Motif ID: HIF1A.p2

Z-value: 1.317


Transcription factors associated with HIF1A.p2:

Gene SymbolEntrez IDGene Name
HIF1A 3091 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIF1Achr14_+_612317950.009.9e-01Click!


Activity profile for motif HIF1A.p2.

activity profile for motif HIF1A.p2


Sorted Z-values histogram for motif HIF1A.p2

Sorted Z-values for motif HIF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIF1A.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_12046020 1.229 NM_001243
 TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr10_-_60606195 1.176


chr11_+_32808045 1.055 NM_024081
 PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr5_-_176760242 1.025 NM_001029886
 PFN3
profilin 3
chr3_-_71916877 1.002 NM_001126128
NM_021935
 PROK2

prokineticin 2

chr6_-_144427340 0.961 NM_001080951
NM_001080955
 PLAGL1

pleiomorphic adenoma gene-like 1

chr2_+_222997456 0.919 SGPP2
sphingosine-1-phosphate phosphatase 2
chr1_+_181025494 0.894 NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr20_+_48781457 0.888 NM_032521
 PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr4_+_107036042 0.886 NM_001033047
NM_001184690
NM_001184691
NM_001184692
NM_001184693
 NPNT




nephronectin




chr17_+_32380287 0.873 NM_012138
 AATF
apoptosis antagonizing transcription factor
chr2_+_222997529 0.856 NM_152386
 SGPP2
sphingosine-1-phosphate phosphatase 2
chr16_+_166678 0.799 NM_000558
 HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr2_+_32142083 0.793 NM_014946
NM_199436
 SPAST

spastin

chr17_-_3814334 0.778 NM_005173
NM_174953
NM_174954
NM_174955
NM_174956
NM_174957
NM_174958
 ATP2A3






ATPase, Ca++ transporting, ubiquitous






chr22_+_38720881 0.776 NM_138435
 FAM83F
family with sequence similarity 83, member F
chr2_-_213724577 0.758 NM_001079526
 IKZF2
IKAROS family zinc finger 2 (Helios)
chr2_+_190981257 0.753 NM_017694
 MFSD6
major facilitator superfamily domain containing 6
chr3_-_123223658 0.724 NM_175924
 ILDR1
immunoglobulin-like domain containing receptor 1
chr4_+_107036076 0.710 NPNT
nephronectin

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 17 of 17 entries
enrichment   p-value GO term description
2.31 2.01e-02 GO:0006112 energy reserve metabolic process
2.07 3.87e-02 GO:0006913 nucleocytoplasmic transport
1.88 3.64e-02 GO:0016567 protein ubiquitination
1.86 2.70e-02 GO:0032446 protein modification by small protein conjugation
1.50 2.52e-02 GO:0046907 intracellular transport
1.31 2.43e-02 GO:0006464 protein modification process
1.30 8.67e-04 GO:0044267 cellular protein metabolic process
1.30 2.92e-02 GO:0043412 macromolecule modification
1.28 2.24e-02 GO:0048523 negative regulation of cellular process
1.24 7.27e-03 GO:0051234 establishment of localization
1.23 3.31e-05 GO:0044260 cellular macromolecule metabolic process
1.23 1.99e-02 GO:0006810 transport
1.21 3.04e-07 GO:0044237 cellular metabolic process
1.19 1.20e-03 GO:0043170 macromolecule metabolic process
1.16 3.60e-05 GO:0008152 metabolic process
1.16 6.19e-04 GO:0044238 primary metabolic process
1.09 5.98e-04 GO:0009987 cellular process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 21 entries
enrichment   p-value GO term description
1.41 2.21e-05 GO:0012505 endomembrane system
1.39 5.21e-07 GO:0031090 organelle membrane
1.36 7.63e-06 GO:0005829 cytosol
1.29 1.42e-03 GO:0044428 nuclear part
1.27 3.36e-14 GO:0044444 cytoplasmic part
1.27 2.68e-03 GO:0070013 intracellular organelle lumen
1.26 5.04e-03 GO:0031974 membrane-enclosed lumen
1.26 6.78e-03 GO:0043233 organelle lumen
1.26 4.98e-02 GO:0031981 nuclear lumen
1.23 5.70e-21 GO:0043231 intracellular membrane-bounded organelle
1.23 9.17e-21 GO:0043227 membrane-bounded organelle
1.23 2.72e-18 GO:0005737 cytoplasm
1.23 1.48e-08 GO:0044446 intracellular organelle part
1.22 6.18e-08 GO:0005634 nucleus
1.21 1.81e-07 GO:0044422 organelle part
1.19 1.13e-28 GO:0044424 intracellular part
1.19 1.75e-18 GO:0043229 intracellular organelle
1.19 3.86e-18 GO:0043226 organelle
1.18 1.36e-26 GO:0005622 intracellular
1.05 9.99e-07 GO:0044464 cell part

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
1.77 1.77e-02 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.45 1.42e-02 GO:0003723 RNA binding
1.29 7.16e-04 GO:0000166 nucleotide binding
1.12 3.16e-03 GO:0005515 protein binding
1.08 3.98e-04 GO:0005488 binding