Motif ID: SPI1.p2

Z-value: 3.892


Transcription factors associated with SPI1.p2:

Gene SymbolEntrez IDGene Name
SPI1 6688 spleen focus forming virus (SFFV) proviral integration oncogene spi1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SPI1chr11_-_473564790.638.3e-03Click!


Activity profile for motif SPI1.p2.

activity profile for motif SPI1.p2


Sorted Z-values histogram for motif SPI1.p2

Sorted Z-values for motif SPI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_35586950 6.432 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr16_-_87570716 5.984 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr11_+_63864263 5.651 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr1_+_159899528 5.428 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr16_-_29664765 5.153 NM_175900
C16orf54
chromosome 16 open reading frame 54
chr10_+_49562866 4.971 WDFY4
WDFY family member 4
chr11_+_65164767 4.624 SIPA1
signal-induced proliferation-associated 1
chr3_-_113334657 4.439 NM_001190259
NM_001190260
NM_152785
GCET2


germinal center expressed transcript 2


chr11_+_107304344 4.437 NM_017516
RAB39
RAB39, member RAS oncogene family
chr1_-_26517342 4.171 NM_145345
UBXN11
UBX domain protein 11
chr10_+_26767698 4.010 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr6_-_32268267 3.975 GPSM3
G-protein signaling modulator 3
chr12_-_51887266 3.966 NM_000889
ITGB7
integrin, beta 7
chr12_-_53071285 3.849 NM_001130967
NM_001130968
ZNF385A

zinc finger protein 385A

chr11_+_66927976 3.782 NM_198517
TBC1D10C
TBC1 domain family, member 10C
chr17_+_44643067 3.776 ABI3
ABI family, member 3
chr1_+_159817752 3.734 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr1_+_26517032 3.695 CD52
CD52 molecule
chr16_+_56134077 3.693 NM_153837
GPR114
G protein-coupled receptor 114
chr17_-_40843530 3.688 ARHGAP27
Rho GTPase activating protein 27
chr19_-_10311262 3.629 NM_002162
ICAM3
intercellular adhesion molecule 3
chr6_+_31648071 3.591 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr1_+_26517045 3.555 CD52
CD52 molecule
chr1_-_31003260 3.450 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chr6_-_33016561 3.445 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr1_+_111544469 3.419


chr11_+_66927955 3.415 TBC1D10C
TBC1 domain family, member 10C
chr16_+_56134037 3.400 GPR114
G protein-coupled receptor 114
chr12_+_25096755 3.365 LRMP
lymphoid-restricted membrane protein
chr17_+_44642587 3.302 NM_001135186
NM_016428
ABI3

ABI family, member 3

chr12_-_55929189 3.217


chr1_-_111544603 3.154


chrX_-_47374187 3.131 NM_001145252
CFP
complement factor properdin
chr12_+_25096472 3.130 NM_006152
LRMP
lymphoid-restricted membrane protein
chr1_-_111544784 3.087 NM_024901
DENND2D
DENN/MADD domain containing 2D
chr22_+_42908612 3.087 PARVG
parvin, gamma
chr5_-_88215034 3.070 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr3_-_159306532 3.051 NM_001163678
NM_003030
NM_006884
SHOX2


