Motif ID: NFE2L1.p2

Z-value: 1.777


Transcription factors associated with NFE2L1.p2:

Gene SymbolEntrez IDGene Name
NFE2L1 4779 nuclear factor (erythroid-derived 2)-like 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFE2L1chr17_+_434807240.572.0e-02Click!


Activity profile for motif NFE2L1.p2.

activity profile for motif NFE2L1.p2


Sorted Z-values histogram for motif NFE2L1.p2

Sorted Z-values for motif NFE2L1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_-_63333487 3.718 DSEL
dermatan sulfate epimerase-like
chr9_-_16717887 2.540 BNC2
basonuclin 2
chrX_+_86659370 2.430 NM_019117
NM_057162
KLHL4

kelch-like 4 (Drosophila)

chr20_+_19903778 2.257 RIN2
Ras and Rab interactor 2
chr8_-_108579270 2.095 NM_001146
ANGPT1
angiopoietin 1
chr5_+_36644187 2.042 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr9_+_119506446 1.973 TLR4
toll-like receptor 4
chr9_+_119506428 1.831 TLR4
toll-like receptor 4
chr1_-_68470585 1.828 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr9_-_14303509 1.765 NFIB
nuclear factor I/B
chr10_-_92671005 1.756 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr3_+_25445071 1.740 RARB
retinoic acid receptor, beta
chr1_-_197173159 1.720 LOC100131234
familial acute myelogenous leukemia related factor
chr9_+_119506274 1.677 NM_138554
TLR4
toll-like receptor 4
chr10_-_92670764 1.623 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr7_-_13992351 1.622 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr16_+_81218074 1.579 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr8_-_93144039 1.511


chr5_-_54317102 1.423 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr20_-_22978141 1.410 NM_000361
THBD
thrombomodulin
chr3_+_29297806 1.404 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr7_+_134114912 1.403 CALD1
caldesmon 1
chr4_-_159311959 1.401 FAM198B
family with sequence similarity 198, member B
chr16_+_81218142 1.388 CDH13
cadherin 13, H-cadherin (heart)
chr2_+_201182187 1.291 AOX1
aldehyde oxidase 1
chr3_+_25444837 1.284 NM_000965
RARB
retinoic acid receptor, beta
chr4_+_30331289 1.275 PCDH7
protocadherin 7
chr7_+_150442652 1.248 AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chrX_+_99785818 1.246 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr2_-_164300758 1.245 NM_018086
FIGN
fidgetin
chr5_-_94443300 1.239 NM_001002796
MCTP1
multiple C2 domains, transmembrane 1
chr13_-_98428244 1.217 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr3_+_25444753 1.216 NM_016152
RARB
retinoic acid receptor, beta
chr1_-_20682541 1.209


chrX_+_28515479 1.204 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chrX_+_99786044 1.203 SRPX2
sushi-repeat containing protein, X-linked 2
chr4_+_30331543 1.194 PCDH7
protocadherin 7
chr11_-_85107569 1.160 NM_206929
SYTL2
synaptotagmin-like 2
chr8_+_70541631 1.155 SULF1
sulfatase 1
chr7_+_110518297 1.148 NM_001099658
NM_001099660
NM_018334
LRRN3


leucine rich repeat neuronal 3


chrX_-_33267646 1.134 NM_000109
DMD
dystrophin
chr5_+_174084137 1.130 NM_002449
MSX2
msh homeobox 2
chr12_+_13240868 1.116 NM_001423
EMP1
epithelial membrane protein 1
chr12_+_13240987 1.113 EMP1
epithelial membrane protein 1
chr2_-_165186064 1.100 GRB14
growth factor receptor-bound protein 14
chr12_+_13240983 1.099 EMP1
epithelial membrane protein 1
chr10_+_128583984 1.079 NM_001380
DOCK1
dedicator of cytokinesis 1
chr19_+_12996745 1.078 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr2_-_160764819 1.076 NM_000888
ITGB6
integrin, beta 6
chr8_+_70541412 1.069 NM_001128204
NM_015170
SULF1

sulfatase 1

chr9_-_14303899 1.047 NFIB
nuclear factor I/B
chr9_-_14303943 1.044 NFIB
nuclear factor I/B
chr15_+_65205107 1.041 NM_001145102
SMAD3
SMAD family member 3
chr17_-_51155073 1.015 NM_018286
TMEM100
transmembrane protein 100
chr16_+_56219802 1.008 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr6_-_112682573 1.007 LAMA4
laminin, alpha 4
chr18_-_51219880 0.996 TCF4
transcription factor 4
chr7_-_41709191 0.945 NM_002192
INHBA
inhibin, beta A
chr9_+_136673534 0.937 COL5A1
collagen, type V, alpha 1
chr5_+_35892747 0.936 NM_002185
IL7R
interleukin 7 receptor
chr7_-_27108826 0.935 NM_006735
HOXA2
homeobox A2
chr2_-_105381855 0.928 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr10_+_124211353 0.927 HTRA1
HtrA serine peptidase 1
chr6_-_112682459 0.925 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr17_-_37034288 0.920 NM_000422
KRT17
keratin 17
chr9_-_131555111 0.918 NM_004878
PTGES
prostaglandin E synthase
chr12_-_50871953 0.915 NM_001081492
NM_182507
KRT80

