Motif ID: SPIB.p2

Z-value: 4.481


Transcription factors associated with SPIB.p2:

Gene SymbolEntrez IDGene Name
SPIB 6689 Spi-B transcription factor (Spi-1/PU.1 related)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SPIBchr19_+_556140060.712.1e-03Click!


Activity profile for motif SPIB.p2.

activity profile for motif SPIB.p2


Sorted Z-values histogram for motif SPIB.p2

Sorted Z-values for motif SPIB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPIB.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_15005761 12.081 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr17_+_44643067 10.559 ABI3
ABI family, member 3
chr17_-_40843530 9.655 ARHGAP27
Rho GTPase activating protein 27
chr6_-_159386007 6.591 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr17_-_44642934 6.472 NM_001198754
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr11_+_63864263 6.450 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr4_+_91035025 6.337 NM_007351
MMRN1
multimerin 1
chr2_-_175207521 5.843 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr6_-_32268267 5.725 GPSM3
G-protein signaling modulator 3
chr6_-_11490487 5.567 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chrX_+_48427137 5.506 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr19_+_3129735 5.415 NM_003775
S1PR4
sphingosine-1-phosphate receptor 4
chr5_+_61910318 5.174 NM_181506
LRRC70
leucine rich repeat containing 70
chrX_+_48427103 5.046 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr2_-_225519974 4.901 DOCK10
dedicator of cytokinesis 10
chr19_-_40925151 4.897 NM_024660
TMEM149
transmembrane protein 149
chr7_+_149778815 4.517 GIMAP8
GTPase, IMAP family member 8
chr3_-_113701073 4.469 NM_001085357
NM_181780
BTLA

B and T lymphocyte associated

chr18_-_65766068 4.456 CD226
CD226 molecule
chr17_+_37693090 4.343 NM_003152
STAT5A
signal transducer and activator of transcription 5A
chr14_+_99601498 4.312 NM_016337
EVL
Enah/Vasp-like
chr7_+_149778869 4.293 NM_175571
GIMAP8
GTPase, IMAP family member 8
chr6_-_56824672 4.290 DST
dystonin
chr5_-_169657192 4.285 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr4_+_39874921 4.274 NM_004310
RHOH
ras homolog gene family, member H
chr14_+_99601517 4.167 EVL
Enah/Vasp-like
chr17_-_18890963 4.067 NM_006613
GRAP
GRB2-related adaptor protein
chr14_+_87541220 3.893 NM_003608
GPR65
G protein-coupled receptor 65
chr17_-_24491521 3.842 MYO18A
myosin XVIIIA
chr17_+_31455332 3.832 NM_002984
CCL4
chemokine (C-C motif) ligand 4
chr7_+_149779011 3.821 GIMAP8
GTPase, IMAP family member 8
chr11_-_60880799 3.816 NM_001161452
CYBASC3
cytochrome b, ascorbate dependent 3
chr5_-_169657312 3.811 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr5_-_169657395 3.778 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr9_+_263025 3.699 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr16_-_3567354 3.683 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr13_-_32678142 3.599 NM_052851
STARD13
StAR-related lipid transfer (START) domain containing 13
chr21_-_38792173 3.570 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr5_-_169657360 3.550 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr1_-_181826086 3.549 NCF2
neutrophil cytosolic factor 2
chr7_+_106293112 3.545 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr16_+_28413421 3.538 NM_018690
APOBR
apolipoprotein B receptor
chr6_-_56824371 3.528 DST
dystonin
chr6_-_32268615 3.527 GPSM3
G-protein signaling modulator 3
chr2_+_96355661 3.504 NM_178495
NM_001163524
ITPRIPL1

inositol 1,4,5-triphosphate receptor interacting protein-like 1

chr1_-_205161821 3.495 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr12_+_45896511 3.479 FAM113B
family with sequence similarity 113, member B
chr15_+_79376295 3.456 NM_004513
IL16
interleukin 16 (lymphocyte chemoattractant factor)
chr17_+_44642587 3.433 NM_001135186
NM_016428
ABI3

