Motif ID: NRF1.p2

Z-value: 6.351


Transcription factors associated with NRF1.p2:

Gene SymbolEntrez IDGene Name
NRF1 4899 nuclear respiratory factor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NRF1chr7_+_1290388150.448.6e-02Click!


Activity profile for motif NRF1.p2.

activity profile for motif NRF1.p2


Sorted Z-values histogram for motif NRF1.p2

Sorted Z-values for motif NRF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NRF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_33677798 15.047 NM_015475
FAM98A
family with sequence similarity 98, member A
chr16_+_27122796 8.721 NM_001145348
JMJD5
jumonji domain containing 5
chr20_-_57051231 8.621 NM_016045
SLMO2
slowmo homolog 2 (Drosophila)
chr1_+_32251988 7.715 NM_006559
KHDRBS1
KH domain containing, RNA binding, signal transduction associated 1
chr2_-_197499584 6.940 NM_024989
PGAP1
post-GPI attachment to proteins 1
chr19_-_51097694 6.914 NM_001012643
MYPOP
Myb-related transcription factor, partner of profilin
chr14_+_22633728 6.799 C14orf119
chromosome 14 open reading frame 119
chr16_+_88102305 6.386 NM_003119
NM_199367
SPG7

spastic paraplegia 7 (pure and complicated autosomal recessive)

chr20_+_48781457 6.345 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr2_+_190234369 5.941 NM_019048
ASNSD1
asparagine synthetase domain containing 1
chr14_-_22127954 5.851 NM_001344
DAD1
defender against cell death 1
chr2_+_254843 5.780 NM_001040649
NM_004300
NM_007099
ACP1


acid phosphatase 1, soluble


chr14_-_22127902 5.759 DAD1
defender against cell death 1
chr17_-_42924828 5.666 MRPL45P2
mitochondrial ribosomal protein L45 pseudogene 2
chr22_+_22996749 5.666 NM_001145468
NM_015330
SPECC1L

sperm antigen with calponin homology and coiled-coil domains 1-like

chr6_+_30142910 5.388 NM_021959
PPP1R11
protein phosphatase 1, regulatory (inhibitor) subunit 11
chr3_+_10132314 5.357 NM_018462
C3orf10
chromosome 3 open reading frame 10
chr2_-_254742 5.312 SH3YL1
SH3 domain containing, Ysc84-like 1 (S. cerevisiae)
chr17_-_24302597 5.291 NM_001033561
NM_020889
PHF12

PHD finger protein 12

chr2_+_100545827 4.813 NM_024065
PDCL3
phosducin-like 3
chr2_-_223229006 4.805 NM_005687
FARSB
phenylalanyl-tRNA synthetase, beta subunit
chr6_-_163754903 4.742 LOC100526820
hypothetical LOC100526820
chr16_+_4415805 4.729 NM_001135110
NM_005147
DNAJA3

DnaJ (Hsp40) homolog, subfamily A, member 3

chr20_-_34835546 4.695 NM_001145316
NM_024918
NM_001145315
NM_001145317
NM_001145318
DSN1




DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)




chr20_-_48163071 4.695 NM_001032288
UBE2V1
ubiquitin-conjugating enzyme E2 variant 1
chr6_-_135417647 4.580 NM_001145158
NM_001145207
NM_006620
HBS1L


HBS1-like (S. cerevisiae)


chr6_-_135417522 4.537 HBS1L
HBS1-like (S. cerevisiae)
chr14_-_22634134 4.460 ACIN1
apoptotic chromatin condensation inducer 1
chr17_-_24302450 4.427 PHF12
PHD finger protein 12
chr16_+_27122307 4.423 NM_024773
JMJD5
jumonji domain containing 5
chr2_+_217071764 4.417 NM_000998
RPL37A
ribosomal protein L37a
chr2_-_112729072 4.297 NM_032494
ZC3H8
zinc finger CCCH-type containing 8
chr17_-_44794325 4.278 NM_001145365
NM_014897
ZNF652

