Motif ID: RREB1.p2

Z-value: 3.308


Transcription factors associated with RREB1.p2:

Gene SymbolEntrez IDGene Name
RREB1 6239 ras responsive element binding protein 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RREB1chr6_+_70527980.572.1e-02Click!


Activity profile for motif RREB1.p2.

activity profile for motif RREB1.p2


Sorted Z-values histogram for motif RREB1.p2

Sorted Z-values for motif RREB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RREB1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_809879 5.416 NM_006651
CPLX1
complexin 1
chrX_+_151617900 3.814 NM_005363
NM_175868
MAGEA6

melanoma antigen family A, 6

chr1_-_30977931 3.787 LAPTM5
lysosomal protein transmembrane 5
chr16_+_86193993 3.548 NM_020655
JPH3
junctophilin 3
chr2_-_96924582 3.500 NM_001172667
FAM178B
family with sequence similarity 178, member B
chrX_-_151688850 3.478 NM_005362
MAGEA3
melanoma antigen family A, 3
chrX_-_152139267 3.450 NM_004988
MAGEA1
melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
chr7_-_100331417 3.405 NM_000665
NM_015831
ACHE

acetylcholinesterase

chrX_-_151653756 3.071 NM_001166386
NM_001166387
NM_005367
MAGEA12


melanoma antigen family A, 12


chr20_+_48032918 3.068 NM_005985
SNAI1
snail homolog 1 (Drosophila)
chr11_-_74740298 3.006 NM_004041
NM_020251
ARRB1

arrestin, beta 1

chrX_+_151653874 2.933 NM_001102576
NM_153478
CSAG1

chondrosarcoma associated gene 1

chr8_+_144706699 2.737 NM_001166237
GSDMD
gasdermin D
chr2_+_174907914 2.724 NM_001145250
SP9
Sp9 transcription factor homolog (mouse)
chr19_+_540849 2.535 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chrX_+_151633730 2.336 NM_005361
NM_175742
NM_175743
MAGEA2


melanoma antigen family A, 2


chr19_+_14405216 2.298 PKN1
protein kinase N1
chr14_+_28305922 2.261 NM_005249
FOXG1
forkhead box G1
chr2_+_42128521 2.227 NM_138370
PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr19_-_8581559 2.180 NM_030957
ADAMTS10
ADAM metallopeptidase with thrombospondin type 1 motif, 10
chr20_-_49592444 2.160 NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr2_+_72998111 2.107 NM_004097
EMX1
empty spiracles homeobox 1
chr6_-_31668476 2.000 NM_001145466
NM_001145467
NM_147130
NCR3


natural cytotoxicity triggering receptor 3


chr12_+_6807831 1.977 NM_014262
LEPREL2
leprecan-like 2
chr1_-_1283770 1.934 NM_032348
MXRA8
matrix-remodelling associated 8
chr4_-_46086528 1.914 NM_000807
GABRA2
gamma-aminobutyric acid (GABA) A receptor, alpha 2
chr17_-_73636386 1.898 NM_001127198
TMC6
transmembrane channel-like 6
chr19_+_14405100 1.896 NM_002741
PKN1
protein kinase N1
chrX_+_152561086 1.889 NM_001395
DUSP9
dual specificity phosphatase 9
chr18_+_75261231 1.866 NM_172387
NM_172389
NFATC1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

chr19_-_51168396 1.854 NM_002516
NOVA2
neuro-oncological ventral antigen 2
chrX_-_1532648 1.843 NM_001173473
ASMTL
acetylserotonin O-methyltransferase-like
chr1_+_945331 1.833 NM_198576
AGRN
agrin
chr22_-_21231421 1.832 NM_206955
NM_206956
NM_006115
NM_206953
NM_206954
PRAME




