Motif ID: FEV.p2

Z-value: 0.891


Transcription factors associated with FEV.p2:

Gene SymbolEntrez IDGene Name
FEV 54738 FEV (ETS oncogene family)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FEVchr2_-_2195585170.087.7e-01Click!


Activity profile for motif FEV.p2.

activity profile for motif FEV.p2


Sorted Z-values histogram for motif FEV.p2

Sorted Z-values for motif FEV.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FEV.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_54790020 0.545 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr3_+_120799411 0.499 NM_015900
PLA1A
phospholipase A1 member A
chr19_-_56567602 0.461 NM_005601
NKG7
natural killer cell group 7 sequence
chr22_+_25398690 0.445 LOC388889
hypothetical LOC388889
chr14_-_24047261 0.435 NM_001836
CMA1
chymase 1, mast cell
chr5_+_61910318 0.422 NM_181506
LRRC70
leucine rich repeat containing 70
chr6_-_153000226 0.419 NM_182961
SYNE1
spectrin repeat containing, nuclear envelope 1
chr4_+_54790190 0.414 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr18_-_59137488 0.413 NM_000633
NM_000657
BCL2

B-cell CLL/lymphoma 2

chr6_+_50789215 0.412 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr11_-_110917632 0.403


chr1_-_79244948 0.385 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr5_-_88214720 0.382 MEF2C
myocyte enhancer factor 2C
chr6_-_127882192 0.375 NM_001012279
C6orf174
chromosome 6 open reading frame 174
chr2_-_175207521 0.362 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr10_+_26767657 0.361 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr21_-_27261276 0.355 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr20_+_2743613 0.344 NM_080739
C20orf141
chromosome 20 open reading frame 141
chr7_+_129634935 0.323 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr5_+_140719773 0.317 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr2_-_220116062 0.312 NM_001195731
CHPF
chondroitin polymerizing factor
chr5_+_140730014 0.309 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr17_-_40655347 0.302 LOC339192
hypothetical LOC339192
chr10_+_26767698 0.299 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr5_-_93472993 0.296 NM_001163417
NM_001163418
NM_032042
FAM172A


family with sequence similarity 172, member A


chr2_-_179623030 0.289 NM_173648
CCDC141
coiled-coil domain containing 141
chr5_-_58370693 0.286 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr14_+_51397113 0.283 GNG2
guanine nucleotide binding protein (G protein), gamma 2
chr2_+_174968701 0.282 NM_001193528
NM_024583
SCRN3

secernin 3

chr1_-_167603623 0.282 NM_013330
NM_197972
NME7

non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)

chr1_+_68070573 0.281


chr5_-_149515331 0.278 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr2_+_33514896 0.277 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr3_+_44571600 0.277 NM_018651
NM_025169
ZNF167

