Motif ID: NRF1.p2

Z-value: 6.351


Transcription factors associated with NRF1.p2:

Gene SymbolEntrez IDGene Name
NRF1 4899 nuclear respiratory factor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NRF1chr7_+_1290388150.448.6e-02Click!


Activity profile for motif NRF1.p2.

activity profile for motif NRF1.p2


Sorted Z-values histogram for motif NRF1.p2

Sorted Z-values for motif NRF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NRF1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_33677798 15.047 NM_015475
 FAM98A
family with sequence similarity 98, member A
chr16_+_27122796 8.721 NM_001145348
 JMJD5
jumonji domain containing 5
chr20_-_57051231 8.621 NM_016045
 SLMO2
slowmo homolog 2 (Drosophila)
chr1_+_32251988 7.715 NM_006559
 KHDRBS1
KH domain containing, RNA binding, signal transduction associated 1
chr2_-_197499584 6.940 NM_024989
 PGAP1
post-GPI attachment to proteins 1
chr19_-_51097694 6.914 NM_001012643
 MYPOP
Myb-related transcription factor, partner of profilin
chr14_+_22633728 6.799 C14orf119
chromosome 14 open reading frame 119
chr16_+_88102305 6.386 NM_003119
NM_199367
 SPG7

spastic paraplegia 7 (pure and complicated autosomal recessive)

chr20_+_48781457 6.345 NM_032521
 PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr2_+_190234369 5.941 NM_019048
 ASNSD1
asparagine synthetase domain containing 1
chr14_-_22127954 5.851 NM_001344
 DAD1
defender against cell death 1
chr2_+_254843 5.780 NM_001040649
NM_004300
NM_007099
 ACP1


acid phosphatase 1, soluble


chr14_-_22127902 5.759 DAD1
defender against cell death 1
chr17_-_42924828 5.666 MRPL45P2
mitochondrial ribosomal protein L45 pseudogene 2
chr22_+_22996749 5.666 NM_001145468
NM_015330
 SPECC1L

sperm antigen with calponin homology and coiled-coil domains 1-like

chr6_+_30142910 5.388 NM_021959
 PPP1R11
protein phosphatase 1, regulatory (inhibitor) subunit 11
chr3_+_10132314 5.357 NM_018462
 C3orf10
chromosome 3 open reading frame 10
chr2_-_254742 5.312 SH3YL1
SH3 domain containing, Ysc84-like 1 (S. cerevisiae)
chr17_-_24302597 5.291 NM_001033561
NM_020889
 PHF12

PHD finger protein 12

chr2_+_100545827 4.813 NM_024065
 PDCL3
phosducin-like 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 94 entries
enrichment   p-value GO term description
3.44 3.54e-02 GO:0070936 protein K48-linked ubiquitination
3.05 2.53e-05 GO:0006302 double-strand break repair
2.69 1.19e-02 GO:0031124 mRNA 3'-end processing
2.68 8.01e-03 GO:0006405 RNA export from nucleus
2.62 4.87e-02 GO:0006406 mRNA export from nucleus
2.52 1.17e-02 GO:0006354 transcription elongation, DNA-dependent
2.51 5.25e-03 GO:0051168 nuclear export
2.49 1.54e-02 GO:0000956 nuclear-transcribed mRNA catabolic process
2.39 2.26e-02 GO:0006402 mRNA catabolic process
2.26 1.56e-06 GO:0000375 RNA splicing, via transesterification reactions
2.25 2.87e-02 GO:0031497 chromatin assembly
2.24 4.28e-06 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.24 4.28e-06 GO:0000398 nuclear mRNA splicing, via spliceosome
2.21 1.04e-09 GO:0008380 RNA splicing
2.20 1.43e-03 GO:0006333 chromatin assembly or disassembly
2.19 4.61e-03 GO:0006323 DNA packaging
2.17 8.43e-04 GO:0071103 DNA conformation change
2.16 3.79e-10 GO:0006281 DNA repair
2.09 2.59e-06 GO:0016567 protein ubiquitination
2.08 5.07e-10 GO:0006397 mRNA processing

Gene overrepresentation in compartment category:

Showing 1 to 20 of 55 entries
enrichment   p-value GO term description
2.87 2.42e-02 GO:0008287 protein serine/threonine phosphatase complex
2.61 4.01e-04 GO:0031461 cullin-RING ubiquitin ligase complex
2.53 7.02e-03 GO:0000922 spindle pole
2.28 4.85e-05 GO:0000151 ubiquitin ligase complex
2.23 6.42e-04 GO:0044455 mitochondrial membrane part
2.17 1.81e-03 GO:0016607 nuclear speck
2.16 8.57e-04 GO:0005681 spliceosomal complex
2.15 4.77e-02 GO:0000776 kinetochore
2.13 3.29e-02 GO:0032993 protein-DNA complex
2.12 3.56e-05 GO:0005819 spindle
2.11 1.82e-17 GO:0005694 chromosome
2.11 1.61e-14 GO:0044427 chromosomal part
2.08 1.98e-04 GO:0044454 nuclear chromosome part
2.03 1.39e-05 GO:0005813 centrosome
2.00 8.50e-03 GO:0000793 condensed chromosome
1.99 1.93e-05 GO:0000785 chromatin
1.96 1.43e-02 GO:0000775 chromosome, centromeric region
1.89 9.79e-04 GO:0000228 nuclear chromosome
1.88 3.66e-10 GO:0030529 ribonucleoprotein complex
1.85 4.87e-27 GO:0005654 nucleoplasm

Gene overrepresentation in function category:

Showing 1 to 20 of 29 entries
enrichment   p-value GO term description
2.21 4.81e-08 GO:0019787 small conjugating protein ligase activity
2.21 1.84e-07 GO:0004842 ubiquitin-protein ligase activity
2.19 4.20e-09 GO:0016881 acid-amino acid ligase activity
2.10 1.05e-08 GO:0016879 ligase activity, forming carbon-nitrogen bonds
2.07 3.32e-02 GO:0016779 nucleotidyltransferase activity
1.90 2.24e-09 GO:0016874 ligase activity
1.85 1.24e-02 GO:0003682 chromatin binding
1.83 2.03e-02 GO:0043566 structure-specific DNA binding
1.80 4.22e-14 GO:0003723 RNA binding
1.61 6.51e-03 GO:0003712 transcription cofactor activity
1.60 7.24e-03 GO:0000988 protein binding transcription factor activity
1.60 7.24e-03 GO:0000989 transcription factor binding transcription factor activity
1.45 1.22e-03 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.44 7.93e-22 GO:0003676 nucleic acid binding
1.44 1.54e-03 GO:0016817 hydrolase activity, acting on acid anhydrides
1.44 1.56e-03 GO:0016462 pyrophosphatase activity
1.40 1.32e-02 GO:0017111 nucleoside-triphosphatase activity
1.35 9.17e-09 GO:0003677 DNA binding
1.34 3.66e-08 GO:0000166 nucleotide binding
1.31 1.45e-03 GO:0030554 adenyl nucleotide binding