Motif ID: NKX3-2.p2

Z-value: 1.857


Transcription factors associated with NKX3-2.p2:

Gene SymbolEntrez IDGene Name
NKX3-2 579 NK3 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX3-2chr4_-_13155135-0.214.4e-01Click!


Activity profile for motif NKX3-2.p2.

activity profile for motif NKX3-2.p2


Sorted Z-values histogram for motif NKX3-2.p2

Sorted Z-values for motif NKX3-2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_17585462 2.376 VSNL1
visinin-like 1
chr1_+_107484151 1.924 NM_001113226
NM_001113228
NM_014917
NTNG1


netrin G1


chr12_+_4253143 1.799 NM_001759
CCND2
cyclin D2
chr2_+_17585287 1.577 NM_003385
VSNL1
visinin-like 1
chr14_+_30098079 1.491 NM_017769
G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chr20_-_42249631 1.437 NM_020433
NM_175913
JPH2

junctophilin 2

chr20_+_51023159 1.358 TSHZ2
teashirt zinc finger homeobox 2
chr18_+_40514772 1.270 NM_015559
SETBP1
SET binding protein 1
chr2_-_24123726 1.209 NM_001142319
NM_025203
C2orf44

chromosome 2 open reading frame 44

chr2_-_70634129 1.200 NM_001099691
NM_003236
TGFA

transforming growth factor, alpha

chr1_+_107485071 1.114 NTNG1
netrin G1
chr5_+_56507029 1.090 NM_001127235
GPBP1
GC-rich promoter binding protein 1
chr2_+_201099093 1.062 NM_001160033
NM_001160046
NM_152524
SGOL2


shugoshin-like 2 (S. pombe)


chr14_-_22840249 1.058


chr14_+_22422270 1.057 NM_173527
REM2
RAS (RAD and GEM)-like GTP binding 2
chr8_+_120289735 1.024 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr4_-_84475328 0.980 NM_001166498
NM_006665
HPSE

heparanase

chr2_+_61986287 0.974 NM_152516
COMMD1
copper metabolism (Murr1) domain containing 1
chr9_-_205892 0.943 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr11_-_119499188 0.911 TRIM29
tripartite motif containing 29
chr2_+_63131466 0.879 NM_014562
OTX1
orthodenticle homeobox 1
chr11_+_116520181 0.862 NM_001184746
NM_001184747
NM_001184748
NM_002572
PAFAH1B2



platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)



chr2_-_220144254 0.860 OBSL1
obscurin-like 1
chr6_+_54819527 0.850 NM_001010872
FAM83B
family with sequence similarity 83, member B
chr10_+_96295511 0.841 NM_018063
HELLS
helicase, lymphoid-specific
chr20_-_33793507 0.839 RBM39
RNA binding motif protein 39
chr6_+_27464461 0.838 NM_001076781
ZNF391
zinc finger protein 391
chr2_-_220144511 0.827 NM_001173408
NM_001173431
NM_015311
OBSL1


obscurin-like 1


chr2_+_85665041 0.823 NM_006634
VAMP5
vesicle-associated membrane protein 5 (myobrevin)
chr3_-_137395966 0.820 NM_001145417
MSL2
male-specific lethal 2 homolog (Drosophila)
chr2_-_220144427 0.819 OBSL1
obscurin-like 1
chr14_-_23878871 0.808 NM_006871
RIPK3
receptor-interacting serine-threonine kinase 3
chr2_-_201082978 0.807 NM_152387
KCTD18
potassium channel tetramerisation domain containing 18
chr6_+_111409933 0.797 NM_032194
RPF2
ribosome production factor 2 homolog (S. cerevisiae)
chr2_+_101981888 0.782 NM_173343
IL1R2
interleukin 1 receptor, type II
chr20_+_2309553 0.775 NM_198994
TGM6
transglutaminase 6
chr19_-_10489111 0.759 NM_030760
S1PR5
sphingosine-1-phosphate receptor 5
chr19_-_6671585 0.757 NM_000064
C3
complement component 3
chr1_-_158182006 0.756 NM_001135050
NM_020789
IGSF9