zinc finger protein 652

chr3_-_46993225 4.277 NM_144716
CCDC12
coiled-coil domain containing 12
chr2_+_118562499 4.163 NM_016133
INSIG2
insulin induced gene 2
chr11_+_64785888 4.128 NM_002689
POLA2
polymerase (DNA directed), alpha 2 (70kD subunit)
chr7_-_101906311 4.072 NM_006234
POLR2J2
POLR2J
polymerase (RNA) II (DNA directed) polypeptide J2
polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
chr16_+_8622974 4.067 NM_024109
METTL22
methyltransferase like 22
chr3_+_51680261 4.051 NM_001129884
NM_015926
TEX264

testis expressed 264

chr16_+_48657381 3.929 NM_182922
HEATR3
HEAT repeat containing 3
chr2_+_26110487 3.861 RAB10
RAB10, member RAS oncogene family
chr2_-_70329067 3.843 NM_022037
NM_022173
TIA1

TIA1 cytotoxic granule-associated RNA binding protein

chr17_-_45110339 3.840 NM_001007226
NM_001007227
NM_001007228
NM_001007229
NM_001007230
NM_003563
SPOP





speckle-type POZ protein





chr1_+_165456572 3.804 NM_001198786
NM_002697
POU2F1

POU class 2 homeobox 1

chr20_-_51644187 3.802 ZNF217
zinc finger protein 217
chr16_-_80761281 3.796 NM_005792
MPHOSPH6
M-phase phosphoprotein 6
chr14_-_23981493 3.791 NM_020195
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr20_-_10362755 3.719 NM_170784
MKKS
McKusick-Kaufman syndrome
chr2_-_38831901 3.705 NM_001031684
NM_001195446
SRSF7

serine/arginine-rich splicing factor 7

chr2_-_20413838 3.653 PUM2
pumilio homolog 2 (Drosophila)
chr10_+_59698891 3.647 NM_018464
CISD1
CDGSH iron sulfur domain 1
chr20_-_32163576 3.643 EIF2S2
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
chr17_-_35510431 3.621 NM_021724
NR1D1
nuclear receptor subfamily 1, group D, member 1
chr16_+_30876959 3.617


chr17_-_24193866 3.607 NM_001077498
NM_018182
C17orf63

chromosome 17 open reading frame 63

chr14_+_22305570 3.603 NM_005015
OXA1L
oxidase (cytochrome c) assembly 1-like
chr20_-_13713509 3.580 NM_016649
ESF1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr2_+_42249896 3.531 NM_001145076
NM_019063
EML4

echinoderm microtubule associated protein like 4

chr11_+_66643311 3.517 NM_012308
KDM2A
lysine (K)-specific demethylase 2A
chr2_+_71412348 3.515 NM_001014972
NM_014497
ZNF638

zinc finger protein 638

chr16_-_68346299 3.412 NM_014062
NOB1
NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)
chr8_-_96350575 3.402 NM_177965
C8orf37
chromosome 8 open reading frame 37
chr9_+_109085643 3.397 RAD23B
RAD23 homolog B (S. cerevisiae)
chr3_+_37259684 3.379 NM_001172713
NM_002078
GOLGA4

golgin A4

chr12_+_120635021 3.357 NM_001080825
TMEM120B
transmembrane protein 120B
chr1_-_28842103 3.356 NM_001135218
NM_005644
TAF12

TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa

chr7_+_98761431 3.321 NM_001190996
NM_006409
ARPC1A

actin related protein 2/3 complex, subunit 1A, 41kDa

chr16_+_48657408 3.318 HEATR3
HEAT repeat containing 3
chr20_+_25176698 3.277 NM_002862
PYGB
phosphorylase, glycogen; brain
chr2_+_131966970 3.266 LOC150776
sphingomyelin phosphodiesterase 4, neutral membrane pseudogene
chr5_+_52131686 3.239 PELO
pelota homolog (Drosophila)
chr12_-_48248132 3.218 NM_006337
MCRS1
microspherule protein 1
chr6_+_30722794 3.176 NM_001109938
NM_001161376
NM_145029
C6orf136


chromosome 6 open reading frame 136


chr9_+_124742932 3.148 NM_012197
RABGAP1
RAB GTPase activating protein 1
chr6_+_41148869 3.131 NFYA
nuclear transcription factor Y, alpha
chr10_-_38186227 3.114 NM_021045
ZNF248
zinc finger protein 248
chr2_-_122123464 3.091 NM_001142273
NM_001142274
NM_015282
CLASP1


cytoplasmic linker associated protein 1


chr1_-_16174859 3.028 NM_003443
ZBTB17
zinc finger and BTB domain containing 17
chr7_+_99865340 3.027 MEPCE
methylphosphate capping enzyme
chr5_+_61744322 2.994 NM_016338
IPO11
importin 11
chr2_-_130655616 2.974 NM_001171083
NM_017751
NM_017951
SMPD4


sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)


chr20_-_10602429 2.946 NM_000214
JAG1
jagged 1
chr6_-_158985727 2.939 NM_006519
DYNLT1
dynein, light chain, Tctex-type 1
chr2_+_187266899 2.935 NM_177454
FAM171B
family with sequence similarity 171, member B
chr14_+_23590939 2.916 NM_138360
LRRC16B
leucine rich repeat containing 16B
chr15_-_41000100 2.866 NM_173500
TTBK2
tau tubulin kinase 2
chr1_-_19409328 2.862 NM_020765
UBR4
ubiquitin protein ligase E3 component n-recognin 4
chr1_+_16046945 2.836 NM_015001
SPEN
spen homolog, transcriptional regulator (Drosophila)
chr20_+_33506322 2.832 NM_007186
CEP250
centrosomal protein 250kDa
chr20_-_32163743 2.798 NM_003908
EIF2S2
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
chr11_+_63463009 2.780 NM_024771
NAA40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr3_+_87359088 2.765 NM_014043
CHMP2B
chromatin modifying protein 2B
chr2_+_28828112 2.751 NM_206876
NM_002709
PPP1CB

protein phosphatase 1, catalytic subunit, beta isozyme

chr16_-_3601580 2.722 NM_032444
SLX4
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
chr14_+_38653177 2.696 NM_001009182
NM_001009183
NM_003616
SIP1


survival of motor neuron protein interacting protein 1


chr17_+_4683280 2.694 NM_001024937
NM_015716
NM_153827
NM_170663
MINK1



misshapen-like kinase 1



chr3_+_139388770 2.670 NM_014154
NM_015396
NM_213654
ARMC8


armadillo repeat containing 8


chr13_+_36291306 2.663 NM_000538
RFXAP
regulatory factor X-associated protein
chr10_-_74526596 2.655 P4HA1
prolyl 4-hydroxylase, alpha polypeptide I
chr8_+_28407613 2.654 NM_017412
FZD3
frizzled homolog 3 (Drosophila)
chr6_-_26767892 2.644 NM_024639
ZNF322A
zinc finger protein 322A
chr17_+_38064787 2.644 NM_016437
TUBG2
tubulin, gamma 2
chr14_-_34078532 2.642 NM_018453
EAPP
E2F-associated phosphoprotein
chr3_-_123617571 2.641 NM_019069
WDR5B
WD repeat domain 5B
chr5_-_90714871 2.606 NM_020801
ARRDC3
arrestin domain containing 3
chr2_+_122124034 2.603 LOC254128
hypothetical LOC254128
chr1_-_232681471 2.598 NM_005646
TARBP1
TAR (HIV-1) RNA binding protein 1
chr1_-_95311031 2.597 NM_144988
ALG14
asparagine-linked glycosylation 14 homolog (S. cerevisiae)
chr7_+_12217343 2.576 NM_001134232
NM_018374
TMEM106B

