Motif ID: IKZF1.p2

Z-value: 1.076


Transcription factors associated with IKZF1.p2:

Gene SymbolEntrez IDGene Name
IKZF1 10320 IKAROS family zinc finger 1 (Ikaros)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IKZF1chr7_+_503148010.302.6e-01Click!


Activity profile for motif IKZF1.p2.

activity profile for motif IKZF1.p2


Sorted Z-values histogram for motif IKZF1.p2

Sorted Z-values for motif IKZF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_95720870 1.779 LOC100288748
hypothetical LOC100288748
chr12_-_56447090 1.445 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr12_-_56445653 1.045 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr13_+_24152548 1.022 NM_001185085
NM_001676
ATP12A

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

chr15_+_38923470 1.013 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr11_+_118259684 0.910 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr17_-_34575939 0.891 NM_001143968
ARL5C
ADP-ribosylation factor-like 5C
chr4_-_155632317 0.778 NM_001142552
NM_001142553
DCHS2

dachsous 2 (Drosophila)

chr3_+_140148765 0.755 NM_001040061
C3orf72
chromosome 3 open reading frame 72
chr3_-_140148671 0.703 NM_023067
FOXL2
forkhead box L2
chr13_-_78075683 0.681 NM_006237
POU4F1
POU class 4 homeobox 1
chr12_+_39372456 0.655 NM_001843
NM_175038
CNTN1

contactin 1

chr16_-_1971180 0.630 NM_172167
NM_172168
NOXO1

NADPH oxidase organizer 1

chr12_-_52980914 0.621 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr5_-_54504590 0.617 NM_001145734
NM_001170402
NM_152623
CDC20B


cell division cycle 20 homolog B (S. cerevisiae)


chr22_+_38720881 0.614 NM_138435
FAM83F
family with sequence similarity 83, member F
chr4_-_155631861 0.561 DCHS2
dachsous 2 (Drosophila)
chr12_-_52980984 0.543 NM_001136023
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr9_+_86473273 0.541 NM_001018064
NM_006180
NTRK2

neurotrophic tyrosine kinase, receptor, type 2

chr17_+_7283412 0.516 NM_004112
FGF11
fibroblast growth factor 11
chr19_-_10558906 0.506 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr1_+_12627152 0.501 NM_001013630
AADACL4
arylacetamide deacetylase-like 4
chr22_-_45037882 0.498 NM_006071
PKDREJ
polycystic kidney disease (polycystin) and REJ homolog (sperm receptor for egg jelly homolog, sea urchin)
chr20_-_3097070 0.493 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr8_-_37916803 0.492 NM_152413
GOT1L1
glutamic-oxaloacetic transaminase 1-like 1
chr10_-_102880892 0.489 NM_001085398
TLX1NB
TLX1 neighbor
chr10_+_103976132 0.480 NM_152310
ELOVL3
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3
chr5_+_76284435 0.479 NM_001882
CRHBP
corticotropin releasing hormone binding protein
chr9_-_97319067 0.474 NM_001083602
NM_001083603
PTCH1

patched 1

chr2_+_120820140 0.473 NM_002193
INHBB
inhibin, beta B
chr1_-_71285847 0.473 NM_001126044
NM_198714
NM_198715
NM_198716
NM_198717
NM_198718
NM_198719
PTGER3






prostaglandin E receptor 3 (subtype EP3)






chr1_+_158603480 0.472 NM_005598
NHLH1
nescient helix loop helix 1
chr15_-_91432755 0.465 NM_001166287
RGMA
RGM domain family, member A
chr1_+_1971762 0.465 NM_002744
PRKCZ
protein kinase C, zeta
chr6_-_94185780 0.460 NM_004440
EPHA7
EPH receptor A7
chr19_+_12805747 0.455 MAST1
microtubule associated serine/threonine kinase 1
chr6_+_132901119 0.447 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr20_-_1113116 0.447 NM_018354
C20orf46
chromosome 20 open reading frame 46
chr1_+_117253882 0.445 NM_020440
PTGFRN
prostaglandin F2 receptor negative regulator
chr1_-_117011824 0.440 NM_001007237
NM_001542
IGSF3

