Motif ID: HIF1A.p2

Z-value: 1.317


Transcription factors associated with HIF1A.p2:

Gene SymbolEntrez IDGene Name
HIF1A 3091 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIF1Achr14_+_612317950.009.9e-01Click!


Activity profile for motif HIF1A.p2.

activity profile for motif HIF1A.p2


Sorted Z-values histogram for motif HIF1A.p2

Sorted Z-values for motif HIF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIF1A.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_12046020 1.229 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr10_-_60606195 1.176


chr11_+_32808045 1.055 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr5_-_176760242 1.025 NM_001029886
PFN3
profilin 3
chr3_-_71916877 1.002 NM_001126128
NM_021935
PROK2

prokineticin 2

chr6_-_144427340 0.961 NM_001080951
NM_001080955
PLAGL1

pleiomorphic adenoma gene-like 1

chr2_+_222997456 0.919 SGPP2
sphingosine-1-phosphate phosphatase 2
chr1_+_181025494 0.894 NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr20_+_48781457 0.888 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr4_+_107036042 0.886 NM_001033047
NM_001184690
NM_001184691
NM_001184692
NM_001184693
NPNT




nephronectin




chr17_+_32380287 0.873 NM_012138
AATF
apoptosis antagonizing transcription factor
chr2_+_222997529 0.856 NM_152386
SGPP2
sphingosine-1-phosphate phosphatase 2
chr16_+_166678 0.799 NM_000558
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr2_+_32142083 0.793 NM_014946
NM_199436
SPAST

spastin

chr17_-_3814334 0.778 NM_005173
NM_174953
NM_174954
NM_174955
NM_174956
NM_174957
NM_174958
ATP2A3






ATPase, Ca++ transporting, ubiquitous






chr22_+_38720881 0.776 NM_138435
FAM83F
family with sequence similarity 83, member F
chr2_-_213724577 0.758 NM_001079526
IKZF2
IKAROS family zinc finger 2 (Helios)
chr2_+_190981257 0.753 NM_017694
MFSD6
major facilitator superfamily domain containing 6
chr3_-_123223658 0.724 NM_175924
ILDR1
immunoglobulin-like domain containing receptor 1
chr4_+_107036076 0.710 NPNT
nephronectin
chr1_+_67546143 0.702 IL12RB2
interleukin 12 receptor, beta 2
chr11_+_69602055 0.679 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr16_+_162845 0.664 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr4_+_89597257 0.663 NM_016323
HERC5
hect domain and RLD 5
chr13_-_99422163 0.658 NM_033132
ZIC5
Zic family member 5 (odd-paired homolog, Drosophila)
chr20_-_538909 0.643 NM_004609
TCF15
transcription factor 15 (basic helix-loop-helix)
chr1_+_231816372 0.632 NM_002245
KCNK1
potassium channel, subfamily K, member 1
chr3_+_127743868 0.625 CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr1_-_146543102 0.620


chr18_+_42167904 0.595 RNF165
ring finger protein 165
chr3_+_77171938 0.592 NM_002942
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr6_+_73388713 0.589 KCNQ5
potassium voltage-gated channel, KQT-like subfamily, member 5
chr17_-_64834780 0.586 NM_172232
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr6_-_28663045 0.581 NM_052923
SCAND3
SCAN domain containing 3
chr13_-_95503566 0.580 NM_020121
UGGT2
UDP-glucose glycoprotein glucosyltransferase 2
chr4_-_90251571 0.573 FAM13A
family with sequence similarity 13, member A
chr1_+_222870573 0.573 CNIH3
cornichon homolog 3 (Drosophila)
chr19_+_1022208 0.565 HMHA1
histocompatibility (minor) HA-1
chr10_+_60606352 0.562 NM_032439
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr12_+_56299959 0.553 NM_133489
SLC26A10
solute carrier family 26, member 10
chr5_+_49998677 0.551 PARP8
poly (ADP-ribose) polymerase family, member 8
chr10_+_112247614 0.547 NM_004419
DUSP5
dual specificity phosphatase 5
chr11_+_65311104 0.539 NM_004561
OVOL1
ovo-like 1(Drosophila)
chr8_+_95722448 0.527 ESRP1
epithelial splicing regulatory protein 1
chr4_+_183302105 0.524 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr4_+_48180033 0.506 NM_152679
SLC10A4
solute carrier family 10 (sodium/bile acid cotransporter family), member 4
chr14_-_70345485 0.503 NM_033141
MAP3K9
mitogen-activated protein kinase kinase kinase 9
chr4_-_119493322 0.494 NM_003619
PRSS12
protease, serine, 12 (neurotrypsin, motopsin)
chr9_+_34948171 0.490 NM_015297
KIAA1045
KIAA1045
chr1_-_142536082 0.488


chr2_-_233060774 0.486 NM_004826
ECEL1
endothelin converting enzyme-like 1
chr13_+_24152548 0.484 NM_001185085
NM_001676
ATP12A