preferentially expressed antigen in melanoma




chr11_+_56984702 1.794 NM_178570
RTN4RL2
reticulon 4 receptor-like 2
chr19_+_17723285 1.779 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chr17_-_73636362 1.775 TMC6
transmembrane channel-like 6
chr19_+_3317589 1.746 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr20_-_62151216 1.692 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chr12_+_54700955 1.674 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chrX_-_148476903 1.661 NM_005365
NM_001080790
MAGEA9
MAGEA9B
melanoma antigen family A, 9
melanoma antigen family A, 9B
chrX_-_151672985 1.655 NM_005361
NM_175742
NM_175743
MAGEA2


melanoma antigen family A, 2


chr21_+_42946719 1.643 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
PDE9A



















phosphodiesterase 9A



















chr17_-_44010543 1.638 NM_024015
HOXB4
homeobox B4
chr19_+_659766 1.602 NM_001040134
NM_002579
PALM

paralemmin

chr15_+_74416156 1.584 NM_145805
ISL2
ISL LIM homeobox 2
chr1_-_199259133 1.571 KIF21B
kinesin family member 21B
chr8_-_145119627 1.569 NM_201378
PLEC
plectin
chr15_+_74416129 1.540 ISL2
ISL LIM homeobox 2
chr11_+_46359821 1.526 MDK
midkine (neurite growth-promoting factor 2)
chr13_-_113066202 1.515 GRTP1
growth hormone regulated TBC protein 1
chr10_+_45189617 1.507 NM_000698
ALOX5
arachidonate 5-lipoxygenase
chr10_-_75085754 1.483 NM_001114133
SYNPO2L
synaptopodin 2-like
chr19_-_60350122 1.476 TNNT1
troponin T type 1 (skeletal, slow)
chr15_-_43267139 1.432 SHF
Src homology 2 domain containing F
chr16_-_28515868 1.427 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr3_-_185578621 1.422 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr10_-_76538859 1.412 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr1_-_149214063 1.408 NM_022075
NM_181746
LASS2

LAG1 homolog, ceramide synthase 2

chr1_-_199259447 1.400 NM_017596
KIF21B
kinesin family member 21B
chr11_+_46359855 1.398 MDK
midkine (neurite growth-promoting factor 2)
chr20_-_55533544 1.384 NM_080618
CTCFL
CCCTC-binding factor (zinc finger protein)-like
chr7_-_100077072 1.381 NM_003227
TFR2
transferrin receptor 2
chr16_+_84202515 1.378 NM_001134473
KIAA0182
KIAA0182
chr8_-_125252884 1.366 C8orf78
chromosome 8 open reading frame 78
chr19_+_3317575 1.363 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr2_-_128149112 1.362 NM_001136037
NM_001161403
LIMS2

LIM and senescent cell antigen-like domains 2

chr22_+_19699441 1.361 NM_001159554
NM_005446
P2RX6

purinergic receptor P2X, ligand-gated ion channel, 6

chr1_-_182273114 1.358 GLT25D2
glycosyltransferase 25 domain containing 2
chr13_-_113066366 1.334 NM_024719
GRTP1
growth hormone regulated TBC protein 1
chr11_+_46359836 1.322 MDK
midkine (neurite growth-promoting factor 2)
chr19_+_3317536 1.316 NM_005597
NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr7_-_150305933 1.310 NM_000238
NM_172056
KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

chr20_-_49592654 1.297 NM_012340
NM_173091
NFATC2

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

chr17_-_71352090 1.288 UNC13D
unc-13 homolog D (C. elegans)
chr19_+_4442610 1.287 HDGFRP2
hepatoma-derived growth factor-related protein 2
chr10_+_45189673 1.277 ALOX5
arachidonate 5-lipoxygenase
chr22_-_28992787 1.276 NM_020530
OSM
oncostatin M
chr2_+_48610567 1.257 NM_001198593
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr19_-_6453224 1.256 NM_006087
TUBB4
tubulin, beta 4
chr16_-_28528780 1.251 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr1_+_199259664 1.247


