Motif ID: SOX17.p2

Z-value: 1.432


Transcription factors associated with SOX17.p2:

Gene SymbolEntrez IDGene Name
SOX17 64321 SRY (sex determining region Y)-box 17

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX17chr8_+_555330470.656.0e-03Click!


Activity profile for motif SOX17.p2.

activity profile for motif SOX17.p2


Sorted Z-values histogram for motif SOX17.p2

Sorted Z-values for motif SOX17.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX17.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_72187168 2.458 C6orf155
chromosome 6 open reading frame 155
chr13_-_98428244 1.563 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr8_-_120033240 1.555 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr7_-_27171673 1.513 NM_152739
HOXA9
homeobox A9
chr12_-_6535481 1.490 NM_001039670
NM_001193457
NM_080730
IFFO1


intermediate filament family orphan 1


chr7_-_27171648 1.487 HOXA9
homeobox A9
chr7_-_27171600 1.381 HOXA9
homeobox A9
chr12_-_6103945 1.236 NM_000552
VWF
von Willebrand factor
chrX_-_83644054 1.235 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr3_+_100840129 1.220 NM_001850
NM_020351
COL8A1

collagen, type VIII, alpha 1

chr1_-_68470585 1.148 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr7_+_27102197 1.136


chr14_+_85066265 1.135 FLRT2
fibronectin leucine rich transmembrane protein 2
chr21_-_27261276 1.135 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr4_+_156899575 1.092 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr14_+_85066207 1.088 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr19_-_45888259 1.052 NM_004756
NUMBL
numb homolog (Drosophila)-like
chr2_-_56266408 1.049 LOC100129434
hypothetical LOC100129434
chr7_-_27102049 0.996 NM_005522
NM_153620
HOXA1

homeobox A1

chr7_+_134114957 0.987 CALD1
caldesmon 1
chr8_+_55533047 0.986 NM_022454
SOX17
SRY (sex determining region Y)-box 17
chr8_-_93184629 0.977 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr15_-_53822468 0.962 NM_173814
PRTG
protogenin
chr17_-_7996409 0.957 NM_002616
PER1
period homolog 1 (Drosophila)
chr7_+_148613304 0.954 LOC155060
AI894139 pseudogene
chr11_+_113672378 0.926 NNMT
nicotinamide N-methyltransferase
chr7_+_27102508 0.925


chrX_+_77889861 0.885 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr3_-_87122958 0.880 VGLL3
vestigial like 3 (Drosophila)
chr6_-_75972473 0.878 COL12A1
collagen, type XII, alpha 1
chr3_-_87122936 0.877 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr11_+_113672407 0.872 NNMT
nicotinamide N-methyltransferase
chr14_-_99842519 0.866 NM_001039355
SLC25A29
solute carrier family 25, member 29
chrX_-_50403412 0.864 SHROOM4
shroom family member 4
chr5_-_146813343 0.861 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr14_-_37795001 0.853 CLEC14A
C-type lectin domain family 14, member A
chr21_-_31853160 0.851 NM_003253
TIAM1
T-cell lymphoma invasion and metastasis 1
chr4_+_151218862 0.849 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr3_+_158637273 0.848 NM_002852
PTX3
pentraxin 3, long
chr1_+_64012154 0.843 NM_001083592
NM_005012
ROR1

receptor tyrosine kinase-like orphan receptor 1

chr2_-_37752272 0.843 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr4_-_2233606 0.830 MXD4
MAX dimerization protein 4
chr8_+_1759502 0.828 NM_014629
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10
chr3_+_48482625 0.821 TREX1
three prime repair exonuclease 1
chr12_-_57600336 0.808 NM_153377
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr7_+_134114912 0.806 CALD1
caldesmon 1
chr12_+_84198015 0.798 NM_006982
ALX1
ALX homeobox 1
chr4_-_122213018 0.796 NM_024574
C4orf31
chromosome 4 open reading frame 31
chr17_-_8474733 0.791 NM_005964
MYH10
myosin, heavy chain 10, non-muscle
chr5_-_83716346 0.789 NM_005711
EDIL3
EGF-like repeats and discoidin I-like domains 3
chr2_+_149895274 0.786 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr5_-_16989290 0.782 MYO10
myosin X
chr8_-_60194099 0.780 NM_014729
TOX
thymocyte selection-associated high mobility group box
chr12_-_57600564 0.778 LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr5_+_175725050 0.778 NM_173664
ARL10
ADP-ribosylation factor-like 10
chr18_-_22382497 0.778 NM_001142730
KCTD1
potassium channel tetramerisation domain containing 1
chr14_-_37795290 0.769 NM_175060
CLEC14A
C-type lectin domain family 14, member A
chr13_+_110653407 0.766 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr5_+_178300799 0.763 NM_001178089
NM_001178090
NM_182594
ZNF454