zinc finger protein 167

chr17_-_35097792 0.276 NM_033419
PGAP3
post-GPI attachment to proteins 3
chr18_+_7221136 0.276 NM_001105581
LRRC30
leucine rich repeat containing 30
chr6_-_89984214 0.276 NM_002042
GABRR1
gamma-aminobutyric acid (GABA) receptor, rho 1
chr2_+_39746525 0.274 NM_152390
TMEM178
transmembrane protein 178
chr4_-_10295412 0.273 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr6_+_29472310 0.271 NM_013936
OR12D2
olfactory receptor, family 12, subfamily D, member 2
chr8_-_49996353 0.270 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr3_+_120700057 0.269 NM_016589
C3orf1
chromosome 3 open reading frame 1
chr11_-_3104413 0.265 OSBPL5
oxysterol binding protein-like 5
chr2_+_169367345 0.265 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr9_+_107464558 0.264 NM_005421
TAL2
T-cell acute lymphocytic leukemia 2
chr17_-_34262862 0.260 RPL23
ribosomal protein L23
chr4_-_5071996 0.258 NM_018659
CYTL1
cytokine-like 1
chr10_+_81882409 0.257 PLAC9
placenta-specific 9
chr17_+_35097851 0.255 NM_001005862
ERBB2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr16_+_29581783 0.252 NM_001030288
SPN
sialophorin
chr5_-_149515502 0.252 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr6_+_32003380 0.252 C2
complement component 2
chr2_-_213724577 0.248 NM_001079526
IKZF2
IKAROS family zinc finger 2 (Helios)
chr17_+_40655060 0.245 NM_005892
FMNL1
formin-like 1
chr2_+_174968751 0.245 SCRN3
secernin 3
chr9_+_134026836 0.244 NTNG2
netrin G2
chr14_+_19365447 0.244 NM_001004723
OR4N2
olfactory receptor, family 4, subfamily N, member 2
chr5_+_40877053 0.243 NM_032587
CARD6
caspase recruitment domain family, member 6
chr16_-_85099941 0.243 LOC400550
hypothetical LOC400550
chr10_-_96112609 0.242 NM_022451
NOC3L
nucleolar complex associated 3 homolog (S. cerevisiae)
chr9_-_90983501 0.240 NM_016848
SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr12_+_8557402 0.240 NM_080387
CLEC4D
C-type lectin domain family 4, member D
chr18_+_21967813 0.237 NM_001025096
NM_001025097
NM_144662
PSMA8


proteasome (prosome, macropain) subunit, alpha type, 8


chr1_+_167604056 0.237 BLZF1
basic leucine zipper nuclear factor 1
chr1_-_155788775 0.237 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr1_-_180822686 0.236 NM_021133
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr10_-_6144119 0.235 NM_000417
IL2RA
interleukin 2 receptor, alpha
chr15_+_91244422 0.234 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr10_+_75174151 0.233 SEC24C
SEC24 family, member C (S. cerevisiae)
chr5_+_140777454 0.233 NM_018927
NM_032101
PCDHGB7

protocadherin gamma subfamily B, 7

chr10_+_75174125 0.231 NM_004922
NM_198597
SEC24C

SEC24 family, member C (S. cerevisiae)

chr10_+_81882477 0.230 PLAC9
placenta-specific 9
chr6_+_126282078 0.226 NCOA7
nuclear receptor coactivator 7
chr11_-_74818685 0.224 KLHL35
kelch-like 35 (Drosophila)
chr10_+_115501202 0.223 NM_001193434
NM_001193435
NM_024889
C10orf81


chromosome 10 open reading frame 81


chr15_+_91244563 0.222 CHD2
chromodomain helicase DNA binding protein 2
chr12_-_6668680 0.222 ZNF384
zinc finger protein 384
chr1_+_167603817 0.222 NM_003666
BLZF1
basic leucine zipper nuclear factor 1
chr12_+_12829807 0.221 NM_030817
APOLD1
apolipoprotein L domain containing 1
chrX_-_153632355 0.218 NM_001081573
NM_080612
GAB3

GRB2-associated binding protein 3

chr12_-_8584658 0.217 NM_014358
CLEC4E
C-type lectin domain family 4, member E
chr9_-_90983195 0.217 SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr18_+_11841388 0.215 NM_020412
CHMP1B
chromatin modifying protein 1B
chr3_-_130600931 0.215 RPL32P3
ribosomal protein L32 pseudogene 3
chr8_-_82186832 0.215 NM_018440
PAG1
phosphoprotein associated with glycosphingolipid microdomains 1
chr5_+_180514548 0.215 NM_206880
OR2V2
olfactory receptor, family 2, subfamily V, member 2
chr14_-_54727958 0.212 NM_001146015
NM_014750
DLGAP5

