ISMARA results for ENCODE cell lines, H3K27me3 (Ernst 2011)

ISMARA - Integrated System for Motif Actitivity Response Analysis is a free online tool that recognizes most important transcription factors that are changing their activity in a set of samples.

All motifs sorted by activity significance

Motif name Z-value Associated genes Profile Logo
RREB1.p2 6.538 RREB1 (HNT)
NRF1.p2 6.351 NRF1 (EWG, ALPHA-PAL)
ELK1,4_GABP{A,B1}.p3 5.123 GABPA (E4TF1A, NFT2, NRF2, E4TF1-60, NRF2A)
GABPB1 (E4TF1-47, GABPB)
ELK4 (SAP1)
ELK1
ZNF143.p2 4.763 ZNF143 (SBF, pHZ-1, STAF)
HIC1.p2 4.747 HIC1 (ZBTB29)
PITX1..3.p2 4.734 PITX2 (IGDS, RS, Brx1, Otlx2, ARP1)
PITX3
PITX1 (PTX1, POTX)
SNAI1..3.p2 4.462 SNAI2 (SLUGH1)
SNAI1 (SNA, SLUGH2, SNAH)
SNAI3 (SMUC, Zfp293)
YY1.p2 4.205 YY1 (NF-E1, DELTA, UCRBP, YIN-YANG-1, INO80S)
TFCP2.p2 3.943 TFCP2 (CP2, LSF, LBP-1C, TFCP2C)
REST.p3 3.794 REST (NRSF, XBR)
TFAP2{A,C}.p2 3.601 TFAP2C (AP2-GAMMA, ERF1, TFAP2G, hAP-2g)
TFAP2A (AP-2)
EHF.p2 3.404 EHF
HMGA1,2.p2 3.385 HMGA1
HMGA2 (BABL, LIPO)
FOS_FOS{B,L1}_JUN{B,D}.p2 3.358 FOS (c-fos, AP-1)
JUNB
FOSL1 (fra-1)
JUND (AP-1)
FOSB (G0S3, GOSB, GOS3, AP-1, MGC42291, DKFZp686C0818)
MZF1.p2 3.317 MZF1 (MZF1B, ZSCAN6, MZF-1, Zfp98)
TFAP2B.p2 3.311 TFAP2B (AP2-B)
MTF1.p2 3.294 MTF1
ZEB1.p2 3.290 ZEB1 (BZP, ZEB, AREB6, NIL-2-A, Zfhep, Zfhx1a)
AHR_ARNT_ARNT2.p2 3.231 ARNT (HIF-1beta, bHLHe2)
AHR
ARNT2 (KIAA0307, bHLHe1)
HOX{A6,A7,B6,B7}.p2 3.121 HOXB6
HOXA7
HOXB7
HOXA6
KLF12.p2 3.102 KLF12 (AP-2rep, HSPC122, AP2REP)
EBF1.p2 2.992 EBF1 (OLF1)
PAX5.p2 2.958 PAX5 (BSAP)
MAZ.p2 2.923 MAZ (ZF87, Pur-1, Zif87, ZNF801)
ZIC1..3.p2 2.829 ZIC1 (ZIC, ZNF201)
ZIC2 (HPE5)
ZIC3 (HTX, ZNF203)
MYFfamily.p2 2.794 MYOD1 (PUM, MYOD, bHLHc1)
MYF6 (MRF4, bHLHc4)
MYF5 (bHLHc2)
MYOG (bHLHc3)
PRRX1,2.p2 2.761 PRRX2 (PRX2, PMX2)
PRRX1 (PHOX1)
ELF1,2,4.p2 2.658 ELF2 (EU32, NERF, NERF-2, NERF-1A, NERF-1B)
