Motif ID: NKX3-1.p2

Z-value: 1.282


Transcription factors associated with NKX3-1.p2:

Gene SymbolEntrez IDGene Name
NKX3-1 4824 NK3 homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX3-1chr8_-_235963460.058.6e-01Click!


Activity profile for motif NKX3-1.p2.

activity profile for motif NKX3-1.p2


Sorted Z-values histogram for motif NKX3-1.p2

Sorted Z-values for motif NKX3-1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_132000134 4.150 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr17_-_53847937 3.717 RNF43
ring finger protein 43
chr14_+_38772870 1.562 NM_054024
MIA2
melanoma inhibitory activity 2
chr3_-_198784590 1.529 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr6_+_30238961 1.452 NM_033229
TRIM15
tripartite motif containing 15
chr10_-_11614279 1.348 NM_001080491
USP6NL
USP6 N-terminal like
chr12_+_91620749 1.278 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr15_+_57691382 1.272 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr17_-_18890963 1.245 NM_006613
GRAP
GRB2-related adaptor protein
chr4_+_166350620 1.223 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chr10_-_74384485 1.222 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr17_-_61655915 1.206 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr6_+_126282078 1.178 NCOA7
nuclear receptor coactivator 7
chr4_-_186969041 1.156 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr4_+_74520796 1.141 NM_001134
AFP
alpha-fetoprotein
chr4_+_74491272 1.119 ALB
albumin
chr6_+_64344307 1.097 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr14_+_87541220 1.089 NM_003608
GPR65
G protein-coupled receptor 65
chr14_-_22516271 1.087 NM_198086
JUB
jub, ajuba homolog (Xenopus laevis)
chr12_+_130004404 1.087 NM_198827
GPR133
G protein-coupled receptor 133
chr6_+_32003180 1.074 NM_000063
NM_001145903
C2

complement component 2

chr6_-_138862271 1.056 NM_001144060
NHSL1
NHS-like 1
chr14_+_66901237 1.052 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chrX_+_105823723 1.035 NM_024539
RNF128
ring finger protein 128
chr6_-_138862273 0.996


chr1_+_205329206 0.977 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr20_-_52120710 0.976 NM_003657
BCAS1
breast carcinoma amplified sequence 1
chr20_+_12937616 0.956 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr4_+_89115862 0.945 SPP1
secreted phosphoprotein 1
chr2_-_165259334 0.936 COBLL1
COBL-like 1
chr4_+_89115892 0.932 SPP1
secreted phosphoprotein 1
chr4_+_89115923 0.906 SPP1
secreted phosphoprotein 1
chr4_+_89115825 0.894 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr1_+_190394214 0.888 NM_130782
RGS18
regulator of G-protein signaling 18
chrX_-_13744933 0.887 GPM6B
glycoprotein M6B
chr2_+_165858586 0.886 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr4_+_39084936 0.868 KLB
klotho beta
chr15_+_57691272 0.835 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr6_+_53043729 0.833 NM_012347
FBXO9
F-box protein 9
chr7_+_115650240 0.832 NM_152829
TES
testis derived transcript (3 LIM domains)
chr1_+_57093030 0.831 NM_000562
C8A
complement component 8, alpha polypeptide
chr2_+_114390975 0.792 ACTR3
ARP3 actin-related protein 3 homolog (yeast)
chr12_-_101835510 0.785 NM_000277
PAH
phenylalanine hydroxylase
chr17_+_50698169 0.781 HLF
hepatic leukemia factor
chr1_-_229627412 0.779 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr3_+_50119261 0.768 RBM5
RNA binding motif protein 5
chr7_+_94377145 0.763 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr2_+_234624084 0.746 NM_006944
SPP2
secreted phosphoprotein 2, 24kDa
chr4_+_74488947 0.743 ALB
albumin
chrX_+_57329834 0.740 NM_174912
FAAH2
fatty acid amide hydrolase 2
chr4_+_74493918 0.740 ALB
albumin
chr9_+_4829763 0.734 RCL1
RNA terminal phosphate cyclase-like 1
chr6_+_32003380 0.731 C2
complement component 2
chr20_-_51633042 0.728 NM_006526
ZNF217
zinc finger protein 217
chr4_-_84254932 0.708 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr2_-_32344192 0.692 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr2_+_61225710 0.687 NM_001143960
C2orf74
chromosome 2 open reading frame 74
chr2_-_233349469 0.682 NM_001172416
NM_001172417
NM_002242
KCNJ13