immunoglobulin superfamily, member 9

chr1_+_199519202 0.751 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr6_-_49538810 0.745 NM_000255
MUT
methylmalonyl CoA mutase
chr2_+_218698980 0.724 NM_001557
CXCR2
chemokine (C-X-C motif) receptor 2
chr2_-_238861830 0.714 NM_022817
PER2
period homolog 2 (Drosophila)
chr8_-_122722674 0.714 NM_005328
HAS2
hyaluronan synthase 2
chr2_+_219141761 0.713 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr2_+_228386800 0.696 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr11_-_101906640 0.690 NM_002423
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr8_-_109868945 0.686 NM_153015
TMEM74
transmembrane protein 74
chr20_-_33793591 0.685 RBM39
RNA binding motif protein 39
chr11_-_64484184 0.676 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr14_-_20807346 0.673 NM_001077442
NM_001077443
NM_004500
NM_031314
HNRNPC



heterogeneous nuclear ribonucleoprotein C (C1/C2)



chr5_-_42847716 0.669 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr20_-_42249146 0.669 JPH2
junctophilin 2
chr1_+_156417302 0.661 CD1D
CD1d molecule
chr6_-_31658044 0.659 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr3_-_192063158 0.658 NM_001146686
GEMC1
geminin coiled-coil domain-containing protein 1
chr12_+_52618815 0.658 NM_017410
HOXC13
homeobox C13
chr2_+_183697327 0.657 NM_138285
NUP35
nucleoporin 35kDa
chr14_+_22305570 0.655 NM_005015
OXA1L
oxidase (cytochrome c) assembly 1-like
chr5_+_148501178 0.646 NM_014945
ABLIM3
actin binding LIM protein family, member 3
chr14_-_20636909 0.640 NM_001101672
ZNF219
zinc finger protein 219
chr1_+_216585298 0.637 NM_001135599
NM_003238
TGFB2

transforming growth factor, beta 2

chr8_+_102573837 0.636 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr6_-_134680888 0.626 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr2_-_27399405 0.621 NM_002437
MPV17
MpV17 mitochondrial inner membrane protein
chr17_-_57497380 0.620 NM_005121
MED13
mediator complex subunit 13
chr4_+_109761170 0.616 NM_000995
NM_033625
RPL34

ribosomal protein L34

chr18_+_50646616 0.610 NM_004163
RAB27B
RAB27B, member RAS oncogene family
chr2_+_54638957 0.609 NM_178313
SPTBN1
spectrin, beta, non-erythrocytic 1
chr1_+_78243181 0.608 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr1_+_234624266 0.606 NM_145861
EDARADD
EDAR-associated death domain
chr14_+_20636935 0.603 NM_001146683
C14orf176
chromosome 14 open reading frame 176
chr8_+_102574012 0.593 GRHL2
grainyhead-like 2 (Drosophila)
chr1_-_154665807 0.587 NM_006365
C1orf61
chromosome 1 open reading frame 61
chr2_+_68445936 0.586 PLEK
pleckstrin
chr5_-_180563945 0.582 NM_203294
NM_203295
NM_203296
TRIM7


tripartite motif containing 7


chr16_+_11978002 0.582 NM_032167
RUNDC2A
RUN domain containing 2A
chr15_+_56217686 0.579 NM_020980
AQP9
aquaporin 9
chr10_-_5436781 0.578 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3

chr12_-_49708279 0.577 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr2_-_37752731 0.575 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr4_+_169789327 0.574 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chr12_-_52980914 0.572 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr12_-_56447090 0.569 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr2_-_3360467 0.569 NM_003310
TSSC1
tumor suppressing subtransferable candidate 1
chr20_+_30161173 0.566 TM9SF4
transmembrane 9 superfamily protein member 4
chr14_-_20642214 0.563


