Motif ID: TFAP2{A,C}.p2

Z-value: 5.892


Transcription factors associated with TFAP2{A,C}.p2:

Gene SymbolEntrez IDGene Name
TFAP2A 7020 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C 7022 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Achr6_-_10523424-0.282.9e-01Click!
TFAP2Cchr20_+_54637714-0.126.5e-01Click!


Activity profile for motif TFAP2{A,C}.p2.

activity profile for motif TFAP2{A,C}.p2


Sorted Z-values histogram for motif TFAP2{A,C}.p2

Sorted Z-values for motif TFAP2{A,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2{A,C}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_52877467 7.857 IRX3
iroquois homeobox 3
chr14_-_24588916 7.386 NM_014178
 STXBP6
syntaxin binding protein 6 (amisyn)
chr16_+_52877009 7.261


chr17_+_56832255 6.652 TBX2
T-box 2
chr19_+_15079141 6.567 NM_033025
 SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr11_-_60819110 6.486 VWCE
von Willebrand factor C and EGF domains
chr17_+_56831951 6.424 NM_005994
 TBX2
T-box 2
chr2_-_45090025 6.330 NM_016932
 SIX2
SIX homeobox 2
chr19_+_39664706 6.281 NM_001080436
 WTIP
Wilms tumor 1 interacting protein
chr9_+_115958051 6.161 NM_032888
 COL27A1
collagen, type XXVII, alpha 1
chr16_-_52876390 5.913 IRX3
iroquois homeobox 3
chr2_+_36436873 5.580 NM_016441
 CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr19_+_38377329 5.578 NM_002333
 LRP3
low density lipoprotein receptor-related protein 3
chr9_-_83493415 5.324 NM_005077
 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr1_+_226937732 5.302 RHOU
ras homolog gene family, member U
chr14_+_92049396 5.262 NM_024832
 RIN3
Ras and Rab interactor 3
chr11_-_60819273 5.191 NM_152718
 VWCE
von Willebrand factor C and EGF domains
chr5_+_129268352 5.140 NM_175856
 CHSY3
chondroitin sulfate synthase 3
chr16_-_49742651 5.076 NM_002968
 SALL1
sal-like 1 (Drosophila)
chr5_-_159672060 5.019 NM_024565
 CCNJL
cyclin J-like

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 140 entries
enrichment   p-value GO term description
1.88 2.13e-03 GO:0035050 embryonic heart tube development
1.54 5.01e-03 GO:0061138 morphogenesis of a branching epithelium
1.46 4.91e-03 GO:0060562 epithelial tube morphogenesis
1.43 9.38e-05 GO:0002009 morphogenesis of an epithelium
1.42 1.15e-03 GO:0045664 regulation of neuron differentiation
1.42 3.64e-03 GO:0035239 tube morphogenesis
1.36 1.33e-03 GO:0035295 tube development
1.35 1.58e-02 GO:0051129 negative regulation of cellular component organization
1.34 2.23e-03 GO:0048729 tissue morphogenesis
1.34 1.78e-02 GO:0050767 regulation of neurogenesis
1.34 1.85e-02 GO:0030036 actin cytoskeleton organization
1.33 2.78e-06 GO:0031175 neuron projection development
1.33 2.52e-03 GO:0060284 regulation of cell development
1.32 5.21e-07 GO:0048666 neuron development
1.32 1.65e-04 GO:0007409 axonogenesis
1.32 2.03e-03 GO:0007411 axon guidance
1.32 4.77e-03 GO:0033043 regulation of organelle organization
1.32 2.95e-02 GO:0051960 regulation of nervous system development
1.31 2.22e-05 GO:0000904 cell morphogenesis involved in differentiation
1.31 1.35e-04 GO:0048812 neuron projection morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 29 entries
enrichment   p-value GO term description
1.46 3.52e-05 GO:0031252 cell leading edge
1.29 3.71e-02 GO:0005635 nuclear envelope
1.22 1.18e-02 GO:0005730 nucleolus
1.21 3.90e-16 GO:0044428 nuclear part
1.21 8.00e-13 GO:0031981 nuclear lumen
1.20 2.33e-03 GO:0044451 nucleoplasm part
1.19 8.31e-07 GO:0005654 nucleoplasm
1.18 1.49e-11 GO:0031974 membrane-enclosed lumen
1.18 3.62e-11 GO:0070013 intracellular organelle lumen
1.17 9.99e-11 GO:0043233 organelle lumen
1.17 3.46e-09 GO:0005829 cytosol
1.13 4.36e-18 GO:0005634 nucleus
1.13 3.23e-03 GO:0012505 endomembrane system
1.11 6.08e-05 GO:0043228 non-membrane-bounded organelle
1.11 6.08e-05 GO:0043232 intracellular non-membrane-bounded organelle
1.10 1.01e-24 GO:0043227 membrane-bounded organelle
1.10 1.37e-24 GO:0005737 cytoplasm
1.10 3.94e-24 GO:0043231 intracellular membrane-bounded organelle
1.10 1.86e-12 GO:0044422 organelle part
1.10 3.12e-12 GO:0044446 intracellular organelle part

Gene overrepresentation in function category:

Showing 1 to 20 of 32 entries
enrichment   p-value GO term description
1.34 2.59e-02 GO:0000975 regulatory region DNA binding
1.34 2.59e-02 GO:0001067 regulatory region nucleic acid binding
1.34 2.59e-02 GO:0044212 transcription regulatory region DNA binding
1.33 4.51e-02 GO:0010843 promoter binding
1.30 6.93e-05 GO:0004674 protein serine/threonine kinase activity
1.30 2.47e-03 GO:0016563 transcription activator activity
1.28 4.05e-08 GO:0019899 enzyme binding
1.28 1.24e-04 GO:0030695 GTPase regulator activity
1.28 2.69e-02 GO:0005083 small GTPase regulator activity
1.27 5.64e-04 GO:0060589 nucleoside-triphosphatase regulator activity
1.26 3.24e-03 GO:0019904 protein domain specific binding
1.24 5.11e-05 GO:0043565 sequence-specific DNA binding
1.23 1.98e-07 GO:0030528 transcription regulator activity
1.23 5.13e-07 GO:0001071 nucleic acid binding transcription factor activity
1.23 5.13e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.23 1.26e-04 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.23 1.18e-03 GO:0004672 protein kinase activity
1.23 5.60e-03 GO:0008092 cytoskeletal protein binding
1.21 3.24e-05 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.21 2.17e-04 GO:0016301 kinase activity