short stature homeobox 2


chr14_-_22354457 3.018 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr14_-_22354389 3.008 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr14_+_20319049 2.992 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr12_-_50004102 2.964 BIN2
bridging integrator 2
chr5_-_88214720 2.936 MEF2C
myocyte enhancer factor 2C
chr6_-_32268615 2.924 GPSM3
G-protein signaling modulator 3
chr12_-_50004172 2.881 NM_016293
BIN2
bridging integrator 2
chr1_+_111217314 2.850 CD53
CD53 molecule
chr12_-_50004208 2.847 BIN2
bridging integrator 2
chr2_+_143603439 2.834 ARHGAP15
Rho GTPase activating protein 15
chr1_+_111217244 2.834 NM_000560
CD53
CD53 molecule
chr1_-_111544820 2.801 DENND2D
DENN/MADD domain containing 2D
chr12_-_51887318 2.801 ITGB7
integrin, beta 7
chr9_+_263025 2.793 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr12_-_53664722 2.790 NM_001136030
KIAA0748
KIAA0748
chr6_+_31647854 2.783 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr2_+_143603368 2.782 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chrX_+_48427137 2.777 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr17_-_31441390 2.753 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chrX_+_48427103 2.738 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr10_+_26767657 2.709 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr3_+_195889845 2.683 FAM43A
family with sequence similarity 43, member A
chr2_-_231498184 2.650 NM_005683
GPR55
G protein-coupled receptor 55
chr6_+_31651319 2.629 NM_000594
TNF
tumor necrosis factor
chr12_-_56422120 2.629 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr19_-_43800374 2.624 NM_001042600
NM_007181
MAP4K1

mitogen-activated protein kinase kinase kinase kinase 1

chr19_-_7672978 2.622 NM_002002
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr5_+_118719591 2.608 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chrX_+_72699834 2.597 CHIC1
cysteine-rich hydrophobic domain 1
chr21_+_25856311 2.573 MIR155HG
MIR155 host gene (non-protein coding)
chr22_-_35970230 2.553 NM_002872
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr2_+_227737524 2.545 NM_000091
COL4A3
collagen, type IV, alpha 3 (Goodpasture antigen)
chr17_-_59363352 2.529 NM_000626
NM_001039933
NM_021602
CD79B


CD79b molecule, immunoglobulin-associated beta


chr1_+_185064654 2.520 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr1_-_159306037 2.506 ARHGAP30
Rho GTPase activating protein 30
chr10_-_98021144 2.466 NM_001114094
NM_013314
BLNK

B-cell linker

chr17_-_44058612 2.446 NM_024017
HOXB9
homeobox B9
chr2_+_108604111 2.432 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr22_-_35970133 2.426 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr19_-_6432765 2.392 NM_024898
DENND1C
DENN/MADD domain containing 1C
chr19_-_55091942 2.367 NM_152899
IL4I1
interleukin 4 induced 1
chr17_-_8809656 2.363 NM_001142633
PIK3R5
phosphoinositide-3-kinase, regulatory subunit 5
chr1_-_181826292 2.352 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr19_-_15436333 2.351 NM_022904
RASAL3
RAS protein activator like 3
chr1_-_181826086 2.345 NCF2
neutrophil cytosolic factor 2
chr17_+_1906262 2.284 NM_001098202
HIC1
hypermethylated in cancer 1
chr18_-_50004770 2.267 MBD2
methyl-CpG binding domain protein 2
chr2_+_68445936 2.265 PLEK
pleckstrin
chr19_+_14412080 2.239 NM_213560
PKN1
protein kinase N1
chr19_+_14412087 2.235 PKN1
protein kinase N1
chr16_+_28413421 2.225 NM_018690
APOBR
apolipoprotein B receptor
chr1_+_149309703 2.224 NM_144618
GABPB2
GA binding protein transcription factor, beta subunit 2
chr2_+_68445821 2.219 NM_002664
PLEK
pleckstrin
chr16_+_29582069 2.219 NM_003123
SPN
sialophorin
chr5_-_33927724 2.218 NM_030955
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr1_-_31003181 2.215 LAPTM5
lysosomal protein transmembrane 5
chr16_+_29582065 2.206 SPN
sialophorin
chr19_+_14412052 2.198 PKN1
protein kinase N1
chr17_-_44642934 2.193 NM_001198754
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr19_+_41085221 2.186 NM_001007469
NM_014266
HCST

