Motif ID: NKX6-1,2.p2

Z-value: 1.141


Transcription factors associated with NKX6-1,2.p2:

Gene SymbolEntrez IDGene Name
NKX6-1 4825 NK6 homeobox 1
NKX6-2 84504 NK6 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX6-1chr4_-_856384100.234.0e-01Click!
NKX6-2chr10_-_1344494670.097.5e-01Click!


Activity profile for motif NKX6-1,2.p2.

activity profile for motif NKX6-1,2.p2


Sorted Z-values histogram for motif NKX6-1,2.p2

Sorted Z-values for motif NKX6-1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX6-1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_185064654 3.308 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr3_-_143230124 3.101 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr1_+_78858675 2.384 NM_006820
IFI44L
interferon-induced protein 44-like
chr9_-_21375258 1.715 NM_000605
IFNA2
interferon, alpha 2
chr1_+_78888064 1.644 NM_006417
IFI44
interferon-induced protein 44
chr4_-_138673078 1.571 NM_019035
PCDH18
protocadherin 18
chr7_+_28692122 1.408 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr8_+_79591074 1.308 PKIA
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr3_-_152585226 1.292 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr7_-_83662152 1.281 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr13_+_23042722 1.220 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr12_-_51887266 1.196 NM_000889
ITGB7
integrin, beta 7
chr3_-_64186151 1.156 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr3_-_15814678 1.152 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr13_-_32658215 1.146 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr6_-_56824371 1.096 DST
dystonin
chr20_-_51633042 1.089 NM_006526
ZNF217
zinc finger protein 217
chrX_-_33139349 1.076 NM_004006
DMD
dystrophin
chr5_-_111119846 1.073 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr4_-_152368492 1.069 SH3D19
SH3 domain containing 19
chr7_-_41709191 1.052 NM_002192
INHBA
inhibin, beta A
chr8_+_26206648 1.036 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr4_-_138673014 1.023 PCDH18
protocadherin 18
chr2_+_68815416 1.016 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr4_-_90978469 1.014 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr2_-_225519974 1.006 DOCK10
dedicator of cytokinesis 10
chr12_-_52939584 1.001 NM_001127322
CBX5
chromobox homolog 5
chr12_+_74071116 0.996 GLIPR1L2
GLI pathogenesis-related 1 like 2
chr4_-_16509126 0.986 LDB2
LIM domain binding 2
chr14_+_62740878 0.974 NM_020663
RHOJ
ras homolog gene family, member J
chr7_-_20223467 0.962 NM_182762
MACC1
metastasis associated in colon cancer 1
chr11_+_1830763 0.957 NM_002339
LSP1
lymphocyte-specific protein 1
chr1_-_89261021 0.942 NM_018284
GBP3
guanylate binding protein 3
chr2_-_217267742 0.923 IGFBP5
insulin-like growth factor binding protein 5
chr1_+_242691295 0.921 NM_001130957
NM_173807
C1orf101

chromosome 1 open reading frame 101

chr8_+_79590890 0.911 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr12_-_52939636 0.905 NM_001127321
CBX5
chromobox homolog 5
chr12_-_51887318 0.902 ITGB7
integrin, beta 7
chr19_+_24061717 0.891 NM_203282
ZNF254
zinc finger protein 254
chr18_+_54013575 0.889 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr20_+_19863716 0.869 RIN2
Ras and Rab interactor 2
chr9_+_81376666 0.865 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr3_-_79899748 0.865 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr7_-_76667045 0.856 NM_006682
FGL2
fibrinogen-like 2
chr2_+_37282516 0.852 LOC100505876
hypothetical LOC100505876
chr20_+_11846536 0.846 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr4_+_75393053 0.844 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr6_+_26548678 0.832 NM_006994
NM_197974
BTN3A3