keratin 80

chr2_-_165186232 0.912 GRB14
growth factor receptor-bound protein 14
chr3_+_64645819 0.910 LOC100507098
hypothetical LOC100507098
chr11_-_27700180 0.908 NM_170731
BDNF
brain-derived neurotrophic factor
chr4_-_16509126 0.906 LDB2
LIM domain binding 2
chr8_-_93144366 0.881 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr11_-_8788765 0.880 NM_213618
ST5
suppression of tumorigenicity 5
chr5_-_58607673 0.876 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr7_+_136203938 0.874 NM_001006627
NM_001006630
CHRM2

cholinergic receptor, muscarinic 2

chr5_+_140733664 0.870 NM_018919
NM_032086
PCDHGA6

protocadherin gamma subfamily A, 6

chr11_-_85108030 0.860 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr14_-_79747592 0.860 NM_001007023
DIO2
deiodinase, iodothyronine, type II
chr2_+_220017617 0.850 SPEG
SPEG complex locus
chr1_-_215329569 0.849 NM_206594
NM_206595
ESRRG

estrogen-related receptor gamma

chr2_-_40593074 0.848 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr1_-_156784518 0.848 NM_001005189
OR6Y1
olfactory receptor, family 6, subfamily Y, member 1
chr2_-_65447370 0.846 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr17_+_36636404 0.843 NM_031961
KRTAP9-2
keratin associated protein 9-2
chr3_-_71262405 0.840 FOXP1
forkhead box P1
chr3_-_71262426 0.831 FOXP1
forkhead box P1
chr5_-_138238877 0.819 LRRTM2
leucine rich repeat transmembrane neuronal 2
chr8_-_93099040 0.817 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr9_+_108665168 0.813 NM_021224
ZNF462
zinc finger protein 462
chr17_-_36475652 0.800 NM_033184
KRTAP2-4
keratin associated protein 2-4
chr7_+_134114957 0.799 CALD1
caldesmon 1
chr3_-_113842553 0.794 CCDC80
coiled-coil domain containing 80
chr13_+_113546943 0.792 GAS6
growth arrest-specific 6
chr3_-_113842652 0.789 NM_199511
NM_199512
CCDC80