hematopoietic cell signal transducer

chr22_-_28992787 2.147 NM_020530
OSM
oncostatin M
chr11_-_66961709 2.139 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr19_+_40895669 2.136 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr9_-_129580732 2.108 NM_170600
SH2D3C
SH2 domain containing 3C
chr5_-_33928049 2.072 ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr1_-_158883666 2.066 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr7_-_3049872 2.049 NM_032415
CARD11
caspase recruitment domain family, member 11
chr17_-_24491521 2.045 MYO18A
myosin XVIIIA
chr16_+_30583278 2.016 NM_001105079
FBRS
fibrosin
chr22_+_35639564 2.016 NM_000395
CSF2RB
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr6_-_30760413 2.005 KIAA1949
KIAA1949
chr8_-_11096257 1.950 NM_173683
XKR6
XK, Kell blood group complex subunit-related family, member 6
chr7_+_106292975 1.945 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr12_+_52132353 1.922 PCBP2
poly(rC) binding protein 2
chr2_-_96174502 1.909 DUSP2
dual specificity phosphatase 2
chr7_+_106292932 1.904 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr1_-_205161821 1.891 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr11_+_65164167 1.888 NM_153253
SIPA1
signal-induced proliferation-associated 1
chr2_-_175207521 1.882 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr7_-_44985175 1.861 MYO1G
myosin IG
chr19_-_47328399 1.851 NM_002698
POU2F2
POU class 2 homeobox 2
chr1_+_207995999 1.841 NM_025228
TRAF3IP3
TRAF3 interacting protein 3
chr7_+_73826244 1.836 NM_000265
NCF1
NCF1B
NCF1C
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
neutrophil cytosolic factor 1C pseudogene
chr5_-_169657192 1.833 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr7_-_44985202 1.828 NM_033054
MYO1G
myosin IG
chr7_-_44985084 1.828 MYO1G
myosin IG
chr7_+_101715137 1.813 SH2B2
SH2B adaptor protein 2
chr16_+_29582480 1.804 SPN
sialophorin
chr6_+_37511383 1.801


chr12_+_6930815 1.800 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chrX_-_153632355 1.795 NM_001081573
NM_080612
GAB3

GRB2-associated binding protein 3

chr22_-_36212160 1.786 NM_001166343
NM_002405
MFNG

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr17_-_73640082 1.784 NM_007267
TMC6
transmembrane channel-like 6
chr10_+_26767288 1.784 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr19_-_13074973 1.775 NM_005583
LYL1
lymphoblastic leukemia derived sequence 1
chr16_+_27320983 1.767 NM_181078
NM_181079
IL21R

interleukin 21 receptor

chr1_-_25128951 1.763 RUNX3
runt-related transcription factor 3
chr7_+_101715110 1.753 NM_020979
SH2B2
SH2B adaptor protein 2
chrX_-_47374647 1.749 NM_002621
CFP
complement factor properdin
chr17_-_35975227 1.736 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr4_-_84475023 1.731 HPSE
heparanase
chr2_-_152663454 1.729 NM_001005746
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr5_-_169657312 1.724 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr11_+_46323575 1.719 DGKZ
diacylglycerol kinase, zeta
chr6_+_37081387 1.717 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr22_-_16080265 1.716 CECR1
cat eye syndrome chromosome region, candidate 1
chr3_-_152585226 1.713 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr17_-_40655347 1.711 LOC339192
hypothetical LOC339192
chr16_-_87297525 1.706 NM_001171816
RNF166
ring finger protein 166
chr7_+_128367961 1.705 NM_001098627
IRF5
interferon regulatory factor 5
chr5_+_140871107 1.699


chr5_-_142795269 1.695 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr10_+_26767268 1.694 NM_019043
APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr6_+_73388713 1.690 KCNQ5
potassium voltage-gated channel, KQT-like subfamily, member 5
chr5_-_169657360 1.682 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr5_-_169657395 1.680 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr19_-_55008172 1.670 NM_001171937
NM_025129
FUZ

fuzzy homolog (Drosophila)

