Motif ID: ESR1.p2

Z-value: 2.009


Transcription factors associated with ESR1.p2:

Gene SymbolEntrez IDGene Name
ESR1 2099 estrogen receptor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ESR1chr6_+_152053323-0.712.1e-03Click!


Activity profile for motif ESR1.p2.

activity profile for motif ESR1.p2


Sorted Z-values histogram for motif ESR1.p2

Sorted Z-values for motif ESR1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESR1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_71442488 3.262 NM_001144885
NM_001144887
CITED1

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1

chr1_+_62433061 2.860 NM_001164835
NM_019079
L1TD1

LINE-1 type transposase domain containing 1

chr1_-_29322993 2.658 NM_001003682
TMEM200B
transmembrane protein 200B
chr8_-_61356436 2.299 NM_004056
CA8
carbonic anhydrase VIII
chr11_-_69228286 2.294 NM_005117
FGF19
fibroblast growth factor 19
chr9_-_85342868 2.223 NM_174938
FRMD3
FERM domain containing 3
chr7_+_6622051 2.110 NM_017560
ZNF853
zinc finger protein 853
chr1_+_1062137 2.099 LOC254099
hypothetical protein LOC254099
chr10_-_120345148 1.972 NM_004248
PRLHR
prolactin releasing hormone receptor
chr22_-_43783449 1.943 PHF21B
PHD finger protein 21B
chr3_-_13089547 1.933 NM_001134382
IQSEC1
IQ motif and Sec7 domain 1
chr16_+_550394 1.909 NM_145270
C16orf11
chromosome 16 open reading frame 11
chr3_-_173648896 1.893 NM_004122
NM_198407
GHSR

growth hormone secretagogue receptor

chr19_+_1236766 1.841 NM_001405
EFNA2
ephrin-A2
chr7_-_28964186 1.770


chr2_-_198358253 1.760 NM_033030
BOLL
bol, boule-like (Drosophila)
chr1_+_1557419 1.730 NM_006983
MMP23B
matrix metallopeptidase 23B
chr17_-_7238546 1.724 NM_020360
PLSCR3
phospholipid scramblase 3
chr16_-_265868 1.700 NM_003834
NM_183337
RGS11

regulator of G-protein signaling 11

chr2_-_233501069 1.697 NM_001114090
NGEF
neuronal guanine nucleotide exchange factor
chr18_-_45975163 1.695 NM_001080467
MYO5B
myosin VB
chr18_+_74841262 1.690 NM_171999
SALL3
sal-like 3 (Drosophila)
chr10_+_23521464 1.617 NM_178161
PTF1A
pancreas specific transcription factor, 1a
chr19_-_18198234 1.599 NM_001098818
PDE4C
phosphodiesterase 4C, cAMP-specific
chr14_+_105063975 1.593 NM_025268
TMEM121
transmembrane protein 121
chr14_+_105024301 1.584 NM_001311
CRIP1
cysteine-rich protein 1 (intestinal)
chr15_+_30797466 1.576 NM_001191322
NM_001191323
NM_013372
GREM1


gremlin 1


chr13_+_112670757 1.551 NM_001112732
MCF2L
MCF.2 cell line derived transforming sequence-like
chr6_+_110406890 1.544 NM_005284
GPR6
G protein-coupled receptor 6
chr1_+_179148935 1.529 NM_020950
KIAA1614
KIAA1614
chr7_-_72676750 1.522 NM_032951
NM_032952
NM_032953
NM_032954
MLXIPL



MLX interacting protein-like



chr4_-_41579325 1.514


chr3_-_129690056 1.514 NM_001145661
GATA2
GATA binding protein 2
chr4_+_151218862 1.513 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr4_+_156808261 1.485 NM_001130684
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr5_-_132976094 1.476 FSTL4
follistatin-like 4
chr22_+_38720881 1.475 NM_138435
FAM83F
family with sequence similarity 83, member F
chr4_+_156807311 1.470 NM_000856
NM_001130682
NM_001130686
NM_001130687
NM_001130683
NM_001130685
GUCY1A3





guanylate cyclase 1, soluble, alpha 3





chr10_+_94811010 1.469 NM_183374
CYP26C1
cytochrome P450, family 26, subfamily C, polypeptide 1
chr10_+_50492088 1.429 NM_001142929
NM_001142933
NM_001142934
NM_020549
CHAT



choline O-acetyltransferase



chr2_-_42574587 1.425 NM_133329
NM_172344
KCNG3

potassium voltage-gated channel, subfamily G, member 3

chr13_-_27967215 1.412 NM_001159920
NM_001160030
NM_001160031
NM_002019
FLT1



fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)



chr10_+_24023680 1.410 NM_001098500
KIAA1217
KIAA1217
chr11_-_1549719 1.408 NM_004420
DUSP8
dual specificity phosphatase 8
chr5_+_132176921 1.383 NM_175873
ANKRD43
ankyrin repeat domain 43
chr1_+_178466064 1.348 NM_033343
LHX4
LIM homeobox 4
chr13_-_52320774 1.343 NM_002590
NM_032949
PCDH8

protocadherin 8

chr1_-_21850874 1.324 NM_001145658
RAP1GAP
RAP1 GTPase activating protein
chr5_+_167889123 1.323


chr1_+_155097230 1.320 NM_001012331
NM_002529
NTRK1

neurotrophic tyrosine kinase, receptor, type 1

chr13_+_112671497 1.309 MCF2L
MCF.2 cell line derived transforming sequence-like
chr11_+_45900731 1.297 GYLTL1B
glycosyltransferase-like 1B
chr12_-_131256525 1.286 NM_021808
GALNT9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
chr9_+_89302574 1.269 NM_004938
DAPK1
death-associated protein kinase 1
chr4_+_4912272 1.257 NM_002448
MSX1
msh homeobox 1
chr10_+_94823221 1.246 NM_057157
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr6_+_72949092 1.236 RIMS1
regulating synaptic membrane exocytosis 1
chr15_-_39593285 1.221 NM_001135685
NM_002344
NM_206961
LTK


leukocyte receptor tyrosine kinase


chr19_+_3536541 1.210 NM_133261
GIPC3
GIPC PDZ domain containing family, member 3
chr3_+_127743868 1.187 CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr21_+_32167175 1.185 NM_014586
HUNK
hormonally up-regulated Neu-associated kinase
chr4_-_5942818 1.165 CRMP1
collapsin response mediator protein 1
chr17_-_44047299 1.154 NM_024016
HOXB8
homeobox B8
chr5_-_577444 1.151 NM_004174
SLC9A3
solute carrier family 9 (sodium/hydrogen exchanger), member 3
chr22_+_49266836 1.143 NM_024866
ADM2
adrenomedullin 2
chr5_-_45731588 1.134 HCN1
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
chrX_+_151975518 1.108 PNMA3
paraneoplastic antigen MA3
chr9_-_129557373 1.100 NM_001142534
NM_001142533
SH2D3C

SH2 domain containing 3C

chr19_+_3884100 1.088 NM_170678
ITGB1BP3
integrin beta 1 binding protein 3
chr2_+_149349643 1.082


chr14_+_89597860 1.082 NM_022054
KCNK13
potassium channel, subfamily K, member 13
chr9_+_78824390 1.073 NM_001013735
FOXB2
forkhead box B2
chr8_+_22465368 1.056 SORBS3
sorbin and SH3 domain containing 3
chr1_+_66990692 1.052 NM_152665
TCTEX1D1
Tctex1 domain containing 1
chrX_-_21586337 1.044 NM_153270
KLHL34
kelch-like 34 (Drosophila)
chr3_-_135231417 1.017 SLCO2A1
solute carrier organic anion transporter family, member 2A1
chr18_+_53170718 1.002 NM_015879
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr3_-_186353321 0.998 C3orf70
chromosome 3 open reading frame 70
chr14_-_103058568 0.993 CKB
creatine kinase, brain
chr7_+_44110470 0.991 NM_001129
AEBP1
AE binding protein 1
chr11_-_70641267 0.984 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr1_-_19473021 0.979 NM_001145289
NM_201252
AKR7L

