Motif ID: NR1H4.p2

Z-value: 1.663


Transcription factors associated with NR1H4.p2:

Gene SymbolEntrez IDGene Name
NR1H4 9971 nuclear receptor subfamily 1, group H, member 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR1H4chr12_+_99391870-0.292.8e-01Click!


Activity profile for motif NR1H4.p2.

activity profile for motif NR1H4.p2


Sorted Z-values histogram for motif NR1H4.p2

Sorted Z-values for motif NR1H4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR1H4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_40674883 1.596


chr1_+_12046020 1.419 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr16_+_1979959 1.220 NM_004209
SYNGR3
synaptogyrin 3
chr3_+_63238854 1.219 NM_001130003
SYNPR
synaptoporin
chr1_-_47468029 1.215 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr14_-_23623657 1.131 NM_006177
NRL
neural retina leucine zipper
chr12_-_7172641 1.014 NM_031491
RBP5
retinol binding protein 5, cellular
chr8_-_57521702 0.989 NM_001135690
PENK
proenkephalin
chr12_+_56299959 0.968 NM_133489
SLC26A10
solute carrier family 26, member 10
chr12_+_56802 0.960 NM_015232
IQSEC3
IQ motif and Sec7 domain 3
chr1_+_11749385 0.928 C1orf167
chromosome 1 open reading frame 167
chr12_-_56422120 0.843 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr7_+_45899080 0.842 IGFBP1
insulin-like growth factor binding protein 1
chr17_-_70367479 0.822 NM_000835
GRIN2C
glutamate receptor, ionotropic, N-methyl D-aspartate 2C
chr22_-_28041650 0.779 NM_001007279
NM_006477
RASL10A

RAS-like, family 10, member A

chr9_-_129557373 0.776 NM_001142534
NM_001142533
SH2D3C

SH2 domain containing 3C

chr13_-_99422163 0.772 NM_033132
ZIC5
Zic family member 5 (odd-paired homolog, Drosophila)
chr11_+_61389756 0.771 FADS2
fatty acid desaturase 2
chr1_-_27113018 0.766 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr3_+_50291521 0.758 NM_153215
C3orf45
chromosome 3 open reading frame 45
chr19_+_1022208 0.742 HMHA1
histocompatibility (minor) HA-1
chr3_-_127719283 0.738 NM_001165974
NM_144639
UROC1

urocanase domain containing 1

chr4_-_108176901 0.732 NM_014421
DKK2
dickkopf homolog 2 (Xenopus laevis)
chr22_-_49315341 0.729 NM_001113755
NM_001953
TYMP

thymidine phosphorylase

chr5_+_149549712 0.716 NM_014228
SLC6A7
solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
chr22_+_43451351 0.698 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr5_+_79366746 0.679 NM_003248
THBS4
thrombospondin 4
chr19_+_59077241 0.673 NM_002739
PRKCG
protein kinase C, gamma
chr19_+_4180494 0.671 NM_005755
EBI3
Epstein-Barr virus induced 3
chr16_-_2276875 0.670


chr11_-_64268126 0.668 NM_001098671
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr1_-_37272295 0.652 NM_000831
GRIK3
glutamate receptor, ionotropic, kainate 3
chr17_-_29930431 0.645 NM_207454
C17orf102
chromosome 17 open reading frame 102
chr20_-_3592045 0.640 NM_022139
NM_145762
GFRA4

GDNF family receptor alpha 4

chr5_+_149550003 0.625 SLC6A7
solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
chr12_-_52015696 0.622 NM_152860
SP7
Sp7 transcription factor
chr22_+_43451600 0.619 PRR5
proline rich 5 (renal)
chr3_-_148605996 0.618 NM_001168379
ZIC4
Zic family member 4
chr10_-_95350949 0.606 NM_006744
RBP4
retinol binding protein 4, plasma
chrX_+_151975518 0.600 PNMA3
paraneoplastic antigen MA3
chr17_-_42250961 0.596 NM_030753
WNT3
wingless-type MMTV integration site family, member 3
chr7_+_44045202 0.582 FLJ35390
hypothetical LOC255031
chr1_-_25619863 0.580 NM_020485
NM_138616
NM_138617
NM_138618
RHCE