chr1_-_159306327 1.668 ARHGAP30
Rho GTPase activating protein 30
chr11_+_46323495 1.667 DGKZ
diacylglycerol kinase, zeta
chr22_+_42908589 1.665 NM_001137606
PARVG
parvin, gamma
chr1_+_26516967 1.662 NM_001803
CD52
CD52 molecule
chr14_-_22354851 1.660 NM_001126105
NM_003982
SLC7A7

solute carrier family 7 (cationic amino acid transporter, y+ system), member 7

chrX_-_74062005 1.659 NM_001008537
KIAA2022
KIAA2022
chr12_+_52132176 1.659 PCBP2
poly(rC) binding protein 2
chr10_+_129735796 1.656 NM_130435
PTPRE
protein tyrosine phosphatase, receptor type, E
chr4_-_105631915 1.652 NM_025212
CXXC4
CXXC finger protein 4
chr10_-_71002998 1.648 NM_020999
NEUROG3
neurogenin 3
chr22_+_42908548 1.644 PARVG
parvin, gamma
chr21_-_45165204 1.641 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr12_+_55018925 1.630 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr17_+_31455332 1.617 NM_002984
CCL4
chemokine (C-C motif) ligand 4
chr1_-_27825178 1.610 NM_001042747
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr16_-_30301634 1.599 NM_052838
SEPT1
septin 1
chr7_+_18296569 1.594 HDAC9
histone deacetylase 9
chr22_+_23153529 1.589 NM_000675
ADORA2A
adenosine A2a receptor
chr11_-_76800525 1.588 PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr4_-_10295412 1.586 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chrX_-_70248022 1.570 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr9_-_35640852 1.570 NM_014450
SIT1
signaling threshold regulating transmembrane adaptor 1
chr19_-_55104875 1.568 NUP62
nucleoporin 62kDa
chr19_-_13074669 1.562 LYL1
lymphoblastic leukemia derived sequence 1
chr16_+_48865521 1.557 ADCY7
adenylate cyclase 7
chr2_-_96174865 1.554 NM_004418
DUSP2
dual specificity phosphatase 2
chr5_+_176493752 1.550 NSD1
nuclear receptor binding SET domain protein 1
chr22_+_23333610 1.547 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr19_-_40925151 1.546 NM_024660
TMEM149
transmembrane protein 149
chr21_-_45165249 1.546 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chrX_-_78509367 1.539 ITM2A
integral membrane protein 2A
chr5_+_88220846 1.538


chr3_+_190831909 1.535 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr12_-_8656705 1.532 NM_020661
AICDA
activation-induced cytidine deaminase
chr21_-_45165302 1.530 NM_000211
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr12_+_53177789 1.516 NCKAP1L
NCK-associated protein 1-like
chrX_-_119578747 1.516 NM_001079872
CUL4B
cullin 4B
chr7_+_114350144 1.509 MDFIC
MyoD family inhibitor domain containing
chr11_-_60475558 1.508 NM_016582
SLC15A3
solute carrier family 15, member 3
chr22_-_30071761 1.506 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr5_+_176717553 1.505


