Motif ID: HNF4A_NR2F1,2.p2

Z-value: 1.460


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
HNF4A 3172 hepatocyte nuclear factor 4, alpha
NR2F1 7025 nuclear receptor subfamily 2, group F, member 1
NR2F2 7026 nuclear receptor subfamily 2, group F, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR2F2chr15_+_94677572-0.591.7e-02Click!
HNF4Achr20_+_424175020.476.8e-02Click!
NR2F1chr5_+_92944680-0.078.0e-01Click!


Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_33753218 1.844 NM_001004334
GPR179
G protein-coupled receptor 179
chr5_+_150008030 1.749 SYNPO
synaptopodin
chr7_+_142885087 1.603 NM_176883
TAS2R41
taste receptor, type 2, member 41
chr10_+_102722275 1.548 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr17_-_31353196 1.515 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr6_+_33280396 1.502 NM_014234
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr22_-_22970850 1.431 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr17_-_31219943 1.389 NM_152781
C17orf66
chromosome 17 open reading frame 66
chr7_-_150515410 1.337 NM_001142459
NM_001142460
ASB10

ankyrin repeat and SOCS box containing 10

chr17_+_75766875 1.286 NM_024110
CARD14
caspase recruitment domain family, member 14
chr3_-_42892195 1.213 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr22_+_20316968 1.156 NM_152612
CCDC116
coiled-coil domain containing 116
chr19_-_17432724 1.114 NM_138454
NXNL1
nucleoredoxin-like 1
chr17_-_44641741 1.105 NM_031498
NM_001198755
NM_001198756
GNGT2


guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2


chr1_-_24307514 1.090 MYOM3
myomesin family, member 3
chr19_-_47328399 1.060 NM_002698
POU2F2
POU class 2 homeobox 2
chr2_+_27573206 1.035 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr16_-_11277806 1.033 NM_002762
PRM2
protamine 2
chr8_+_22909305 1.029 NM_001160037
RHOBTB2
Rho-related BTB domain containing 2
chr22_+_20899155 1.007


chr11_-_6418705 1.004 NM_000613
HPX
hemopexin
chr5_+_67558217 1.003 NM_181523
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr11_+_118332217 0.997 NM_006760
UPK2
uroplakin 2
chr1_+_15941503 0.984 NM_001013641
TMEM82
transmembrane protein 82
chr19_+_46640902 0.961 NM_001130514
C19orf69
chromosome 19 open reading frame 69
chr22_+_18330049 0.944 NM_007310
COMT
catechol-O-methyltransferase
chr12_-_53065758 0.942 ZNF385A
zinc finger protein 385A
chr12_+_107797985 0.935 NM_001917
DAO
D-amino-acid oxidase
chr1_+_154386358 0.927 NM_001193301
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr16_+_68542126 0.927 NM_001136214
CLEC18A
C-type lectin domain family 18, member A
chr19_-_53558961 0.921 NM_018273
TMEM143
transmembrane protein 143
chr2_-_241480058 0.901 NM_024861
C2orf54
chromosome 2 open reading frame 54
chr3_-_52454082 0.900 NM_020163
SEMA3G
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr22_+_21559959 0.897 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr11_-_4893468 0.894 NM_001005238
OR51G2
olfactory receptor, family 51, subfamily G, member 2
chr1_-_202726068 0.856 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr6_-_31246159 0.854 NM_002701
POU5F1
POU5F1B
POU5F1P3
POU class 5 homeobox 1
POU class 5 homeobox 1B
POU class 5 homeobox 1 pseudogene 3
chr10_-_76529253 0.853 NM_016364
DUSP13
dual specificity phosphatase 13
chr20_-_62208627 0.838 NM_005286
NPBWR2
neuropeptides B/W receptor 2
chr16_-_66558197 0.832 NM_001145964
SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr17_-_8588829 0.832 NM_001158261
NM_144681
CCDC42

coiled-coil domain containing 42

chr17_-_3766441 0.830 P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr5_+_159589014 0.824 NM_001445
FABP6
fatty acid binding protein 6, ileal
chr3_+_46514488 0.810 NM_031440
RTP3
receptor (chemosensory) transporter protein 3
chr16_-_87646856 0.805