ABI family, member 3

chr3_-_122862447 3.430 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr3_-_122862391 3.407 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr3_-_120761092 3.386 NM_005191
CD80
CD80 molecule
chr2_+_233633348 3.358 INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr6_-_25044156 3.349 FAM65B
family with sequence similarity 65, member B
chr12_+_25096755 3.345 LRMP
lymphoid-restricted membrane protein
chr1_+_207995999 3.340 NM_025228
TRAF3IP3
TRAF3 interacting protein 3
chr13_+_110653407 3.315 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr11_-_66961709 3.277 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr7_+_128367961 3.261 NM_001098627
IRF5
interferon regulatory factor 5
chrX_-_100527799 3.254 NM_000061
BTK
Bruton agammaglobulinemia tyrosine kinase
chr17_+_73638430 3.237 NM_152468
TMC8
transmembrane channel-like 8
chr19_-_6432765 3.237 NM_024898
DENND1C
DENN/MADD domain containing 1C
chr2_+_233633279 3.224 NM_001017915
NM_005541
INPP5D

inositol polyphosphate-5-phosphatase, 145kDa

chr1_+_154390939 3.216 SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr4_-_10295412 3.175 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr17_+_7180571 3.138 NM_014716
ACAP1
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr9_-_129580732 3.125 NM_170600
SH2D3C
SH2 domain containing 3C
chr7_+_139175420 3.121 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr7_+_149895390 3.102 NM_018326
GIMAP4
GTPase, IMAP family member 4
chr5_-_71838875 3.042 NM_152625
ZNF366
zinc finger protein 366
chr12_+_53177789 3.002 NCKAP1L
NCK-associated protein 1-like
chr5_-_176869148 2.978


chr12_+_25096472 2.976 NM_006152
LRMP
lymphoid-restricted membrane protein
chr11_+_59979857 2.972 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr12_+_53177806 2.945 NCKAP1L
NCK-associated protein 1-like
chr12_-_120725210 2.918 LOC338799
hypothetical LOC338799
chr6_-_32742265 2.906 NM_002123
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr16_-_30301357 2.872 SEPT1
septin 1
chr1_-_158759606 2.869 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr12_+_53177758 2.865 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr19_+_14554895 2.862 NM_207390
CLEC17A
C-type lectin domain family 17, member A
chr12_-_56157898 2.842 NM_001080156
ARHGAP9
Rho GTPase activating protein 9
chr1_+_242281199 2.836 ZNF238
zinc finger protein 238
chr1_+_159943385 2.832 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr1_-_154727014 2.779 MEF2D
myocyte enhancer factor 2D
chr7_+_106292975 2.760 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr12_+_45896318 2.747 NM_138371
FAM113B
family with sequence similarity 113, member B
chrX_-_70248022 2.744 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr7_+_106292932 2.731 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr3_+_195889845 2.712 FAM43A
family with sequence similarity 43, member A
chr1_+_242281175 2.659 NM_205768
ZNF238
zinc finger protein 238
chr5_+_168996852 2.621 DOCK2
dedicator of cytokinesis 2
chr2_-_224974954 2.620 NM_001122779
NM_024785
FAM124B

family with sequence similarity 124B

chr11_+_46323575 2.610 DGKZ
diacylglycerol kinase, zeta
chr16_+_31105579 2.581


chr7_-_38341697 2.574 TRGV7
T cell receptor gamma variable 7 pseudogene
chr5_-_176869463 2.548 NM_024872
DOK3
docking protein 3
chr1_-_25164061 2.535 NM_001031680
RUNX3
runt-related transcription factor 3
chr10_+_70517863 2.534 SRGN
serglycin
chr19_-_40325194 2.532 LGI4
leucine-rich repeat LGI family, member 4
chr1_-_181826292 2.524 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr6_+_31662454 2.507 NM_205837
LST1
leukocyte specific transcript 1
chr5_-_176869440 2.506 DOK3
docking protein 3
chr10_+_70517823 2.480 NM_002727
SRGN
serglycin
chr11_-_33847507 2.463 LMO2
LIM domain only 2 (rhombotin-like 1)
chr16_-_30301634 2.455 NM_052838
SEPT1
septin 1
chr7_-_37454933 2.429 NM_014800
ELMO1
engulfment and cell motility 1
chr21_-_46528594 2.418 MCM3AP
minichromosome maintenance complex component 3 associated protein
chr6_+_31647854 2.414 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr1_-_25128951 2.408 RUNX3
runt-related transcription factor 3
chr19_+_54530458 2.400 CD37
CD37 molecule
chr19_-_53935648 2.392 NM_017805
RASIP1
Ras interacting protein 1
chr1_+_111818111 2.379 NM_174896
C1orf162
chromosome 1 open reading frame 162
chr19_+_54530497 2.371 CD37
CD37 molecule
chr19_+_54530485 2.370 NM_001040031
NM_001774
CD37