chr12_+_56291484 1.245 NM_182947
ARHGEF25
Rho guanine nucleotide exchange factor (GEF) 25
chr1_+_144183811 1.226 ANKRD34A
ankyrin repeat domain 34A
chr14_-_20563698 1.225 NDRG2
NDRG family member 2
chr11_-_2115077 1.224


chr6_-_167195647 1.219 NM_001006932
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr17_-_44058612 1.215 NM_024017
HOXB9
homeobox B9
chr19_+_12805747 1.213 MAST1
microtubule associated serine/threonine kinase 1
chr1_+_21708428 1.209 NM_000478
NM_001127501
NM_001177520
ALPL


alkaline phosphatase, liver/bone/kidney


chr12_-_47679176 1.205 NM_015086
DDN
dendrin
chr11_+_10433241 1.205 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr11_-_8695974 1.205 ST5
suppression of tumorigenicity 5
chr21_-_46428768 1.203 C21orf56
chromosome 21 open reading frame 56
chr1_-_154318412 1.203 NM_001093725
MEX3A
mex-3 homolog A (C. elegans)
chr5_-_138746917 1.198 NM_005847
NM_152685
SLC23A1

solute carrier family 23 (nucleobase transporters), member 1

chr16_+_86194075 1.195 JPH3
junctophilin 3
chr11_+_46359781 1.190 NM_002391
MDK
midkine (neurite growth-promoting factor 2)
chr1_-_32574185 1.188 NM_023009
MARCKSL1
MARCKS-like 1
chr16_-_69030421 1.184 NM_006927
ST3GAL2
ST3 beta-galactoside alpha-2,3-sialyltransferase 2
chr6_-_167289659 1.181


chr11_+_279113 1.175 NM_025092
ATHL1
ATH1, acid trehalase-like 1 (yeast)
chr2_-_227737518 1.175 NM_000092
COL4A4
collagen, type IV, alpha 4
chr3_+_187917791 1.174 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chrX_+_148671394 1.159 NM_005365
NM_001080790
MAGEA9
MAGEA9B
melanoma antigen family A, 9
melanoma antigen family A, 9B
chr21_-_46428728 1.146 C21orf56
chromosome 21 open reading frame 56
chr20_-_22513050 1.141 NM_021784
FOXA2
forkhead box A2
chr5_-_138746840 1.136 SLC23A1
solute carrier family 23 (nucleobase transporters), member 1
chr14_-_20563722 1.125 NM_016250
NM_201535
NM_201536
NM_201537
NDRG2



NDRG family member 2



chr4_-_109308893 1.121 NM_001130713
NM_001130714
NM_016269
LEF1


lymphoid enhancer-binding factor 1


chr6_+_14032655 1.119 NM_001165034
RNF182
ring finger protein 182
chr7_-_150306169 1.118 KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr11_+_10434056 1.111 NM_001025390
AMPD3
adenosine monophosphate deaminase 3
chr1_+_20385164 1.111 NM_152376
UBXN10
UBX domain protein 10
chr20_+_55359551 1.111 NM_003610
RAE1
RAE1 RNA export 1 homolog (S. pombe)
chr6_+_44295219 1.109 NM_001078174
NM_004955
SLC29A1

solute carrier family 29 (nucleoside transporters), member 1

chr11_+_359723 1.106 NM_178537
B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr17_+_77582774 1.103 NM_005052
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr2_+_200031333 1.093


chr12_-_52980984 1.093 NM_001136023
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr6_-_167195987 1.092 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr4_+_191235959 1.091 NM_001177376
DUX4L4
double homeobox 4 like 4
chr19_+_6723801 1.085


chr19_-_34897802 1.083 NM_001031726
C19orf12
chromosome 19 open reading frame 12
chr19_-_18409788 1.078 NM_001170939
ISYNA1
inositol-3-phosphate synthase 1
chr8_+_145136226 1.075 GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr10_-_98470164 1.075 NM_152309
PIK3AP1
phosphoinositide-3-kinase adaptor protein 1
chr19_+_811615 1.065 CFD
complement factor D (adipsin)
chr9_-_122679283 1.065 PHF19
PHD finger protein 19
chr19_-_60350118 1.060 TNNT1
troponin T type 1 (skeletal, slow)
chr21_-_46428788 1.056 NM_001142854
NM_032261
C21orf56