chrX_-_148484772 0.795 NM_001164415
NM_016153
HSFX2
HSFX1
heat shock transcription factor family, X linked 2
heat shock transcription factor family, X linked 1
chr6_-_32034607 0.794 NM_002904
RDBP
RD RNA binding protein
chr6_-_31953425 0.770 NM_001178045
SLC44A4
solute carrier family 44, member 4
chr3_-_46879883 0.767 NM_000258
MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr6_+_32034767 0.766 SKIV2L
superkiller viralicidic activity 2-like (S. cerevisiae)
chr19_-_15451203 0.755 NM_052890
PGLYRP2
peptidoglycan recognition protein 2
chr16_+_56230707 0.753 NM_001145774
GPR56
G protein-coupled receptor 56
chr1_-_206263170 0.749 PLXNA2
plexin A2
chr22_+_21407066 0.748


chr7_+_128802719 0.746 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr6_+_29799095 0.734 NM_001098478
NM_001098479
NM_018950
HLA-F


major histocompatibility complex, class I, F


chrX_+_148663533 0.730 NM_001164415
NM_016153
HSFX2
HSFX1
heat shock transcription factor family, X linked 2
heat shock transcription factor family, X linked 1
chr16_-_86527608 0.728 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr22_+_20715340 0.724


chr1_+_226404037 0.723 NM_020435
GJC2
gap junction protein, gamma 2, 47kDa
chr12_+_48630790 0.721 NM_000486
AQP2
aquaporin 2 (collecting duct)
chr9_-_129557373 0.721 NM_001142534
NM_001142533
SH2D3C

SH2 domain containing 3C

chr2_-_74606819 0.720 NM_133637
DQX1
DEAQ box RNA-dependent ATPase 1
chr9_-_34554800 0.716 CNTFR
ciliary neurotrophic factor receptor
chr16_+_31312097 0.713 NM_005353
ITGAD
integrin, alpha D
chr19_+_53747233 0.712 NM_177973
SULT2B1
sulfotransferase family, cytosolic, 2B, member 1
chr1_-_20374273 0.707 NM_001105572
PLA2G2C
phospholipase A2, group IIC
chr1_+_144152864 0.706 TXNIP
thioredoxin interacting protein
chr17_+_24394281 0.699 PIPOX
pipecolic acid oxidase
chr1_-_181889070 0.695 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr22_-_35835548 0.693 TMPRSS6
transmembrane protease, serine 6
chr17_+_33867169 0.676 NM_020876
ARHGAP23
Rho GTPase activating protein 23
chr1_-_120285753 0.674 NOTCH2
notch 2
chr6_-_168222645 0.673 NM_024919
FRMD1
FERM domain containing 1
chr12_-_109842736 0.673 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr1_+_22200735 0.667 NM_005747
CELA3A
chymotrypsin-like elastase family, member 3A
chr19_+_18357966 0.667 NM_004864
GDF15
growth differentiation factor 15
chr13_-_25687062 0.663 RNF6
ring finger protein (C3H2C3 type) 6
chr7_+_142205266 0.662


chr4_-_9632192 0.658 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr6_-_31658044 0.655 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr12_-_192752 0.653 NM_003044
SLC6A12
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chrX_+_135079461 0.650 NM_001167819
FHL1
four and a half LIM domains 1
chr1_-_54861656 0.646 NM_176782
FAM151A
family with sequence similarity 151, member A
chr22_+_19651446 0.642 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr12_-_1791146 0.641 CACNA2D4
calcium channel, voltage-dependent, alpha 2/delta subunit 4
chr2_-_219404755 0.641 NM_017431
PRKAG3
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
chr7_-_72609458 0.637 BCL7B
B-cell CLL/lymphoma 7B
chr16_+_80086454 0.629 NM_030629
CMIP
c-Maf-inducing protein
chr7_-_72609804 0.625 BCL7B
B-cell CLL/lymphoma 7B
chr7_-_150352484 0.624 NM_173681
ATG9B
ATG9 autophagy related 9 homolog B (S. cerevisiae)
chr6_+_29799182 0.620 HLA-F
major histocompatibility complex, class I, F
chr1_-_23393808 0.617 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr6_+_30238961 0.616 NM_033229
TRIM15
tripartite motif containing 15
chr11_-_66245288 0.616 NM_006946
SPTBN2
spectrin, beta, non-erythrocytic 2
chrX_-_152844838 0.611 ARHGAP4
Rho GTPase activating protein 4
chr11_-_2517390 0.604


chrX_-_152844904 0.601 NM_001164741
NM_001666
ARHGAP4

Rho GTPase activating protein 4

chr6_+_29515694 0.601 NM_013941
OR10C1
olfactory receptor, family 10, subfamily C, member 1
chr20_-_7869068 0.600 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr7_-_42918013 0.599 NM_001099858
NM_024054
C7orf25

chromosome 7 open reading frame 25

chr16_+_82540172 0.598 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr1_+_3597092 0.598 NM_001126240
NM_001126241
NM_001126242
TP73