ELF1
ELF4 (MEF, ELFR)
NFY{A,B,C}.p2 2.639 NFYC (CBF-C)
NFYB (CBF-A, HAP3)
NFYA (HAP2, CBF-B)
TFDP1.p2 2.634 TFDP1 (Dp-1, DRTF1, DP1)
ZNF384.p2 2.620 ZNF384 (CAGH1A, CIZ, NMP4, NP)
SP1.p2 2.575 SP1
TEAD1.p2 2.544 TEAD1 (TEF-1)
TEAD2 (ETF, TEF4, TEF-4, TEAD-2)
TEAD3 (TEF5, TEAD5, TEF-5, DTEF-1, ETFR-1, TEAD-3)
TEAD4 (TEF3, RTEF1, TEF-3, EFTR-2, TEFR-1, TCF13L1, hRTEF-1B)
CREB1.p2 2.509 CREB1
SMAD1..7,9.p2 2.502 SMAD5 (Dwfc, JV5-1)
SMAD1 (MADR1, JV4-1)
SMAD3 (JV15-2, HsT17436)
SMAD4 (DPC4)
SMAD2 (MADR2, JV18-1)
SMAD6 (HsT17432)
SMAD7
SMAD9
HNF4A_NR2F1,2.p2 2.496 NR2F1 (EAR-3, COUP-TFI, TCFCOUP1, SVP44)
NR2F2 (COUP-TFII, COUPTFB, SVP40)
HNF4A (NR2A1, HNF4)
ZNF423.p2 2.474 ZNF423 (KIAA0760, OAZ, Roaz, Ebfaz, Zfp104)
NFE2L1.p2 2.459 NFE2L1 (NRF1, LCR-F1, FLJ00380, TCF11)
GATA1..3.p2 2.458 GATA1 (ERYF1, NFE1)
GATA2 (NFE1B)
GATA3 (HDR)
CRX.p2 2.447 CRX (CRD, LCA7, OTX3)
IRF1,2,7.p3 2.439 IRF1 (MAR, IRF-1)
IRF2 (IRF-2, DKFZp686F0244)
IRF7 (IRF7A, IRF-7H)
HMX1.p2 2.404 HMX1 (H6, NKX5-3)
MYOD1.p2 2.394 MYOD1 (PUM, MYOD, bHLHc1)
GTF2I.p2 2.382 GTF2I (TFII-I, BAP-135, SPIN, BTKAP1, DIWS, IB291)
NHLH1,2.p2 2.342 NHLH1 (NSCL, NSCL1, bHLHa35)
NHLH2 (NSCL2, bHLHa34)
KLF4.p3 2.289 KLF4 (EZF, GKLF)
MAFB.p2 2.268 MAFB
TLX1..3_NFIC{dimer}.p2 2.254 TLX1
TLX3 (RNX)
ATF5_CREB3.p2 2.248 ATF5
CREB3 (LZIP, Luman)
EP300.p2 2.213 EP300 (p300, KAT3B)
IKZF2.p2 2.204 IKZF2 (Helios)
BPTF.p2 2.202 BPTF (FAC1, NURF301)
EN1,2.p2 2.181 EN1
EN2
EGR1..3.p2 2.168 EGR3 (PILOT)
EGR1 (TIS8, G0S30, NGFI-A, KROX-24, ZIF-268, AT225, ZNF225)
EGR2
HBP1_HMGB_SSRP1_UBTF.p2 2.147 HMGB2
HMGB3 (HMG2A, MGC90319)
SSRP1 (FACT80)
UBTF (UBF, NOR-90)
HBP1
RUNX1..3.p2 2.143 RUNX1 (PEBP2A2, AMLCR1)
RUNX3 (AML2, PEBP2A3)
RUNX2 (AML3, PEBP2A1, PEBP2aA1)
FOX{D1,D2}.p2 2.126 FOXD2 (FREAC9)
FOXD1 (FREAC4)
TCF4_dimer.p2 2.112 TCF4 (E2-2, ITF2, PTHS, SEF2, SEF2-1, SEF2-1A, SEF2-1B, bHLHb19, MGC149723, MGC149724)