zinc finger protein 454


chr1_-_194844299 0.760 KCNT2
potassium channel, subfamily T, member 2
chr10_+_22765996 0.759 LOC100289455
hypothetical LOC100289455
chr1_+_238321794 0.753 NM_020066
FMN2
formin 2
chr11_+_65357972 0.748 NM_152760
SNX32
sorting nexin 32
chr9_+_108665168 0.743 NM_021224
ZNF462
zinc finger protein 462
chr5_-_16989371 0.740 NM_012334
MYO10
myosin X
chr20_+_42644633 0.736 PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr1_-_197173159 0.730 LOC100131234
familial acute myelogenous leukemia related factor
chr5_-_136862317 0.722 SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr7_-_5535726 0.722 ACTB
actin, beta
chr8_-_70908130 0.720 NM_001146008
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr3_+_174598937 0.713 NM_014932
NLGN1
neuroligin 1
chr5_+_14493905 0.704 TRIO
triple functional domain (PTPRF interacting)
chr5_-_83715947 0.696 EDIL3
EGF-like repeats and discoidin I-like domains 3
chr1_+_199975674 0.694 NAV1
neuron navigator 1
chr14_+_23711044 0.693 NM_001048205
NM_005132
REC8

REC8 homolog (yeast)

chr5_-_136862130 0.691 SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr9_+_123501186 0.686 DAB2IP
DAB2 interacting protein
chr6_-_128883125 0.673 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr6_+_17390910 0.672 NM_153020
RBM24
RNA binding motif protein 24
chr19_-_63092099 0.667 NM_001144989
ZNF814
zinc finger protein 814
chr7_+_882766 0.659 GET4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr7_+_882704 0.657 NM_015949
GET4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr13_-_40138607 0.651 NM_002015
FOXO1
forkhead box O1
chr18_-_29412148 0.643


chr14_+_62740878 0.638 NM_020663
RHOJ
ras homolog gene family, member J
chr3_-_147361912 0.635 NM_000935
NM_182943
PLOD2

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

chr2_-_175578156 0.633 NM_001025201
NM_001822
CHN1

chimerin (chimaerin) 1

chr14_-_22458134 0.633 RBM23
RNA binding motif protein 23
chr9_+_91409746 0.628 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr2_+_149894744 0.618 NM_001195685
LYPD6
LY6/PLAUR domain containing 6
chrX_-_1470862 0.617 NM_001636
SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr19_+_17281352 0.616 DDA1
DET1 and DDB1 associated 1
chr9_+_81377419 0.615 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr12_-_87498225 0.613 NM_000899
NM_003994
KITLG

KIT ligand

chr14_-_22458220 0.610 NM_001077351
NM_001077352
NM_018107
RBM23


RNA binding motif protein 23


chr10_+_17312654 0.603 VIM
vimentin
chr2_+_12775814 0.602


chr1_-_85703198 0.599 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr6_+_116939500 0.594 NM_153711
FAM26E
family with sequence similarity 26, member E
chr7_+_134114701 0.594 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr11_-_66976775 0.593 NM_206997
GPR152
G protein-coupled receptor 152
chr5_+_177564139 0.592 HNRNPAB
heterogeneous nuclear ribonucleoprotein A/B
chr15_+_37660568 0.591 NM_003246
THBS1
thrombospondin 1
chr9_+_27099138 0.590 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr1_-_194844061 0.588 NM_198503
KCNT2
potassium channel, subfamily T, member 2
chr2_-_128138435 0.587 NM_017980
LIMS2
LIM and senescent cell antigen-like domains 2
chrX_-_106846253 0.576 NM_001015881
TSC22D3
TSC22 domain family, member 3
chr14_-_22458199 0.574 RBM23
RNA binding motif protein 23
chr19_+_54723044 0.572 RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr4_-_138673014 0.570 PCDH18
protocadherin 18
chr11_+_17697685 0.568 NM_002478
MYOD1
myogenic differentiation 1
chrX_+_15428820 0.567 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr10_+_124211353 0.566 HTRA1
HtrA serine peptidase 1
chr4_-_2233504 0.566 NM_006454
MXD4
MAX dimerization protein 4
chr15_-_42274760 0.563 FRMD5
FERM domain containing 5
chr8_-_101187346 0.562 RGS22
regulator of G-protein signaling 22
chr13_-_32658215 0.561 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr3_+_148593911 0.561


