Motif ID: ADNP_IRX_SIX_ZHX.p2

Z-value: 1.328


Transcription factors associated with ADNP_IRX_SIX_ZHX.p2:

Gene SymbolEntrez IDGene Name
ADNP 23394 activity-dependent neuroprotector homeobox
IRX4 50805 iroquois homeobox 4
IRX5 10265 iroquois homeobox 5
SIX2 10736 SIX homeobox 2
SIX5 147912 SIX homeobox 5
ZHX1 11244 zinc fingers and homeoboxes 1
ZHX2 22882 zinc fingers and homeoboxes 2
ZHX3 23051 zinc fingers and homeoboxes 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IRX5chr16_+_53522611-0.302.5e-01Click!
ADNPchr20_-_489808580.263.3e-01Click!
IRX4chr5_-_1935764-0.253.4e-01Click!
ZHX2chr8_+_1238631690.204.5e-01Click!
ZHX3chr20_-_39379533-0.204.6e-01Click!
SIX2chr2_-_45090025-0.175.4e-01Click!
ZHX1chr8_-_124355670-0.097.3e-01Click!
SIX5chr19_-_50964336-0.058.6e-01Click!


Activity profile for motif ADNP_IRX_SIX_ZHX.p2.

activity profile for motif ADNP_IRX_SIX_ZHX.p2


Sorted Z-values histogram for motif ADNP_IRX_SIX_ZHX.p2

Sorted Z-values for motif ADNP_IRX_SIX_ZHX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ADNP_IRX_SIX_ZHX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_556968 1.806


chr6_+_12398514 1.670 NM_001168319
NM_001955
EDN1

endothelin 1

chr6_+_21701942 1.590 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr11_+_113280727 1.418 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr2_-_87102453 1.332 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr6_+_167445284 1.270 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr6_+_29249289 1.178 NM_030905
OR2J2
olfactory receptor, family 2, subfamily J, member 2
chr15_+_47502666 1.175 NM_002009
FGF7
fibroblast growth factor 7
chr4_+_74520796 1.137 NM_001134
AFP
alpha-fetoprotein
chr6_+_155579788 1.074 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr6_-_89984214 1.048 NM_002042
GABRR1
gamma-aminobutyric acid (GABA) receptor, rho 1
chr7_+_129771865 1.013 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr1_+_198263352 0.971 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr1_+_557269 0.941


chr12_+_54172413 0.916 NM_001005519
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chr2_-_131073329 0.866 NM_032545
NM_001079530
CFC1
CFC1B
cripto, FRL-1, cryptic family 1
cripto, FRL-1, cryptic family 1B
chr3_-_33675484 0.850 CLASP2
cytoplasmic linker associated protein 2
chr1_-_155936904 0.844 NM_052939
FCRL3
Fc receptor-like 3
chr4_-_79322295 0.840


chr2_+_166137091 0.833 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr6_+_29534109 0.826 NM_030883
OR2H1
olfactory receptor, family 2, subfamily H, member 1
chr4_+_120029426 0.799 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr8_-_82536312 0.786 NM_001080526
FABP9
fatty acid binding protein 9, testis
chr21_-_38792173 0.782 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr2_+_178893216 0.770 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr17_+_3324096 0.767 NM_001128085
ASPA
aspartoacylase
chr6_+_36752244 0.767 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr5_+_73145098 0.765 RGNEF
190 kDa guanine nucleotide exchange factor
chr2_-_69033515 0.759 NM_182536
GKN2
gastrokine 2
chr8_-_49996353 0.753 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr12_+_100394787 0.745 NM_152323
SPIC
Spi-C transcription factor (Spi-1/PU.1 related)
chr12_-_25041639 0.738 NM_001101339
C12orf77
chromosome 12 open reading frame 77
chr5_-_37220702 0.730 C5orf42
chromosome 5 open reading frame 42
chr1_+_63861474 0.718 NM_001172818
PGM1
phosphoglucomutase 1
chr11_-_16454493 0.711 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr6_+_161043214 0.706 NM_000301
NM_001168338
PLG

plasminogen

chr12_-_103846186 0.703 NM_032148
SLC41A2
solute carrier family 41, member 2
chr10_+_77212524 0.686 NM_032024
C10orf11
chromosome 10 open reading frame 11
chr6_+_46869052 0.677 NM_005588
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr2_-_21081694 0.673 APOB
apolipoprotein B (including Ag(x) antigen)
chr4_-_77547481 0.669 NM_001042784
CCDC158
coiled-coil domain containing 158
chr2_-_180135559 0.665 NM_001113398
ZNF385B
zinc finger protein 385B
chr22_+_21116283 0.658