ETS1,2.p2 2.111 ETS2
ETS1 (FLJ10768, ETS-1)
ESR1.p2 2.066 ESR1 (NR3A1, Era)
SPI1.p2 2.061 SPI1 (PU.1, SPI-A, OF, SFPI1, SPI-1)
HLF.p2 2.039 HLF (MGC33822)
bHLH_family.p2 2.035 ARNTL (MOP3, JAP3, BMAL1, PASD3, bHLHe5)
MITF (WS2A, MI, bHLHe32)
MXI1 (MXD2, MAD2, MXI, bHLHc11)
TFE3 (TFEA, bHLHe33)
CLOCK (KIAA0334, KAT13D, bHLHe8)
OLIG2 (RACK17, OLIGO2, bHLHe19)
MXD4 (MAD4, MSTP149, MST149, bHLHc12)
HEY2 (bHLHb32)
HEY1 (HESR-1, CHF2, HESR1, HRT-1, CHF-2, HERP2, BHLHb31)
HEYL (bHLHb33)
MLXIPL (WS-bHLH, MIO, CHREBP, MONDOB)
HES6 (bHLHc23)
MXD3 (MAD3, bHLHc13)
ARNTL2 (BMAL2, MOP9, CLIF, PASD9, bHLHe6)
ID1 (dJ857M17.1.2, bHLHb24)
MNT (ROX, MXD6, MAD6, bHLHd3)
OLIG1 (BHLHB6, bHLHe21)
NPAS2 (MOP4, PASD4, bHLHe9)
NFATC1..3.p2 2.034 NFATC3 (NFAT4, NFATX)
NFATC2 (NF-ATP, NFATp, NFAT1)
NFATC1 (NF-ATC, NFATc, NFAT2)
TFAP4.p2 2.031 TFAP4 (AP-4)
DBP.p2 1.967 DBP (DABP)
E2F1..5.p2 1.931 E2F4 (E2F-4)
E2F5
E2F2 (E2F-2)
E2F1 (RBP3)
E2F3
NR5A1,2.p2 1.926 NR5A1 (FTZ1, SF-1, ELP, AD4BP)
NR5A2 (FTZ-F1beta, hB1F, LRH-1, FTZ-F1, hB1F-2, B1F2)
RXR{A,B,G}.p2 1.890 RXRA (NR2B1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
ZFP161.p2 1.879 ZFP161 (ZNF478, ZBTB14)
MYB.p2 1.866 MYB (c-myb)
ZBTB16.p2 1.859 ZBTB16 (PLZF)
PAX2.p2 1.853 PAX2
SRY.p2 1.845 SRY (TDF)
HAND1,2.p2 1.816 HAND1 (eHand, Thing1, Hxt, bHLHa27)
HAND2 (dHand, Thing2, Hed, bHLHa26)
TBP.p2 1.782 TBP (TFIID)
STAT2,4,6.p2 1.772 STAT2 (STAT113)
STAT4
STAT6 (D12S1644, IL-4-STAT)
EVI1.p2 1.755 EVI1 (MDS1-EVI1, PRDM3)
CDX1,2,4.p2 1.748 CDX1
CDX2
CDX4
ONECUT1,2.p2 1.727 ONECUT2 (OC-2)
ONECUT1 (HNF-6)
ZNF148.p2 1.696 ZNF148 (BERF-1, ZBP-89, BFCOL1, HT-BETA, ZFP148, pHZ-52)
SOX5.p2 1.695 SOX5 (L-SOX5, MGC35153)
FOXL1.p2 1.677 FOXL1 (FREAC7, FKH6)
POU1F1.p2 1.669 POU1F1 (GHF-1)
SPZ1.p2 1.656 SPZ1 (NYD-TSP1, FLJ25709)
POU5F1.p2 1.640 POU5F1 (OCT3, Oct4, MGC22487)
SRF.p3 1.618 SRF (MCM1)