RHD
Rh blood group, CcEe antigens



Rh blood group, D antigen
chr21_-_26867138 0.579 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr5_-_35266305 0.578 PRLR
prolactin receptor
chr10_+_112394094 0.576 NM_001134363
RBM20
RNA binding motif protein 20
chr12_-_56159631 0.576 NM_001080157
ARHGAP9
Rho GTPase activating protein 9
chr6_-_33016561 0.570 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr5_-_35266550 0.560 NM_000949
PRLR
prolactin receptor
chr11_-_6633427 0.560 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr20_+_35964962 0.557 VSTM2L
V-set and transmembrane domain containing 2 like
chr3_+_52803823 0.556 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chr12_+_58369392 0.546 NM_004731
SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr15_-_76700174 0.546 CHRNA3
cholinergic receptor, nicotinic, alpha 3
chr1_+_32512298 0.544 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr9_-_37024358 0.533 NM_016734
PAX5
paired box 5
chr2_+_73294852 0.523 NM_006062
SMYD5
SMYD family member 5
chr11_-_116168316 0.522 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chrX_+_151975421 0.511 NM_013364
PNMA3
paraneoplastic antigen MA3
chr17_+_71097147 0.511 MYO15B
myosin XVB pseudogene
chrX_+_102918453 0.509 PLP1
proteolipid protein 1
chr14_-_73962557 0.501 NM_001105579
TMEM90A
transmembrane protein 90A
chr19_+_10424581 0.496 NM_006202
PDE4A
phosphodiesterase 4A, cAMP-specific
chr17_-_71535076 0.489 NM_001988
EVPL
envoplakin
chr8_-_71146022 0.484 PRDM14
PR domain containing 14
chr10_+_46413551 0.474 NM_014696
GPRIN2
G protein regulated inducer of neurite outgrowth 2
chr15_+_45263517 0.473 NM_001198999
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr6_+_96132064 0.469 NM_024641
MANEA
mannosidase, endo-alpha
chr9_+_83733162 0.466 NM_001145197
FAM75D4
family with sequence similarity 75, member D4
chr1_+_150902495 0.461 NM_178430
LCE2D
late cornified envelope 2D
chr2_+_176724583 0.458


chr1_-_25128951 0.457 RUNX3
runt-related transcription factor 3
chr17_-_35017691 0.444 NM_006160
NEUROD2
neurogenic differentiation 2
chr20_+_35964912 0.442 NM_080607
VSTM2L
V-set and transmembrane domain containing 2 like
chrX_-_106033202 0.438 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chr16_+_273118 0.437 NM_006849
PDIA2
protein disulfide isomerase family A, member 2
chr1_-_25129354 0.431 NM_004350
RUNX3
runt-related transcription factor 3
chr3_+_123779122 0.429 NM_001113523
PARP15
poly (ADP-ribose) polymerase family, member 15
chr6_-_96131974 0.422


chr8_-_71146103 0.421 NM_024504
PRDM14
PR domain containing 14
chr2_+_176724358 0.418 NM_014621
HOXD4
homeobox D4
chr17_+_7474128 0.418 SHBG
sex hormone-binding globulin
chr5_-_59225377 0.417 NM_001104631
PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_-_35017650 0.416 NEUROD2
neurogenic differentiation 2
chr17_+_18796202 0.416 NM_001042450
NM_152351
SLC5A10

solute carrier family 5 (sodium/glucose cotransporter), member 10

chr17_+_2627099 0.415 RAP1GAP2
RAP1 GTPase activating protein 2
chr1_+_32489426 0.414 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr14_-_90780604 0.412 NM_001177676
GPR68
G protein-coupled receptor 68
chr6_-_85529031 0.411 TBX18
T-box 18
chr5_-_95774444 0.405 NM_001177876
PCSK1
proprotein convertase subtilisin/kexin type 1
chr8_+_21938299 0.402 NM_182795
NPM2
nucleophosmin/nucleoplasmin 2
chrX_+_106336517 0.399 NM_001169154
NM_173494
CXorf41

chromosome X open reading frame 41

chr3_+_188043172 0.398 ADIPOQ
adiponectin, C1Q and collagen domain containing
chr7_+_150376537 0.397 NM_004769
NM_020321
NM_020322
ACCN3


amiloride-sensitive cation channel 3


chr19_+_7647934 0.397 NM_174918
C19orf59
chromosome 19 open reading frame 59
chr17_+_38166759 0.396 RAMP2
receptor (G protein-coupled) activity modifying protein 2
chrX_-_111953009 0.394 NM_001113490
AMOT
angiomotin
chr1_-_158306570 0.394 NM_002241
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chr2_-_21079145 0.389 APOB
apolipoprotein B (including Ag(x) antigen)
chr17_+_77910411 0.386 NM_207459
TEX19
testis expressed 19
chr8_+_110443881 0.384 NM_177531
PKHD1L1
polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1
chr3_+_188043156 0.381 NM_001177800
NM_004797
ADIPOQ

adiponectin, C1Q and collagen domain containing

chr15_+_41672543 0.379 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr9_+_83748234 0.378 NM_207416
FAM75D3
family with sequence similarity 75, member D3
chr3_-_129777618 0.375 NM_007354
C3orf27
chromosome 3 open reading frame 27
chr17_+_7474177 0.369 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr17_+_18588050 0.369 NM_031456
FBXW10
CDRT1
F-box and WD repeat domain containing 10
CMT1A duplicated region transcript 1
chr11_+_92342436 0.368 NM_005959
MTNR1B
melatonin receptor 1B
chr17_-_71534906 0.368 EVPL
envoplakin
chr6_+_31662954 0.367 NM_001166538
NM_007161
NM_205840
LST1


leukocyte specific transcript 1


chr13_+_32488477 0.363 NM_004795
KL
klotho
chrX_-_132377087 0.363 GPC4
glypican 4
chr22_-_29231597 0.357 NM_001161368
NM_174977
SEC14L4