chr17_-_58237742 0.561 NM_001100875
MARCH10
membrane-associated ring finger (C3HC4) 10
chr2_+_220033777 0.556 NM_001173476
SPEG
SPEG complex locus
chr4_-_84475023 0.555 HPSE
heparanase
chr20_-_60435983 0.554 NM_080833
C20orf151
chromosome 20 open reading frame 151
chr6_+_122973240 0.554 PKIB
protein kinase (cAMP-dependent, catalytic) inhibitor beta
chr4_+_169654742 0.552 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr2_-_148495642 0.551 NM_181742
ORC4
origin recognition complex, subunit 4
chr1_+_216586199 0.546 TGFB2
transforming growth factor, beta 2
chr10_-_123343761 0.544 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr5_+_174084137 0.541 NM_002449
MSX2
msh homeobox 2
chr2_+_148495043 0.541 NM_018328
MBD5
methyl-CpG binding domain protein 5
chr16_-_14695930 0.537 NM_003561
PLA2G10
phospholipase A2, group X
chr4_-_84474919 0.535 HPSE
heparanase
chr3_+_46894239 0.532 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr20_-_16501911 0.531 NM_024704
KIF16B
kinesin family member 16B
chr11_+_129823667 0.530 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr5_+_66160359 0.529 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr20_-_33793593 0.528 NM_004902
NM_184234
RBM39

RNA binding motif protein 39

chr3_+_120375053 0.518 NM_006952
UPK1B
uroplakin 1B
chr14_+_38714111 0.518 NM_002687
PNN
pinin, desmosome associated protein
chr10_-_116154212 0.517 AFAP1L2
actin filament associated protein 1-like 2
chr6_-_46997579 0.517 NM_001098518
GPR116
G protein-coupled receptor 116
chr16_-_80602546 0.517 NM_145168
SDR42E1
short chain dehydrogenase/reductase family 42E, member 1
chr18_+_27332024 0.516 NM_001943
DSG2
desmoglein 2
chr22_+_35586950 0.515 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr2_-_104834344 0.513 LOC100506421
hypothetical LOC100506421
chr14_-_23781328 0.512 TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr2_-_197499584 0.512 NM_024989
PGAP1
post-GPI attachment to proteins 1
chr12_-_52980984 0.511 NM_001136023
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr6_+_146961828 0.510 NM_024694
C6orf103
chromosome 6 open reading frame 103
chr4_+_8935987 0.509 NM_001105662
USP17L2
USP17L6P
USP17
ubiquitin specific peptidase 17-like 2
ubiquitin specific peptidase 17-like 6 (pseudogene)
ubiquitin specific peptidase 17
chr17_+_19999784 0.507 NM_001033554
NM_001033555
SPECC1

sperm antigen with calponin homology and coiled-coil domains 1

chr14_-_24115268 0.506 NM_001911
CTSG
cathepsin G
chr11_-_57054756 0.503 NM_012456
TIMM10
translocase of inner mitochondrial membrane 10 homolog (yeast)
chr16_-_31054563 0.499 NM_002773
PRSS8
protease, serine, 8
chr14_+_34831355 0.494 PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr14_-_23623657 0.493 NM_006177
NRL
neural retina leucine zipper
chr5_-_159730196 0.493 NM_031908
C1QTNF2
C1q and tumor necrosis factor related protein 2
chr3_+_185762233 0.489 NM_004443
EPHB3
EPH receptor B3
chr8_+_22075112 0.488 NM_001172357
NM_001172410
NM_003018
SFTPC