chr7_-_91632525 0.648 NM_001161528
LOC401387
leucine-rich repeat and death domain-containing protein
chr16_+_7322751 0.643 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr8_+_92330691 0.638 NM_052832
NM_134266
SLC26A7

solute carrier family 26, member 7

chr18_+_27210737 0.637 NM_001134453
NM_177986
DSG4

desmoglein 4

chr1_-_205012348 0.635 NM_000572
IL10
interleukin 10
chr4_-_152366970 0.634 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr1_-_115039614 0.605 NM_000036
NM_001172626
AMPD1

adenosine monophosphate deaminase 1

chr2_+_130995136 0.605 NM_032545
NM_001079530
CFC1
CFC1B
cripto, FRL-1, cryptic family 1
cripto, FRL-1, cryptic family 1B
chr5_-_124108672 0.602 NM_020747
ZNF608
zinc finger protein 608
chr6_+_49575629 0.599 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr9_+_101628829 0.597 NM_173200
NR4A3
nuclear receptor subfamily 4, group A, member 3
chr5_+_55182963 0.590 NM_139017
IL31RA
interleukin 31 receptor A
chr6_-_2580296 0.588 NM_152554
C6orf195
chromosome 6 open reading frame 195
chr6_+_158990982 0.583 NM_001009991
SYTL3
synaptotagmin-like 3
chr1_+_109057078 0.575 NM_001144937
FNDC7
fibronectin type III domain containing 7
chr3_-_152403636 0.575 NM_013308
GPR171
G protein-coupled receptor 171
chr6_-_29163027 0.574 NM_001005226
OR2B3
olfactory receptor, family 2, subfamily B, member 3
chr1_+_13903936 0.572 NM_012231
NM_015866
PRDM2

PR domain containing 2, with ZNF domain

chr10_-_85975263 0.564 NM_001017924
LRIT2
leucine-rich repeat, immunoglobulin-like and transmembrane domains 2
chr6_-_42527760 0.559 NM_033502
TRERF1
transcriptional regulating factor 1
chr10_+_118370441 0.554 NM_005396
PNLIPRP2
pancreatic lipase-related protein 2
chr11_-_8921155 0.552 NM_020646
ASCL3
achaete-scute complex homolog 3 (Drosophila)
chr16_+_20370359 0.551 NM_001010845
ACSM2A
acyl-CoA synthetase medium-chain family member 2A
chr14_-_89155078 0.547 NM_001085471
FOXN3
forkhead box N3
chr3_-_69254226 0.547 NM_198271
LMOD3
leiomodin 3 (fetal)
chr1_+_242281175 0.546 NM_205768
ZNF238
zinc finger protein 238
chr6_+_12825818 0.542 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr7_+_113853790 0.539 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr17_+_25292748 0.529 NM_198529
EFCAB5
EF-hand calcium binding domain 5
chrX_+_7147471 0.526 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr5_+_110435288 0.517 NM_033035
TSLP
thymic stromal lymphopoietin
chr17_+_59875623 0.517 NM_001085423
C17orf60
chromosome 17 open reading frame 60
chr12_+_8557402 0.517 NM_080387
CLEC4D
C-type lectin domain family 4, member D
chr1_+_17779528 0.517 NM_001011722
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr1_-_163680941 0.514 NM_006917
RXRG
retinoid X receptor, gamma
chr1_-_42738535 0.502 TMSB4XP1
thymosin beta 4, X-linked pseudogene 1
chrX_+_135058402 0.495 NM_001159700
FHL1
four and a half LIM domains 1
chr5_-_88235624 0.490 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr2_-_207738858 0.488 NM_003709
KLF7
Kruppel-like factor 7 (ubiquitous)
chr22_+_21006814 0.485


chr3_-_152541129 0.478 NM_176876
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr7_-_30032649 0.477 NM_017946
FKBP14
FK506 binding protein 14, 22 kDa
chr21_+_38550739 0.477 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr6_+_7524691 0.475 DSP
desmoplakin
chr11_+_120478584 0.475 NM_005422
TECTA
tectorin alpha
chr3_+_3056307 0.471 NM_175612
CNTN4
contactin 4
chr7_+_89870647 0.470 NM_001185072
NM_001185073
NM_012129
CLDN12