transmembrane protein 106B

chr3_-_17759100 2.550 NM_001134380
TBC1D5
TBC1 domain family, member 5
chr1_-_3763480 2.507 KIAA0562
KIAA0562
chr17_-_18526296 2.505 NM_001145045
ZNF286B
zinc finger protein 286B
chr17_+_35629080 2.476 NM_133264
WIPF2
WAS/WASL interacting protein family, member 2
chr16_+_79132354 2.452 NM_130897
DYNLRB2
dynein, light chain, roadblock-type 2
chr6_+_33044378 2.446 NM_005104
BRD2
bromodomain containing 2
chr16_-_25176607 2.436 ZKSCAN2
zinc finger with KRAB and SCAN domains 2
chr20_+_1254033 2.434 LOC100507495
hypothetical LOC100507495
chr10_-_74526662 2.412 NM_000917
NM_001017962
NM_001142595
NM_001142596
P4HA1



prolyl 4-hydroxylase, alpha polypeptide I



chr10_+_27833167 2.385 NM_021252
RAB18
RAB18, member RAS oncogene family
chr16_-_11852862 2.382 NM_015659
RSL1D1
ribosomal L1 domain containing 1
chr2_+_69910424 2.362 GMCL1
germ cell-less homolog 1 (Drosophila)
chr16_-_15889968 2.362 C16orf63
chromosome 16 open reading frame 63
chr20_+_11819364 2.361 NM_181443
BTBD3
BTB (POZ) domain containing 3
chr19_-_44715289 2.359 NM_152361
EID2B
EP300 interacting inhibitor of differentiation 2B
chr9_+_132990834 2.350 NUP214
nucleoporin 214kDa
chr11_+_66140628 2.341 NM_001198845
NM_001198846
NM_001198836
NM_001198837
NM_006328
RBM14-RBM4

RBM14


RBM14-RBM4 readthrough

RNA binding motif protein 14


chr8_+_87424074 2.341 NM_007013
WWP1
WW domain containing E3 ubiquitin protein ligase 1
chr20_-_42373151 2.341 NM_001080472
FITM2
fat storage-inducing transmembrane protein 2
chr2_-_150152361 2.339 MMADHC
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
chr6_-_8380623 2.336 NM_001142540
NM_001142541
NM_015948
SLC35B3


solute carrier family 35, member B3


chr20_-_54400628 2.331 NM_003600
NM_198433
NM_198434
NM_198435
NM_198436
NM_198437
AURKA





aurora kinase A





chr2_+_130655970 2.331 NM_025029
MZT2B
mitotic spindle organizing protein 2B
chr5_-_132101042 2.328 NM_007054
KIF3A
kinesin family member 3A
chr5_+_170747543 2.308 NPM1
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
chr12_+_92295738 2.287 NM_019094
NM_199040
NUDT4

NUDT4P1
nudix (nucleoside diphosphate linked moiety X)-type motif 4

nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene 1
chr6_-_121697305 2.287 NM_152730
C6orf170
chromosome 6 open reading frame 170
chr6_-_24774797 2.277 NM_016614
TDP2
tyrosyl-DNA phosphodiesterase 2
chr13_+_39127758 2.274 NM_001145079
NM_020751
COG6

component of oligomeric golgi complex 6

chr18_+_9465528 2.273 NM_006788
RALBP1
ralA binding protein 1
chr22_-_30072217 2.245 NM_014323
NM_032050
NM_032051
NM_032052
PATZ1