surfactant protein C


chr20_-_55719946 0.483 NM_199171
PMEPA1
prostate transmembrane protein, androgen induced 1
chr18_-_28304392 0.482 NM_022751
FAM59A
family with sequence similarity 59, member A
chr14_+_34831294 0.482 NM_002791
PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr22_-_22714230 0.477 NM_000853
GSTT1
glutathione S-transferase theta 1
chr2_-_223229006 0.471 NM_005687
FARSB
phenylalanyl-tRNA synthetase, beta subunit
chr3_+_77171938 0.470 NM_002942
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr15_+_38318528 0.470 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr1_-_17638797 0.470 NM_018715
RCC2
regulator of chromosome condensation 2
chr9_-_33437527 0.468 NM_004925
AQP3
aquaporin 3 (Gill blood group)
chr3_+_143797895 0.468 NM_001145319
PLS1
plastin 1
chr2_-_156897286 0.467 NM_006186
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr1_+_35020425 0.465 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr2_+_69093641 0.465 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr14_-_23874083 0.460 NM_001198568
NM_001198592
NM_139247
ADCY4


adenylate cyclase 4


chr7_+_134893185 0.458 NM_015135
NUP205
nucleoporin 205kDa
chr19_+_59061422 0.458 NM_001020820
MYADM
myeloid-associated differentiation marker
chr17_-_34575939 0.457 NM_001143968
ARL5C
ADP-ribosylation factor-like 5C
chr1_+_158636987 0.456 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr10_+_124310170 0.455 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr2_-_37727472 0.454 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr14_+_36200867 0.453 PAX9
paired box 9
chr5_+_118632316 0.452 NM_001077654
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr19_-_44214972 0.451 NM_178820
FBXO27
F-box protein 27
chr7_+_130445394 0.450 NM_001145354
MKLN1
muskelin 1, intracellular mediator containing kelch motifs
chr18_+_3584056 0.447 FLJ35776
hypothetical LOC649446
chr10_-_5035967 0.447 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr3_-_55490401 0.445 WNT5A
wingless-type MMTV integration site family, member 5A
chr2_-_158439868 0.444 NM_001105
ACVR1
activin A receptor, type I
chr4_-_171184003 0.442 NM_021647
MFAP3L
microfibrillar-associated protein 3-like
chr12_-_41269679 0.440 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr11_-_10630408 0.439 NM_001098579
MRVI1
murine retrovirus integration site 1 homolog
chr3_+_122769467 0.439 NM_001012659
ARGFX
arginine-fifty homeobox
chr2_+_32244406 0.438 NM_001193513
NM_001193514
NM_001193515
NM_017964
SLC30A6



solute carrier family 30 (zinc transporter), member 6



chr2_-_127694123 0.438 CYP27C1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr20_+_43531806 0.437 NM_006103
WFDC2
WAP four-disulfide core domain 2
chr2_-_178645718 0.433 NM_016953
PDE11A
phosphodiesterase 11A
chr6_+_49539049 0.432 NM_018132
CENPQ
centromere protein Q
chr6_-_52060327 0.432 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr4_-_84475024 0.431 HPSE
heparanase
chr2_+_68815416 0.428 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr6_-_157664464 0.427 C6orf35
chromosome 6 open reading frame 35
chr4_-_84475036 0.426 NM_001098540
HPSE
heparanase
chr11_+_93114365 0.425 NM_014039
C11orf54
chromosome 11 open reading frame 54
chr17_+_64922420 0.424 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr10_-_116154504 0.421 NM_001001936
NM_032550
AFAP1L2

actin filament associated protein 1-like 2

chr20_+_44083667 0.420 NM_001134771
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr6_+_26212082 0.417 NM_003542
HIST1H4C
histone cluster 1, H4c
chr2_-_201461945 0.416 NM_032472
NM_130906
PPIL3

peptidylprolyl isomerase (cyclophilin)-like 3

chr12_+_112071930 0.415 NM_001144872
CCDC42B
coiled-coil domain containing 42B
chr2_-_86418143 0.414 NM_001164731
NM_001164732
NM_022912
REEP1


receptor accessory protein 1


chr2_+_17861266 0.412 NM_001105569
MSGN1
mesogenin 1
chr2_+_201462294 0.410 NM_001136039
NM_001142355
NM_021824
NIF3L1