discs, large (Drosophila) homolog-associated protein 5

chr5_-_149515613 0.210 NM_002609
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr2_-_27469947 0.210 FTH1P3
ferritin, heavy polypeptide 1 pseudogene 3
chr2_-_200028977 0.209 SATB2
SATB homeobox 2
chr12_-_56157898 0.208 NM_001080156
ARHGAP9
Rho GTPase activating protein 9
chr11_+_63412562 0.204 NM_017490
MARK2
MAP/microtubule affinity-regulating kinase 2
chr2_-_220116508 0.203 NM_024536
CHPF
chondroitin polymerizing factor
chr12_+_6950338 0.202 EMG1
EMG1 nucleolar protein homolog (S. cerevisiae)
chr12_-_6668880 0.202 NM_001039917
NM_001039919
NM_001039920
NM_001135734
ZNF384



zinc finger protein 384



chr6_+_28237529 0.201 NM_001145129
ZNF389
zinc finger protein 389
chr14_+_51397134 0.200 GNG2
guanine nucleotide binding protein (G protein), gamma 2
chr16_+_85169615 0.200 NM_005250
FOXL1
forkhead box L1
chr1_+_204797214 0.199 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr2_-_174968595 0.199 NM_004882
CIR1
corepressor interacting with RBPJ, 1
chr12_-_29828958 0.198 NM_175861
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr8_-_23768242 0.196 NM_003155
STC1
stanniocalcin 1
chr5_+_143171918 0.194 NM_021182
HMHB1
histocompatibility (minor) HB-1
chr12_+_21570457 0.194 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr17_+_55269974 0.193


chr14_+_51397059 0.192 GNG2
guanine nucleotide binding protein (G protein), gamma 2
chr14_+_51397166 0.191 GNG2
guanine nucleotide binding protein (G protein), gamma 2
chr11_-_74818858 0.191 KLHL35
kelch-like 35 (Drosophila)
chr8_-_78074851 0.190 NM_000318
NM_001079867
PEX2

peroxisomal biogenesis factor 2

chr6_-_34632061 0.190 NM_012391
SPDEF
SAM pointed domain containing ets transcription factor
chrX_-_110542040 0.187 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr3_+_25445071 0.187 RARB
retinoic acid receptor, beta
chr2_+_102401580 0.187 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chrX_+_12795111 0.186 NM_016562
TLR7
toll-like receptor 7
chr2_+_182029863 0.186 NM_000885
ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr8_+_42247991 0.184 NM_001190720
IKBKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
chr11_+_22644732 0.183 NM_001143830
GAS2
growth arrest-specific 2
chrX_-_74292800 0.183 NM_004299
ABCB7
ATP-binding cassette, sub-family B (MDR/TAP), member 7
chrX_-_31000079 0.182 NM_031894
FTHL17
ferritin, heavy polypeptide-like 17
chr6_-_41148061 0.182 NM_145063
C6orf130
chromosome 6 open reading frame 130
chr22_-_17892859 0.181 NM_001130861
NM_003277
CLDN5

claudin 5

chr3_+_114733907 0.181 NM_017699
SIDT1
SID1 transmembrane family, member 1
chr3_+_120495906 0.180 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr9_-_98368913 0.180 NM_001077181
CDC14B
CDC14 cell division cycle 14 homolog B (S. cerevisiae)
chr8_+_126054719 0.180 NM_152412
ZNF572
zinc finger protein 572
chr20_+_9406460 0.179 PLCB4
phospholipase C, beta 4
chr12_-_6950089 0.179 NM_007273
NM_001144831
PHB2

prohibitin 2

chr10_+_31650069 0.178 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr17_+_53587492 0.177 NM_012374
OR4D1
olfactory receptor, family 4, subfamily D, member 1
chr21_-_34820916 0.176 NM_203418
RCAN1
regulator of calcineurin 1
chr4_-_156517394 0.176 MAP9
microtubule-associated protein 9
chr2_+_31310485 0.176 EHD3
EH-domain containing 3
chr7_+_93388951 0.175 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr4_+_15080586 0.174 NM_001080522
NM_001164720
NM_020785
CC2D2A


coiled-coil and C2 domain containing 2A


chr1_+_204797120 0.173 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr5_+_71538456 0.172 MAP1B
microtubule-associated protein 1B
chr6_+_32003180 0.172 NM_000063
NM_001145903
C2