immunoglobulin superfamily, member 3

chrX_+_21302317 0.436 NM_001168647
NM_001168648
NM_001168649
NM_014927
CNKSR2



connector enhancer of kinase suppressor of Ras 2



chr6_+_150505849 0.435 NM_030949
PPP1R14C
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr18_+_3441589 0.432 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr7_-_87774130 0.432 NM_024636
STEAP4
STEAP family member 4
chr9_+_17568952 0.428 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr2_-_108972100 0.427 NM_022336
EDAR
ectodysplasin A receptor
chr17_+_50333021 0.425 NM_005486
TOM1L1
target of myb1 (chicken)-like 1
chr3_-_171786468 0.424 NM_020949
SLC7A14
solute carrier family 7 (cationic amino acid transporter, y+ system), member 14
chr11_+_6216905 0.417 NM_001037329
CNGA4
cyclic nucleotide gated channel alpha 4
chr1_+_158636987 0.413 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr20_-_22978141 0.402 NM_000361
THBD
thrombomodulin
chr3_-_69517913 0.400 FRMD4B
FERM domain containing 4B
chr2_-_142605739 0.399 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr19_+_17843753 0.398 NM_000453
SLC5A5
solute carrier family 5 (sodium iodide symporter), member 5
chr14_+_80491461 0.395 NM_000369
NM_001018036
NM_001142626
TSHR


thyroid stimulating hormone receptor


chr2_+_47449790 0.391 NM_002354
EPCAM
epithelial cell adhesion molecule
chr2_-_108972048 0.390 EDAR
ectodysplasin A receptor
chr4_-_109308893 0.389 NM_001130713
NM_001130714
NM_016269
LEF1


lymphoid enhancer-binding factor 1


chr19_-_38408449 0.386 NM_019849
SLC7A10
solute carrier family 7, (neutral amino acid transporter, y+ system) member 10
chr5_-_35974493 0.386 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr9_+_99655227 0.379 NM_004473
FOXE1
forkhead box E1 (thyroid transcription factor 2)
chr10_-_21502993 0.377 NEBL
nebulette
chr17_+_41424665 0.369 MAPT
microtubule-associated protein tau
chr17_-_31281398 0.367 NM_001163122
NM_001163124
NM_001163125
NM_001163130
RDM1



RAD52 motif 1



chr7_-_75876830 0.367 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr10_-_97190885 0.367 NM_001034954
NM_001034955
NM_001034956
NM_001034957
NM_006434
SORBS1




sorbin and SH3 domain containing 1




chr17_-_3814334 0.366 NM_005173
NM_174953
NM_174954
NM_174955
NM_174956
NM_174957
NM_174958
ATP2A3






ATPase, Ca++ transporting, ubiquitous






chr17_+_7457988 0.365 SHBG
sex hormone-binding globulin
chr15_+_69626594 0.354 THSD4
thrombospondin, type I, domain containing 4
chr6_+_54281161 0.352 NM_014464
TINAG
tubulointerstitial nephritis antigen
chr19_+_19183763 0.348 NM_004386
NCAN
neurocan
chr11_+_71580816 0.347 NM_016729
FOLR1
folate receptor 1 (adult)
chr10_-_62163083 0.346 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr16_+_23101538 0.345 NM_001039
SCNN1G
sodium channel, nonvoltage-gated 1, gamma
chr12_-_56159631 0.340 NM_001080157
ARHGAP9
Rho GTPase activating protein 9
chr19_-_49523747 0.337 ZFP112
zinc finger protein 112 homolog (mouse)
chr2_-_100088760 0.337 AFF3
AF4/FMR2 family, member 3
chr10_+_102881050 0.336 NM_001195517
NM_005521
TLX1