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

chr11_+_75157414 0.483 NM_032564
DGAT2
diacylglycerol O-acyltransferase 2
chr11_-_74819165 0.482 NM_001039548
KLHL35
kelch-like 35 (Drosophila)
chr17_-_8643163 0.482 NM_152599
MFSD6L
major facilitator superfamily domain containing 6-like
chr8_+_69405510 0.481 NM_001195639
NM_052958
C8orf34

chromosome 8 open reading frame 34

chr21_-_38954433 0.480 ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr13_-_19704533 0.480 NM_001110219
NM_001110220
NM_001110221
GJB6


gap junction protein, beta 6, 30kDa


chr19_+_40431678 0.479 LSR
lipolysis stimulated lipoprotein receptor
chr2_+_111594921 0.476 NM_006538
NM_138621
NM_207002
BCL2L11


BCL2-like 11 (apoptosis facilitator)


chr19_+_60283571 0.475 NM_017729
EPS8L1
EPS8-like 1
chr9_-_111300350 0.469 NM_001145368
NM_002829
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr19_-_19599973 0.465 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr13_+_97426713 0.463 IPO5
importin 5
chr1_+_67545634 0.457 NM_001559
IL12RB2
interleukin 12 receptor, beta 2
chr1_+_65385799 0.447 NM_203464
NM_001005353
AK4

adenylate kinase 4

chr7_-_22363036 0.444 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr7_+_48041632 0.440 NM_001100159
C7orf57
chromosome 7 open reading frame 57
chr9_-_21965131 0.439 NM_000077
NM_001195132
CDKN2A

cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

chr2_-_6923215 0.437 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr11_-_19219720 0.436 E2F8
E2F transcription factor 8
chr1_-_173428455 0.436 NM_001162895
NM_014656
NM_001162893
NM_001162894
KIAA0040



KIAA0040



chr11_+_65311142 0.433 OVOL1
ovo-like 1(Drosophila)
chr13_+_78068246 0.430 LOC780529
hypothetical LOC780529
chr5_+_63497408 0.429 NM_001113561
NM_178532
RNF180

ring finger protein 180

chr7_-_72077805 0.425 NM_198853
TRIM73
TRIM74
tripartite motif containing 73
tripartite motif containing 74
chr11_+_125279481 0.423 NM_013264
DDX25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr1_+_231816540 0.417 KCNK1
potassium channel, subfamily K, member 1
chr20_+_18516541 0.417 NM_080820
DTD1
D-tyrosyl-tRNA deacylase 1 homolog (S. cerevisiae)
chr10_+_104394185 0.414 NM_030912
TRIM8
tripartite motif containing 8
chr13_-_19633182 0.410 NM_021954
GJA3
gap junction protein, alpha 3, 46kDa
chr11_-_73149705 0.409 NM_002869
NM_198896
RAB6A

RAB6A, member RAS oncogene family

chr5_+_89890366 0.408 NM_032119
GPR98
G protein-coupled receptor 98
chr1_+_88922424 0.405 NM_006256
PKN2
protein kinase N2
chr10_-_43390014 0.405 NM_001099282
NM_001099283
NM_001099284
ZNF239


zinc finger protein 239


chr8_+_28407613 0.404 NM_017412
FZD3
frizzled homolog 3 (Drosophila)
chr16_-_18845223 0.401 NM_015092
SMG1
SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
chr4_-_17392232 0.399 NM_015688
FAM184B
family with sequence similarity 184, member B
chr11_+_566482 0.398 NM_020901
PHRF1
PHD and ring finger domains 1
chr1_+_222870798 0.393 NM_152495
CNIH3
cornichon homolog 3 (Drosophila)
chr8_-_30635112 0.386 GTF2E2
general transcription factor IIE, polypeptide 2, beta 34kDa
chr5_+_3649167 0.384 NM_024337
IRX1
iroquois homeobox 1
chr5_+_110587546 0.379 NM_001744
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr22_-_29231597 0.376 NM_001161368
NM_174977
SEC14L4