chromosome 21 open reading frame 56

chr3_+_12304332 1.046 NM_005037
NM_138712
PPARG

peroxisome proliferator-activated receptor gamma

chr6_-_6265896 1.039 NM_000129
F13A1
coagulation factor XIII, A1 polypeptide
chr9_+_70509925 1.035 NM_003558
PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr9_+_89302239 1.028 DAPK1
death-associated protein kinase 1
chr2_+_149349643 1.016


chr19_-_7896974 1.006 NM_206833
CTXN1
cortexin 1
chr12_+_52665196 1.000 NM_017409
HOXC10
homeobox C10
chr3_-_159306214 1.000


chr2_-_200030944 0.998 NM_001172509
SATB2
SATB homeobox 2
chr12_+_6808025 0.995 LEPREL2
leprecan-like 2
chr22_+_49333327 0.989 NM_138433
KLHDC7B
kelch domain containing 7B
chr12_-_52980914 0.988 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr14_+_102458745 0.986 NM_030943
AMN
amnionless homolog (mouse)
chr1_+_945399 0.985


chr17_+_50697319 0.978 NM_002126
HLF
hepatic leukemia factor
chr6_-_6265874 0.974 F13A1
coagulation factor XIII, A1 polypeptide
chr11_+_46359878 0.973 NM_001012333
MDK
midkine (neurite growth-promoting factor 2)
chr9_-_129699389 0.972 ST6GALNAC6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr17_+_16259812 0.971 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr6_+_34541827 0.971 NM_020804
PACSIN1
protein kinase C and casein kinase substrate in neurons 1
chr10_+_70257568 0.969 NM_001130162
STOX1
storkhead box 1
chrX_-_1291526 0.964 NM_001012288
NM_022148
CRLF2

cytokine receptor-like factor 2

chr2_-_130603264 0.961 NM_001099771
POTEF
POTE ankyrin domain family, member F
chr20_+_55359706 0.960 RAE1
RAE1 RNA export 1 homolog (S. pombe)
chr16_+_86194170 0.960 JPH3
junctophilin 3
chr17_+_50697355 0.958 HLF
hepatic leukemia factor
chr1_+_12046020 0.958 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr2_+_219532590 0.957 NM_003936
CDK5R2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr2_-_163403274 0.956 KCNH7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr15_-_43267441 0.948 SHF
Src homology 2 domain containing F
chr12_-_54387732 0.947 ITGA7
integrin, alpha 7
chr19_+_10261646 0.946 NM_003259
ICAM5
intercellular adhesion molecule 5, telencephalin
chr7_+_134567270 0.946 NM_182489
STRA8
stimulated by retinoic acid gene 8 homolog (mouse)
chr10_-_135000358 0.945 CALY
calcyon neuron-specific vesicular protein
chr17_-_76754466 0.944 NM_001080395
AATK
apoptosis-associated tyrosine kinase
chr7_+_100792841 0.944 NM_133457
EMID2
EMI domain containing 2
chr9_-_122679387 0.944 NM_001009936
NM_015651
PHF19

PHD finger protein 19

chr11_-_110755112 0.939 POU2AF1
POU class 2 associating factor 1
chr20_+_41576459 0.935 NM_015478
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr16_+_84204424 0.930 NM_014615
KIAA0182
KIAA0182
chr19_+_60487578 0.929 BRSK1
BR serine/threonine kinase 1
chr11_-_66961709 0.928 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr9_+_138760432 0.926 LOC100128593
hypothetical LOC100128593
chr1_-_202647526 0.917 NM_032833
PPP1R15B
protein phosphatase 1, regulatory (inhibitor) subunit 15B
chr1_+_154318954 0.913 LMNA
lamin A/C
chr9_+_129962292 0.910 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr5_+_139008667 0.907 CXXC5
CXXC finger protein 5
chr17_+_16259636 0.904 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr7_+_150390566 0.903 SLC4A2
solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)
chr17_+_58908152 0.896 NM_000789
ACE
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr5_+_176446425 0.896 NM_002011
NM_213647
FGFR4