T-cell leukemia homeobox 1

chr7_-_92693716 0.333 NM_001039372
HEPACAM2
HEPACAM family member 2
chr14_-_47213906 0.333 NM_001113498
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr11_-_57792206 0.331 NM_207374
OR10W1
olfactory receptor, family 10, subfamily W, member 1
chrX_+_122922058 0.329 NM_001042749
STAG2
stromal antigen 2
chr10_+_44726635 0.328 NM_001123376
TMEM72
transmembrane protein 72
chr1_+_153366559 0.325 EFNA1
ephrin-A1
chr8_-_132122016 0.322 NM_001115
ADCY8
adenylate cyclase 8 (brain)
chr14_-_64416307 0.319 SPTB
spectrin, beta, erythrocytic
chr5_+_180514548 0.317 NM_206880
OR2V2
olfactory receptor, family 2, subfamily V, member 2
chr19_+_60283571 0.314 NM_017729
EPS8L1
EPS8-like 1
chr11_+_45863774 0.314 NM_005456
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr19_+_447453 0.314 NM_130760
NM_130762
MADCAM1

mucosal vascular addressin cell adhesion molecule 1

chr10_-_21503025 0.312 NM_001173484
NM_213569
NEBL

nebulette

chr3_-_69518119 0.312 NM_015123
FRMD4B
FERM domain containing 4B
chr13_+_38159172 0.310 NM_207361
FREM2
FRAS1 related extracellular matrix protein 2
chr4_+_81325447 0.310 NM_020226
PRDM8
PR domain containing 8
chr19_-_11452439 0.309 NM_001420
NM_032281
ELAVL3

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)

chr5_-_95794416 0.309 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr7_-_22363036 0.308 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr16_-_31135895 0.307 NM_152901
PYDC1
PYD (pyrin domain) containing 1
chr2_-_104834344 0.307 LOC100506421
hypothetical LOC100506421
chr3_+_131547048 0.305 NM_153264
COL6A5
collagen, type VI, alpha 5
chr10_-_21826211 0.305 NM_001010911
C10orf114
chromosome 10 open reading frame 114
chr5_+_140690387 0.305 NM_018912
NM_031993
PCDHGA1

protocadherin gamma subfamily A, 1

chr18_-_26935883 0.299 NM_004949
NM_024422
DSC2

desmocollin 2

chr10_-_21826192 0.299 C10orf114
chromosome 10 open reading frame 114
chr3_+_35697432 0.297 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr14_+_78815406 0.297 NM_001105250
NM_138970
NRXN3

neurexin 3

chr17_-_57295451 0.296 NM_032043
BRIP1
BRCA1 interacting protein C-terminal helicase 1
chr17_+_45401560 0.293 NM_138281
DLX4
distal-less homeobox 4
chr20_+_41621079 0.291 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr3_-_185578621 0.289 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr20_+_19141364 0.287 SLC24A3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr14_+_23575460 0.287 NM_001082488
DHRS4L1
dehydrogenase/reductase (SDR family) member 4 like 1
chr15_-_38908197 0.286 NM_001130143
NM_017726
PPP1R14D

protein phosphatase 1, regulatory (inhibitor) subunit 14D

chr8_+_95722516 0.286 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr19_+_40431122 0.284 LSR
lipolysis stimulated lipoprotein receptor
chr17_-_53973177 0.283 NM_001198713
SEPT4
septin 4
chr9_+_8848130 0.283