CD37 molecule

chr18_-_51219880 2.369 TCF4
transcription factor 4
chr11_+_120966280 2.364 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr19_+_54530546 2.344 CD37
CD37 molecule
chr16_+_29581783 2.343 NM_001030288
SPN
sialophorin
chr19_+_54530512 2.306 CD37
CD37 molecule
chr11_+_65164167 2.300 NM_153253
SIPA1
signal-induced proliferation-associated 1
chr8_+_11388918 2.294 NM_001715
BLK
B lymphoid tyrosine kinase
chr4_-_101658094 2.279 NM_001159694
NM_016242
EMCN

endomucin

chr6_+_31661934 2.247 NM_205838
NM_205839
LST1

leukocyte specific transcript 1

chr16_+_29582065 2.242 SPN
sialophorin
chr1_-_181826633 2.235 NM_001127651
NCF2
neutrophil cytosolic factor 2
chr5_-_138822475 2.228 NM_001077693
ECSCR
endothelial cell-specific chemotaxis regulator
chr1_+_84540921 2.223 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr2_+_102401580 2.221 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr19_+_46774370 2.218 NM_001098506
NM_033543
CEACAM21

carcinoembryonic antigen-related cell adhesion molecule 21

chr1_-_171442937 2.208 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr9_+_92629525 2.185 NM_001174167
SYK
spleen tyrosine kinase
chr2_-_96174865 2.181 NM_004418
DUSP2
dual specificity phosphatase 2
chr17_+_2646481 2.174 NM_001100398
NM_015085
RAP1GAP2

RAP1 GTPase activating protein 2

chr12_+_53178834 2.153 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr1_+_202000906 2.143 NM_001136190
NM_017773
LAX1

lymphocyte transmembrane adaptor 1

chr4_+_68107039 2.140 NM_012108
STAP1
signal transducing adaptor family member 1
chr1_-_111848265 2.131 NM_000677
NM_020683
ADORA3

adenosine A3 receptor

chr16_+_29582069 2.122 NM_003123
SPN
sialophorin
chr19_-_13074973 2.099 NM_005583
LYL1
lymphoblastic leukemia derived sequence 1
chr12_+_6930815 2.063 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr19_+_14412080 2.051 NM_213560
PKN1
protein kinase N1
chr11_+_5602782 2.036 NM_021616
TRIM34
tripartite motif containing 34
chrX_-_134257624 1.999 NM_001185063
NM_007131
ZNF75D

zinc finger protein 75D

chr11_-_33847834 1.997 LMO2
LIM domain only 2 (rhombotin-like 1)
chr19_+_14412052 1.991 PKN1
protein kinase N1
chr19_+_14412087 1.988 PKN1
protein kinase N1
chr11_-_58736897 1.979 NM_001039396
MPEG1
macrophage expressed 1
chr5_-_156468614 1.977 NM_032782
HAVCR2
hepatitis A virus cellular receptor 2
chr12_+_6930778 1.974 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr7_+_150013716 1.970 NM_015660
GIMAP2
GTPase, IMAP family member 2
chr16_-_49272741 1.968 NM_001144972
NM_153337
NM_182854
SNX20


sorting nexin 20


chr12_+_6930799 1.960 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr11_-_33847937 1.939 NM_001142316
LMO2
LIM domain only 2 (rhombotin-like 1)
chr1_+_149877955 1.933 SNX27
sorting nexin family member 27
chr13_+_107720475 1.932 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr16_-_49272617 1.929 SNX20
sorting nexin 20
chr12_+_6930804 1.922 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr5_+_143171918 1.917 NM_021182
HMHB1
histocompatibility (minor) HB-1
chr12_+_6930792 1.914 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr5_+_140772691 1.911 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr1_+_100957883 1.899 NM_001078
NM_080682
VCAM1

vascular cell adhesion molecule 1

chr1_-_171441234 1.896 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr15_+_38849450 1.879 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr10_+_26767268 1.873 NM_019043
APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr10_+_26767288 1.872 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr6_-_33085290 1.860 HLA-DOA
major histocompatibility complex, class II, DO alpha
chr17_-_53764867 1.848


chr19_+_10083196 1.846 NM_002566
P2RY11
purinergic receptor P2Y, G-protein coupled, 11
chr17_-_44058612 1.835 NM_024017
HOXB9
homeobox B9
chr12_+_6930734 1.835 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr6_+_31651319 1.816 NM_000594
TNF
tumor necrosis factor
chr5_+_140844810 1.810 NM_018928
NM_032406
PCDHGC4

