Motif ID: ADNP_IRX_SIX_ZHX.p2

Z-value: 1.328


Transcription factors associated with ADNP_IRX_SIX_ZHX.p2:

Gene SymbolEntrez IDGene Name
ADNP 23394 activity-dependent neuroprotector homeobox
IRX4 50805 iroquois homeobox 4
IRX5 10265 iroquois homeobox 5
SIX2 10736 SIX homeobox 2
SIX5 147912 SIX homeobox 5
ZHX1 11244 zinc fingers and homeoboxes 1
ZHX2 22882 zinc fingers and homeoboxes 2
ZHX3 23051 zinc fingers and homeoboxes 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IRX5chr16_+_53522611-0.302.5e-01Click!
ADNPchr20_-_489808580.263.3e-01Click!
IRX4chr5_-_1935764-0.253.4e-01Click!
ZHX2chr8_+_1238631690.204.5e-01Click!
ZHX3chr20_-_39379533-0.204.6e-01Click!
SIX2chr2_-_45090025-0.175.4e-01Click!
ZHX1chr8_-_124355670-0.097.3e-01Click!
SIX5chr19_-_50964336-0.058.6e-01Click!


Activity profile for motif ADNP_IRX_SIX_ZHX.p2.

activity profile for motif ADNP_IRX_SIX_ZHX.p2


Sorted Z-values histogram for motif ADNP_IRX_SIX_ZHX.p2

Sorted Z-values for motif ADNP_IRX_SIX_ZHX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ADNP_IRX_SIX_ZHX.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_556968 1.806


chr6_+_12398514 1.670 NM_001168319
NM_001955
 EDN1

endothelin 1

chr6_+_21701942 1.590 NM_003107
 SOX4
SRY (sex determining region Y)-box 4
chr11_+_113280727 1.418 NM_006028
 HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr2_-_87102453 1.332 NM_002665
NM_001032392
 PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr6_+_167445284 1.270 NM_004367
 CCR6
chemokine (C-C motif) receptor 6
chr6_+_29249289 1.178 NM_030905
 OR2J2
olfactory receptor, family 2, subfamily J, member 2
chr15_+_47502666 1.175 NM_002009
 FGF7
fibroblast growth factor 7
chr4_+_74520796 1.137 NM_001134
 AFP
alpha-fetoprotein
chr6_+_155579788 1.074 NM_001010927
 TIAM2
T-cell lymphoma invasion and metastasis 2
chr6_-_89984214 1.048 NM_002042
 GABRR1
gamma-aminobutyric acid (GABA) receptor, rho 1
chr7_+_129771865 1.013 NM_001127441
NM_001127442
NM_080385
 CPA5


carboxypeptidase A5


chr1_+_198263352 0.971 NM_003822
NM_205860
 NR5A2

nuclear receptor subfamily 5, group A, member 2

chr1_+_557269 0.941


chr12_+_54172413 0.916 NM_001005519
 OR6C68
olfactory receptor, family 6, subfamily C, member 68
chr2_-_131073329 0.866 NM_032545
NM_001079530
 CFC1
CFC1B
cripto, FRL-1, cryptic family 1
cripto, FRL-1, cryptic family 1B
chr3_-_33675484 0.850 CLASP2
cytoplasmic linker associated protein 2
chr1_-_155936904 0.844 NM_052939
 FCRL3
Fc receptor-like 3
chr4_-_79322295 0.840


chr2_+_166137091 0.833 NM_024969
 CSRNP3
cysteine-serine-rich nuclear protein 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
2.56 1.94e-13 GO:0007608 sensory perception of smell
2.50 4.02e-14 GO:0007606 sensory perception of chemical stimulus
2.04 7.16e-13 GO:0007600 sensory perception
1.67 2.66e-09 GO:0050877 neurological system process
1.61 4.34e-10 GO:0003008 system process
1.26 3.96e-07 GO:0032501 multicellular organismal process
1.20 2.42e-05 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
1.30 6.74e-03 GO:0005576 extracellular region
1.27 1.37e-06 GO:0005886 plasma membrane
1.27 1.55e-06 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
2.66 6.67e-15 GO:0004984 olfactory receptor activity
1.85 2.06e-09 GO:0004930 G-protein coupled receptor activity
1.60 2.55e-07 GO:0004888 transmembrane receptor activity
1.56 2.22e-09 GO:0004872 receptor activity
1.45 1.86e-07 GO:0004871 signal transducer activity
1.45 1.86e-07 GO:0060089 molecular transducer activity