claudin 12


chr1_+_205344200 0.470 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr9_+_117955890 0.469 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr1_+_203106600 0.469 NFASC
neurofascin
chr6_-_29120930 0.468 NM_030903
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chr7_-_135083906 0.468 NM_205855
FAM180A
family with sequence similarity 180, member A
chr2_+_33592445 0.464 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr3_+_162697289 0.462 NM_001080440
OTOL1
otolin 1 homolog (zebrafish)
chr15_+_46285789 0.462 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr9_+_102380156 0.462 NM_001018116
MURC
muscle-related coiled-coil protein
chr3_+_46386636 0.458 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr8_+_128497038 0.451 NM_001159542
POU5F1B
POU class 5 homeobox 1B
chr17_-_61655915 0.445 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr7_+_129693938 0.445 NM_001869
CPA2
carboxypeptidase A2 (pancreatic)
chr6_+_167624792 0.445 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr4_+_54790020 0.444 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr11_-_5946299 0.443 NM_001146033
OR56A5
olfactory receptor, family 56, subfamily A, member 5
chr4_-_72868598 0.442 NM_000583
GC
group-specific component (vitamin D binding protein)
chr11_-_62668268 0.440 NM_001136506
SLC22A24
solute carrier family 22, member 24
chr7_-_25234582 0.440 NM_022150
NPVF
neuropeptide VF precursor
chr11_-_85107569 0.439 NM_206929
SYTL2
synaptotagmin-like 2
chr15_+_91244422 0.432 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr2_-_183095308 0.431 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr17_-_36209672 0.422 NM_181535
KRT28
keratin 28
chr6_+_25760352 0.422 NM_006998
SCGN
secretagogin, EF-hand calcium binding protein
chr9_-_124280025 0.421 NM_001004451
OR1J1
olfactory receptor, family 1, subfamily J, member 1
chr11_-_4924905 0.418 NM_001005329
OR51A4
olfactory receptor, family 51, subfamily A, member 4
chr15_+_91244563 0.417 CHD2
chromodomain helicase DNA binding protein 2
chr13_+_97856148 0.414


chr7_+_94953148 0.414 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr5_-_134290789 0.413


chr7_+_150077756 0.411 NM_001162367
LOC100128542
hypothetical protein LOC100128542
chr6_+_144654565 0.405 NM_007124
UTRN
utrophin
chr1_+_203204667 0.405 NFASC
neurofascin
chr1_-_197173159 0.404 LOC100131234
familial acute myelogenous leukemia related factor
chr10_-_69736600 0.403 PBLD
phenazine biosynthesis-like protein domain containing
chr17_-_52248248 0.401 NM_001085430
C17orf67
chromosome 17 open reading frame 67
chr7_+_128136347 0.401 FAM71F1
family with sequence similarity 71, member F1
chr4_-_47678187 0.400 NM_001142564
CNGA1
cyclic nucleotide gated channel alpha 1
chr7_-_126670804 0.399 NM_000845
GRM8
glutamate receptor, metabotropic 8
chr12_-_51360439 0.396 NM_006121
KRT1
keratin 1
chr6_-_49820030 0.395 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chr9_-_122679283 0.393 PHF19
PHD finger protein 19
chr7_+_89870707 0.392 CLDN12
claudin 12
chr1_+_168898898 0.392 PRRX1
paired related homeobox 1
chr6_-_25982418 0.390 NM_001098486
NM_006632
SLC17A3

solute carrier family 17 (sodium phosphate), member 3

chr5_-_125956996 0.389 ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr7_-_99312591 0.389 NM_001005276
OR2AE1
olfactory receptor, family 2, subfamily AE, member 1
chr17_-_36376663 0.389 NM_213656
KRT39
keratin 39
chr2_+_158666627 0.389 NM_173355
UPP2
uridine phosphorylase 2
chr3_+_99484421 0.388 NM_001005482
OR5H2
olfactory receptor, family 5, subfamily H, member 2
chr1_+_115373937 0.387 NM_000549
TSHB
thyroid stimulating hormone, beta
chr2_-_198248828 0.386 NM_144629
RFTN2
raftlin family member 2
chr9_-_103397023 0.384 NM_147180
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr1_+_195503956 0.379 NM_001193640
NM_201253
CRB1

crumbs homolog 1 (Drosophila)

chr12_+_79362256 0.377 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr11_+_59902598 0.377 MS4A7
membrane-spanning 4-domains, subfamily A, member 7
chr1_+_163780063 0.376 NM_001005214
LRRC52
leucine rich repeat containing 52
chr8_-_7207899 0.375 NM_001164457
ZNF705G
zinc finger protein 705G
chr7_+_123083096 0.374 NM_207163
LMOD2
leiomodin 2 (cardiac)
chr3_-_115960807 0.372 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr11_+_59001421 0.372 NM_001004705
OR4D10
olfactory receptor, family 4, subfamily D, member 10
chr5_+_140573692 0.371 NM_018933
PCDHB13
protocadherin beta 13
chr10_+_129237602 0.371 NM_001030013
NPS
neuropeptide S
chr2_-_200030412 0.370 SATB2
SATB homeobox 2
chr7_-_96471544 0.369 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr16_-_11270619 0.369 NM_005425
TNP2
transition protein 2 (during histone to protamine replacement)
chr17_-_36346240 0.369 KRT23
keratin 23 (histone deacetylase inducible)
chr9_+_104797413 0.369 NM_001340
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chr16_-_20495126 0.369 NM_001105069
NM_182617
ACSM2B