protocadherin gamma subfamily C, 4

chr6_-_33085329 1.810 NM_002119
HLA-DOA
major histocompatibility complex, class II, DO alpha
chr17_+_69974361 1.808 CD300A
CD300a molecule
chr11_-_60475558 1.775 NM_016582
SLC15A3
solute carrier family 15, member 3
chr17_+_31664143 1.768 NM_207007
NM_001001435
CCL4L2
CCL4L1
chemokine (C-C motif) ligand 4-like 2
chemokine (C-C motif) ligand 4-like 1
chr4_-_105631915 1.759 NM_025212
CXXC4
CXXC finger protein 4
chr12_+_9713472 1.751 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr22_+_35639564 1.748 NM_000395
CSF2RB
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr12_+_6930694 1.740 NM_002831
NM_080549
PTPN6

protein tyrosine phosphatase, non-receptor type 6

chr11_+_65026382 1.732


chr2_+_68445821 1.731 NM_002664
PLEK
pleckstrin
chr19_-_56567602 1.730 NM_005601
NKG7
natural killer cell group 7 sequence
chr11_+_46323558 1.723 NM_201533
DGKZ
diacylglycerol kinase, zeta
chr1_+_148511806 1.713 NM_024579
C1orf54
chromosome 1 open reading frame 54
chr18_-_59137488 1.711 NM_000633
NM_000657
BCL2

B-cell CLL/lymphoma 2

chr9_+_70509925 1.711 NM_003558
PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr22_+_35586950 1.707 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr3_-_33675484 1.703 CLASP2
cytoplasmic linker associated protein 2
chr1_+_157441133 1.701 NM_002036
DARC
Duffy blood group, chemokine receptor
chr3_+_46423682 1.697 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr9_+_126094067 1.689 NM_001166170
NM_001166171
NEK6

NIMA (never in mitosis gene a)-related kinase 6

chr15_+_91248706 1.682 CHD2
chromodomain helicase DNA binding protein 2
chr7_+_73145481 1.679 LIMK1
LIM domain kinase 1
chr17_+_18971506 1.672 NM_001129778
GRAPL
GRB2-related adaptor protein-like
chr12_+_91620749 1.663 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr17_-_44010543 1.660 NM_024015
HOXB4
homeobox B4
chr1_-_158883666 1.659 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr11_+_46323495 1.656 DGKZ
diacylglycerol kinase, zeta