ATF2.p2 1.607 ATF2 (TREB7, CRE-BP1, HB16)
NKX3-2.p2 1.566 NKX3-2 (NKX3B, NKX3.2)
RFX1..5_RFXANK_RFXAP.p2 1.555 RFX1 (EF-C)
RFXAP
RFX5
RFXANK (BLS, RFX-B, ANKRA1, F14150_1, MGC138628)
RFX4
RFX3
RFX2 (FLJ14226)
POU5F1_SOX2{dimer}.p2 1.537 POU5F1 (OCT3, Oct4, MGC22487)
SOX2
ZBTB6.p2 1.531 ZBTB6 (ZID)
FOXN1.p2 1.526 FOXN1 (FKHL20)
CTCF.p2 1.510 CTCF
NR3C1.p2 1.507 NR3C1 (GR)
ESRRA.p2 1.499 ESRRA (ERR1, ERRalpha, NR3B1, ERRa)
SPIB.p2 1.487 SPIB (SPI-B)
TBX4,5.p2 1.457 TBX5
TBX4
TGIF1.p2 1.448 TGIF1
FOXO1,3,4.p2 1.441 FOXO1 (FKH1)
FOXO4 (AFX1)
FOXO3 (AF6q21, FOXO2)
BACH2.p2 1.435 BACH2
ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2 1.425 ARNT (HIF-1beta, bHLHe2)
MAX (bHLHd4)
MYC (c-Myc, bHLHe39)
USF1 (UEF, MLTFI, bHLHb11)
BHLHB2 (DEC1, bHLHe40)
ARNT2 (KIAA0307, bHLHe1)
GLI1..3.p2 1.422 GLI1
GLI2 (THP2, HPE9, THP1)
GLI3 (PAP-A, PAPA, PAPA1, PAPB, ACLS, PPDIV)
SOX2.p2 1.406 SOX2
EOMES.p2 1.405 EOMES (TBR2)
FOXA2.p3 1.405 FOXA2
NFKB1_REL_RELA.p2 1.391 RELA (p65)
REL (I-Rel)
NFKB1 (KBF1, p105)
GATA6.p2 1.386 GATA6
TLX2.p2 1.385 TLX2 (Enx, Tlx2, NCX)
CEBPA,B_DDIT3.p2 1.373 DDIT3 (CHOP10, GADD153, CHOP)
CEBPA (C/EBP-alpha)
CEBPB (LAP, CRP2, NFIL6, IL6DBP)
HSF1,2.p2 1.364 HSF1 (HSTF1)
HSF2
NR1H4.p2 1.334 NR1H4 (FXR, RIP14, HRR1, HRR-1)
ADNP_IRX_SIX_ZHX.p2 1.328 SIX5
ZHX1
IRX4
ADNP (KIAA0784, ADNP1)
ZHX3 (KIAA0395)
ZHX2 (KIAA0854)
IRX5 (IRX-2a)
SIX2
MEF2{A,B,C,D}.p2 1.327 MEF2A (RSRFC4, RSRFC9)
MEF2C
MEF2D
MEF2BNB-MEF2B (MEF2B, LOC729991-MEF2B)
MEF2B (RSRFR2, FLJ32648)
LMO2.p2 1.324 LMO2 (TTG2, RHOM2, RBTN2)
HOX{A4,D4}.p2 1.324 HOXA4
HOXD4
HIF1A.p2 1.317 HIF1A (MOP1, HIF-1alpha, PASD8, HIF1)
GTF2A1,2.p2 1.317 GTF2A1 (TFIIA)
GTF2A2 (TFIIA, HsT18745)
NKX3-1.p2 1.305 NKX3-1 (NKX3.1, BAPX2)
NKX2-2,8.p2 1.303 NKX2-2 (NKX2.2)
NKX2-8 (NKX2.8, Nkx2-9)
FOXD3.p2 1.286 FOXD3 (Genesis, HFH2)
GFI1.p2 1.278 GFI1
PAX4.p2 1.235 PAX4
POU3F1..4.p2 1.228 POU3F1 (OCT6, SCIP)