potassium inwardly-rectifying channel, subfamily J, member 13


chr20_+_30160952 0.682 NM_014742
TM9SF4
transmembrane 9 superfamily protein member 4
chr2_-_21106291 0.675 APOB
apolipoprotein B (including Ag(x) antigen)
chr3_+_113200696 0.662 NM_001008273
TAGLN3
transgelin 3
chr14_+_38804226 0.645 NM_203354
CTAGE5
CTAGE family, member 5
chr14_+_31868229 0.636 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr14_+_94148466 0.635 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr18_-_50776276 0.635 NM_001143829
CCDC68
coiled-coil domain containing 68
chr3_-_42892195 0.634 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr20_-_34707971 0.627 NM_032214
NM_175077
SLA2

Src-like-adaptor 2

chr20_-_43163021 0.621 NM_002251
KCNS1
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
chr2_+_37282516 0.621 LOC100505876
hypothetical LOC100505876
chr8_-_17797127 0.609 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr16_+_82540172 0.603 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr12_+_40117751 0.601 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr4_+_74488835 0.594 NM_000477
ALB
albumin
chrX_-_130792297 0.594 LOC286467
hypothetical LOC286467
chr17_+_58440629 0.586 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr10_-_98021144 0.582 NM_001114094
NM_013314
BLNK

B-cell linker

chr2_-_39310176 0.579 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr6_+_31538934 0.570 NM_006674
HCP5
HLA complex P5
chr14_-_105681377 0.568 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr4_+_17125885 0.563 NM_001079827
CLRN2
clarin 2
chr2_+_183290912 0.558 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr9_+_109131814 0.554 RAD23B
RAD23 homolog B (S. cerevisiae)
chr2_+_135312655 0.554 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr6_-_48186868 0.552 C6orf138
chromosome 6 open reading frame 138
chr10_-_73953699 0.540 NM_001195519
CBARA1
calcium binding atopy-related autoantigen 1
chr3_-_195670256 0.535 NM_024524
ATP13A3
ATPase type 13A3
chr1_-_202449659 0.535 NM_198447
GOLT1A
golgi transport 1A
chr3_-_195553297 0.533 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr6_+_36752244 0.533 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr16_+_80626331 0.532 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr7_+_45899080 0.522 IGFBP1
insulin-like growth factor binding protein 1
chr1_+_74473672 0.521 NM_015978
TNNI3K
TNNI3 interacting kinase
chr5_+_43645018 0.520 NNT
nicotinamide nucleotide transhydrogenase
chr19_-_56549853 0.507 NM_001014763
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr2_+_228064531 0.497 AGFG1
ArfGAP with FG repeats 1
chr14_-_101617680 0.493 HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr3_-_121883647 0.491 HGD
homogentisate 1,2-dioxygenase
chr16_+_80626459 0.486 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr2_+_201806410 0.485 NM_001080124
NM_001228
NM_033355
NM_033358
CASP8



caspase 8, apoptosis-related cysteine peptidase



chr4_-_10295412 0.485 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chrX_-_2892288 0.481 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr3_-_25658829 0.475 TOP2B
topoisomerase (DNA) II beta 180kDa
chr7_+_94953148 0.474 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr5_-_158690047 0.474 NM_002187
IL12B
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
chr8_-_59575249 0.473 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr3_+_173043832 0.472 NM_001164436
TMEM212
transmembrane protein 212
chr3_+_129124591 0.460 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr20_+_56919233 0.459 GNAS
GNAS complex locus
chr10_-_69267774 0.451 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr20_+_30161173 0.450 TM9SF4
transmembrane 9 superfamily protein member 4
chr1_+_66230977 0.448 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr6_+_88021644 0.447 ZNF292
zinc finger protein 292
chr2_+_64534774 0.441 NM_014181
HSPC159
galectin-related protein
chr1_+_220977180 0.441 NM_207468
FAM177B
family with sequence similarity 177, member B
chr16_+_11346812 0.440 C16orf75
chromosome 16 open reading frame 75
chr3_+_171183203 0.439 SEC62
SEC62 homolog (S. cerevisiae)
chr18_+_27210737 0.439 NM_001134453
NM_177986
DSG4