complement component 2

chr8_+_42247954 0.172 NM_001190722
NM_001556
IKBKB

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

chr11_+_46256161 0.171 CREB3L1
cAMP responsive element binding protein 3-like 1
chr6_-_116488458 0.171 NM_002031
FRK
fyn-related kinase
chrX_-_15312390 0.171 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr7_-_3049872 0.171 NM_032415
CARD11
caspase recruitment domain family, member 11
chr12_-_642786 0.171 NM_016533
NINJ2
ninjurin 2
chr11_-_9292581 0.170 TMEM41B
transmembrane protein 41B
chr14_-_44500840 0.170 KLHL28
kelch-like 28 (Drosophila)
chr17_+_4784524 0.169 RNF167
ring finger protein 167
chr11_-_60886038 0.169 NM_001161454
NM_153611
CYBASC3

cytochrome b, ascorbate dependent 3

chr6_-_46997579 0.169 NM_001098518
GPR116
G protein-coupled receptor 116
chr6_+_36961617 0.168 NM_152734
C6orf89
chromosome 6 open reading frame 89
chr4_-_156517423 0.168 MAP9
microtubule-associated protein 9
chr3_+_148610516 0.168 ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr20_+_19815075 0.168 RIN2
Ras and Rab interactor 2
chr6_+_12825818 0.168 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr14_-_56805118 0.167


chr17_-_43977273 0.166 NM_002145
HOXB2
homeobox B2
chr12_-_109372462 0.165 ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr5_+_140767953 0.164 NM_018926
NM_032100
PCDHGB6

protocadherin gamma subfamily B, 6

chr12_-_102968044 0.164 NM_031302
GLT8D2
glycosyltransferase 8 domain containing 2
chr14_+_23008723 0.164 NM_001042635
NM_015514
NGDN

neuroguidin, EIF4E binding protein

chr14_+_73073570 0.163 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr11_-_102219450 0.163 NM_002422
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr2_-_153282104 0.163 NM_017892
PRPF40A
PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
chr5_+_134012133 0.163 NM_021982
SEC24A
SEC24 family, member A (S. cerevisiae)
chr2_+_97696462 0.163 NM_001079
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr13_+_25726755 0.162 NM_001260
CDK8
cyclin-dependent kinase 8
chr4_-_101658094 0.161 NM_001159694
NM_016242
EMCN

endomucin

chr17_+_11405798 0.161 SHISA6
shisa homolog 6 (Xenopus laevis)
chr6_+_45497796 0.161 NM_004348
RUNX2
runt-related transcription factor 2
chrX_-_111809929 0.159 NM_178175
LHFPL1
lipoma HMGIC fusion partner-like 1
chr1_-_53972464 0.158 NM_147193
GLIS1
GLIS family zinc finger 1
chr17_-_64108843 0.158 FAM20A
family with sequence similarity 20, member A
chr20_+_33223434 0.158 NM_006404
PROCR
protein C receptor, endothelial
chr13_-_42464301 0.156 NM_001002264
NM_033255
EPSTI1

epithelial stromal interaction 1 (breast)

chr4_+_86615275 0.155 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr7_-_91347915 0.155 NM_006980
MTERF
mitochondrial transcription termination factor
chr12_+_6950204 0.154 NM_006331
EMG1
EMG1 nucleolar protein homolog (S. cerevisiae)
chr11_-_33847507 0.154 LMO2
LIM domain only 2 (rhombotin-like 1)
chr9_+_129226535 0.154 ZNF79
zinc finger protein 79
chr20_+_5679032 0.153 NM_152504
C20orf196
chromosome 20 open reading frame 196
chr1_+_204797079 0.153 NM_182665
RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr8_+_42248008 0.152 NM_001190721
IKBKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
chr17_-_10362583 0.152 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr11_-_31789168 0.151 PAX6
paired box 6
chr22_+_35586950 0.151 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr8_-_13416554 0.151 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chr2_+_165858586 0.151 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr16_+_67931178 0.150 NIP7
nuclear import 7 homolog (S. cerevisiae)
chr9_+_129226473 0.148 NM_007135
ZNF79
zinc finger protein 79
chr3_-_130362563 0.148 NM_020701
ISY1
ISY1 splicing factor homolog (S. cerevisiae)
chr6_-_116799548 0.148 LOC100287467
hypothetical LOC100287467
chr21_+_42697058 0.147 NM_001001895
NM_018961
UBASH3A