chr21_+_42512271 0.283 NM_004915
NM_016818
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr8_+_95722575 0.283 ESRP1
epithelial splicing regulatory protein 1
chr9_-_33437527 0.282 NM_004925
AQP3
aquaporin 3 (Gill blood group)
chr11_+_22646229 0.282 NM_177553
GAS2
growth arrest-specific 2
chr7_-_16471817 0.280 NM_015464
SOSTDC1
sclerostin domain containing 1
chr19_+_1397268 0.279 APC2
adenomatosis polyposis coli 2
chr14_-_23107106 0.278 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr8_+_21956335 0.277 NM_003867
FGF17
fibroblast growth factor 17
chr17_-_37586716 0.277 NM_012285
KCNH4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr12_-_47545816 0.276 NM_014470
RND1
Rho family GTPase 1
chr7_-_126679540 0.275 NM_001127323
GRM8
glutamate receptor, metabotropic 8
chr10_+_94823636 0.275 NM_000783
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr20_+_41621119 0.273 SGK2
serum/glucocorticoid regulated kinase 2
chr17_+_7289564 0.272 CHRNB1
cholinergic receptor, nicotinic, beta 1 (muscle)
chr6_+_126112588 0.271 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr15_-_87679046 0.270 POLG
polymerase (DNA directed), gamma
chr9_+_33667169 0.268


chr15_-_40236061 0.266 NM_213600
PLA2G4F
phospholipase A2, group IVF
chr17_-_58877276 0.265 NM_001017916
NM_001915
CYB561

cytochrome b-561

chr7_+_156496360 0.264 LOC645249
hypothetical LOC645249
chr1_+_26389638 0.264 NM_198137
CATSPER4
cation channel, sperm associated 4
chr15_-_39593285 0.264 NM_001135685
NM_002344
NM_206961
LTK


leukocyte receptor tyrosine kinase


chr10_-_116154212 0.261 AFAP1L2
actin filament associated protein 1-like 2
chr3_+_143925904 0.259 NM_003304
TRPC1
transient receptor potential cation channel, subfamily C, member 1
chr11_-_10630408 0.259 NM_001098579
MRVI1
murine retrovirus integration site 1 homolog
chr10_-_21825879 0.258 C10orf114
chromosome 10 open reading frame 114
chr9_-_126573349 0.257 NM_001489
NM_033334
NR6A1

nuclear receptor subfamily 6, group A, member 1

chr1_-_2451543 0.256 NM_001010926
HES5
hairy and enhancer of split 5 (Drosophila)
chr4_+_81475897 0.256 NM_152770
C4orf22
chromosome 4 open reading frame 22
chr16_+_66128843 0.255 NM_001193524
FAM65A
family with sequence similarity 65, member A
chr18_+_46340400 0.255 NM_002747
MAPK4
mitogen-activated protein kinase 4
chr2_+_17585462 0.254 VSNL1
visinin-like 1
chr4_-_176970895 0.254 GPM6A
glycoprotein M6A
chr13_-_37341859 0.253 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr9_+_138810610 0.253 NM_001039374
KIAA1984
KIAA1984
chr20_+_13150417 0.252 NM_080826
ISM1
isthmin 1 homolog (zebrafish)
chr5_-_180560535 0.252 NM_203297
TRIM7
tripartite motif containing 7
chr12_-_49708279 0.251 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr8_+_124263932 0.250 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr2_-_72228427 0.250 NM_019885
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr19_-_19245022 0.248 NM_001001524
TM6SF2
transmembrane 6 superfamily member 2
chr5_-_131591380 0.246 NM_001017974
NM_001142598
NM_001142599
P4HA2