fibroblast growth factor receptor 4

chr7_+_733182 0.895 HEATR2
HEAT repeat containing 2
chr10_-_135000464 0.893 NM_015722
CALY
calcyon neuron-specific vesicular protein
chrX_-_119095544 0.893 NM_001099685
NM_032498
RHOXF2B
RHOXF2
Rhox homeobox family, member 2B
Rhox homeobox family, member 2
chr15_+_89299060 0.891 NM_001017919
NM_033544
RCCD1

RCC1 domain containing 1

chrX_+_119176494 0.884 NM_001099685
NM_032498
RHOXF2B
RHOXF2
Rhox homeobox family, member 2B
Rhox homeobox family, member 2
chr17_+_35751796 0.884 NM_001024809
RARA
retinoic acid receptor, alpha
chr8_-_145136125 0.883 PARP10
poly (ADP-ribose) polymerase family, member 10
chr7_-_130891861 0.877 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr7_+_101715110 0.873 NM_020979
SH2B2
SH2B adaptor protein 2
chr14_-_21064182 0.873 SALL2
sal-like 2 (Drosophila)
chr8_-_145725289 0.869 C8orf82
chromosome 8 open reading frame 82
chr19_+_6723705 0.868 NM_005428
VAV1
vav 1 guanine nucleotide exchange factor
chr17_-_74361975 0.867 TIMP2
TIMP metallopeptidase inhibitor 2
chr14_+_104267270 0.867 NM_199165
ADSSL1
adenylosuccinate synthase like 1
chr3_-_10522340 0.866 ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr7_-_102044419 0.865 NM_001079877
NM_006989
RASA4