POU3F3 (BRN1, OTF8)
POU3F2 (POUF3, BRN2, OCT7)
POU3F4 (BRN4, OTF9)
STAT5{A,B}.p2 1.223 STAT5B
STAT5A (MGF)
EWSR1-FLI1.p2 1.215 FLI1 (EWSR2, SIC-1)
EWSR1 (EWS, K984G1.4)
HOX{A5,B5}.p2 1.207 HOXB5
HOXA5
PRDM1.p3 1.202 PRDM1 (PRDI-BF1)
GFI1B.p2 1.197 GFI1B
MYBL2.p2 1.185 MYBL2 (BMYB, B-MYB)
NFE2L2.p2 1.185 NFE2L2 (NRF2)
PATZ1.p2 1.185 PATZ1 (MAZR, dJ400N23, ZBTB19, ZSG, RIAZ, PATZ)
ARID5B.p2 1.161 ARID5B (FLJ21150, MRF2)
CDC5L.p2 1.157 CDC5L (PCDC5RP, hCDC5, CEF1)
FOXP3.p2 1.148 FOXP3 (JM2, XPID, AIID, PIDX, DIETER, SCURFIN)
TP53.p2 1.116 TP53 (p53, LFS1)
HES1.p2 1.115 HES1 (FLJ20408, HES-1, Hes1, bHLHb39)
HNF1A.p2 1.111 HNF1A (HNF1, LFB1)
NFIL3.p2 1.102 NFIL3 (E4BP4, NFIL3A, NF-IL3A)
FOXQ1.p2 1.094 FOXQ1 (HFH1)
ATF4.p2 1.076 ATF4 (TAXREB67, CREB-2)
XBP1.p3 1.072 XBP1
SOX17.p2 1.072 SOX17
DMAP1_NCOR{1,2}_SMARC.p2 1.034 SMARCA1 (SNF2LB, NURF140, ISWI, SWI)
SMARCC2 (BAF170, Rsc8, CRACC2)
SMARCA5 (hSNF2H, hISWI, ISWI)
NCOR1 (N-CoR, hCIT529I10, TRAC1, hN-CoR, KIAA1047, MGC104216)
NCOR2 (SMRT, SMRTE, TRAC-1, CTG26, TNRC14)
DMAP1 (DNMAP1, FLJ11543, KIAA1425, DNMTAP1, EAF2, SWC4)
LEF1_TCF7_TCF7L1,2.p2 1.033 TCF7 (TCF-1)
TCF7L2 (TCF-4)
LEF1 (TCF1ALPHA)
TCF7L1
LHX3,4.p2 1.023 LHX3
LHX4 (Gsh4)
FOSL2.p2 1.007 FOSL2 (FRA2, FLJ23306)
IKZF1.p2 0.996 IKZF1 (hIk-1, LyF-1, Hs.54452, IKAROS)
RXRG_dimer.p3 0.991 NR1H2 (NER, NER-I, RIP15, LXR-b)
RXRA (NR2B1)
PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
PPARA (hPPAR, NR1C1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
NANOG{mouse}.p2 0.991 NANOG (FLJ12581, FLJ40451)
NKX2-3_NKX2-5.p2 0.984 NKX2-5 (CSX1, NKX2.5, NKX4-1)
NKX2-3 (NKX2.3, CSX3, NKX4-3)
NKX6-1,2.p2 0.982 NKX6-1 (Nkx6.1)
NKX6-2 (NKX6B, GTX, NKX6.1)
ZNF238.p2 0.980 ZNF238 (C2H2-171, TAZ-1, RP58, ZBTB18)
JUN.p2 0.979 JUN (c-Jun, AP-1)
JUND (AP-1)
JUNB
PBX1.p2 0.965 PBX1
AIRE.p2 0.959 AIRE (PGA1, APS1)