tumor protein p73


chr21_+_44818033 0.598 NM_198687
KRTAP10-4
keratin associated protein 10-4
chr19_-_14944729 0.595 NM_005071
SLC1A6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr3_-_184756101 0.593 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr3_-_140677990 0.593 NM_004164
RBP2
retinol binding protein 2, cellular
chr21_+_44530148 0.592 NM_000383
AIRE
autoimmune regulator
chr17_+_7753428 0.589 CHD3
chromodomain helicase DNA binding protein 3
chr1_+_43837096 0.589 PTPRF
protein tyrosine phosphatase, receptor type, F
chr12_+_52126131 0.586 PRR13
proline rich 13
chr17_+_3326045 0.585 NM_000049
ASPA
aspartoacylase
chr16_+_8722068 0.584 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr16_+_4546491 0.581 NM_001145011
LOC342346
hypothetical protein LOC342346
chr6_-_42798286 0.578 NM_000322
PRPH2
peripherin 2 (retinal degeneration, slow)
chr10_-_74384485 0.576 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr1_-_172153087 0.575 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr11_-_73397929 0.573 NM_003356
NM_022803
UCP3

uncoupling protein 3 (mitochondrial, proton carrier)

chr1_-_172153024 0.573 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr4_-_7487514 0.572 NM_001085382
PSAPL1
prosaposin-like 1 (gene/pseudogene)
chr7_+_150321771 0.572 NM_001160109
NM_001160110
NM_001160111
NOS3


nitric oxide synthase 3 (endothelial cell)


chr7_+_137411717 0.569 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr20_+_34937928 0.567 NM_080628
C20orf118
chromosome 20 open reading frame 118
chrX_+_152454773 0.566 NM_001001344
NM_021949
ATP2B3

ATPase, Ca++ transporting, plasma membrane 3

chr5_+_96237399 0.565 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr6_-_24985432 0.565 NM_015864
FAM65B
family with sequence similarity 65, member B
chr12_-_52015696 0.563 NM_152860
SP7
Sp7 transcription factor
chr17_+_35075124 0.561 NM_003673
TCAP
titin-cap (telethonin)
chr17_+_73638430 0.560 NM_152468
TMC8
transmembrane channel-like 8
chr8_+_22075112 0.560 NM_001172357
NM_001172410
NM_003018
SFTPC


surfactant protein C


chr11_+_4799126 0.559 NM_001004753
OR51F2
olfactory receptor, family 51, subfamily F, member 2
chr10_-_128199986 0.559 NM_001004298
C10orf90
chromosome 10 open reading frame 90
chr19_+_40716153 0.558 NM_014364
GAPDHS
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr14_-_59264044 0.556 NM_206857
RTN1
reticulon 1
chr11_+_73036241 0.554 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr8_-_142307854 0.553 NM_001080431
SLC45A4
solute carrier family 45, member 4
chrX_+_48803459 0.552 NM_001163322
NM_033626
NM_001163321
NM_001163323
CCDC120



coiled-coil domain containing 120



chr3_-_195553297 0.550 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr2_-_26717713 0.549 NM_001029881
CIB4
calcium and integrin binding family member 4
chr1_-_23567084 0.547 NM_030634
ZNF436
zinc finger protein 436
chr7_-_101059295 0.545 NM_138403
MYL10
myosin, light chain 10, regulatory
chr2_+_17861266 0.544 NM_001105569
MSGN1
mesogenin 1
chr4_-_185376012 0.544 NM_153343
ENPP6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr16_-_82830804 0.544 NM_172347
KCNG4
potassium voltage-gated channel, subfamily G, member 4
chr1_-_228916559 0.542 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr1_-_20122638 0.541 NM_014589
PLA2G2E
phospholipase A2, group IIE
chr11_-_62508946 0.541 NM_004790
NM_153276
NM_153277
NM_153278
SLC22A6



solute carrier family 22 (organic anion transporter), member 6



chr19_-_50506883 0.541 CKM
creatine kinase, muscle
chr2_+_95303947 0.541 PROM2
prominin 2
chr17_-_31332568 0.541 NM_004590
CCL16
chemokine (C-C motif) ligand 16
chr19_+_50086357 0.541 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr6_+_37081387 0.537 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr17_+_21249040 0.537 NM_001194958
KCNJ18
potassium inwardly-rectifying channel, subfamily J, member 18
chr22_+_35586950 0.536 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr1_+_1104939 0.535 NM_153254
TTLL10
tubulin tyrosine ligase-like family, member 10
chr19_+_4104593 0.532 NM_032607
CREB3L3
cAMP responsive element binding protein 3-like 3
chr5_-_9683462 0.531 NM_019599
TAS2R1
taste receptor, type 2, member 1
chr3_+_188043156 0.529 NM_001177800
NM_004797
ADIPOQ