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.53 9.34e-19 GO:0002376 immune system process
1.13 6.21e-10 GO:0050794 regulation of cellular process
1.52 8.13e-10 GO:0006955 immune response
1.12 2.11e-09 GO:0065007 biological regulation
1.12 8.67e-09 GO:0050789 regulation of biological process
1.18 1.19e-08 GO:0044260 cellular macromolecule metabolic process
1.21 2.24e-08 GO:0007165 signal transduction
1.18 3.48e-08 GO:0051716 cellular response to stimulus
1.07 6.26e-08 GO:0009987 cellular process
1.99 3.24e-07 GO:0051251 positive regulation of lymphocyte activation
1.48 3.32e-07 GO:0002682 regulation of immune system process
1.94 3.44e-07 GO:0050867 positive regulation of cell activation
1.24 3.47e-07 GO:0006950 response to stress
1.86 4.40e-07 GO:0051249 regulation of lymphocyte activation
1.79 8.15e-07 GO:0050865 regulation of cell activation
1.81 9.12e-07 GO:0002694 regulation of leukocyte activation
1.92 9.49e-07 GO:0002696 positive regulation of leukocyte activation
1.59 1.05e-06 GO:0002684 positive regulation of immune system process
1.18 1.09e-06 GO:0023052 signaling
1.94 1.86e-06 GO:0050863 regulation of T cell activation
1.54 2.19e-06 GO:0001775 cell activation
2.02 6.45e-06 GO:0050870 positive regulation of T cell activation
1.38 7.79e-06 GO:0009611 response to wounding
1.14 1.15e-05 GO:0043170 macromolecule metabolic process
1.26 1.36e-05 GO:0016070 RNA metabolic process
1.23 1.49e-05 GO:0090304 nucleic acid metabolic process
1.25 1.91e-05 GO:0010467 gene expression
1.51 2.89e-05 GO:0007599 hemostasis
1.51 3.14e-05 GO:0007596 blood coagulation
1.51 3.14e-05 GO:0050817 coagulation
1.72 4.78e-05 GO:0045321 leukocyte activation
1.25 4.82e-05 GO:0007166 cell surface receptor linked signaling pathway
1.19 8.09e-05 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.24 1.11e-04 GO:0048583 regulation of response to stimulus
1.36 2.17e-04 GO:0006952 defense response
1.76 2.37e-04 GO:0046649 lymphocyte activation
1.84 3.69e-04 GO:0050900 leukocyte migration
1.10 4.01e-04 GO:0044237 cellular metabolic process
1.47 7.65e-04 GO:0050776 regulation of immune response
1.10 1.25e-03 GO:0050896 response to stimulus
1.41 1.46e-03 GO:0050878 regulation of body fluid levels
1.17 1.48e-03 GO:0048518 positive regulation of biological process
1.19 1.52e-03 GO:0048519 negative regulation of biological process
1.18 2.49e-03 GO:0048522 positive regulation of cellular process
1.39 2.73e-03 GO:0042060 wound healing
1.29 2.86e-03 GO:0010941 regulation of cell death
1.28 4.24e-03 GO:0043067 regulation of programmed cell death
2.21 5.28e-03 GO:0031294 lymphocyte costimulation
2.21 5.28e-03 GO:0031295 T cell costimulation
1.09 5.36e-03 GO:0044238 primary metabolic process
1.28 5.91e-03 GO:0042981 regulation of apoptosis
1.19 7.12e-03 GO:0048523 negative regulation of cellular process
1.17 7.94e-03 GO:0044267 cellular protein metabolic process
1.13 1.09e-02 GO:0031323 regulation of cellular metabolic process
1.21 1.16e-02 GO:0009059 macromolecule biosynthetic process
1.67 1.27e-02 GO:0002764 immune response-regulating signaling pathway
1.21 1.31e-02 GO:0034645 cellular macromolecule biosynthetic process
1.89 1.71e-02 GO:0050670 regulation of lymphocyte proliferation
1.66 2.29e-02 GO:0002757 immune response-activating signal transduction
1.86 2.30e-02 GO:0070663 regulation of leukocyte proliferation
1.27 2.33e-02 GO:0032774 RNA biosynthetic process
1.87 2.35e-02 GO:0032944 regulation of mononuclear cell proliferation
1.36 3.64e-02 GO:0006928 cellular component movement
1.44 3.85e-02 GO:0045087 innate immune response
2.11 4.01e-02 GO:0045619 regulation of lymphocyte differentiation
2.00 4.73e-02 GO:0050671 positive regulation of lymphocyte proliferation
2.18 4.87e-02 GO:0045580 regulation of T cell differentiation
1.33 4.94e-02 GO:0051276 chromosome organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.07 6.54e-09 GO:0005622 intracellular
1.07 7.96e-09 GO:0044424 intracellular part
1.14 1.59e-08 GO:0005634 nucleus
1.09 3.02e-07 GO:0043227 membrane-bounded organelle
1.09 3.71e-07 GO:0043231 intracellular membrane-bounded organelle
1.22 1.20e-05 GO:0005829 cytosol
1.21 1.57e-05 GO:0044428 nuclear part
1.03 1.57e-05 GO:0005623 cell
1.03 2.01e-05 GO:0044464 cell part
1.07 5.44e-05 GO:0043229 intracellular organelle
1.08 7.04e-05 GO:0005737 cytoplasm
1.07 7.62e-05 GO:0043226 organelle
1.22 7.94e-05 GO:0031981 nuclear lumen
1.19 1.92e-04 GO:0031974 membrane-enclosed lumen
1.18 5.94e-04 GO:0043233 organelle lumen
1.18 6.71e-04 GO:0070013 intracellular organelle lumen
1.14 7.62e-04 GO:0032991 macromolecular complex
1.23 1.66e-03 GO:0005654 nucleoplasm
1.09 4.01e-03 GO:0044446 intracellular organelle part
1.14 7.35e-03 GO:0043234 protein complex
1.09 7.99e-03 GO:0044422 organelle part
1.08 1.02e-02 GO:0044444 cytoplasmic part
1.52 1.98e-02 GO:0016604 nuclear body

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 7.15e-13 GO:0005515 protein binding
1.06 9.57e-08 GO:0005488 binding
1.37 1.20e-05 GO:0003723 RNA binding
1.16 3.43e-05 GO:0003676 nucleic acid binding
1.31 5.91e-03 GO:0019899 enzyme binding
1.26 7.17e-03 GO:0001071 nucleic acid binding transcription factor activity
1.26 7.17e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.55 8.38e-03 GO:0019900 kinase binding
1.16 1.58e-02 GO:0000166 nucleotide binding
1.15 4.85e-02 GO:0003677 DNA binding