coiled-coil domain containing 80

chr11_-_123353607 0.788 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr20_+_59260847 0.788 NM_001794
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr15_+_99207555 0.785 LOC145757
hypothetical LOC145757
chr1_+_183970093 0.785 NM_031935
HMCN1
hemicentin 1
chr19_+_12996830 0.785 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr3_-_145049853 0.785 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr9_+_35528628 0.782 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr4_+_183302105 0.776 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr9_+_35528890 0.775 RUSC2
RUN and SH3 domain containing 2
chr19_-_14944729 0.773 NM_005071
SLC1A6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr4_+_86918882 0.772 ARHGAP24
Rho GTPase activating protein 24
chr1_-_59020875 0.771 JUN
jun proto-oncogene
chr18_+_54681657 0.768 ZNF532
zinc finger protein 532
chr3_+_69895310 0.766 NM_001184967
MITF
microphthalmia-associated transcription factor
chr7_+_134114701 0.762 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr2_-_65447267 0.759 SPRED2
sprouty-related, EVH1 domain containing 2
chr4_-_75183860 0.757 NM_002089
CXCL2
chemokine (C-X-C motif) ligand 2
chr10_+_75343352 0.755 PLAU
plasminogen activator, urokinase
chr3_-_64647325 0.752 ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr2_-_192767494 0.751 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr7_-_135083906 0.751 NM_205855
FAM180A
family with sequence similarity 180, member A
chr11_-_6870306 0.746 NM_003700
OR2D2
olfactory receptor, family 2, subfamily D, member 2
chr8_-_42184194 0.746 PLAT
plasminogen activator, tissue
chr17_-_36996611 0.744 NM_000526
KRT14
keratin 14
chr7_-_78920806 0.741 NM_012301
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr3_-_45242072 0.739 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr4_-_177950658 0.730 NM_005429
VEGFC
vascular endothelial growth factor C
chr13_+_113546841 0.729 NM_000820
GAS6
growth arrest-specific 6
chr8_-_42184350 0.726 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr12_+_12829807 0.723 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr15_+_41597097 0.723 NM_002373
MAP1A
microtubule-associated protein 1A
chr12_-_3472245 0.721 LOC100129223
hypothetical LOC100129223
chr11_+_123625632 0.720 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr4_-_16509446 0.719 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr4_-_16509354 0.714 LDB2
LIM domain binding 2
chr5_-_138238891 0.702 CTNNA1
LRRTM2
catenin (cadherin-associated protein), alpha 1, 102kDa
leucine rich repeat transmembrane neuronal 2
chr11_-_1725924 0.696 NM_001170820
LOC402778
CD225 family protein FLJ76511
chr13_-_32658215 0.694 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr1_-_154041393 0.689 GON4L
gon-4-like (C. elegans)
chrX_-_10548458 0.684 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chrX_-_34585287 0.683 NM_031442
TMEM47
transmembrane protein 47
chr2_-_160765008 0.682 ITGB6
integrin, beta 6
chr11_-_1725662 0.681 LOC402778
CD225 family protein FLJ76511
chr11_-_62213577 0.680 LRRN4CL
LRRN4 C-terminal like
chr2_-_101457596 0.674 NM_001145664
RFX8
regulatory factor X, 8
chr11_+_131285747 0.672 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr7_-_27153892 0.669 NM_024014
HOXA6
homeobox A6
chr11_-_65860450 0.667 NM_004292
RIN1
Ras and Rab interactor 1
chr5_-_138238953 0.666 NM_015564
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr14_+_100362204 0.663 MEG3
maternally expressed 3 (non-protein coding)
chr3_-_69674412 0.659 FRMD4B
FERM domain containing 4B
chr4_+_74953971 0.645 NM_001511
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr8_-_23768242 0.644 NM_003155
STC1
stanniocalcin 1
chr5_-_9599157 0.643 NM_003966
SEMA5A
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr5_-_124108672 0.643 NM_020747
ZNF608
zinc finger protein 608
chrX_-_99778340 0.640 NM_003270
TSPAN6
tetraspanin 6
chr3_+_158637273 0.635 NM_002852
PTX3
pentraxin 3, long
chr4_+_126457016 0.630 NM_024582
FAT4
FAT tumor suppressor homolog 4 (Drosophila)
chr10_-_33663305 0.630 NRP1
neuropilin 1
chr1_-_153209625 0.630 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr3_-_64648370 0.629 NM_182920
ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr9_-_36266930 0.617 NM_001128227
NM_001190388
GNE

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

chr8_-_37847095 0.616 RAB11FIP1
RAB11 family interacting protein 1 (class I)
chr14_+_100362236 0.613 MEG3
maternally expressed 3 (non-protein coding)
chr1_+_66772393 0.610 NM_032291
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chrX_+_134482387 0.605 DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr1_+_199519202 0.605 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr8_-_122722674 0.603 NM_005328
HAS2
hyaluronan synthase 2
chr18_-_57711283 0.603 NM_173557
RNF152
ring finger protein 152
chr10_+_124210980 0.598 NM_002775
HTRA1
HtrA serine peptidase 1
chr9_-_72673753 0.597 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr1_-_202595666 0.596 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr2_-_192419896 0.589 SDPR
serum deprivation response
chr22_+_29974368 0.588 LIMK2
LIM domain kinase 2
chr9_+_35782405 0.586 NM_003995
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr3_-_12561962 0.583 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr9_-_109290107 0.582 KLF4
Kruppel-like factor 4 (gut)
chr10_-_98315090 0.574 TM9SF3
transmembrane 9 superfamily member 3
chr3_-_102194938 0.573 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr4_+_19864332 0.571 NM_004787
SLIT2
slit homolog 2 (Drosophila)
chr7_+_120416680 0.568 NM_001105533
C7orf58
chromosome 7 open reading frame 58
chr16_-_52876390 0.565 IRX3
iroquois homeobox 3
chr15_-_37999519 0.565


chr8_+_32698892 0.564 NM_001159996
NRG1
neuregulin 1
chr7_+_129720209 0.561 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr3_+_191588354 0.559 NM_006580
CLDN16
claudin 16
chr9_-_106420305 0.559 NM_001001956
OR13C9
olfactory receptor, family 13, subfamily C, member 9
chr11_-_65395248 0.559 EFEMP2
EGF containing fibulin-like extracellular matrix protein 2
chr17_-_44037332 0.553 NM_018952
HOXB6
homeobox B6
chrX_+_106956115 0.550 MID2
midline 2
chr6_-_56615544 0.545 NM_001723
NM_015548
DST