butyrophilin, subfamily 3, member A3

chr9_+_81377419 0.822 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr13_-_98757634 0.818 NM_004951
GPR183
G protein-coupled receptor 183
chr6_-_133126278 0.810 NM_078488
VNN2
vanin 2
chr12_+_9871343 0.809 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr2_-_136590210 0.809 NM_001008540
CXCR4
chemokine (C-X-C motif) receptor 4
chr1_+_12149662 0.808 TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr6_+_32713160 0.804 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr1_+_85300580 0.792 NM_145172
WDR63
WD repeat domain 63
chr3_-_113495763 0.785 NM_183061
SLC9A10
solute carrier family 9, member 10
chr3_+_179759181 0.777 NM_005832
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr1_-_205161821 0.775 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr6_-_56824672 0.773 DST
dystonin
chr12_+_46799279 0.748 NM_000289
PFKM
phosphofructokinase, muscle
chr7_-_33047042 0.746 NM_001166118
NM_016489
NT5C3

5'-nucleotidase, cytosolic III

chr4_-_16509446 0.744 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr2_-_151052391 0.738 NM_005168
RND3
Rho family GTPase 3
chr4_-_10295412 0.735 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr8_-_122722674 0.733 NM_005328
HAS2
hyaluronan synthase 2
chr12_-_53664722 0.720 NM_001136030
KIAA0748
KIAA0748
chr11_+_65026382 0.703


chr6_-_32892705 0.701 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr7_-_22518200 0.700 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr9_+_92629525 0.684 NM_001174167
SYK
spleen tyrosine kinase
chr3_-_21767819 0.675 NM_024697
ZNF385D
zinc finger protein 385D
chr16_-_3567354 0.655 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr21_-_34820916 0.654 NM_203418
RCAN1
regulator of calcineurin 1
chr13_-_98708549 0.647 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr5_+_140780797 0.639 PCDHGA11
protocadherin gamma subfamily A, 11
chr1_+_205068844 0.638 NM_013371
IL19
interleukin 19
chr13_-_47885248 0.629 LPAR6
lysophosphatidic acid receptor 6
chr19_+_45973139 0.625 NM_006533
MIA
melanoma inhibitory activity
chr10_-_100985548 0.597 NM_001166244
NM_001166245
NM_001166246
NM_021828
HPSE2



heparanase 2



chr1_+_207944807 0.595 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr6_+_37511383 0.595


chr1_+_12149637 0.595 NM_001066
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr4_-_140420789 0.588 NM_032623
C4orf49
chromosome 4 open reading frame 49
chr1_+_144188375 0.577 NM_153713
LIX1L
Lix1 homolog (mouse)-like
chr2_+_190248955 0.576 NM_144708
ANKAR
ankyrin and armadillo repeat containing
chr3_-_52269467 0.575 WDR82
WD repeat domain 82
chrX_+_55951280 0.573


chr6_+_147568795 0.570 STXBP5
syntaxin binding protein 5 (tomosyn)
chr14_-_63076155 0.567 PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr14_-_19867372 0.563 NM_182852
NM_182851
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chrX_-_78509662 0.559 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr3_-_17757402 0.553 NM_014744
TBC1D5
TBC1 domain family, member 5
chr10_+_26545241 0.548 NM_000818
NM_001134366
GAD2

glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

chr11_+_122258600 0.546 NM_024806
NM_199124
C11orf63

chromosome 11 open reading frame 63

chr8_-_82557956 0.542 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr1_-_114215768 0.541 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr17_+_55269974 0.541