desmoglein 4

chr4_-_84254873 0.439 PLAC8
placenta-specific 8
chr17_+_7682355 0.435


chr4_-_84254912 0.434 PLAC8
placenta-specific 8
chr5_-_179040580 0.434 NM_001164444
CBY3
chibby homolog 3 (Drosophila)
chrX_-_131989963 0.431 NM_031907
USP26
ubiquitin specific peptidase 26
chr9_+_21399132 0.429 NM_002170
IFNA8
interferon, alpha 8
chr6_+_167445284 0.422 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr13_+_51496679 0.420 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr16_+_80626402 0.420 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr1_+_165565006 0.419 POU2F1
POU class 2 homeobox 1
chr17_+_3324096 0.418 NM_001128085
ASPA
aspartoacylase
chr6_-_33016561 0.417 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr2_+_42649105 0.415 NM_020744
MTA3
metastasis associated 1 family, member 3
chr1_-_246869181 0.409 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr11_-_30558495 0.409 NM_001584
MPPED2
metallophosphoesterase domain containing 2
chr7_+_141457977 0.403 LOC93432
maltase-glucoamylase-like pseudogene
chr4_+_88748704 0.403 NM_014208
DSPP
dentin sialophosphoprotein
chr12_+_100394787 0.403 NM_152323
SPIC
Spi-C transcription factor (Spi-1/PU.1 related)
chr14_-_22515725 0.399 JUB
jub, ajuba homolog (Xenopus laevis)
chr17_-_64752550 0.398 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr14_-_24148658 0.393 NM_033423
GZMH
granzyme H (cathepsin G-like 2, protein h-CCPX)
chrX_+_99726445 0.392 NM_022144
TNMD
tenomodulin
chr6_+_153113624 0.387 NM_003381
NM_194435
VIP

vasoactive intestinal peptide

chr15_+_92700167 0.386 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr3_+_85858321 0.386 NM_153184
CADM2
cell adhesion molecule 2
chr6_+_46869052 0.385 NM_005588
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr12_+_25096472 0.381 NM_006152
LRMP
lymphoid-restricted membrane protein
chr20_+_43691797 0.380 NM_080753
WFDC10A
WAP four-disulfide core domain 10A
chr4_+_71418886 0.377 NM_212557
AMTN
amelotin
chr12_+_8167494 0.373 NM_016184
NM_194447
NM_194448
NM_194450
CLEC4A



C-type lectin domain family 4, member A



chrX_-_130251068 0.371 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr10_-_93992982 0.370 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr14_-_74669864 0.368 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr2_-_144768529 0.368 NM_001006636
GTDC1
glycosyltransferase-like domain containing 1
chr1_+_158975662 0.365 NM_021181
SLAMF7
SLAM family member 7
chr2_+_227900471 0.365 NM_020194
MFF
mitochondrial fission factor
chr5_+_67622242 0.361 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_+_54132447 0.359 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr3_-_156876798 0.357 NM_001130960
NM_001130961
PLCH1