SEC14-like 4 (S. cerevisiae)

chr17_-_42924828 0.376 MRPL45P2
mitochondrial ribosomal protein L45 pseudogene 2
chr8_+_75050930 0.375 NM_001040613
NM_017866
TMEM70

transmembrane protein 70

chr1_-_146543016 0.373


chr7_+_26298018 0.373 NM_013322
SNX10
sorting nexin 10
chr11_+_133706977 0.371 NM_138342
GLB1L2
galactosidase, beta 1-like 2
chr16_-_66571863 0.371 NM_001129758
NM_022357
DPEP3

dipeptidase 3

chr1_+_191357906 0.363 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr8_+_31616809 0.362 NM_013962
NRG1
neuregulin 1
chr2_-_96174865 0.360 NM_004418
DUSP2
dual specificity phosphatase 2
chr10_+_52420936 0.358 NM_001098512
PRKG1
protein kinase, cGMP-dependent, type I
chr18_+_53253775 0.355 NM_004852
ONECUT2
one cut homeobox 2
chr2_+_17585462 0.355 VSNL1
visinin-like 1
chr19_-_55999677 0.353 NM_199250
NM_199249
C19orf48

chromosome 19 open reading frame 48

chr5_+_176951802 0.352 NM_017510
TMED9
transmembrane emp24 protein transport domain containing 9
chrX_-_131919896 0.352 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr2_+_122229590 0.350 NM_004622
TSN
translin
chr8_-_9046460 0.350 PPP1R3B
protein phosphatase 1, regulatory (inhibitor) subunit 3B
chr1_-_180840016 0.349 NM_002928
RGS16
regulator of G-protein signaling 16
chr7_+_115637795 0.348 NM_015641
TES
testis derived transcript (3 LIM domains)
chr10_-_98470164 0.348 NM_152309
PIK3AP1
phosphoinositide-3-kinase adaptor protein 1
chr8_-_30635207 0.347 NM_002095
GTF2E2
general transcription factor IIE, polypeptide 2, beta 34kDa
chr22_+_24290738 0.347 NM_005160
ADRBK2
adrenergic, beta, receptor kinase 2
chr2_+_17585287 0.345 NM_003385
VSNL1
visinin-like 1
chr1_+_20385164 0.345 NM_152376
UBXN10
UBX domain protein 10
chr13_-_40604587 0.341 NM_152903
KBTBD6
kelch repeat and BTB (POZ) domain containing 6
chr17_-_34084682 0.339 NM_001130677
C17orf96
chromosome 17 open reading frame 96
chr2_-_60633908 0.338 NM_018014
NM_022893
NM_138559
BCL11A


B-cell CLL/lymphoma 11A (zinc finger protein)


chr12_-_123965099 0.338 UBC
ubiquitin C
chr19_+_2427122 0.337 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr11_+_104986620 0.336 NM_001112812
GRIA4
glutamate receptor, ionotrophic, AMPA 4
chr2_-_112729072 0.332 NM_032494
ZC3H8
zinc finger CCCH-type containing 8
chr11_-_65895640 0.330 NM_001532
SLC29A2
solute carrier family 29 (nucleoside transporters), member 2
chr2_-_101370291 0.330 CREG2
cellular repressor of E1A-stimulated genes 2
chr20_+_41519882 0.330 NM_006275
SRSF6
serine/arginine-rich splicing factor 6
chr2_+_219432789 0.330 NM_006522
WNT6
wingless-type MMTV integration site family, member 6
chr1_-_146398501 0.330 LOC100286793
FLJ39739
hypothetical LOC100286793
hypothetical FLJ39739
chr9_+_34948320 0.329 KIAA1045
KIAA1045
chr6_+_111515341 0.328 SLC16A10
solute carrier family 16, member 10 (aromatic amino acid transporter)
chr11_+_133707107 0.327 GLB1L2
galactosidase, beta 1-like 2
chr15_-_76700563 0.325 NM_000743
NM_001166694
CHRNA3