chr2_+_66519949 0.538 MEIS1
Meis homeobox 1
chr15_-_91078307 0.537 FAM174B
family with sequence similarity 174, member B
chr1_+_53253204 0.532 SCP2
sterol carrier protein 2
chr5_+_35892747 0.525 NM_002185
IL7R
interleukin 7 receptor
chr1_+_242281199 0.524 ZNF238
zinc finger protein 238
chr8_-_28403652 0.518 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr9_+_76302071 0.514 NM_006914
RORB
RAR-related orphan receptor B
chr8_-_23768242 0.514 NM_003155
STC1
stanniocalcin 1
chr5_-_64813459 0.513 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr18_+_30544193 0.500 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr7_+_72034735 0.497 POM121
POM121 membrane glycoprotein
chr21_+_30937053 0.494 NM_001128077
KRTAP20-3
keratin associated protein 20-3
chr8_+_86287161 0.492 NM_001083589
E2F5
E2F transcription factor 5, p130-binding
chr1_-_149115667 0.486 ARNT
aryl hydrocarbon receptor nuclear translocator
chr8_-_42742729 0.485 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr12_-_9804682 0.483 NM_001781
CD69
CD69 molecule
chr7_-_26198673 0.481 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr13_-_47885653 0.473 NM_001162498
LPAR6
lysophosphatidic acid receptor 6
chr12_+_53178834 0.472 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr4_-_71751070 0.470 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr9_+_81377289 0.463 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr5_-_58331515 0.462 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr14_-_74600469 0.460 NM_001107
NM_203488
ACYP1

acylphosphatase 1, erythrocyte (common) type

chr4_-_17415918 0.458 DCAF16
DDB1 and CUL4 associated factor 16
chr3_+_39346200 0.453 NM_005201
CCR8
chemokine (C-C motif) receptor 8
chrX_-_102973762 0.452 NM_016370
RAB9B
RAB9B, member RAS oncogene family
chrX_+_51503219 0.448 NM_018094
GSPT2
G1 to S phase transition 2
chr15_+_47502666 0.446 NM_002009
FGF7
fibroblast growth factor 7
chr1_+_245835478 0.444 NM_001001914
OR2G3
olfactory receptor, family 2, subfamily G, member 3
chr6_+_136214495 0.444 NM_018945
PDE7B
phosphodiesterase 7B
chr12_-_52281050 0.443 NM_001130059
ATF7
activating transcription factor 7
chr14_+_87541220 0.439 NM_003608
GPR65
G protein-coupled receptor 65
chr7_-_13992351 0.438 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr4_+_187227302 0.437 NM_003265
TLR3
toll-like receptor 3
chr1_+_53253161 0.435 NM_001007099
NM_001007100
NM_001007250
SCP2


sterol carrier protein 2


chr4_-_71751205 0.431 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr9_+_115303527 0.430 NM_130795
RGS3
regulator of G-protein signaling 3
chr10_+_63478974 0.424 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr15_+_91244422 0.419 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr2_-_207291364 0.417 NM_001093730
DYTN
dystrotelin
chr4_-_83566246 0.415 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr1_+_242582559 0.415 NM_001012970
C1orf100
chromosome 1 open reading frame 100
chr2_+_161701711 0.414 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr2_-_65447267 0.414 SPRED2
sprouty-related, EVH1 domain containing 2
chr2_+_17861266 0.413 NM_001105569
MSGN1
mesogenin 1
chrX_+_47326746 0.412 TIMP1
TIMP metallopeptidase inhibitor 1
chr3_-_150903749 0.412 NM_001168278
WWTR1
WW domain containing transcription regulator 1
chr21_-_35343065 0.409 RUNX1
runt-related transcription factor 1
chr14_+_100365162 0.408 MEG3
maternally expressed 3 (non-protein coding)
chr19_-_53444733 0.407 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr1_-_27825633 0.406 NM_001042729
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr7_-_22828922 0.405 NM_019059
TOMM7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr1_+_115198977 0.405 NM_003176
SYCP1
synaptonemal complex protein 1
chr10_-_64698831 0.402 NM_004241
JMJD1C
jumonji domain containing 1C
chr13_-_37070862 0.401 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr5_+_140780720 0.396 NM_018914
NM_032091
NM_032092
PCDHGA11


protocadherin gamma subfamily A, 11


chr4_-_87593306 0.394 NM_002753
MAPK10
mitogen-activated protein kinase 10
chr1_+_242281175 0.393 NM_205768
ZNF238
zinc finger protein 238
chr13_+_96672705 0.393 MBNL2
muscleblind-like 2 (Drosophila)
chr10_-_90601655 0.393 NM_144590
ANKRD22
ankyrin repeat domain 22
chr4_+_166097548 0.392 NM_153027
C4orf39
chromosome 4 open reading frame 39
chr2_+_165858586 0.391 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr7_+_18502342 0.386 NM_058176
NM_178425
HDAC9