prolyl 4-hydroxylase, alpha polypeptide II


chr13_-_26232777 0.246 NM_005288
GPR12
G protein-coupled receptor 12
chr8_-_145881968 0.242 ARHGAP39
Rho GTPase activating protein 39
chr16_-_65510230 0.241 NM_004062
CDH16
cadherin 16, KSP-cadherin
chr12_+_52618815 0.240 NM_017410
HOXC13
homeobox C13
chr21_+_33364316 0.240 NM_138983
OLIG1
oligodendrocyte transcription factor 1
chr19_+_10242763 0.239 ICAM1
intercellular adhesion molecule 1
chr16_-_695719 0.238 NM_153350
FBXL16
F-box and leucine-rich repeat protein 16
chr22_-_29866339 0.238 NM_015715
PLA2G3
phospholipase A2, group III
chr8_-_79880095 0.237 NM_000880
IL7
interleukin 7
chr4_-_17392232 0.237 NM_015688
FAM184B
family with sequence similarity 184, member B
chr14_+_22422270 0.236 NM_173527
REM2
RAS (RAD and GEM)-like GTP binding 2
chr18_+_53865455 0.235 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr6_-_2696152 0.235 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr14_+_67069668 0.235 NM_020715
PLEKHH1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr1_-_1171964 0.234 NM_001014980
FAM132A
family with sequence similarity 132, member A
chr2_-_227372574 0.233 IRS1
insulin receptor substrate 1
chr20_+_44070946 0.232 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr11_+_3622933 0.231 NM_004314
ART1
ADP-ribosyltransferase 1
chr14_+_22845851 0.227 NM_004050
BCL2L2-PABPN1
BCL2L2
BCL2L2-PABPN1 read-through transcript
BCL2-like 2
chr11_+_63815348 0.227 NM_033310
KCNK4
potassium channel, subfamily K, member 4
chr12_-_53044495 0.225 NM_020370
GPR84
G protein-coupled receptor 84
chr13_-_45654296 0.223 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr4_-_176971175 0.223 NM_201591
GPM6A
glycoprotein M6A
chr20_-_24986501 0.223 ACSS1
acyl-CoA synthetase short-chain family member 1
chr13_-_98202884 0.222 NM_005073
SLC15A1
solute carrier family 15 (oligopeptide transporter), member 1
chr14_+_23527866 0.221 NM_198083
DHRS4
DHRS4L2
dehydrogenase/reductase (SDR family) member 4
dehydrogenase/reductase (SDR family) member 4 like 2
chr11_-_64582568 0.221 NM_005468
NAALADL1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr11_-_64484184 0.220 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr19_+_10388448 0.219 PDE4A
phosphodiesterase 4A, cAMP-specific
chr12_-_55168168 0.219 NM_013267
GLS2
glutaminase 2 (liver, mitochondrial)
chr18_-_6404900 0.218 NM_173464
L3MBTL4
l(3)mbt-like 4 (Drosophila)
chr19_+_60580015 0.217 NM_139172
TMEM190
transmembrane protein 190
chr1_-_27582368 0.216 NM_207397
CD164L2
CD164 sialomucin-like 2
chr17_+_35277942 0.215 NM_198844
NM_199321
ZPBP2

zona pellucida binding protein 2

chr3_+_32834513 0.213 NM_001039111
TRIM71
tripartite motif containing 71
chr17_-_24425342 0.212 TIAF1
TGFB1-induced anti-apoptotic factor 1
chr14_+_23508922 0.212 NM_001193636
NM_001193637
NM_001193635
DHRS4L2


DHRS4L1
dehydrogenase/reductase (SDR family) member 4 like 2


dehydrogenase/reductase (SDR family) member 4 like 1
chr9_-_34652629 0.211 NM_006664
CCL27
chemokine (C-C motif) ligand 27
chr22_+_36531246 0.211 H1F0
H1 histone family, member 0
chr16_+_55261226 0.210 NM_005951
MT1H
metallothionein 1H
chr10_+_105026773 0.210 NM_032727
INA
internexin neuronal intermediate filament protein, alpha

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.12 3.17e-10 GO:0009987 cellular process
1.14 7.71e-03 GO:0044237 cellular metabolic process
1.87 4.25e-02 GO:0051129 negative regulation of cellular component organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.13 1.02e-02 GO:0044444 cytoplasmic part
1.24 3.73e-02 GO:0005829 cytosol

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 5.55e-04 GO:0005515 protein binding
1.07 7.68e-03 GO:0005488 binding