RAS p21 protein activator 4

chr3_-_10522267 0.863 NM_001001331
NM_001683
ATP2B2

ATPase, Ca++ transporting, plasma membrane 2

chr19_-_44503328 0.862



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.17 3.68e-17 GO:0065007 biological regulation
1.59 1.90e-14 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.32 7.94e-14 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.16 8.67e-14 GO:0050789 regulation of biological process
1.35 2.96e-13 GO:0051252 regulation of RNA metabolic process
1.31 4.57e-13 GO:0051171 regulation of nitrogen compound metabolic process
1.16 1.45e-12 GO:0050794 regulation of cellular process
1.26 1.64e-12 GO:0080090 regulation of primary metabolic process
1.26 2.40e-12 GO:0031323 regulation of cellular metabolic process
1.23 2.56e-11 GO:0019222 regulation of metabolic process
1.33 6.26e-11 GO:0006355 regulation of transcription, DNA-dependent
1.25 1.06e-10 GO:0060255 regulation of macromolecule metabolic process
1.29 1.06e-10 GO:0009889 regulation of biosynthetic process
1.29 1.21e-10 GO:0010468 regulation of gene expression
1.29 1.43e-10 GO:0031326 regulation of cellular biosynthetic process
1.60 7.73e-10 GO:0010628 positive regulation of gene expression
1.59 2.01e-09 GO:0051254 positive regulation of RNA metabolic process
1.22 2.04e-09 GO:0032502 developmental process
1.29 3.81e-09 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.23 5.58e-09 GO:0007275 multicellular organismal development
1.28 6.59e-09 GO:0010556 regulation of macromolecule biosynthetic process
1.54 7.98e-09 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.52 1.89e-08 GO:0051173 positive regulation of nitrogen compound metabolic process
1.58 3.29e-08 GO:0045893 positive regulation of transcription, DNA-dependent
1.67 3.41e-08 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.25 5.85e-08 GO:0048518 positive regulation of biological process
1.35 1.47e-07 GO:0007399 nervous system development
1.38 2.28e-07 GO:0009893 positive regulation of metabolic process
1.68 9.64e-07 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.38 1.00e-06 GO:0010604 positive regulation of macromolecule metabolic process
1.21 1.24e-06 GO:0048856 anatomical structure development
1.37 1.28e-06 GO:0031325 positive regulation of cellular metabolic process
1.70 1.34e-06 GO:0016568 chromatin modification
1.25 1.37e-06 GO:0048522 positive regulation of cellular process
1.44 1.91e-06 GO:0009891 positive regulation of biosynthetic process
1.25 2.55e-06 GO:0048519 negative regulation of biological process
1.47 2.72e-06 GO:0010557 positive regulation of macromolecule biosynthetic process
1.44 2.84e-06 GO:0031328 positive regulation of cellular biosynthetic process
1.26 3.36e-06 GO:0048523 negative regulation of cellular process
1.22 4.60e-06 GO:0048731 system development
1.56 5.94e-06 GO:0045892 negative regulation of transcription, DNA-dependent
1.26 7.79e-06 GO:0030154 cell differentiation
1.18 8.28e-06 GO:0023052 signaling
1.42 8.97e-06 GO:0048699 generation of neurons
1.51 9.48e-06 GO:0010629 negative regulation of gene expression
1.53 1.60e-05 GO:0051253 negative regulation of RNA metabolic process
1.60 1.77e-05 GO:0007268 synaptic transmission
1.40 1.97e-05 GO:0022008 neurogenesis
1.46 2.03e-05 GO:0030182 neuron differentiation
1.41 2.37e-05 GO:0006351 transcription, DNA-dependent
1.07 2.83e-05 GO:0009987 cellular process
1.25 3.05e-05 GO:0048869 cellular developmental process
1.55 3.09e-05 GO:0019226 transmission of nerve impulse
1.55 3.09e-05 GO:0035637 multicellular organismal signaling
1.45 7.69e-05 GO:0045595 regulation of cell differentiation
1.45 7.70e-05 GO:0009890 negative regulation of biosynthetic process
1.38 1.42e-04 GO:0048468 cell development
1.41 1.57e-04 GO:0007267 cell-cell signaling
1.44 1.92e-04 GO:0031327 negative regulation of cellular biosynthetic process
1.44 2.85e-04 GO:0010558 negative regulation of macromolecule biosynthetic process
1.50 3.16e-04 GO:0007417 central nervous system development
1.37 3.58e-04 GO:0050793 regulation of developmental process
1.45 3.69e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
1.45 4.21e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.22 6.90e-04 GO:0065008 regulation of biological quality
1.29 7.50e-04 GO:0051239 regulation of multicellular organismal process