histone deacetylase 9

chr2_+_218698980 0.386 NM_001557
CXCR2
chemokine (C-X-C motif) receptor 2
chr5_+_49997489 0.384 NM_001178055
PARP8
poly (ADP-ribose) polymerase family, member 8
chr6_+_26071255 0.379 TRIM38
tripartite motif containing 38
chr13_+_48582389 0.376 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr7_+_93862137 0.376 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1
chr1_-_149115686 0.374 ARNT
aryl hydrocarbon receptor nuclear translocator
chr18_+_59705918 0.374 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chrX_+_135058402 0.371 NM_001159700
FHL1
four and a half LIM domains 1
chr12_-_92489652 0.370 LOC144481
hypothetical protein LOC144481
chr2_-_202271598 0.369 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr11_+_93916653 0.366 NM_002033
PIWIL4
FUT4
piwi-like 4 (Drosophila)
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr8_-_52884456 0.365 NM_144651
PXDNL
peroxidasin homolog (Drosophila)-like
chr6_+_96132064 0.363 NM_024641
MANEA
mannosidase, endo-alpha
chr6_-_26151863 0.362 NM_021062
HIST1H2BB
histone cluster 1, H2bb
chr13_+_107720561 0.360 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr4_-_163304567 0.360 NM_001128427
NM_001128428
NM_020116
FSTL5


follistatin-like 5


chr12_+_111829121 0.360 NM_001032409
NM_002534
NM_016816
OAS1


2',5'-oligoadenylate synthetase 1, 40/46kDa


chr6_+_114285209 0.359 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr5_+_162862808 0.352 NM_182796
MAT2B
methionine adenosyltransferase II, beta
chr4_+_54790190 0.352 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr3_-_122862447 0.351 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr1_+_199884152 0.350 NAV1
neuron navigator 1
chr4_-_164754106 0.342 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chr4_+_54790020 0.341 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr22_+_38903825 0.338 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr3_+_157877146 0.335 NM_001184718
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr3_-_122862391 0.332 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr22_+_38627129 0.331 GRAP2
GRB2-related adaptor protein 2
chr1_+_159817752 0.325 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr4_+_166097579 0.324 C4orf39
chromosome 4 open reading frame 39
chr1_+_159899528 0.323 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr5_+_96237923 0.323 ERAP2
endoplasmic reticulum aminopeptidase 2
chr3_+_188397967 0.321 NM_153708
RTP1
receptor (chemosensory) transporter protein 1
chr19_+_57564981 0.320 NM_001145434
ZNF880
zinc finger protein 880
chr1_+_194887630 0.320 NM_000186
NM_001014975
CFH

complement factor H

chr3_-_170348215 0.319 NM_001164000
MECOM
MDS1 and EVI1 complex locus
chr15_+_46271158 0.319 NM_001145668
CTXN2
SLC12A1
cortexin 2
solute carrier family 12 (sodium/potassium/chloride transporters), member 1
chr12_-_56422120 0.318 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr18_-_53438854 0.318



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.61 2.56e-03 GO:0002376 immune system process
1.80 3.58e-03 GO:0006955 immune response
1.20 2.28e-02 GO:0050896 response to stimulus
1.28 3.44e-02 GO:0023052 signaling
5.58 4.26e-02 GO:0048806 genitalia development
1.29 4.32e-02 GO:0007165 signal transduction

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.59 7.25e-03 GO:0005102 receptor binding
5.75 2.26e-02 GO:0001608 nucleotide receptor activity, G-protein coupled
5.75 2.26e-02 GO:0045028 purinergic nucleotide receptor activity, G-protein coupled
5.06 2.37e-02 GO:0001614 purinergic nucleotide receptor activity
5.06 2.37e-02 GO:0016502 nucleotide receptor activity