acyl-CoA synthetase medium-chain family member 2B

chr5_-_16795336 0.368 MYO10
myosin X
chr15_+_100163424 0.368 NM_001005326
OR4F6
olfactory receptor, family 4, subfamily F, member 6
chrX_-_15243647 0.367 NM_080873
ASB11
ankyrin repeat and SOCS box containing 11
chr19_+_40632456 0.363 NM_005306
FFAR2
free fatty acid receptor 2
chr11_-_4675524 0.363 NM_030774
OR51E2
olfactory receptor, family 51, subfamily E, member 2
chr12_+_26096757 0.361 NM_001164746
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr4_+_71492581 0.361 NM_016519
AMBN
ameloblastin (enamel matrix protein)
chr3_-_11660395 0.360 NM_001128219
VGLL4
vestigial like 4 (Drosophila)
chr6_-_38671741 0.360 NM_001172418
NM_152733
BTBD9

BTB (POZ) domain containing 9

chr11_-_113971607 0.357 FAM55D
family with sequence similarity 55, member D
chr13_+_51933228 0.356 CKAP2
cytoskeleton associated protein 2
chr4_-_185376012 0.353 NM_153343
ENPP6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr6_+_55300225 0.353 NM_207410
GFRAL
GDNF family receptor alpha like
chr12_+_54045161 0.347 NM_001005497
OR6C75
olfactory receptor, family 6, subfamily C, member 75
chr20_-_49747397 0.347 ATP9A
ATPase, class II, type 9A
chr11_+_59902530 0.347 NM_021201
NM_206938
NM_206939
NM_206940
MS4A7



membrane-spanning 4-domains, subfamily A, member 7



chr6_-_33016561 0.346 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr17_-_36294962 0.345 NM_019010
KRT20
keratin 20
chr18_+_28023984 0.345 NM_005925
MEP1B
meprin A, beta
chr9_-_122679387 0.344 NM_001009936
NM_015651
PHF19

PHD finger protein 19

chr5_-_22889192 0.343 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr18_+_27425727 0.343 NM_000371
TTR
transthyretin
chr8_-_108579270 0.340 NM_001146
ANGPT1
angiopoietin 1
chr3_+_131761867 0.339 NM_001102608
COL6A6
collagen, type VI, alpha 6
chr2_-_26395420 0.339 NM_001145168
NM_001145169
GPR113

G protein-coupled receptor 113

chr1_-_156923111 0.339 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr21_+_24722913 0.339 FLJ42200
FLJ42200 protein
chr6_+_144513324 0.337 NM_003764
STX11
syntaxin 11
chr4_-_20914626 0.336 NM_147183
KCNIP4
Kv channel interacting protein 4
chr3_-_152517204 0.336 NM_023915
GPR87
G protein-coupled receptor 87
chr1_+_185064654 0.336 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr12_-_7547552 0.334 NM_004244
NM_203416
CD163

CD163 molecule

chr10_-_62002672 0.330 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr4_+_72321113 0.328 SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr1_-_53972464 0.327 NM_147193
GLIS1
GLIS family zinc finger 1
chr7_+_113842284 0.326 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr17_-_36877002 0.326 NM_002278
KRT32
keratin 32
chr15_+_71522551 0.325 NM_001042367
C15orf60
chromosome 15 open reading frame 60
chr11_-_4747722 0.325 NM_001004752
OR51F1
olfactory receptor, family 51, subfamily F, member 1
chr2_+_173394560 0.325 NM_001100397
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr18_+_19826734 0.322 NM_153211
TTC39C
tetratricopeptide repeat domain 39C

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.50 4.02e-14 GO:0007606 sensory perception of chemical stimulus
2.56 1.94e-13 GO:0007608 sensory perception of smell
2.04 7.16e-13 GO:0007600 sensory perception
1.61 4.34e-10 GO:0003008 system process
1.67 2.66e-09 GO:0050877 neurological system process
1.26 3.96e-07 GO:0032501 multicellular organismal process
1.20 2.42e-05 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.27 1.37e-06 GO:0005886 plasma membrane
1.27 1.55e-06 GO:0071944 cell periphery
1.30 6.74e-03 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.66 6.67e-15 GO:0004984 olfactory receptor activity
1.85 2.06e-09 GO:0004930 G-protein coupled receptor activity
1.56 2.22e-09 GO:0004872 receptor activity
1.45 1.86e-07 GO:0004871 signal transducer activity
1.45 1.86e-07 GO:0060089 molecular transducer activity
1.60 2.55e-07 GO:0004888 transmembrane receptor activity