adiponectin, C1Q and collagen domain containing

chr2_+_241193492 0.528 NM_001195381
NM_001195382
GPR35

G protein-coupled receptor 35

chr17_-_3766708 0.527 NM_002558
P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr2_+_73294852 0.526 NM_006062
SMYD5
SMYD family member 5
chr2_+_95326753 0.525 NM_013434
KCNIP3
Kv channel interacting protein 3, calsenilin
chr17_-_31369046 0.521 NM_005064
NM_145898
CCL23

chemokine (C-C motif) ligand 23

chr12_+_51783540 0.520 NM_003578
SOAT2
sterol O-acyltransferase 2
chr17_+_71229110 0.518 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr17_-_39822366 0.518 NM_000419
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr12_+_6424293 0.517 NM_001242
CD27
CD27 molecule
chr15_+_41672543 0.517 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr12_-_55637648 0.513 NM_003708
RDH16
retinol dehydrogenase 16 (all-trans)
chr16_+_29819647 0.512 NM_181718
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr2_-_25418856 0.511 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr19_-_56221681 0.510 NM_001136032
KLK11
kallikrein-related peptidase 11
chr13_+_112825113 0.510 NM_000504
F10
coagulation factor X
chr15_-_40173949 0.509 NM_178034
PLA2G4D
phospholipase A2, group IVD (cytosolic)
chr16_+_79829794 0.508 NM_017429
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr20_+_30831298 0.507 NM_175850
DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta
chr10_-_101831579 0.506 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr12_+_51783554 0.505 SOAT2
sterol O-acyltransferase 2
chr1_-_41259973 0.505 NM_001168247
NM_144990
SLFNL1

schlafen-like 1

chr1_+_158352143 0.505 NM_000702
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr3_+_188397967 0.501 NM_153708
RTP1
receptor (chemosensory) transporter protein 1
chr20_+_29492071 0.500 NM_153324
DEFB123
defensin, beta 123
chr1_+_3531410 0.500 NM_182752
TPRG1L
tumor protein p63 regulated 1-like
chr12_+_50981915 0.500 NM_002284
KRT86
keratin 86
chr5_-_141318810 0.500 NM_016580
PCDH12
protocadherin 12
chr3_-_46481346 0.499 NM_002343
LTF
lactotransferrin
chr10_-_74384569 0.499 PLA2G12B
phospholipase A2, group XIIB
chr3_-_42892636 0.498 NM_004391
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr6_+_32034559 0.498 NM_006929
SKIV2L
superkiller viralicidic activity 2-like (S. cerevisiae)
chr11_+_112763722 0.497 NM_178510
ANKK1
ankyrin repeat and kinase domain containing 1
chr8_-_143820825 0.495 NM_020427
SLURP1
secreted LY6/PLAUR domain containing 1
chr17_+_24394043 0.494 NM_016518
PIPOX
pipecolic acid oxidase
chr11_-_116199145 0.494 NM_000482
APOA4
apolipoprotein A-IV
chr11_+_5024331 0.492 NM_001001916
OR52J3
olfactory receptor, family 52, subfamily J, member 3
chr15_+_72892205 0.490 NM_021819
LMAN1L
lectin, mannose-binding, 1 like
chr1_-_9008990 0.490 NM_207420
SLC2A7
solute carrier family 2 (facilitated glucose transporter), member 7
chr7_+_27191534 0.490 HOXA11-AS1
HOXA11 antisense RNA 1 (non-protein coding)
chr7_+_101704145 0.489 CUX1
cut-like homeobox 1
chr19_+_51492136 0.489 NM_152795
HIF3A
hypoxia inducible factor 3, alpha subunit
chr19_-_55156118 0.488 NM_001135163
NM_052884
SIGLEC11

sialic acid binding Ig-like lectin 11


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.24 1.62e-03 GO:0042221 response to chemical stimulus
3.68 2.02e-02 GO:0006942 regulation of striated muscle contraction
2.29 3.35e-02 GO:0009746 response to hexose stimulus
2.26 4.46e-02 GO:0034284 response to monosaccharide stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.45 3.17e-05 GO:0005626 insoluble fraction
1.44 5.68e-05 GO:0005624 membrane fraction
1.33 9.60e-04 GO:0000267 cell fraction
1.08 1.47e-02 GO:0016020 membrane

Nothing significant found in function category.