dystonin

chr3_-_116272911 0.544 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr4_+_160408447 0.543 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr5_+_148186348 0.541 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr6_+_29472310 0.540 NM_013936
OR12D2
olfactory receptor, family 12, subfamily D, member 2
chr21_-_35343065 0.537 RUNX1
runt-related transcription factor 1
chr6_-_46401363 0.535 NM_005822
RCAN2
regulator of calcineurin 2
chr2_+_5750229 0.535 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr17_+_36642240 0.535 NM_031962
KRTAP9-9
KRTAP9-3
keratin associated protein 9-9
keratin associated protein 9-3
chr21_-_30510113 0.533 NM_199328
CLDN8
claudin 8
chr1_+_200775864 0.533 NM_001197131
PPP1R12B
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr20_+_8997660 0.533 NM_001172646
PLCB4
phospholipase C, beta 4
chr11_+_101488380 0.530 NM_001195045
YAP1
Yes-associated protein 1
chr15_-_68781662 0.528 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr4_-_159313613 0.527 NM_001031700
NM_001128424
FAM198B

family with sequence similarity 198, member B

chr4_-_40631397 0.524 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.78 2.82e-49 GO:0007608 sensory perception of smell
2.55 2.65e-42 GO:0007606 sensory perception of chemical stimulus
1.66 3.17e-32 GO:0003008 system process
1.97 1.23e-30 GO:0007600 sensory perception
1.69 2.21e-27 GO:0050877 neurological system process
1.23 1.27e-14 GO:0032501 multicellular organismal process
1.18 3.60e-11 GO:0050896 response to stimulus
1.31 4.33e-04 GO:0033036 macromolecule localization
1.33 2.62e-03 GO:0008104 protein localization
1.38 2.83e-03 GO:0051128 regulation of cellular component organization
1.90 1.10e-02 GO:0007156 homophilic cell adhesion
3.24 1.71e-02 GO:0016339 calcium-dependent cell-cell adhesion
1.18 2.43e-02 GO:0071842 cellular component organization at cellular level
1.18 2.45e-02 GO:0071841 cellular component organization or biogenesis at cellular level
1.15 2.71e-02 GO:0016043 cellular component organization
1.33 3.71e-02 GO:0015031 protein transport
1.15 3.73e-02 GO:0071840 cellular component organization or biogenesis
1.32 3.86e-02 GO:0045184 establishment of protein localization
5.18 4.00e-02 GO:0000266 mitochondrial fission

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.27 2.56e-16 GO:0005886 plasma membrane
1.26 5.17e-16 GO:0071944 cell periphery
1.13 1.47e-08 GO:0016020 membrane
1.33 5.29e-07 GO:0005856 cytoskeleton
1.13 3.06e-06 GO:0044425 membrane part
1.22 9.22e-06 GO:0043228 non-membrane-bounded organelle
1.22 9.22e-06 GO:0043232 intracellular non-membrane-bounded organelle
1.18 4.77e-05 GO:0032991 macromolecular complex
1.33 1.32e-04 GO:0044430 cytoskeletal part
1.65 1.91e-04 GO:0015629 actin cytoskeleton
1.13 2.02e-04 GO:0016021 integral to membrane
1.18 3.16e-04 GO:0043234 protein complex
1.12 6.59e-04 GO:0031224 intrinsic to membrane
1.11 2.83e-03 GO:0044422 organelle part
1.03 4.51e-03 GO:0044464 cell part
1.03 4.73e-03 GO:0005623 cell
1.74 6.13e-03 GO:0005882 intermediate filament
1.88 9.62e-03 GO:0030016 myofibril
1.66 9.85e-03 GO:0045111 intermediate filament cytoskeleton
1.81 2.05e-02 GO:0043292 contractile fiber
1.10 2.57e-02 GO:0044446 intracellular organelle part
2.12 2.71e-02 GO:0030117 membrane coat
2.12 2.71e-02 GO:0048475 coated membrane
1.83 2.75e-02 GO:0044449 contractile fiber part
1.31 3.22e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.64 3.96e-02 GO:0030424 axon
1.92 4.38e-02 GO:0042470 melanosome
1.92 4.38e-02 GO:0048770 pigment granule
1.30 4.46e-02 GO:0031988 membrane-bounded vesicle

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.85 8.62e-51 GO:0004984 olfactory receptor activity
1.92 1.11e-29 GO:0004930 G-protein coupled receptor activity
1.58 1.45e-18 GO:0004888 transmembrane receptor activity
1.39 2.64e-11 GO:0004872 receptor activity
1.34 5.61e-11 GO:0004871 signal transducer activity
1.34 5.61e-11 GO:0060089 molecular transducer activity
1.41 1.89e-03 GO:0005198 structural molecule activity
1.39 1.60e-02 GO:0008092 cytoskeletal protein binding