ubiquitin associated and SH3 domain containing A

chr12_-_21985433 0.146 ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr1_+_9926072 0.146 NM_022787
NMNAT1
nicotinamide nucleotide adenylyltransferase 1
chr5_+_140411144 0.145 NM_013340
PCDHB1
protocadherin beta 1
chr12_-_68369322 0.145 NM_152439
BEST3
bestrophin 3
chr3_-_148607096 0.144 NM_032153
ZIC4
Zic family member 4
chr2_+_201099093 0.144 NM_001160033
NM_001160046
NM_152524
SGOL2


shugoshin-like 2 (S. pombe)


chr6_-_69401639 0.144


chr1_-_182273114 0.144 GLT25D2
glycosyltransferase 25 domain containing 2
chr16_-_30992574 0.143 ZNF668
zinc finger protein 668

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.21 1.87e-06 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.23 6.62e-06 GO:0090304 nucleic acid metabolic process
1.15 2.80e-05 GO:0044260 cellular macromolecule metabolic process
1.25 7.62e-05 GO:0016070 RNA metabolic process
1.49 7.93e-05 GO:0001775 cell activation
1.43 8.08e-04 GO:0016071 mRNA metabolic process
1.12 2.23e-03 GO:0043170 macromolecule metabolic process
1.06 2.68e-03 GO:0009987 cellular process
1.32 3.41e-03 GO:0015031 protein transport
1.31 6.98e-03 GO:0045184 establishment of protein localization
1.13 8.92e-03 GO:0051716 cellular response to stimulus
1.40 9.96e-03 GO:0006974 response to DNA damage stimulus
1.20 1.09e-02 GO:0010467 gene expression
1.65 1.09e-02 GO:0046649 lymphocyte activation
1.44 2.01e-02 GO:0006397 mRNA processing
1.59 2.09e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.23 2.73e-02 GO:0033036 macromolecule localization
1.14 2.75e-02 GO:0034641 cellular nitrogen compound metabolic process
1.55 3.29e-02 GO:0045321 leukocyte activation
1.87 3.60e-02 GO:0030098 lymphocyte differentiation
1.13 3.71e-02 GO:0071840 cellular component organization or biogenesis
1.25 4.59e-02 GO:0008104 protein localization
1.29 4.85e-02 GO:0033554 cellular response to stress
1.87 5.00e-02 GO:0050851 antigen receptor-mediated signaling pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.26 1.88e-08 GO:0044428 nuclear part
1.27 1.54e-07 GO:0031981 nuclear lumen
1.22 4.78e-06 GO:0043233 organelle lumen
1.21 8.79e-06 GO:0031974 membrane-enclosed lumen
1.16 4.00e-05 GO:0032991 macromolecular complex
1.20 4.11e-05 GO:0070013 intracellular organelle lumen
1.17 1.38e-04 GO:0043228 non-membrane-bounded organelle
1.17 1.38e-04 GO:0043232 intracellular non-membrane-bounded organelle
1.11 1.97e-04 GO:0044446 intracellular organelle part
1.11 3.09e-04 GO:0044422 organelle part
1.16 3.25e-04 GO:0043234 protein complex
1.25 4.17e-04 GO:0005654 nucleoplasm
1.19 6.04e-04 GO:0005829 cytosol
1.05 1.53e-03 GO:0044424 intracellular part
1.05 3.14e-03 GO:0005622 intracellular
1.09 1.73e-02 GO:0005634 nucleus

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 6.42e-08 GO:0005515 protein binding
1.04 2.49e-02 GO:0005488 binding