase 1
chr3_+_159771646 0.732 NM_001130156
NM_001130157
NM_001195432
NM_001195433
NM_001195434
NM_022443
MLF1





myeloid leukemia factor 1





chr11_-_62213577 0.729 LRRN4CL
LRRN4 C-terminal like
chr5_+_34723420 0.729 NM_001145523
RAI14
retinoic acid induced 14
chr1_-_20916789 0.728 NM_001122819
NM_020816
KIF17

kinesin family member 17

chr15_-_32875040 0.723 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr10_-_62373828 0.719 NM_014836
RHOBTB1
Rho-related BTB domain containing 1
chr6_-_46401174 0.717 RCAN2
regulator of calcineurin 2
chr7_-_37922902 0.717 SFRP4
secreted frizzled-related protein 4
chr20_+_54533191 0.716 NM_001012971
C20orf106
C20orf107
chromosome 20 open reading frame 106
chromosome 20 open reading frame 107
chr19_+_16048306 0.716 TPM4
tropomyosin 4
chrX_-_47364173 0.715 NM_006950
NM_133499
SYN1

synapsin I

chr7_+_116447527 0.703 ST7
suppression of tumorigenicity 7
chr20_+_33667160 0.702 NM_003116
SPAG4
sperm associated antigen 4
chr7_+_100025131 0.698 NM_001163499
NM_012172
FBXO24

F-box protein 24

chr6_-_32184975 0.698 NM_019105
TNXB
tenascin XB
chr15_+_29406335 0.687 NM_015995
KLF13
Kruppel-like factor 13
chr1_+_165330710 0.686 NM_001080426
DUSP27
dual specificity phosphatase 27 (putative)
chr8_+_23442307 0.684 NM_016612
SLC25A37
solute carrier family 25, member 37
chr8_+_23442413 0.681 SLC25A37
solute carrier family 25, member 37
chr12_+_130004404 0.675 NM_198827
GPR133
G protein-coupled receptor 133
chr3_+_197851052 0.674 NM_198565
LRRC33
leucine rich repeat containing 33
chr11_+_65236261 0.673 KAT5
K(lysine) acetyltransferase 5
chr1_+_22251706 0.672 NM_001039802
NM_001791
NM_044472
CDC42


cell division cycle 42 (GTP binding protein, 25kDa)


chr2_+_151922350 0.670 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr6_+_47553399 0.667 NM_012120
CD2AP
CD2-associated protein
chrX_+_102471769 0.662 NM_152278
TCEAL7
transcription elongation factor A (SII)-like 7
chr14_-_103058568 0.660 CKB
creatine kinase, brain
chr2_-_26554413 0.659 NM_004802
NM_194322
NM_194323
OTOF


otoferlin


chr3_+_38181972 0.653 NM_005109
OXSR1
oxidative-stress responsive 1
chr20_+_55569542 0.652 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr7_-_37923040 0.647 NM_003014
SFRP4
secreted frizzled-related protein 4
chr19_+_60688349 0.640 NM_020378
NAT14
N-acetyltransferase 14 (GCN5-related, putative)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.30 4.39e-02 GO:0051252 regulation of RNA metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.17 3.61e-03 GO:0005634 nucleus
2.68 6.71e-03 GO:0030017 sarcomere
2.43 2.29e-02 GO:0044449 contractile fiber part
2.33 3.23e-02 GO:0043292 contractile fiber
2.37 3.50e-02 GO:0030016 myofibril

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.56 3.10e-04 GO:0001071 nucleic acid binding transcription factor activity
1.56 3.10e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.15 1.69e-03 GO:0005515 protein binding
1.71 2.37e-03 GO:0008092 cytoskeletal protein binding
1.82 2.65e-02 GO:0003779 actin binding