SEC14-like 4 (S. cerevisiae)

chr19_+_531666 0.355 BSG
basigin (Ok blood group)
chr11_+_75106512 0.355 NM_025098
MOGAT2
monoacylglycerol O-acyltransferase 2
chr11_+_60391590 0.355 NM_207341
ZP1
zona pellucida glycoprotein 1 (sperm receptor)
chr2_+_220087135 0.354 NM_018674
NM_182847
ACCN4

amiloride-sensitive cation channel 4, pituitary

chr20_+_30103642 0.354 NM_001172129
NM_001172130
NM_001172131
NM_001172132
NM_001172133
NM_002110
HCK





hemopoietic cell kinase





chr6_-_85529884 0.352 TBX18
T-box 18
chr17_-_19592178 0.351 NM_000691
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr11_-_57054756 0.350 NM_012456
TIMM10
translocase of inner mitochondrial membrane 10 homolog (yeast)
chr7_-_37454933 0.349 NM_014800
ELMO1
engulfment and cell motility 1
chr1_+_45046740 0.349 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr1_-_25129305 0.346 RUNX3
runt-related transcription factor 3
chr4_-_170915602 0.345 NM_017867
C4orf27
chromosome 4 open reading frame 27
chrX_-_151996613 0.343 NM_032882
PNMA6A
paraneoplastic antigen like 6A
chr9_+_83793506 0.341 NM_001001670
FAM75D1
family with sequence similarity 75, member D1
chrX_-_21686079 0.340 NM_014332
SMPX
small muscle protein, X-linked
chr3_+_46717826 0.339 NM_147196
TMIE
transmembrane inner ear
chr3_+_48388712 0.333 NM_001159927
NM_001159929
NM_207102
FBXW12


F-box and WD repeat domain containing 12


chrX_-_106336199 0.333 NM_017681
NUP62CL
nucleoporin 62kDa C-terminal like
chr13_+_30404809 0.332 NM_152325
C13orf26
chromosome 13 open reading frame 26
chr8_-_37941970 0.331 ADRB3
adrenergic, beta-3-, receptor
chr11_+_61276576 0.330 NM_001127392
C11orf9
chromosome 11 open reading frame 9
chr8_+_134272463 0.330 NM_003882
NM_080838
WISP1

WNT1 inducible signaling pathway protein 1

chr7_+_49783774 0.327 NM_198570
VWC2
von Willebrand factor C domain containing 2
chr19_-_40995564 0.327 PRODH2
proline dehydrogenase (oxidase) 2
chr22_-_29290875 0.323 NM_004861
GAL3ST1
galactose-3-O-sulfotransferase 1
chr3_+_123385870 0.322 NM_001178065
CASR
calcium-sensing receptor
chr19_-_11550765 0.321 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr1_+_45565126 0.320 NM_032756
HPDL
4-hydroxyphenylpyruvate dioxygenase-like
chr8_+_103633023 0.319 NM_024410
ODF1
outer dense fiber of sperm tails 1
chr22_+_23329113 0.314 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr4_+_100957003 0.313 NM_014395
DAPP1
dual adaptor of phosphotyrosine and 3-phosphoinositides
chr20_-_22512893 0.312 FOXA2
forkhead box A2
chr2_+_219432789 0.308 NM_006522
WNT6
wingless-type MMTV integration site family, member 6
chr18_-_55136673 0.304 NM_181654
CPLX4
complexin 4
chr1_+_29086206 0.301 EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr11_+_74539679 0.301 NM_001145212
NM_007256
SLCO2B1