POZ (BTB) and AT hook containing zinc finger 1



chr20_+_36534871 2.243 NM_020336
RALGAPB
Ral GTPase activating protein, beta subunit (non-catalytic)
chr10_-_27429325 2.240 NM_014915
ANKRD26
ankyrin repeat domain 26
chr16_-_15889947 2.238 NM_144600
C16orf63
chromosome 16 open reading frame 63
chr1_-_16812274 2.234 NM_017940
NBPF1
neuroblastoma breakpoint family, member 1
chr4_+_689529 2.232 NM_006315
PCGF3
polycomb group ring finger 3
chr4_-_52599181 2.231 NM_000232
SGCB
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
chr6_+_237033 2.217 NM_020185
DUSP22
dual specificity phosphatase 22
chr2_+_26110232 2.215 NM_016131
RAB10
RAB10, member RAS oncogene family
chr4_+_6768800 2.213 CNO
cappuccino homolog (mouse)
chr16_+_29734785 2.213 C16orf53
chromosome 16 open reading frame 53
chr10_+_21863099 2.212 NM_001195627
NM_001195628
NM_001195630
NM_004641
MLLT10



myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10



chr4_+_84596141 2.197 NM_016067
MRPS18C
mitochondrial ribosomal protein S18C
chr6_+_27208763 2.196 NM_021064
HIST1H2AG
histone cluster 1, H2ag
chr15_-_73719546 2.186 NM_018285
IMP3
IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr21_-_32573195 2.185 NM_018944
MIS18A
MIS18 kinetochore protein homolog A (S. pombe)
chr15_-_61680003 2.182 LOC100130855
hypothetical LOC100130855
chr22_+_17539198 2.182


chr16_+_14072380 2.180 NM_014048
MKL2
MKL/myocardin-like 2
chr1_+_28752106 2.180 NM_017846
TRNAU1AP
tRNA selenocysteine 1 associated protein 1
chr16_+_29892714 2.180 NM_004783
NM_016151
TAOK2

TAO kinase 2

chr7_-_44025235 2.171 POLR2J2
POLR2J3
POLR2J4
polymerase (RNA) II (DNA directed) polypeptide J2
polymerase (RNA) II (DNA directed) polypeptide J3
polymerase (RNA) II (DNA directed) polypeptide J4, pseudogene
chr3_+_43303005 2.170 NM_001100594
NM_017719
SNRK

SNF related kinase

chr5_-_162819633 2.169 NUDCD2
NudC domain containing 2
chr1_-_45924770 2.164 NM_021639
GPBP1L1
GC-rich promoter binding protein 1-like 1
chr2_-_175754366 2.159 NM_001002258
NM_001190329
NM_001689
ATP5G3


ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)


chr7_+_71937980 2.157 SBDSP1
Shwachman-Bodian-Diamond syndrome pseudogene 1
chr9_-_138277467 2.155 NM_181701
QSOX2
quiescin Q6 sulfhydryl oxidase 2
chr15_+_46957556 2.155 NM_014335
EID1
EP300 interacting inhibitor of differentiation 1
chr6_-_39190728 2.152 NM_018322
C6orf64
chromosome 6 open reading frame 64
chr6_+_33044353 2.139


chr6_-_27208507 2.139 NM_021058
HIST1H2BJ
histone cluster 1, H2bj
chr14_+_74606051 2.128 NM_001042430
NM_024643
FAM164C

family with sequence similarity 164, member C

chr7_-_102099283 2.127 NM_032959
POLR2J2
POLR2J3
polymerase (RNA) II (DNA directed) polypeptide J2
polymerase (RNA) II (DNA directed) polypeptide J3
chr17_-_23244499 2.125 NM_001076680
C17orf108
chromosome 17 open reading frame 108
chr6_+_24511123 2.116 NM_020662
MRS2
MRS2 magnesium homeostasis factor homolog (S. cerevisiae)
chr5_+_162820094 2.114 NM_001142556
NM_001142557
NM_012484
NM_012485
HMMR



hyaluronan-mediated motility receptor (RHAMM)



chr2_+_138975946 2.106


chr7_-_66097838 2.103 NM_016038
SBDS
Shwachman-Bodian-Diamond syndrome
chr14_-_30565275 2.088 NM_001083893
NM_014574
STRN3

striatin, calmodulin binding protein 3

chr2_+_69910277 2.055 NM_178439
GMCL1
germ cell-less homolog 1 (Drosophila)
chr11_+_18374388 2.053 NM_001165414
LDHA
lactate dehydrogenase A
chr4_+_39376058 2.040 NM_001111112
NM_001111113
NM_005339
UBE2K


ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)


chr6_+_99979490 2.038


chr20_-_3133286 2.036 NM_023935
DDRGK1
DDRGK domain containing 1
chr11_-_62379788 2.028 SNHG1
small nucleolar RNA host gene 1 (non-protein coding)
chr7_+_107171809 2.025 CBLL1
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
chr3_-_40473723 2.018


chr17_+_32924049 2.008 NM_007026
DUSP14
dual specificity phosphatase 14
chr6_+_24775241 2.006 NM_001160094
NM_018473
ACOT13

acyl-CoA thioesterase 13

chr2_+_98427737 1.992 NM_001134224
NM_001134225
NM_001566
NM_004027
INPP4A



inositol polyphosphate-4-phosphatase, type I, 107kDa



chr1_-_16843764 1.987 CROCCP2
ciliary rootlet coiled-coil, rootletin pseudogene 2
chr6_-_153346283 1.975 NM_001142522
FBXO5
F-box protein 5
chr12_+_123023521 1.969 NM_152437
ZNF664
zinc finger protein 664
chr2_-_86186788 1.964 NM_015425
POLR1A
polymerase (RNA) I polypeptide A, 194kDa
chr2_-_150152531 1.962 NM_015702
MMADHC
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
chr14_+_64949447 1.962 FUT8
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr20_-_35013459 1.961 SAMHD1
SAM domain and HD domain 1
chr20_+_25124333 1.960 NM_001114089
NM_001247
ENTPD6

ectonucleoside triphosphate diphosphohydrolase 6 (putative)