phospholipase C, eta 1

chr1_-_39119845 0.354 NM_030772
GJA9-MYCBP
GJA9
GJA9-MYCBP read-through transcript
gap junction protein, alpha 9, 59kDa
chr1_-_158815850 0.353 CD84
CD84 molecule
chr1_-_205272619 0.351 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr16_+_80626456 0.351 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr6_+_16251260 0.349 MYLIP
myosin regulatory light chain interacting protein
chr10_+_124660206 0.348 NM_001029888
FAM24A
family with sequence similarity 24, member A
chr1_-_205012348 0.348 NM_000572
IL10
interleukin 10
chr14_+_22859236 0.346 NM_004643
PABPN1
poly(A) binding protein, nuclear 1
chr2_-_127817143 0.343 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr3_-_180452096 0.343 NM_014407
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr14_+_88130482 0.341 NM_207662
ZC3H14
zinc finger CCCH-type containing 14
chr10_+_102111361 0.341 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr11_-_83661878 0.340 NM_001142700
DLG2
discs, large homolog 2 (Drosophila)
chr6_-_99955987 0.338 SFRS18
splicing factor, arginine/serine-rich 18
chr13_+_23042722 0.331 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr4_+_75393053 0.330 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr5_+_140583098 0.327 NM_018934
PCDHB14
protocadherin beta 14
chr19_+_56671649 0.327 NM_001080405
CEACAM18
carcinoembryonic antigen-related cell adhesion molecule 18
chr4_-_100575313 0.326 NM_001166504
NM_000673
ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr18_-_22699650 0.325 NM_001650
AQP4
aquaporin 4
chr1_+_246682699 0.323 NM_001004136
OR2T2
olfactory receptor, family 2, subfamily T, member 2
chr11_+_73036241 0.323 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr10_+_98054074 0.323 NM_001017520
NM_004088
DNTT

deoxynucleotidyltransferase, terminal

chr4_+_74498042 0.323 ALB
albumin
chrX_-_131375217 0.322 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr18_-_22696532 0.320 NM_004028
AQP4
aquaporin 4
chr10_+_101078784 0.320 NM_020348
CNNM1
cyclin M1
chr6_+_49575629 0.318 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr11_-_30910074 0.317 NM_020869
DCDC5
doublecortin domain containing 5
chr12_+_63510481 0.316


chr14_-_80475636 0.315 NM_152446
C14orf145
chromosome 14 open reading frame 145
chr8_-_37576515 0.315 LOC157860
hypothetical protein LOC157860
chr11_-_16953135 0.315 RPL36A
ribosomal protein L36a
chr17_-_16816113 0.310 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr3_-_99236520 0.309 NM_001105580
GABRR3
gamma-aminobutyric acid (GABA) receptor, rho 3
chr5_+_102493155 0.307 NM_015216
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr20_+_17622319 0.307 NM_001159495
BANF2
barrier to autointegration factor 2
chr3_+_123279439 0.301 NM_006889
CD86
CD86 molecule
chr2_-_121964373 0.299 CLASP1
cytoplasmic linker associated protein 1
chr11_-_104332631 0.299 NM_033306
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr9_-_103237851 0.298 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr11_-_48330574 0.297 NM_001005513
OR4C45
olfactory receptor, family 4, subfamily C, member 45
chr16_-_21221872 0.297 NM_001014444
NM_001888
CRYM

crystallin, mu

chr3_-_42892636 0.296 NM_004391
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.95 1.29e-10 GO:0007608 sensory perception of smell
2.77 5.01e-10 GO:0007606 sensory perception of chemical stimulus
1.98 1.27e-05 GO:0007600 sensory perception
1.25 1.40e-04 GO:0050896 response to stimulus
1.27 5.73e-04 GO:0032501 multicellular organismal process
9.20 1.53e-03 GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation
9.20 1.53e-03 GO:2000514 regulation of CD4-positive, alpha-beta T cell activation
1.79 4.56e-03 GO:0006952 defense response
1.50 7.37e-03 GO:0003008 system process
19.55 1.43e-02 GO:0032693 negative regulation of interleukin-10 production
1.55 1.92e-02 GO:0050877 neurological system process
9.77 2.62e-02 GO:0045622 regulation of T-helper cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.33 2.32e-05 GO:0005886 plasma membrane
1.32 3.77e-05 GO:0071944 cell periphery
1.48 1.69e-04 GO:0005576 extracellular region
1.17 3.62e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.99 4.68e-11 GO:0004984 olfactory receptor activity
2.04 2.56e-07 GO:0004930 G-protein coupled receptor activity
1.64 2.51e-06 GO:0004872 receptor activity
1.76 2.87e-06 GO:0004888 transmembrane receptor activity
1.53 1.61e-05 GO:0004871 signal transducer activity
1.53 1.61e-05 GO:0060089 molecular transducer activity
12.22 8.29e-03 GO:0005132 interferon-alpha/beta receptor binding
9.02 1.08e-02 GO:0004522 pancreatic ribonuclease activity
7.33 4.41e-02 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters