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• Activity deltas table
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Motif ID: HIF1A.p2

Z-value: 1.644

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr1_+_12046020	1.229	NM_001243	TNFRSF8	tumor necrosis factor receptor superfamily, member 8
chr10_-_60606195	1.176
chr11_+_32808045	1.055	NM_024081	PRRG4	proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr5_-_176760242	1.025	NM_001029886	PFN3	profilin 3
chr3_-_71916877	1.002	NM_001126128 NM_021935	PROK2	prokineticin 2
chr6_-_144427340	0.961	NM_001080951 NM_001080955	PLAGL1	pleiomorphic adenoma gene-like 1
chr2_+_222997456	0.919		SGPP2	sphingosine-1-phosphate phosphatase 2
chr1_+_181025494	0.894		NPL	N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr20_+_48781457	0.888	NM_032521	PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)
chr4_+_107036042	0.886	NM_001033047 NM_001184690 NM_001184691 NM_001184692 NM_001184693	NPNT	nephronectin
chr17_+_32380287	0.873	NM_012138	AATF	apoptosis antagonizing transcription factor
chr2_+_222997529	0.856	NM_152386	SGPP2	sphingosine-1-phosphate phosphatase 2
chr16_+_166678	0.799	NM_000558	HBA1 HBA2	hemoglobin, alpha 1 hemoglobin, alpha 2
chr2_+_32142083	0.793	NM_014946 NM_199436	SPAST	spastin
chr17_-_3814334	0.778	NM_005173 NM_174953 NM_174954 NM_174955 NM_174956 NM_174957 NM_174958	ATP2A3	ATPase, Ca++ transporting, ubiquitous
chr22_+_38720881	0.776	NM_138435	FAM83F	family with sequence similarity 83, member F
chr2_-_213724577	0.758	NM_001079526	IKZF2	IKAROS family zinc finger 2 (Helios)
chr2_+_190981257	0.753	NM_017694	MFSD6	major facilitator superfamily domain containing 6
chr3_-_123223658	0.724	NM_175924	ILDR1	immunoglobulin-like domain containing receptor 1
chr4_+_107036076	0.710		NPNT	nephronectin
chr1_+_67546143	0.702		IL12RB2	interleukin 12 receptor, beta 2
chr11_+_69602055	0.679	NM_018043	ANO1	anoctamin 1, calcium activated chloride channel
chr16_+_162845	0.664	NM_000517	HBA1 HBA2	hemoglobin, alpha 1 hemoglobin, alpha 2
chr4_+_89597257	0.663	NM_016323	HERC5	hect domain and RLD 5
chr13_-_99422163	0.658	NM_033132	ZIC5	Zic family member 5 (odd-paired homolog, Drosophila)
chr20_-_538909	0.643	NM_004609	TCF15	transcription factor 15 (basic helix-loop-helix)
chr1_+_231816372	0.632	NM_002245	KCNK1	potassium channel, subfamily K, member 1
chr3_+_127743868	0.625		CHST13	carbohydrate (chondroitin 4) sulfotransferase 13
chr1_-_146543102	0.620
chr18_+_42167904	0.595		RNF165	ring finger protein 165
chr3_+_77171938	0.592	NM_002942	ROBO2	roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr6_+_73388713	0.589		KCNQ5	potassium voltage-gated channel, KQT-like subfamily, member 5
chr17_-_64834780	0.586	NM_172232	ABCA5	ATP-binding cassette, sub-family A (ABC1), member 5
chr6_-_28663045	0.581	NM_052923	SCAND3	SCAN domain containing 3
chr13_-_95503566	0.580	NM_020121	UGGT2	UDP-glucose glycoprotein glucosyltransferase 2
chr4_-_90251571	0.573		FAM13A	family with sequence similarity 13, member A
chr1_+_222870573	0.573		CNIH3	cornichon homolog 3 (Drosophila)
chr19_+_1022208	0.565		HMHA1	histocompatibility (minor) HA-1
chr10_+_60606352	0.562	NM_032439	PHYHIPL	phytanoyl-CoA 2-hydroxylase interacting protein-like
chr12_+_56299959	0.553	NM_133489	SLC26A10	solute carrier family 26, member 10
chr5_+_49998677	0.551		PARP8	poly (ADP-ribose) polymerase family, member 8
chr10_+_112247614	0.547	NM_004419	DUSP5	dual specificity phosphatase 5
chr11_+_65311104	0.539	NM_004561	OVOL1	ovo-like 1(Drosophila)
chr8_+_95722448	0.527		ESRP1	epithelial splicing regulatory protein 1
chr4_+_183302105	0.524		ODZ3	odz, odd Oz/ten-m homolog 3 (Drosophila)
chr4_+_48180033	0.506	NM_152679	SLC10A4	solute carrier family 10 (sodium/bile acid cotransporter family), member 4
chr14_-_70345485	0.503	NM_033141	MAP3K9	mitogen-activated protein kinase kinase kinase 9
chr4_-_119493322	0.494	NM_003619	PRSS12	protease, serine, 12 (neurotrypsin, motopsin)
chr9_+_34948171	0.490	NM_015297	KIAA1045	KIAA1045
chr1_-_142536082	0.488
chr2_-_233060774	0.486	NM_004826	ECEL1	endothelin converting enzyme-like 1
chr13_+_24152548	0.484	NM_001185085 NM_001676	ATP12A	ATPase, H+/K+ transporting, nongastric, alpha polypeptide
chr11_+_75157414	0.483	NM_032564	DGAT2	diacylglycerol O-acyltransferase 2
chr11_-_74819165	0.482	NM_001039548	KLHL35	kelch-like 35 (Drosophila)
chr17_-_8643163	0.482	NM_152599	MFSD6L	major facilitator superfamily domain containing 6-like
chr8_+_69405510	0.481	NM_001195639 NM_052958	C8orf34	chromosome 8 open reading frame 34
chr21_-_38954433	0.480		ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr13_-_19704533	0.480	NM_001110219 NM_001110220 NM_001110221	GJB6	gap junction protein, beta 6, 30kDa
chr19_+_40431678	0.479		LSR	lipolysis stimulated lipoprotein receptor
chr2_+_111594921	0.476	NM_006538 NM_138621 NM_207002	BCL2L11	BCL2-like 11 (apoptosis facilitator)
chr19_+_60283571	0.475	NM_017729	EPS8L1	EPS8-like 1
chr9_-_111300350	0.469	NM_001145368 NM_002829	PTPN3	protein tyrosine phosphatase, non-receptor type 3
chr19_-_19599973	0.465	NM_004720	LPAR2	lysophosphatidic acid receptor 2
chr13_+_97426713	0.463		IPO5	importin 5
chr1_+_67545634	0.457	NM_001559	IL12RB2	interleukin 12 receptor, beta 2
chr1_+_65385799	0.447	NM_203464 NM_001005353	AK4	adenylate kinase 4
chr7_-_22363036	0.444	NM_012294	RAPGEF5	Rap guanine nucleotide exchange factor (GEF) 5
chr7_+_48041632	0.440	NM_001100159	C7orf57	chromosome 7 open reading frame 57
chr9_-_21965131	0.439	NM_000077 NM_001195132	CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr2_-_6923215	0.437	NM_207315	CMPK2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr11_-_19219720	0.436		E2F8	E2F transcription factor 8
chr1_-_173428455	0.436	NM_001162895 NM_014656 NM_001162893 NM_001162894	KIAA0040	KIAA0040
chr11_+_65311142	0.433		OVOL1	ovo-like 1(Drosophila)
chr13_+_78068246	0.430		LOC780529	hypothetical LOC780529
chr5_+_63497408	0.429	NM_001113561 NM_178532	RNF180	ring finger protein 180
chr7_-_72077805	0.425	NM_198853	TRIM73 TRIM74	tripartite motif containing 73 tripartite motif containing 74
chr11_+_125279481	0.423	NM_013264	DDX25	DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr1_+_231816540	0.417		KCNK1	potassium channel, subfamily K, member 1
chr20_+_18516541	0.417	NM_080820	DTD1	D-tyrosyl-tRNA deacylase 1 homolog (S. cerevisiae)
chr10_+_104394185	0.414	NM_030912	TRIM8	tripartite motif containing 8
chr13_-_19633182	0.410	NM_021954	GJA3	gap junction protein, alpha 3, 46kDa
chr11_-_73149705	0.409	NM_002869 NM_198896	RAB6A	RAB6A, member RAS oncogene family
chr5_+_89890366	0.408	NM_032119	GPR98	G protein-coupled receptor 98
chr1_+_88922424	0.405	NM_006256	PKN2	protein kinase N2
chr10_-_43390014	0.405	NM_001099282 NM_001099283 NM_001099284	ZNF239	zinc finger protein 239
chr8_+_28407613	0.404	NM_017412	FZD3	frizzled homolog 3 (Drosophila)
chr16_-_18845223	0.401	NM_015092	SMG1	SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
chr4_-_17392232	0.399	NM_015688	FAM184B	family with sequence similarity 184, member B
chr11_+_566482	0.398	NM_020901	PHRF1	PHD and ring finger domains 1
chr1_+_222870798	0.393	NM_152495	CNIH3	cornichon homolog 3 (Drosophila)
chr8_-_30635112	0.386		GTF2E2	general transcription factor IIE, polypeptide 2, beta 34kDa
chr5_+_3649167	0.384	NM_024337	IRX1	iroquois homeobox 1
chr5_+_110587546	0.379	NM_001744	CAMK4	calcium/calmodulin-dependent protein kinase IV
chr22_-_29231597	0.376	NM_001161368 NM_174977	SEC14L4	SEC14-like 4 (S. cerevisiae)
chr17_-_42924828	0.376		MRPL45P2	mitochondrial ribosomal protein L45 pseudogene 2
chr8_+_75050930	0.375	NM_001040613 NM_017866	TMEM70	transmembrane protein 70
chr1_-_146543016	0.373
chr7_+_26298018	0.373	NM_013322	SNX10	sorting nexin 10
chr11_+_133706977	0.371	NM_138342	GLB1L2	galactosidase, beta 1-like 2
chr16_-_66571863	0.371	NM_001129758 NM_022357	DPEP3	dipeptidase 3
chr1_+_191357906	0.363		CDC73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr8_+_31616809	0.362	NM_013962	NRG1	neuregulin 1
chr2_-_96174865	0.360	NM_004418	DUSP2	dual specificity phosphatase 2
chr10_+_52420936	0.358	NM_001098512	PRKG1	protein kinase, cGMP-dependent, type I
chr18_+_53253775	0.355	NM_004852	ONECUT2	one cut homeobox 2
chr2_+_17585462	0.355		VSNL1	visinin-like 1
chr19_-_55999677	0.353	NM_199250 NM_199249	C19orf48	chromosome 19 open reading frame 48
chr5_+_176951802	0.352	NM_017510	TMED9	transmembrane emp24 protein transport domain containing 9
chrX_-_131919896	0.352		HS6ST2	heparan sulfate 6-O-sulfotransferase 2
chr2_+_122229590	0.350	NM_004622	TSN	translin
chr8_-_9046460	0.350		PPP1R3B	protein phosphatase 1, regulatory (inhibitor) subunit 3B
chr1_-_180840016	0.349	NM_002928	RGS16	regulator of G-protein signaling 16
chr7_+_115637795	0.348	NM_015641	TES	testis derived transcript (3 LIM domains)
chr10_-_98470164	0.348	NM_152309	PIK3AP1	phosphoinositide-3-kinase adaptor protein 1
chr8_-_30635207	0.347	NM_002095	GTF2E2	general transcription factor IIE, polypeptide 2, beta 34kDa
chr22_+_24290738	0.347	NM_005160	ADRBK2	adrenergic, beta, receptor kinase 2
chr2_+_17585287	0.345	NM_003385	VSNL1	visinin-like 1
chr1_+_20385164	0.345	NM_152376	UBXN10	UBX domain protein 10
chr13_-_40604587	0.341	NM_152903	KBTBD6	kelch repeat and BTB (POZ) domain containing 6
chr17_-_34084682	0.339	NM_001130677	C17orf96	chromosome 17 open reading frame 96
chr2_-_60633908	0.338	NM_018014 NM_022893 NM_138559	BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)
chr12_-_123965099	0.338		UBC	ubiquitin C
chr19_+_2427122	0.337	NM_015675	GADD45B	growth arrest and DNA-damage-inducible, beta
chr11_+_104986620	0.336	NM_001112812	GRIA4	glutamate receptor, ionotrophic, AMPA 4
chr2_-_112729072	0.332	NM_032494	ZC3H8	zinc finger CCCH-type containing 8
chr11_-_65895640	0.330	NM_001532	SLC29A2	solute carrier family 29 (nucleoside transporters), member 2
chr2_-_101370291	0.330		CREG2	cellular repressor of E1A-stimulated genes 2
chr20_+_41519882	0.330	NM_006275	SRSF6	serine/arginine-rich splicing factor 6
chr2_+_219432789	0.330	NM_006522	WNT6	wingless-type MMTV integration site family, member 6
chr1_-_146398501	0.330		LOC100286793 FLJ39739	hypothetical LOC100286793 hypothetical FLJ39739
chr9_+_34948320	0.329		KIAA1045	KIAA1045
chr6_+_111515341	0.328		SLC16A10	solute carrier family 16, member 10 (aromatic amino acid transporter)
chr11_+_133707107	0.327		GLB1L2	galactosidase, beta 1-like 2
chr15_-_76700563	0.325	NM_000743 NM_001166694	CHRNA3	cholinergic receptor, nicotinic, alpha 3
chr12_+_56230073	0.323		KIF5A	kinesin family member 5A
chr17_+_50697355	0.320		HLF	hepatic leukemia factor
chr11_-_565848	0.320		LOC143666	hypothetical LOC143666
chr10_-_95350949	0.319	NM_006744	RBP4	retinol binding protein 4, plasma
chr17_+_45778381	0.318	NM_022167	XYLT2	xylosyltransferase II
chr16_+_73739890	0.316	NM_153688	ZFP1	zinc finger protein 1 homolog (mouse)
chr10_+_105334704	0.316		NEURL	neuralized homolog (Drosophila)
chr9_+_129199204	0.315	NM_014580	SLC2A8	solute carrier family 2 (facilitated glucose transporter), member 8
chr6_+_111515473	0.313	NM_018593	SLC16A10	solute carrier family 16, member 10 (aromatic amino acid transporter)
chr6_+_1336077	0.313
chr6_-_153346283	0.312	NM_001142522	FBXO5	F-box protein 5
chr3_-_159306532	0.311	NM_001163678 NM_003030 NM_006884	SHOX2	short stature homeobox 2
chr3_+_52694975	0.310	NM_014366 NM_206825 NM_206826	GNL3	guanine nucleotide binding protein-like 3 (nucleolar)
chr7_+_43118721	0.310	NM_015052	HECW1	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr17_-_69151821	0.309	NM_001144952	SDK2	sidekick homolog 2 (chicken)
chr19_+_40431618	0.309		LSR	lipolysis stimulated lipoprotein receptor
chr11_+_75157450	0.307		DGAT2	diacylglycerol O-acyltransferase 2
chr2_+_84986273	0.305	NM_021103	TMSB10	thymosin beta 10
chr17_+_50697319	0.305	NM_002126	HLF	hepatic leukemia factor
chr19_-_54267690	0.304		KCNA7	potassium voltage-gated channel, shaker-related subfamily, member 7
chr3_-_107070400	0.304	NM_170662	CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr2_-_60634271	0.303		BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)
chr4_+_119419354	0.302		SNHG8	small nucleolar RNA host gene 8 (non-protein coding)
chr7_+_156624392	0.302	NM_014671	UBE3C	ubiquitin protein ligase E3C
chr1_-_142535878	0.302		LOC100286793 FLJ39739	hypothetical LOC100286793 hypothetical FLJ39739
chr19_+_40431359	0.301	NM_015925 NM_205834 NM_205835	LSR	lipolysis stimulated lipoprotein receptor
chr7_+_26298136	0.300		SNX10	sorting nexin 10
chr19_-_54267932	0.298	NM_031886	KCNA7	potassium voltage-gated channel, shaker-related subfamily, member 7
chr12_-_56111054	0.298		R3HDM2	R3H domain containing 2
chr8_+_24827173	0.297	NM_005382	NEFM	neurofilament, medium polypeptide
chr3_+_173240983	0.297	NM_001135095	FNDC3B	fibronectin type III domain containing 3B
chr3_+_37259684	0.297	NM_001172713 NM_002078	GOLGA4	golgin A4
chr4_+_158361185	0.296	NM_000826 NM_001083619 NM_001083620	GRIA2	glutamate receptor, ionotropic, AMPA 2
chr12_-_123965539	0.295	NM_021009	UBC	ubiquitin C
chr8_-_110726201	0.295	NM_001099753 NM_001099754 NM_001099755	SYBU	syntabulin (syntaxin-interacting)
chr20_+_3399615	0.293	NM_139321 NM_139322	ATRN	attractin
chr2_-_88533167	0.293	NM_001135649	FOXI3	forkhead box I3
chr17_-_33043514	0.293	NM_001163544 NM_001163545 NM_001163546 NM_001163547 NM_007247 NM_080550 NM_198882	SYNRG	synergin, gamma
chrX_+_150614385	0.293	NM_024082	PRRG3	proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
chr10_+_105716925	0.293		SLK	STE20-like kinase
chr12_+_56230110	0.292	NM_004984	KIF5A	kinesin family member 5A
chr3_-_88190737	0.291	NM_001008390 NM_003663	CGGBP1	CGG triplet repeat binding protein 1
chr8_+_85259654	0.291	NM_001100391	RALYL	RALY RNA binding protein-like
chr12_+_120810982	0.290	NM_002813	PSMD9	proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
chr9_-_135847106	0.288	NM_001134398 NM_003371	VAV2	vav 2 guanine nucleotide exchange factor
chr2_+_68238490	0.287	NM_020143	PNO1	partner of NOB1 homolog (S. cerevisiae)
chr3_+_53503626	0.287		CACNA1D	calcium channel, voltage-dependent, L type, alpha 1D subunit
chr8_+_24827181	0.287		NEFM	neurofilament, medium polypeptide
chr2_-_27195401	0.287	NM_001166240 NM_006569	CGREF1	cell growth regulator with EF-hand domain 1
chr20_-_24986501	0.287		ACSS1	acyl-CoA synthetase short-chain family member 1
chr14_+_101297887	0.286	NM_001161725 NM_001161726	PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma
chr3_+_40473785	0.286	NM_003973 NM_001034996	RPL14	ribosomal protein L14
chr10_-_43082372	0.285	NM_145313	RASGEF1A	RasGEF domain family, member 1A
chr1_+_65386359	0.285	NM_013410	AK4	adenylate kinase 4
chr1_-_143232275	0.284		LOC728855	hypothetical LOC728855
chr20_-_50241930	0.284	NM_018197 NM_022088 NM_199426 NM_199427	ZFP64	zinc finger protein 64 homolog (mouse)
chr6_-_28475478	0.283	NM_001163391	ZSCAN12	zinc finger and SCAN domain containing 12