1.27 7.51e-04 GO:0009653 anatomical structure morphogenesis
1.43 1.04e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.23 1.26e-03 GO:0048513 organ development
1.33 1.34e-03 GO:0007154 cell communication
1.56 1.63e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.33 1.68e-03 GO:0009892 negative regulation of metabolic process
1.33 1.96e-03 GO:0032774 RNA biosynthetic process
1.25 2.08e-03 GO:0023051 regulation of signaling
1.65 2.43e-03 GO:0045596 negative regulation of cell differentiation
1.48 2.45e-03 GO:0006325 chromatin organization
1.76 4.37e-03 GO:0016569 covalent chromatin modification
1.33 4.88e-03 GO:0031324 negative regulation of cellular metabolic process
1.33 5.72e-03 GO:0010605 negative regulation of macromolecule metabolic process
1.15 8.71e-03 GO:0007165 signal transduction
1.47 9.15e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.80 9.65e-03 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.37 1.11e-02 GO:0009790 embryo development
1.74 1.12e-02 GO:0016570 histone modification
1.48 1.18e-02 GO:0007409 axonogenesis
1.13 1.18e-02 GO:0051716 cellular response to stimulus
1.44 1.23e-02 GO:0000904 cell morphogenesis involved in differentiation
1.40 1.47e-02 GO:0048666 neuron development
1.46 1.58e-02 GO:0032583 regulation of gene-specific transcription
2.52 1.66e-02 GO:0048663 neuron fate commitment
1.34 1.96e-02 GO:2000026 regulation of multicellular organismal development
1.50 2.09e-02 GO:0007420 brain development
1.11 2.31e-02 GO:0032501 multicellular organismal process
1.52 2.44e-02 GO:0051093 negative regulation of developmental process
1.38 3.15e-02 GO:0009887 organ morphogenesis
1.51 3.91e-02 GO:0007411 axon guidance
1.44 3.96e-02 GO:0048812 neuron projection morphogenesis
1.20 4.04e-02 GO:0007166 cell surface receptor linked signaling pathway
1.41 4.90e-02 GO:0031175 neuron projection development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.15 9.23e-09 GO:0005634 nucleus
1.64 2.99e-03 GO:0034702 ion channel complex
1.20 5.35e-03 GO:0031981 nuclear lumen
1.05 7.24e-03 GO:0005622 intracellular
1.05 8.65e-03 GO:0044424 intracellular part
1.32 1.02e-02 GO:0044451 nucleoplasm part
1.75 1.38e-02 GO:0034703 cation channel complex
1.17 1.59e-02 GO:0044428 nuclear part
1.06 1.71e-02 GO:0043226 organelle
1.06 2.25e-02 GO:0043229 intracellular organelle
1.41 2.89e-02 GO:0045202 synapse
1.14 3.38e-02 GO:0043234 protein complex
3.04 4.49e-02 GO:0031519 PcG protein complex
2.14 4.70e-02 GO:0034708 methyltransferase complex
2.14 4.70e-02 GO:0035097 histone methyltransferase complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.69 4.55e-15 GO:0043565 sequence-specific DNA binding
1.54 5.57e-14 GO:0030528 transcription regulator activity
1.54 1.32e-13 GO:0001071 nucleic acid binding transcription factor activity
1.54 1.32e-13 GO:0003700 sequence-specific DNA binding transcription factor activity
1.15 2.84e-13 GO:0005515 protein binding
1.27 3.02e-08 GO:0003677 DNA binding
1.06 4.63e-06 GO:0005488 binding
1.84 2.30e-05 GO:0010843 promoter binding
1.65 2.65e-05 GO:0016563 transcription activator activity
1.81 2.96e-05 GO:0000975 regulatory region DNA binding
1.81 2.96e-05 GO:0001067 regulatory region nucleic acid binding
1.81 2.96e-05 GO:0044212 transcription regulatory region DNA binding
1.83 5.49e-05 GO:0003682 chromatin binding
1.61 2.66e-04 GO:0016564 transcription repressor activity
1.16 2.97e-04 GO:0003676 nucleic acid binding
1.90 3.24e-04 GO:0022843 voltage-gated cation channel activity
1.59 2.68e-03 GO:0005261 cation channel activity
1.48 3.09e-03 GO:0005216 ion channel activity
1.70 3.31e-03 GO:0005244 voltage-gated ion channel activity
1.70 3.31e-03 GO:0022832 voltage-gated channel activity
1.47 4.11e-03 GO:0022838 substrate-specific channel activity
1.83 6.94e-03 GO:0005267 potassium channel activity
1.75 1.21e-02 GO:0003714 transcription corepressor activity
1.50 1.36e-02 GO:0022836 gated channel activity
1.42 1.99e-02 GO:0015267 channel activity
1.48 2.17e-02 GO:0003779 actin binding
1.42 2.25e-02 GO:0022803 passive transmembrane transporter activity
1.92 2.55e-02 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
1.95 3.54e-02 GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
1.87 3.92e-02 GO:0005249 voltage-gated potassium channel activity
1.42 4.90e-02 GO:0003712 transcription cofactor activity