chrX_-_63531968 1.504 MTMR8
myotubularin related protein 8
chr17_+_40655060 1.502 NM_005892
FMNL1
formin-like 1
chr1_-_158815895 1.501 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr1_+_26744929 1.501 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.23 1.35e-22 GO:0044260 cellular macromolecule metabolic process
1.20 1.05e-19 GO:0043170 macromolecule metabolic process
1.09 6.67e-18 GO:0009987 cellular process
1.13 3.34e-17 GO:0065007 biological regulation
1.13 8.47e-15 GO:0050789 regulation of biological process
1.13 3.31e-14 GO:0050794 regulation of cellular process
1.18 1.90e-12 GO:0051716 cellular response to stimulus
1.13 5.13e-12 GO:0044238 primary metabolic process
1.24 1.84e-11 GO:0044267 cellular protein metabolic process
1.13 2.15e-11 GO:0044237 cellular metabolic process
1.56 7.30e-11 GO:0001775 cell activation
1.25 4.09e-10 GO:0090304 nucleic acid metabolic process
1.21 1.13e-09 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.21 1.58e-09 GO:0048518 positive regulation of biological process
1.26 1.93e-09 GO:0006464 protein modification process
1.26 3.24e-09 GO:0048583 regulation of response to stimulus
1.32 5.29e-09 GO:0002376 immune system process
1.21 3.14e-08 GO:0006950 response to stress
1.21 3.39e-08 GO:0048522 positive regulation of cellular process
1.16 4.14e-08 GO:0023052 signaling
1.17 6.71e-08 GO:0007165 signal transduction
1.24 7.12e-08 GO:0043412 macromolecule modification
1.18 8.03e-08 GO:0019538 protein metabolic process
1.10 1.80e-07 GO:0008152 metabolic process
1.21 3.03e-07 GO:0048519 negative regulation of biological process
1.67 5.27e-07 GO:0045321 leukocyte activation
1.36 5.48e-07 GO:0033554 cellular response to stress
1.21 7.79e-07 GO:0048523 negative regulation of cellular process
1.25 1.11e-06 GO:0023051 regulation of signaling
1.23 2.63e-06 GO:0016070 RNA metabolic process
1.29 3.24e-06 GO:0051649 establishment of localization in cell
1.26 3.27e-06 GO:0009966 regulation of signal transduction
1.40 3.90e-06 GO:0051726 regulation of cell cycle
1.27 4.61e-06 GO:0051641 cellular localization
1.44 6.59e-06 GO:0007599 hemostasis
1.43 7.08e-06 GO:0006974 response to DNA damage stimulus
1.45 1.89e-05 GO:0002684 positive regulation of immune system process
1.43 2.06e-05 GO:0007596 blood coagulation
1.43 2.06e-05 GO:0050817 coagulation
1.14 3.45e-05 GO:0071840 cellular component organization or biogenesis
1.35 4.66e-05 GO:0002682 regulation of immune system process
1.15 4.98e-05 GO:0016043 cellular component organization
1.15 5.23e-05 GO:0034641 cellular nitrogen compound metabolic process
1.67 5.30e-05 GO:0046649 lymphocyte activation
1.22 5.93e-05 GO:0006996 organelle organization
1.13 6.33e-05 GO:0019222 regulation of metabolic process
1.14 9.12e-05 GO:0031323 regulation of cellular metabolic process
1.32 9.19e-05 GO:0048584 positive regulation of response to stimulus
1.50 9.63e-05 GO:0070647 protein modification by small protein conjugation or removal
1.32 1.16e-04 GO:0046907 intracellular transport
1.14 1.18e-04 GO:0006807 nitrogen compound metabolic process
1.20 1.38e-04 GO:0010467 gene expression
1.28 1.49e-04 GO:0032268 regulation of cellular protein metabolic process
1.37 1.64e-04 GO:0050878 regulation of body fluid levels
1.90 2.03e-04 GO:0030098 lymphocyte differentiation
1.32 2.20e-04 GO:0006955 immune response
1.27 3.25e-04 GO:0006793 phosphorus metabolic process
1.27 3.25e-04 GO:0006796 phosphate metabolic process
1.27 3.30e-04 GO:0007049 cell cycle