aldo-keto reductase family 7-like

chr6_-_33268177 0.978 NM_001163771
NM_080679
NM_080680
NM_080681
COL11A2



collagen, type XI, alpha 2



chr22_-_17517795 0.977 NM_005315
GSC2
goosecoid homeobox 2
chr8_-_101187519 0.975 NM_015668
RGS22
regulator of G-protein signaling 22
chr20_-_61933012 0.972 ZBTB46
zinc finger and BTB domain containing 46
chr22_-_43784093 0.964 NM_138415
PHF21B
PHD finger protein 21B
chr18_-_42590989 0.957 NM_013305
ST8SIA5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr16_+_1974017 0.955 NM_005262
GFER
growth factor, augmenter of liver regeneration
chr10_-_62882930 0.950 TMEM26
transmembrane protein 26
chr17_+_59429442 0.950 NM_001164257
NM_001191029
NM_001191030
NM_001191031
C17orf72



chromosome 17 open reading frame 72



chr3_-_186353421 0.949 NM_001025266
C3orf70
chromosome 3 open reading frame 70
chr5_-_16232896 0.943 NM_001102562
MARCH11
membrane-associated ring finger (C3HC4) 11
chr6_-_117193505 0.943 NM_001085480
FAM162B
family with sequence similarity 162, member B
chr16_-_790699 0.940 NM_016541
GNG13
guanine nucleotide binding protein (G protein), gamma 13
chr8_+_16929116 0.938 NM_181723
EFHA2
EF-hand domain family, member A2
chr14_+_105024576 0.929 CRIP1
cysteine-rich protein 1 (intestinal)
chr9_-_135140425 0.928 ABO
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
chr10_-_133971136 0.922 NM_173575
STK32C
serine/threonine kinase 32C
chr13_-_32822759 0.920 STARD13
StAR-related lipid transfer (START) domain containing 13
chr10_-_103525646 0.918 NM_006119
NM_033163
NM_033164
NM_033165
FGF8



fibroblast growth factor 8 (androgen-induced)



chr13_+_48692472 0.917 NM_001507
MLNR
motilin receptor
chr12_+_3470685 0.916 NM_019854
PRMT8
protein arginine methyltransferase 8
chr7_+_153215316 0.912 NM_001039350
DPP6
dipeptidyl-peptidase 6
chr10_+_26545241 0.910 NM_000818
NM_001134366
GAD2

glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

chr19_+_1442000 0.910 NM_138393
REEP6
receptor accessory protein 6
chr6_+_107917965 0.902 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr9_-_135140450 0.899 NM_020469
ABO
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
chr17_+_19377732 0.881 NM_018242
SLC47A1
solute carrier family 47, member 1
chr22_-_36245155 0.877 NM_014550
CARD10
caspase recruitment domain family, member 10
chr19_-_54267690 0.875 KCNA7
potassium voltage-gated channel, shaker-related subfamily, member 7
chr11_-_63014986 0.867 NM_001146728
NM_001146729
NM_054108
HRASLS5