solute carrier organic anion transporter family, member 2B1

chrX_-_153397566 0.300 NM_001171132
NM_001171133
NM_001171134
NM_021806
FAM3A



family with sequence similarity 3, member A



chr19_-_56567602 0.297 NM_005601
NKG7
natural killer cell group 7 sequence
chr3_-_148604760 0.294 NM_001168378
ZIC4
Zic family member 4
chr7_+_26298136 0.294 SNX10
sorting nexin 10
chr1_-_150070849 0.294 NM_005060
RORC
RAR-related orphan receptor C
chr20_+_34357604 0.294 DLGAP4
discs, large (Drosophila) homolog-associated protein 4
chr20_-_3097070 0.291 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr11_+_22646229 0.290 NM_177553
GAS2
growth arrest-specific 2
chr16_+_51690564 0.290 CHD9
chromodomain helicase DNA binding protein 9
chr1_+_154816142 0.289 NM_001105669
TTC24
tetratricopeptide repeat domain 24
chr17_-_8006979 0.285 NM_014232
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr3_-_181237210 0.284 NM_016559
PEX5L
peroxisomal biogenesis factor 5-like
chr16_+_65552600 0.283 NM_001185177
NM_024922
CES3

carboxylesterase 3

chr1_+_25471470 0.282 NM_001127691
NM_016124
RHD

Rh blood group, D antigen

chr22_-_28041474 0.281 RASL10A
RAS-like, family 10, member A
chr5_+_133478252 0.280 NM_003202
TCF7
transcription factor 7 (T-cell specific, HMG-box)
chr17_-_38166800 0.278 LOC100190938
hypothetical LOC100190938
chr19_-_11550576 0.278 NM_001111034
ACP5
acid phosphatase 5, tartrate resistant
chr19_-_17377383 0.277 NM_004335
BST2
bone marrow stromal cell antigen 2
chr11_-_117628211 0.277 NM_198275
MPZL3
myelin protein zero-like 3
chrX_+_77041612 0.274 NM_001866
COX7B
cytochrome c oxidase subunit VIIb
chr9_-_115880366 0.272 AMBP
alpha-1-microglobulin/bikunin precursor
chrX_-_132947290 0.271 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chr16_+_52081836 0.271 RBL2
retinoblastoma-like 2 (p130)
chr9_-_66233945 0.270


chr14_+_23095028 0.269 NM_001126339
NM_024328
THTPA

thiamine triphosphatase

chr16_+_25135783 0.267 NM_001169
AQP8
aquaporin 8
chr1_-_205186330 0.265 NM_002644
PIGR
polymeric immunoglobulin receptor
chr1_+_152560179 0.264 NM_080429
AQP10
aquaporin 10
chr1_+_29086156 0.264 NM_001166005
NM_001166007
NM_004437
NM_203342
NM_203343
EPB41




erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)




chr2_-_25048276 0.264 NM_001198559
NM_016544
DNAJC27

DnaJ (Hsp40) homolog, subfamily C, member 27

chr16_+_23754997 0.264 PRKCB
protein kinase C, beta
chr2_+_192251105 0.263 NM_001031716
OBFC2A
oligonucleotide/oligosaccharide-binding fold containing 2A
chr16_-_28425632 0.262 NM_145659
IL27
interleukin 27
chr7_-_100092003 0.261 NM_016188
ACTL6B
actin-like 6B
chr20_-_43767069 0.259 NM_172006
NM_172131
WFDC10B

WAP four-disulfide core domain 10B

chr12_-_56200547 0.259 NM_001195053
NM_001195054
NM_001195055
NM_001195056
NM_001195057
NM_004083
DDIT3





DNA-damage-inducible transcript 3





chr6_+_53991672 0.259 NM_138569
C6orf142
chromosome 6 open reading frame 142
chr14_-_56342097 0.258 NM_172337
OTX2
orthodenticle homeobox 2
chr16_+_23754822 0.257 PRKCB
protein kinase C, beta
chr6_+_30082331 0.256 HLA-J
major histocompatibility complex, class I, J (pseudogene)
chr7_+_7646840 0.255 LOC729852
hypothetical LOC729852
chr15_+_79304694 0.254 NM_172217
IL16
interleukin 16 (lymphocyte chemoattractant factor)
chr16_+_23754772 0.253 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr17_-_15463742 0.253 NM_006382
CDRT1
CMT1A duplicated region transcript 1
chr5_-_22248630 0.252 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr9_-_85342868 0.250 NM_174938
FRMD3
FERM domain containing 3
chr16_-_70080678 0.248 NM_006961
ZNF19
zinc finger protein 19
chr1_-_99242765 0.247 NM_001010861
NM_001037317
LPPR5

lipid phosphate phosphatase-related protein type 5

chrX_-_71709622 0.246 NM_001166418
NM_001166419
NM_001166420
NM_001166422
NM_001166448
NM_018486
HDAC8





histone deacetylase 8





chr7_-_100091912 0.243 ACTL6B
actin-like 6B

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.15 6.26e-04 GO:0065007 biological regulation
1.15 1.06e-03 GO:0050789 regulation of biological process
1.15 7.62e-03 GO:0050794 regulation of cellular process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.66 1.74e-02 GO:0003823 antigen binding