cholinergic receptor, nicotinic, alpha 3

chr12_+_56230073 0.323 KIF5A
kinesin family member 5A
chr17_+_50697355 0.320 HLF
hepatic leukemia factor
chr11_-_565848 0.320 LOC143666
hypothetical LOC143666
chr10_-_95350949 0.319 NM_006744
RBP4
retinol binding protein 4, plasma
chr17_+_45778381 0.318 NM_022167
XYLT2
xylosyltransferase II
chr16_+_73739890 0.316 NM_153688
ZFP1
zinc finger protein 1 homolog (mouse)
chr10_+_105334704 0.316 NEURL
neuralized homolog (Drosophila)
chr9_+_129199204 0.315 NM_014580
SLC2A8
solute carrier family 2 (facilitated glucose transporter), member 8
chr6_+_111515473 0.313 NM_018593
SLC16A10
solute carrier family 16, member 10 (aromatic amino acid transporter)
chr6_+_1336077 0.313


chr6_-_153346283 0.312 NM_001142522
FBXO5
F-box protein 5
chr3_-_159306532 0.311 NM_001163678
NM_003030
NM_006884
SHOX2


short stature homeobox 2


chr3_+_52694975 0.310 NM_014366
NM_206825
NM_206826
GNL3


guanine nucleotide binding protein-like 3 (nucleolar)


chr7_+_43118721 0.310 NM_015052
HECW1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr17_-_69151821 0.309 NM_001144952
SDK2
sidekick homolog 2 (chicken)
chr19_+_40431618 0.309 LSR
lipolysis stimulated lipoprotein receptor
chr11_+_75157450 0.307 DGAT2
diacylglycerol O-acyltransferase 2
chr2_+_84986273 0.305 NM_021103
TMSB10
thymosin beta 10
chr17_+_50697319 0.305 NM_002126
HLF
hepatic leukemia factor
chr19_-_54267690 0.304 KCNA7
potassium voltage-gated channel, shaker-related subfamily, member 7
chr3_-_107070400 0.304 NM_170662
CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr2_-_60634271 0.303 BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
chr4_+_119419354 0.302 SNHG8
small nucleolar RNA host gene 8 (non-protein coding)
chr7_+_156624392 0.302 NM_014671
UBE3C
ubiquitin protein ligase E3C
chr1_-_142535878 0.302 LOC100286793
FLJ39739
hypothetical LOC100286793
hypothetical FLJ39739
chr19_+_40431359 0.301 NM_015925
NM_205834
NM_205835
LSR


lipolysis stimulated lipoprotein receptor


chr7_+_26298136 0.300 SNX10
sorting nexin 10
chr19_-_54267932 0.298 NM_031886
KCNA7
potassium voltage-gated channel, shaker-related subfamily, member 7
chr12_-_56111054 0.298 R3HDM2
R3H domain containing 2
chr8_+_24827173 0.297 NM_005382
NEFM
neurofilament, medium polypeptide
chr3_+_173240983 0.297 NM_001135095
FNDC3B
fibronectin type III domain containing 3B
chr3_+_37259684 0.297 NM_001172713
NM_002078
GOLGA4

golgin A4

chr4_+_158361185 0.296 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr12_-_123965539 0.295 NM_021009
UBC
ubiquitin C
chr8_-_110726201 0.295 NM_001099753
NM_001099754
NM_001099755
SYBU


syntabulin (syntaxin-interacting)


chr20_+_3399615 0.293 NM_139321
NM_139322
ATRN

attractin

chr2_-_88533167 0.293 NM_001135649
FOXI3
forkhead box I3
chr17_-_33043514 0.293 NM_001163544
NM_001163545
NM_001163546
NM_001163547
NM_007247
NM_080550
NM_198882
SYNRG






synergin, gamma






chrX_+_150614385 0.293 NM_024082
PRRG3
proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
chr10_+_105716925 0.293 SLK
STE20-like kinase
chr12_+_56230110 0.292 NM_004984
KIF5A
kinesin family member 5A
chr3_-_88190737 0.291 NM_001008390
NM_003663
CGGBP1

CGG triplet repeat binding protein 1

chr8_+_85259654 0.291 NM_001100391
RALYL
RALY RNA binding protein-like
chr12_+_120810982 0.290 NM_002813
PSMD9
proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
chr9_-_135847106 0.288 NM_001134398
NM_003371
VAV2

vav 2 guanine nucleotide exchange factor

chr2_+_68238490 0.287 NM_020143
PNO1
partner of NOB1 homolog (S. cerevisiae)
chr3_+_53503626 0.287 CACNA1D
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr8_+_24827181 0.287 NEFM
neurofilament, medium polypeptide
chr2_-_27195401 0.287 NM_001166240
NM_006569
CGREF1

cell growth regulator with EF-hand domain 1

chr20_-_24986501 0.287 ACSS1
acyl-CoA synthetase short-chain family member 1
chr14_+_101297887 0.286 NM_001161725
NM_001161726
PPP2R5C