HRAS-like suppressor family, member 5


chr5_+_1061900 0.865 NM_033120
NKD2
naked cuticle homolog 2 (Drosophila)
chr6_+_30082331 0.864 HLA-J
major histocompatibility complex, class I, J (pseudogene)
chr6_-_11152340 0.857 NM_017770
ELOVL2
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2
chr3_-_135231518 0.840 NM_005630
SLCO2A1
solute carrier organic anion transporter family, member 2A1
chr11_-_118716244 0.840 MFRP
membrane frizzled-related protein
chr19_-_19245022 0.838 NM_001001524
TM6SF2
transmembrane 6 superfamily member 2
chr12_-_61614930 0.833 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr16_-_87535106 0.831 NM_175931
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr14_+_51804180 0.831 NM_000953
PTGDR
prostaglandin D2 receptor (DP)
chr15_-_49174107 0.829 TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr9_+_89302239 0.825 DAPK1
death-associated protein kinase 1
chr10_-_125641484 0.825 NM_198148
CPXM2
carboxypeptidase X (M14 family), member 2
chr8_+_1937711 0.822 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr3_-_10724715 0.820 ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr3_+_156280129 0.820 NM_000902
MME
membrane metallo-endopeptidase
chr11_+_56984702 0.820 NM_178570
RTN4RL2
reticulon 4 receptor-like 2
chr16_-_1971360 0.816 NM_144603
NOXO1
NADPH oxidase organizer 1
chr2_-_200044233 0.801 NM_015265
SATB2
SATB homeobox 2
chr8_-_101187346 0.800 RGS22
regulator of G-protein signaling 22
chrX_+_113724806 0.795 NM_000868
HTR2C
5-hydroxytryptamine (serotonin) receptor 2C
chr19_-_47190061 0.793 ATP1A3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr1_+_66990736 0.790 TCTEX1D1
Tctex1 domain containing 1
chr17_-_7106497 0.789 CLDN7
claudin 7
chr22_+_22445035 0.787 NM_005940
MMP11
matrix metallopeptidase 11 (stromelysin 3)
chr15_-_77024408 0.782 NM_004390
CTSH
cathepsin H
chr17_-_34635446 0.781 NM_198993
STAC2
SH3 and cysteine rich domain 2
chr1_-_239587007 0.779 RGS7
regulator of G-protein signaling 7
chr19_-_47190160 0.775 NM_152296
ATP1A3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr16_+_88512769 0.774 MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chr19_-_14447163 0.771 NM_000955
PTGER1
prostaglandin E receptor 1 (subtype EP1), 42kDa
chr2_+_238200922 0.769 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr16_+_971808 0.767 NM_014587
SOX8
SRY (sex determining region Y)-box 8
chr3_+_50217692 0.759 NM_006841
SLC38A3
solute carrier family 38, member 3
chr11_-_75599433 0.758 WNT11
wingless-type MMTV integration site family, member 11
chr9_-_16860719 0.757 NM_017637
BNC2
basonuclin 2
chr4_+_2013517 0.752 NM_001168243
NM_001141936
C4orf48

chromosome 4 open reading frame 48

chr16_+_1143241 0.749 NM_001005407
NM_021098
CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr19_-_44503328 0.745


chr22_-_19122047 0.744 SCARF2
scavenger receptor class F, member 2
chr1_-_13712744 0.739 NM_001010847
LRRC38
leucine rich repeat containing 38
chr10_+_118990573 0.738 NM_003054
SLC18A2
solute carrier family 18 (vesicular monoamine), member 2
chrX_+_151975421 0.737 NM_013364
PNMA3
paraneoplastic antigen MA3
chr17_-_47590975 0.731 CA10
carbonic anhydrase X
chr14_+_99273751 0.730 EML1
echinoderm microtubule associated protein like 1
chr13_+_50694364 0.728 NM_145019
FAM124A
family with sequence similarity 124A
chr18_+_61569136 0.726 NM_004361
CDH7
cadherin 7, type 2
chr1_-_19487790 0.725 NM_012067
AKR7A3
aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
chr19_+_10392128 0.714 NM_001111307
PDE4A
phosphodiesterase 4A, cAMP-specific
chr10_-_62883213 0.711 NM_178505
TMEM26
transmembrane protein 26
chr6_+_168584722 0.703 SMOC2
SPARC related modular calcium binding 2
chr22_-_19122107 0.703 NM_153334
NM_182895
SCARF2

scavenger receptor class F, member 2

chr4_+_184257337 0.698 NM_024949
WWC2
WW and C2 domain containing 2
chr22_+_43442987 0.697 NM_001017528
NM_001017529
PRR5