1.23 3.73e-04 GO:0035556 intracellular signal transduction
1.26 3.83e-04 GO:0051246 regulation of protein metabolic process
1.16 3.91e-04 GO:0071842 cellular component organization at cellular level
1.47 4.01e-04 GO:0006281 DNA repair
1.09 5.62e-04 GO:0050896 response to stimulus
1.15 5.93e-04 GO:0071841 cellular component organization or biogenesis at cellular level
1.26 6.27e-04 GO:0043067 regulation of programmed cell death
1.13 6.34e-04 GO:0060255 regulation of macromolecule metabolic process
1.24 8.90e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.25 9.13e-04 GO:0010941 regulation of cell death
1.50 1.03e-03 GO:0032446 protein modification by small protein conjugation
1.26 1.03e-03 GO:0042981 regulation of apoptosis
1.63 1.05e-03 GO:0002757 immune response-activating signal transduction
1.25 1.32e-03 GO:0010646 regulation of cell communication
1.40 1.41e-03 GO:0007243 intracellular protein kinase cascade
1.40 1.41e-03 GO:0023014 signal transduction via phosphorylation event
1.22 1.81e-03 GO:0009893 positive regulation of metabolic process
1.33 1.89e-03 GO:0006259 DNA metabolic process
1.53 2.25e-03 GO:0030168 platelet activation
1.33 2.57e-03 GO:0042060 wound healing
1.12 2.62e-03 GO:0051179 localization
1.23 2.74e-03 GO:0031325 positive regulation of cellular metabolic process
1.38 2.77e-03 GO:0050776 regulation of immune response
1.54 2.95e-03 GO:0045786 negative regulation of cell cycle
1.28 3.09e-03 GO:0031399 regulation of protein modification process
1.12 3.52e-03 GO:0080090 regulation of primary metabolic process
1.53 3.52e-03 GO:0071156 regulation of cell cycle arrest
1.59 3.58e-03 GO:0002764 immune response-regulating signaling pathway
1.54 3.86e-03 GO:0051249 regulation of lymphocyte activation
1.61 5.23e-03 GO:0006417 regulation of translation
1.59 6.65e-03 GO:0051251 positive regulation of lymphocyte activation
1.50 6.75e-03 GO:0002694 regulation of leukocyte activation
1.16 6.87e-03 GO:0065008 regulation of biological quality
1.53 7.19e-03 GO:0000075 cell cycle checkpoint
1.33 7.95e-03 GO:0016071 mRNA metabolic process
1.48 8.30e-03 GO:0050865 regulation of cell activation
1.28 8.33e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.28 9.38e-03 GO:0006468 protein phosphorylation
1.33 9.91e-03 GO:0080134 regulation of response to stress
1.24 1.02e-02 GO:0009605 response to external stimulus
1.45 1.06e-02 GO:0050778 positive regulation of immune response
1.46 1.07e-02 GO:0010608 posttranscriptional regulation of gene expression
2.23 1.13e-02 GO:0021987 cerebral cortex development
1.55 1.13e-02 GO:0050867 positive regulation of cell activation
1.25 1.51e-02 GO:0040011 locomotion
1.48 1.66e-02 GO:0030097 hemopoiesis
1.26 1.69e-02 GO:0022402 cell cycle process
1.24 1.69e-02 GO:0009611 response to wounding
1.28 1.71e-02 GO:0019220 regulation of phosphate metabolic process
1.28 1.71e-02 GO:0051174 regulation of phosphorus metabolic process
1.46 1.78e-02 GO:0016567 protein ubiquitination
1.94 1.83e-02 GO:0030217 T cell differentiation
1.31 1.84e-02 GO:0006928 cellular component movement
1.54 2.13e-02 GO:0002696 positive regulation of leukocyte activation
1.25 2.17e-02 GO:0009891 positive regulation of biosynthetic process
2.18 2.30e-02 GO:0045727 positive regulation of translation
1.65 2.36e-02 GO:0002521 leukocyte differentiation
1.67 2.53e-02 GO:0042110 T cell activation
2.68 2.58e-02 GO:0046631 alpha-beta T cell activation
1.32 2.59e-02 GO:0044265 cellular macromolecule catabolic process