protein phosphatase 2, regulatory subunit B', gamma

chr3_+_40473785 0.286 NM_003973
NM_001034996
RPL14

ribosomal protein L14

chr10_-_43082372 0.285 NM_145313
RASGEF1A
RasGEF domain family, member 1A
chr1_+_65386359 0.285 NM_013410
AK4
adenylate kinase 4
chr1_-_143232275 0.284 LOC728855
hypothetical LOC728855
chr20_-_50241930 0.284 NM_018197
NM_022088
NM_199426
NM_199427
ZFP64



zinc finger protein 64 homolog (mouse)



chr6_-_28475478 0.283 NM_001163391
ZSCAN12
zinc finger and SCAN domain containing 12
chr9_-_126573349 0.282 NM_001489
NM_033334
NR6A1

nuclear receptor subfamily 6, group A, member 1

chr21_+_33364316 0.282 NM_138983
OLIG1
oligodendrocyte transcription factor 1
chr19_-_44386731 0.282 NM_001080468
SYCN
syncollin
chr8_+_26296439 0.282 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr10_-_21503025 0.282 NM_001173484
NM_213569
NEBL

nebulette

chr7_+_23603495 0.282 NM_138771
CCDC126
coiled-coil domain containing 126
chr5_-_43432969 0.281 CCL28
chemokine (C-C motif) ligand 28
chr16_+_716936 0.281 NM_207112
NM_032304
HAGHL

hydroxyacylglutathione hydrolase-like

chr11_-_47620590 0.280 NM_014342
MTCH2
mitochondrial carrier homolog 2 (C. elegans)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.21 3.04e-07 GO:0044237 cellular metabolic process
1.23 3.31e-05 GO:0044260 cellular macromolecule metabolic process
1.16 3.60e-05 GO:0008152 metabolic process
1.09 5.98e-04 GO:0009987 cellular process
1.16 6.19e-04 GO:0044238 primary metabolic process
1.30 8.67e-04 GO:0044267 cellular protein metabolic process
1.19 1.20e-03 GO:0043170 macromolecule metabolic process
1.24 7.27e-03 GO:0051234 establishment of localization
1.23 1.99e-02 GO:0006810 transport
2.31 2.01e-02 GO:0006112 energy reserve metabolic process
1.28 2.24e-02 GO:0048523 negative regulation of cellular process
1.31 2.43e-02 GO:0006464 protein modification process
1.50 2.52e-02 GO:0046907 intracellular transport
1.86 2.70e-02 GO:0032446 protein modification by small protein conjugation
1.30 2.92e-02 GO:0043412 macromolecule modification
1.88 3.64e-02 GO:0016567 protein ubiquitination
2.07 3.87e-02 GO:0006913 nucleocytoplasmic transport

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.19 1.13e-28 GO:0044424 intracellular part
1.18 1.36e-26 GO:0005622 intracellular
1.23 5.70e-21 GO:0043231 intracellular membrane-bounded organelle
1.23 9.17e-21 GO:0043227 membrane-bounded organelle
1.19 1.75e-18 GO:0043229 intracellular organelle
1.23 2.72e-18 GO:0005737 cytoplasm
1.19 3.86e-18 GO:0043226 organelle
1.27 3.36e-14 GO:0044444 cytoplasmic part
1.23 1.48e-08 GO:0044446 intracellular organelle part
1.22 6.18e-08 GO:0005634 nucleus
1.21 1.81e-07 GO:0044422 organelle part
1.39 5.21e-07 GO:0031090 organelle membrane
1.05 9.99e-07 GO:0044464 cell part
1.05 1.04e-06 GO:0005623 cell
1.36 7.63e-06 GO:0005829 cytosol
1.41 2.21e-05 GO:0012505 endomembrane system
1.29 1.42e-03 GO:0044428 nuclear part
1.27 2.68e-03 GO:0070013 intracellular organelle lumen
1.26 5.04e-03 GO:0031974 membrane-enclosed lumen
1.26 6.78e-03 GO:0043233 organelle lumen
1.26 4.98e-02 GO:0031981 nuclear lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.08 3.98e-04 GO:0005488 binding
1.29 7.16e-04 GO:0000166 nucleotide binding
1.12 3.16e-03 GO:0005515 protein binding
1.45 1.42e-02 GO:0003723 RNA binding
1.77 1.77e-02 GO:0016879 ligase activity, forming carbon-nitrogen bonds