chr2_-_45090025 0.560 NM_016932
SIX2
SIX homeobox 2
chr19_+_47593137 0.560


chr4_+_119174947 0.559 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr3_+_106568334 0.557 NM_001627
ALCAM
activated leukocyte cell adhesion molecule
chr3_-_107070400 0.555 NM_170662
CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr12_-_24606616 0.551 NM_152989
SOX5
SRY (sex determining region Y)-box 5
chr5_+_40715799 0.550 PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr19_+_63482118 0.550 NM_021089
ZNF8
zinc finger protein 8
chr19_+_17281216 0.548 NM_024050
DDA1
DET1 and DDB1 associated 1
chr10_+_124210980 0.547 NM_002775
HTRA1
HtrA serine peptidase 1
chr3_+_48482213 0.541 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr14_+_76298693 0.540 VASH1
vasohibin 1
chr15_-_32875040 0.539 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr5_+_177564102 0.536 NM_004499
NM_031266
HNRNPAB

heterogeneous nuclear ribonucleoprotein A/B

chr21_+_33320080 0.535 NM_005806
OLIG2
oligodendrocyte lineage transcription factor 2
chr3_-_11736946 0.534 NM_014667
VGLL4
vestigial like 4 (Drosophila)
chr3_+_106568243 0.528 ALCAM
activated leukocyte cell adhesion molecule
chr9_+_81377289 0.528 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr5_+_40715778 0.525 NM_000958
PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr19_+_17281374 0.525 DDA1
DET1 and DDB1 associated 1
chr5_-_111782637 0.524 NM_022140
EPB41L4A
erythrocyte membrane protein band 4.1 like 4A
chr11_+_13646727 0.523 NM_032228
FAR1
fatty acyl CoA reductase 1
chr11_+_128068982 0.521 NM_002017
FLI1
Friend leukemia virus integration 1
chr14_+_23710924 0.520 REC8
REC8 homolog (yeast)
chr16_+_580092 0.519 RAB40C
RAB40C, member RAS oncogene family
chr5_-_124108672 0.518 NM_020747
ZNF608
zinc finger protein 608
chr15_-_43457916 0.518 GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr10_-_116434102 0.517 ABLIM1
actin binding LIM protein 1
chr8_-_6407882 0.511 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr3_+_106568430 0.510 ALCAM
activated leukocyte cell adhesion molecule
chr4_+_156900053 0.510 GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr7_+_68702516 0.507 AUTS2
autism susceptibility candidate 2
chr19_-_58449919 0.506 NM_182609
ZNF677
zinc finger protein 677
chr7_-_117300702 0.506 CTTNBP2
cortactin binding protein 2
chr8_+_60194328 0.500


chr1_+_175406685 0.498 FAM5B
family with sequence similarity 5, member B
chr10_+_3099708 0.498 NM_002627
PFKP
phosphofructokinase, platelet
chr6_-_134680888 0.497 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr17_-_1478293 0.495 SLC43A2
solute carrier family 43, member 2
chr1_-_152431175 0.493 NM_152263
TPM3
tropomyosin 3
chr1_+_43539239 0.492 NM_005424
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr6_-_56824371 0.489 DST
dystonin
chr16_+_580057 0.488 NM_001172665
NM_001172666
RAB40C

RAB40C, member RAS oncogene family

chr5_+_53787187 0.485 NM_006308
HSPB3
heat shock 27kDa protein 3
chr7_-_5535432 0.485 ACTB
actin, beta
chr8_+_69027143 0.484 NM_024870
NM_025170
PREX2

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

chr15_-_70277163 0.482 NM_001012642
GRAMD2
GRAM domain containing 2
chr5_+_177564140 0.480 HNRNPAB
heterogeneous nuclear ribonucleoprotein A/B
chr1_+_153560841 0.480 NM_014328
RUSC1
RUN and SH3 domain containing 1
chr5_+_139761579 0.480 NM_020690
NM_001197030
NM_017747
NM_017978
NM_024668
ANKHD1-EIF4EBP3
ANKHD1