chr19_+_16169664 1.950 NM_001130524
NM_032493
AP1M1

adaptor-related protein complex 1, mu 1 subunit

chr1_-_16843744 1.944 CROCCP2
ciliary rootlet coiled-coil, rootletin pseudogene 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.51 6.11e-41 GO:0044260 cellular macromolecule metabolic process
1.40 2.39e-30 GO:0043170 macromolecule metabolic process
1.33 7.82e-30 GO:0044237 cellular metabolic process
1.65 7.85e-27 GO:0090304 nucleic acid metabolic process
1.54 1.61e-24 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.26 5.32e-22 GO:0008152 metabolic process
1.28 3.59e-21 GO:0044238 primary metabolic process
1.44 2.42e-19 GO:0034641 cellular nitrogen compound metabolic process
1.43 5.59e-19 GO:0006807 nitrogen compound metabolic process
1.49 4.32e-18 GO:0044267 cellular protein metabolic process
1.59 1.14e-17 GO:0010467 gene expression
1.60 5.50e-17 GO:0016070 RNA metabolic process
1.97 6.51e-14 GO:0051276 chromosome organization
1.92 6.59e-13 GO:0006396 RNA processing
2.01 1.42e-12 GO:0016071 mRNA metabolic process
1.52 6.93e-12 GO:0006996 organelle organization
1.67 2.66e-11 GO:0007049 cell cycle
1.97 3.31e-11 GO:0006974 response to DNA damage stimulus
1.83 4.23e-11 GO:0022403 cell cycle phase
1.35 8.90e-11 GO:0019538 protein metabolic process
1.99 1.67e-10 GO:0006325 chromatin organization
1.88 2.67e-10 GO:0000278 mitotic cell cycle
2.16 3.79e-10 GO:0006281 DNA repair
1.91 4.91e-10 GO:0044265 cellular macromolecule catabolic process
2.08 5.07e-10 GO:0006397 mRNA processing
2.21 1.04e-09 GO:0008380 RNA splicing
1.84 1.71e-09 GO:0006259 DNA metabolic process
1.47 2.22e-09 GO:0034645 cellular macromolecule biosynthetic process
1.69 3.21e-09 GO:0022402 cell cycle process
1.46 3.57e-09 GO:0009059 macromolecule biosynthetic process
1.34 4.24e-09 GO:0071841 cellular component organization or biogenesis at cellular level
1.68 5.63e-09 GO:0033554 cellular response to stress
1.10 1.20e-08 GO:0009987 cellular process
1.78 1.56e-08 GO:0009057 macromolecule catabolic process
1.91 6.32e-08 GO:0000279 M phase
1.33 6.73e-08 GO:0071842 cellular component organization at cellular level
1.40 1.14e-07 GO:0006464 protein modification process
2.08 1.52e-07 GO:0000087 M phase of mitotic cell cycle
1.39 1.86e-07 GO:0043412 macromolecule modification
1.95 4.53e-07 GO:0016568 chromatin modification
1.99 6.29e-07 GO:0070647 protein modification by small protein conjugation or removal
2.03 1.45e-06 GO:0000280 nuclear division
2.03 1.45e-06 GO:0007067 mitosis
2.26 1.56e-06 GO:0000375 RNA splicing, via transesterification reactions
2.06 1.78e-06 GO:0032446 protein modification by small protein conjugation
1.32 2.33e-06 GO:0044249 cellular biosynthetic process
2.09 2.59e-06 GO:0016567 protein ubiquitination
2.00 2.93e-06 GO:0048285 organelle fission
2.24 4.28e-06 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.24 4.28e-06 GO:0000398 nuclear mRNA splicing, via spliceosome
1.24 8.36e-06 GO:0071840 cellular component organization or biogenesis
1.91 1.17e-05 GO:0044257 cellular protein catabolic process
1.29 2.04e-05 GO:0009058 biosynthetic process
1.91 2.12e-05 GO:0043632 modification-dependent macromolecule catabolic process
1.89 2.38e-05 GO:0051603 proteolysis involved in cellular protein catabolic process
3.05 2.53e-05 GO:0006302 double-strand break repair
1.91 3.15e-05 GO:0006511 ubiquitin-dependent protein catabolic process
1.90 3.54e-05 GO:0019941 modification-dependent protein catabolic process
1.91 3.84e-05 GO:0006412 translation
1.71 4.42e-05 GO:0034621 cellular macromolecular complex subunit organization
1.23 6.26e-05 GO:0016043 cellular component organization
1.82 6.51e-05 GO:0030163 protein catabolic process
1.77 5.07e-04 GO:0051301 cell division
1.70 6.72e-04 GO:0016032 viral reproduction
1.50 7.63e-04 GO:0046907 intracellular transport
1.82 8.19e-04 GO:0051325 interphase
2.17 8.43e-04 GO:0071103 DNA conformation change