chr9_-_126573349	0.282	NM_001489 NM_033334	NR6A1	nuclear receptor subfamily 6, group A, member 1
chr21_+_33364316	0.282	NM_138983	OLIG1	oligodendrocyte transcription factor 1
chr19_-_44386731	0.282	NM_001080468	SYCN	syncollin
chr8_+_26296439	0.282	NM_004331	BNIP3L	BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr10_-_21503025	0.282	NM_001173484 NM_213569	NEBL	nebulette
chr7_+_23603495	0.282	NM_138771	CCDC126	coiled-coil domain containing 126
chr5_-_43432969	0.281		CCL28	chemokine (C-C motif) ligand 28
chr16_+_716936	0.281	NM_207112 NM_032304	HAGHL	hydroxyacylglutathione hydrolase-like
chr11_-_47620590	0.280	NM_014342	MTCH2	mitochondrial carrier homolog 2 (C. elegans)

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.21	3.04e-07	GO:0044237	cellular metabolic process
1.23	3.31e-05	GO:0044260	cellular macromolecule metabolic process
1.16	3.60e-05	GO:0008152	metabolic process
1.09	5.98e-04	GO:0009987	cellular process
1.16	6.19e-04	GO:0044238	primary metabolic process
1.30	8.67e-04	GO:0044267	cellular protein metabolic process
1.19	1.20e-03	GO:0043170	macromolecule metabolic process
1.24	7.27e-03	GO:0051234	establishment of localization
1.23	1.99e-02	GO:0006810	transport
2.31	2.01e-02	GO:0006112	energy reserve metabolic process
1.28	2.24e-02	GO:0048523	negative regulation of cellular process
1.31	2.43e-02	GO:0006464	protein modification process
1.50	2.52e-02	GO:0046907	intracellular transport
1.86	2.70e-02	GO:0032446	protein modification by small protein conjugation
1.30	2.92e-02	GO:0043412	macromolecule modification
1.88	3.64e-02	GO:0016567	protein ubiquitination
2.07	3.87e-02	GO:0006913	nucleocytoplasmic transport

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.19	1.13e-28	GO:0044424	intracellular part
1.18	1.36e-26	GO:0005622	intracellular
1.23	5.70e-21	GO:0043231	intracellular membrane-bounded organelle
1.23	9.17e-21	GO:0043227	membrane-bounded organelle
1.19	1.75e-18	GO:0043229	intracellular organelle
1.23	2.72e-18	GO:0005737	cytoplasm
1.19	3.86e-18	GO:0043226	organelle
1.27	3.36e-14	GO:0044444	cytoplasmic part
1.23	1.48e-08	GO:0044446	intracellular organelle part
1.22	6.18e-08	GO:0005634	nucleus
1.21	1.81e-07	GO:0044422	organelle part
1.39	5.21e-07	GO:0031090	organelle membrane
1.05	9.99e-07	GO:0044464	cell part
1.05	1.04e-06	GO:0005623	cell
1.36	7.63e-06	GO:0005829	cytosol
1.41	2.21e-05	GO:0012505	endomembrane system
1.29	1.42e-03	GO:0044428	nuclear part
1.27	2.68e-03	GO:0070013	intracellular organelle lumen
1.26	5.04e-03	GO:0031974	membrane-enclosed lumen
1.26	6.78e-03	GO:0043233	organelle lumen
1.26	4.98e-02	GO:0031981	nuclear lumen

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.08	3.98e-04	GO:0005488	binding
1.29	7.16e-04	GO:0000166	nucleotide binding
1.12	3.16e-03	GO:0005515	protein binding
1.45	1.42e-02	GO:0003723	RNA binding
1.77	1.77e-02	GO:0016879	ligase activity, forming carbon-nitrogen bonds

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