1.39 2.62e-02 GO:0010564 regulation of cell cycle process
1.25 2.76e-02 GO:0031328 positive regulation of cellular biosynthetic process
1.66 2.96e-02 GO:0007050 cell cycle arrest
1.42 3.06e-02 GO:0002520 immune system development
1.28 3.07e-02 GO:0006396 RNA processing
1.25 3.12e-02 GO:0016310 phosphorylation
1.40 3.55e-02 GO:0031347 regulation of defense response
1.27 3.68e-02 GO:0042325 regulation of phosphorylation
1.18 3.82e-02 GO:0065009 regulation of molecular function
1.57 3.87e-02 GO:0050900 leukocyte migration
1.55 4.36e-02 GO:0031349 positive regulation of defense response
1.19 4.37e-02 GO:0051239 regulation of multicellular organismal process
1.60 4.81e-02 GO:0050870 positive regulation of T cell activation
1.13 4.83e-02 GO:0010468 regulation of gene expression
1.43 4.94e-02 GO:0048534 hemopoietic or lymphoid organ development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.09 1.41e-24 GO:0005622 intracellular
1.10 2.05e-24 GO:0044424 intracellular part
1.16 2.76e-16 GO:0005634 nucleus
1.11 4.07e-16 GO:0043227 membrane-bounded organelle
1.11 4.47e-16 GO:0043231 intracellular membrane-bounded organelle
1.28 6.86e-15 GO:0044428 nuclear part
1.11 1.96e-14 GO:0005737 cytoplasm
1.09 4.10e-14 GO:0043229 intracellular organelle
1.09 6.71e-14 GO:0043226 organelle
1.33 5.85e-12 GO:0005654 nucleoplasm
1.14 1.30e-11 GO:0044446 intracellular organelle part
1.04 1.40e-11 GO:0005623 cell
1.04 1.87e-11 GO:0044464 cell part
1.27 1.90e-11 GO:0031981 nuclear lumen
1.13 2.39e-11 GO:0044422 organelle part
1.24 1.55e-10 GO:0005829 cytosol
1.22 2.73e-09 GO:0031974 membrane-enclosed lumen
1.22 4.70e-09 GO:0043233 organelle lumen
1.21 2.02e-08 GO:0070013 intracellular organelle lumen
1.15 1.89e-07 GO:0032991 macromolecular complex
1.10 3.25e-07 GO:0044444 cytoplasmic part
1.16 2.23e-06 GO:0043234 protein complex
1.32 3.14e-05 GO:0044451 nucleoplasm part
1.32 1.05e-03 GO:0005694 chromosome
1.35 1.79e-03 GO:0005768 endosome
2.79 2.97e-03 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
1.17 3.01e-03 GO:0012505 endomembrane system
1.12 1.25e-02 GO:0043228 non-membrane-bounded organelle
1.12 1.25e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.71 1.42e-02 GO:0016585 chromatin remodeling complex
1.91 1.44e-02 GO:0016605 PML body
1.20 3.19e-02 GO:0005794 Golgi apparatus
1.23 4.21e-02 GO:0031988 membrane-bounded vesicle
1.42 4.33e-02 GO:0016604 nuclear body
1.33 4.61e-02 GO:0048471 perinuclear region of cytoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.18 3.40e-34 GO:0005515 protein binding
1.08 4.67e-17 GO:0005488 binding
1.39 9.88e-05 GO:0060589 nucleoside-triphosphatase regulator activity
1.39 1.48e-04 GO:0030695 GTPase regulator activity
1.28 1.08e-03 GO:0019899 enzyme binding
1.15 1.14e-03 GO:0000166 nucleotide binding
1.49 3.31e-03 GO:0046982 protein heterodimerization activity
1.23 3.68e-03 GO:0030528 transcription regulator activity
1.45 5.38e-03 GO:0005096 GTPase activator activity
1.34 5.74e-03 GO:0004674 protein serine/threonine kinase activity
1.33 1.12e-02 GO:0019904 protein domain specific binding
1.11 1.14e-02 GO:0003676 nucleic acid binding
1.25 2.82e-02 GO:0043565 sequence-specific DNA binding
1.15 3.29e-02 GO:0035639 purine ribonucleoside triphosphate binding
1.43 3.54e-02 GO:0019787 small conjugating protein ligase activity
1.24 3.55e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.14 4.33e-02 GO:0032553 ribonucleotide binding
1.14 4.33e-02 GO:0032555 purine ribonucleotide binding