NIF3 NGG1 interacting factor 3-like 1 (S. pombe)


chr14_+_36200815 0.409 PAX9
paired box 9
chr5_+_118632403 0.407 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr17_+_78267868 0.406 NM_024619
FN3KRP
fructosamine 3 kinase related protein
chr17_-_57023322 0.406 NM_199290
NACA2
nascent polypeptide-associated complex alpha subunit 2
chr2_+_178986617 0.405


chr16_+_18903009 0.405 NM_001160364
TMC7
transmembrane channel-like 7
chr14_+_22633728 0.404 C14orf119
chromosome 14 open reading frame 119
chr12_+_52806103 0.404 LOC400043
hypothetical LOC400043
chr19_+_56766342 0.403 NM_007147
ZNF175
zinc finger protein 175
chr2_-_210798232 0.401 NM_001608
ACADL
acyl-CoA dehydrogenase, long chain
chr6_-_138935359 0.399 NM_020464
NHSL1
NHS-like 1
chr6_+_26359805 0.399 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr6_-_29824748 0.398 LOC285830
hypothetical LOC285830
chr21_+_42512271 0.398 NM_004915
NM_016818
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr20_-_57051231 0.397 NM_016045
SLMO2
slowmo homolog 2 (Drosophila)
chr2_+_28828332 0.396 PPP1CB
protein phosphatase 1, catalytic subunit, beta isozyme
chr18_+_27152049 0.396 NM_001942
DSG1
desmoglein 1
chr6_-_30820264 0.396 NM_003897
IER3
immediate early response 3
chr12_+_52689062 0.395 NM_022658
HOXC8
homeobox C8
chr3_-_172660545 0.395 NM_001161560
NM_001161561
NM_001161562
NM_001161563
NM_001161564
NM_001161565
NM_001161566
NM_015028
TNIK







TRAF2 and NCK interacting kinase







chr2_+_187163232 0.395 ITGAV
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.19 3.56e-07 GO:0044260 cellular macromolecule metabolic process
1.17 1.25e-06 GO:0043170 macromolecule metabolic process
1.08 3.01e-06 GO:0009987 cellular process
1.12 2.27e-05 GO:0008152 metabolic process
1.13 8.11e-05 GO:0044238 primary metabolic process
1.13 1.43e-04 GO:0044237 cellular metabolic process
1.23 2.69e-04 GO:0044267 cellular protein metabolic process
1.48 4.29e-03 GO:0016071 mRNA metabolic process
1.18 5.10e-03 GO:0019538 protein metabolic process
1.24 5.73e-03 GO:0010467 gene expression
1.27 2.63e-02 GO:0033036 macromolecule localization
1.21 3.77e-02 GO:0043412 macromolecule modification

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.09 3.31e-12 GO:0005622 intracellular
1.09 7.24e-12 GO:0044424 intracellular part
1.13 7.34e-10 GO:0005737 cytoplasm
1.09 8.39e-07 GO:0043229 intracellular organelle
1.09 1.04e-06 GO:0043226 organelle
1.10 2.83e-06 GO:0043231 intracellular membrane-bounded organelle
1.10 4.16e-06 GO:0043227 membrane-bounded organelle
1.14 6.41e-06 GO:0005634 nucleus
1.11 3.20e-03 GO:0044444 cytoplasmic part
1.15 3.99e-03 GO:0032991 macromolecular complex
1.25 1.50e-02 GO:0005654 nucleoplasm
1.15 1.90e-02 GO:0043234 protein complex
1.19 3.87e-02 GO:0031981 nuclear lumen
1.10 4.21e-02 GO:0044446 intracellular organelle part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 7.89e-09 GO:0005515 protein binding
1.06 2.18e-04 GO:0005488 binding
1.35 5.09e-03 GO:0003723 RNA binding