ANKHD1-EIF4EBP3 readthrough
ankyrin repeat and KH domain containing 1



chr10_-_125843092 0.480 CHST15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr1_+_45565126 0.479 NM_032756
HPDL
4-hydroxyphenylpyruvate dioxygenase-like
chr12_+_77782648 0.478 SYT1
synaptotagmin I
chr10_-_116434364 0.478 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr6_-_85529884 0.476 TBX18
T-box 18
chr17_-_59817456 0.472 PECAM1
platelet/endothelial cell adhesion molecule
chr13_+_94052022 0.470 NM_180989
GPR180
G protein-coupled receptor 180
chr7_-_13995811 0.469 ETV1
ets variant 1
chr12_-_24946495 0.467 NM_001178094
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr10_+_123912930 0.467 TACC2
transforming, acidic coiled-coil containing protein 2
chr3_+_44665220 0.464 NM_003420
ZNF35
zinc finger protein 35
chr8_-_70907957 0.463 NM_001146009
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr8_-_38444398 0.463 NM_001174065
NM_001174066
NM_001174067
FGFR1


fibroblast growth factor receptor 1


chr4_-_138673078 0.462 NM_019035
PCDH18
protocadherin 18
chr10_+_104667991 0.461 NM_017649
NM_199076
NM_199077
CNNM2


cyclin M2


chr11_+_13646806 0.459 FAR1
fatty acyl CoA reductase 1
chr1_+_98899734 0.457 NM_015976
NM_152238
SNX7

sorting nexin 7

chrX_+_136475979 0.457 NM_003413
ZIC3
Zic family member 3 (odd-paired homolog, Drosophila)
chr6_+_142665057 0.457 GPR126
G protein-coupled receptor 126
chr13_-_29067795 0.456 NM_003045
SLC7A1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr2_-_71307705 0.456 NM_020459
PAIP2B
poly(A) binding protein interacting protein 2B
chr11_-_4585947 0.454 NM_018073
TRIM68
tripartite motif containing 68
chr6_+_17390273 0.453 NM_001143941
RBM24
RNA binding motif protein 24
chr7_-_27186400 0.453 NM_153715
HOXA10
homeobox A10
chr2_-_144991386 0.450 ZEB2
zinc finger E-box binding homeobox 2
chr11_-_74914514 0.450 GDPD5
glycerophosphodiester phosphodiesterase domain containing 5
chr3_-_189354510 0.450 LOC339929
hypothetical LOC339929
chr7_-_130891861 0.448 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr14_+_102870301 0.446 EIF5
eukaryotic translation initiation factor 5
chr17_-_59817575 0.446 PECAM1
platelet/endothelial cell adhesion molecule
chr11_-_27679617 0.445 NM_170733
BDNF
brain-derived neurotrophic factor
chr5_+_140835727 0.444 NM_002588
NM_032402
NM_032403
PCDHGC3


protocadherin gamma subfamily C, 3



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.22 5.54e-07 GO:0032501 multicellular organismal process
1.27 1.07e-05 GO:0007275 multicellular organismal development
1.24 4.68e-05 GO:0032502 developmental process
1.28 7.36e-05 GO:0048731 system development
1.83 7.82e-05 GO:0007608 sensory perception of smell
1.26 1.98e-04 GO:0048856 anatomical structure development
1.71 8.03e-04 GO:0007606 sensory perception of chemical stimulus
1.31 1.72e-03 GO:0030154 cell differentiation
1.30 2.36e-03 GO:0048869 cellular developmental process
1.37 2.44e-03 GO:0007399 nervous system development
1.50 7.95e-03 GO:2000026 regulation of multicellular organismal development
1.13 1.06e-02 GO:0050794 regulation of cellular process
1.31 1.10e-02 GO:0003008 system process
1.87 2.14e-02 GO:0046578 regulation of Ras protein signal transduction
1.69 3.13e-02 GO:0051056 regulation of small GTPase mediated signal transduction
1.42 4.08e-02 GO:0050793 regulation of developmental process
1.43 4.44e-02 GO:0007600 sensory perception

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.72 9.66e-03 GO:0015629 actin cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.96 7.05e-06 GO:0003779 actin binding
1.87 9.85e-06 GO:0004984 olfactory receptor activity
1.51 2.87e-03 GO:0043565 sequence-specific DNA binding
1.56 4.69e-03 GO:0008092 cytoskeletal protein binding
1.38 1.37e-02 GO:0001071 nucleic acid binding transcription factor activity
1.38 1.37e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.36 3.73e-02 GO:0030528 transcription regulator activity