POU6F1.p2 0.951 POU6F1 (BRN5, MPOU, TCFB1)
SOX{8,9,10}.p2 0.945 SOX9 (SRA1)
SOX8
SOX10 (DOM, WS4, WS2E)
FOX{F1,F2,J1}.p2 0.932 FOXF2 (FREAC2)
FOXJ1 (HFH-4, HFH4)
FOXF1 (FREAC1)
NFIX.p2 0.924 NFIX (NF1A)
POU2F1..3.p2 0.921 POU2F2 (OCT2)
POU2F1 (OCT1)
POU2F3 (OCT11, PLA-1, Skn-1a, Epoc-1)
NFE2.p2 0.919 NFE2 (NF-E2)
FOX{I1,J2}.p2 0.916 FOXI1 (FREAC6)
FOXJ2 (FHX)
FEV.p2 0.891 FEV (PET-1, HSRNAFEV)
NANOG.p2 0.890 NANOG (FLJ12581, FLJ40451)
ALX1.p2 0.884 ALX1
AR.p2 0.879 AR (AIS, NR3C4, SMAX1, HUMARA)
SREBF1,2.p2 0.866 SREBF1 (SREBP1, bHLHd1)
SREBF2 (SREBP2, bHLHd2)
RXRA_VDR{dimer}.p2 0.850 VDR (NR1I1)
TAL1_TCF{3,4,12}.p2 0.849 TCF3 (E2A, ITF1, MGC129647, MGC129648, bHLHb21)
TCF4 (SEF2-1B, ITF2, bHLHb19)
TAL1 (SCL, bHLHa17)
TCF12 (HEB, HTF4, HsT17266, bHLHb20)
ATF6.p2 0.842 ATF6 (ATF6A)
NKX2-1,4.p2 0.796 NKX2-1 (TTF-1)
NKX2-4 (NKX2.4)
PPARG.p2 0.796 PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
TFEB.p2 0.748 TFEB
FOX{C1,C2}.p2 0.725 FOXC1 (FREAC3, ARA, IGDA, IHG1)
FOXC2 (MFH-1)
T.p2 0.711 T
MSX1,2.p2 0.625 MSX1 (HYD1, OFC5)
MSX2 (CRS2, FPP, HOX8, MSH, PFM)
RBPJ.p2 0.615 RBPJ (SUH, IGKJRB, RBPJK, KBF2, RBP-J, CBF1)
NR6A1.p2 0.580 NR6A1 (GCNF1, RTR)
HOXA9_MEIS1.p2 0.575 MEIS1
HOXA9
STAT1,3.p3 0.559 STAT1 (STAT91, ISGF-3)
STAT3 (APRF)
PDX1.p2 0.548 PDX1 (IDX-1, STF-1, PDX-1, MODY4)
CUX2.p2 0.535 CUX2 (KIAA0293, CDP2)
RORA.p2 0.529 RORA (RZRA, ROR1, ROR2, ROR3, NR1F1)
PAX6.p2 0.498 PAX6 (D11S812E, AN, WAGR)
VSX1,2.p2 0.351 VSX2 (RET1)
VSX1 (PPD)
GZF1.p2 0.232 GZF1 (dJ322G13.2, ZBTB23)
PAX3,7.p2 0.155 PAX7 (Hup1)
PAX3 (HUP2)
PAX8.p2 0.115 PAX8

All samples sorted alphabetically


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Project name:

Sample name Condition Replicate/Batch
Rep1_GM12878
Rep1_HMEC
Rep1_HSMM
Rep1_HepG2
Rep1_Huvec
Rep1_K562
Rep1_NHEK
Rep1_NHLF
Rep2_GM12878
Rep2_HMEC
Rep2_HSMM
Rep2_HepG2
Rep2_Huvec
Rep2_K562
Rep2_NHEK
Rep2_NHLF