proline rich 5 (renal)

chr5_-_59225377 0.691 NM_001104631
PDE4D
phosphodiesterase 4D, cAMP-specific
chr19_+_44697592 0.690 NM_182704
SELV
selenoprotein V
chr12_-_21818881 0.689 NM_004982
KCNJ8
potassium inwardly-rectifying channel, subfamily J, member 8
chr15_-_56145140 0.688 NM_003888
NM_170696
ALDH1A2

aldehyde dehydrogenase 1 family, member A2

chr20_-_930806 0.675 NM_001029871
NM_001040007
RSPO4

R-spondin family, member 4

chr9_-_16860664 0.667 BNC2
basonuclin 2
chr15_-_77024375 0.664 CTSH
cathepsin H
chr17_+_71095733 0.660 MYO15B
myosin XVB pseudogene
chr9_-_139047112 0.650 NM_004479
FUT7
fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
chr13_+_112681626 0.646 NM_024979
MCF2L
MCF.2 cell line derived transforming sequence-like
chr7_+_100047660 0.642 NM_001040097
MOSPD3
motile sperm domain containing 3
chr11_+_110675175 0.641 NM_001136105
C11orf93
chromosome 11 open reading frame 93
chr1_+_108765634 0.638 LOC400768
hypothetical LOC400768
chr17_+_31082791 0.631 NM_033315
RASL10B
RAS-like, family 10, member B
chr17_+_77910411 0.630 NM_207459
TEX19
testis expressed 19
chr1_+_213323182 0.630 NM_001017425
NM_014217
KCNK2

potassium channel, subfamily K, member 2

chr17_+_70431964 0.629 NM_178160
OTOP2
otopetrin 2
chr19_+_56506907 0.629 NM_001101372
IGLON5
IgLON family member 5
chr14_+_99507848 0.629 EVL
Enah/Vasp-like
chr19_-_50518072 0.628 NM_001824
CKM
creatine kinase, muscle
chr8_+_144428083 0.624 GLI4
GLI family zinc finger 4
chr19_+_61711008 0.623 NM_020813
ZNF471
zinc finger protein 471
chr15_-_62854749 0.622 NM_194272
RBPMS2
RNA binding protein with multiple splicing 2
chr17_-_70401299 0.621 NM_178128
FADS6
fatty acid desaturase domain family, member 6
chr5_-_1165106 0.619 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr14_+_105012106 0.618 NM_001312
CRIP2
cysteine-rich protein 2
chr10_-_135232865 0.617 NM_130784
SYCE1
synaptonemal complex central element protein 1
chr3_-_124650081 0.616 NM_183357
ADCY5
adenylate cyclase 5
chr17_+_41327808 0.615 MAPT
microtubule-associated protein tau
chr10_+_122206455 0.614 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr19_-_14447122 0.614 PTGER1
prostaglandin E receptor 1 (subtype EP1), 42kDa
chr9_-_138778780 0.613 NM_203347
LCN15
lipocalin 15
chr16_+_1974182 0.612 GFER
growth factor, augmenter of liver regeneration
chr17_+_26742903 0.611 RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr13_-_25523164 0.608 NM_001007538
SHISA2
shisa homolog 2 (Xenopus laevis)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.39 6.65e-03 GO:0007399 nervous system development
1.22 7.05e-03 GO:0032502 developmental process
1.22 7.58e-03 GO:0023052 signaling
1.23 1.17e-02 GO:0007275 multicellular organismal development
1.08 1.28e-02 GO:0009987 cellular process
1.12 1.50e-02 GO:0065007 biological regulation
1.14 1.72e-02 GO:0050794 regulation of cellular process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.10 3.59e-02 GO:0005737 cytoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.02 5.90e-03 GO:0004714 transmembrane receptor protein tyrosine kinase activity
1.13 6.27e-03 GO:0005515 protein binding
2.72 7.74e-03 GO:0019199 transmembrane receptor protein kinase activity
1.07 3.87e-02 GO:0005488 binding