1.73 1.35e-03 GO:0034622 cellular macromolecular complex assembly
2.20 1.43e-03 GO:0006333 chromatin assembly or disassembly
1.80 1.86e-03 GO:0051329 interphase of mitotic cell cycle
1.38 2.40e-03 GO:0044248 cellular catabolic process
2.19 4.61e-03 GO:0006323 DNA packaging
1.69 5.11e-03 GO:0044419 interspecies interaction between organisms
2.51 5.25e-03 GO:0051168 nuclear export
2.06 6.03e-03 GO:0010498 proteasomal protein catabolic process
2.06 6.03e-03 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
1.99 6.98e-03 GO:0006913 nucleocytoplasmic transport
2.68 8.01e-03 GO:0006405 RNA export from nucleus
1.50 9.17e-03 GO:0051726 regulation of cell cycle
1.42 9.30e-03 GO:0045184 establishment of protein localization
1.40 9.83e-03 GO:0032774 RNA biosynthetic process
1.97 9.87e-03 GO:0051169 nuclear transport
2.52 1.17e-02 GO:0006354 transcription elongation, DNA-dependent
2.69 1.19e-02 GO:0031124 mRNA 3'-end processing
1.42 1.31e-02 GO:0015031 protein transport
2.49 1.54e-02 GO:0000956 nuclear-transcribed mRNA catabolic process
2.07 1.88e-02 GO:0006310 DNA recombination
1.95 2.05e-02 GO:0043687 post-translational protein modification
2.39 2.26e-02 GO:0006402 mRNA catabolic process
2.25 2.87e-02 GO:0031497 chromatin assembly
1.35 3.07e-02 GO:0008104 protein localization
3.44 3.54e-02 GO:0070936 protein K48-linked ubiquitination
1.69 4.82e-02 GO:0006366 transcription from RNA polymerase II promoter
2.62 4.87e-02 GO:0006406 mRNA export from nucleus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.22 2.38e-56 GO:0005622 intracellular
1.22 6.02e-55 GO:0044424 intracellular part
1.31 1.06e-52 GO:0043231 intracellular membrane-bounded organelle
1.31 1.22e-52 GO:0043227 membrane-bounded organelle
1.27 8.14e-52 GO:0043229 intracellular organelle
1.27 3.63e-51 GO:0043226 organelle
1.43 7.47e-45 GO:0005634 nucleus
1.39 7.20e-37 GO:0044446 intracellular organelle part
1.38 2.90e-35 GO:0044422 organelle part
1.72 3.19e-34 GO:0044428 nuclear part
1.72 3.96e-28 GO:0031981 nuclear lumen
1.63 4.28e-28 GO:0070013 intracellular organelle lumen
1.61 1.69e-27 GO:0031974 membrane-enclosed lumen
1.61 3.67e-27 GO:0043233 organelle lumen
1.85 4.87e-27 GO:0005654 nucleoplasm
1.40 5.54e-20 GO:0032991 macromolecular complex
2.11 1.82e-17 GO:0005694 chromosome
1.19 1.41e-16 GO:0005737 cytoplasm
2.11 1.61e-14 GO:0044427 chromosomal part
1.80 2.72e-12 GO:0044451 nucleoplasm part
1.88 3.66e-10 GO:0030529 ribonucleoprotein complex
1.32 4.40e-10 GO:0043234 protein complex
1.33 8.05e-10 GO:0043228 non-membrane-bounded organelle
1.33 8.05e-10 GO:0043232 intracellular non-membrane-bounded organelle
1.19 1.27e-09 GO:0044444 cytoplasmic part
1.34 3.14e-07 GO:0005829 cytosol
1.42 1.69e-06 GO:0005739 mitochondrion
1.04 7.25e-06 GO:0044464 cell part
1.04 7.61e-06 GO:0005623 cell
1.84 9.26e-06 GO:0005815 microtubule organizing center
2.03 1.39e-05 GO:0005813 centrosome
1.99 1.93e-05 GO:0000785 chromatin
2.12 3.56e-05 GO:0005819 spindle
1.55 3.75e-05 GO:0015630 microtubule cytoskeleton
2.28 4.85e-05 GO:0000151 ubiquitin ligase complex
1.54 6.58e-05 GO:0044429 mitochondrial part
2.08 1.98e-04 GO:0044454 nuclear chromosome part
2.61 4.01e-04 GO:0031461 cullin-RING ubiquitin ligase complex
2.23 6.42e-04 GO:0044455 mitochondrial membrane part
2.16 8.57e-04 GO:0005681 spliceosomal complex
1.89 9.79e-04 GO:0000228 nuclear chromosome
2.17 1.81e-03 GO:0016607 nuclear speck
1.52 5.14e-03 GO:0005730 nucleolus
2.53 7.02e-03 GO:0000922 spindle pole
2.00 8.50e-03 GO:0000793 condensed chromosome
1.77 9.23e-03 GO:0016604 nuclear body
1.41 1.15e-02 GO:0031967 organelle envelope
1.96 1.43e-02 GO:0000775 chromosome, centromeric region
2.87 2.42e-02 GO:0008287 protein serine/threonine phosphatase complex
1.39 2.67e-02 GO:0031975 envelope
2.13 3.29e-02 GO:0032993 protein-DNA complex
1.59 3.66e-02 GO:0005743 mitochondrial inner membrane
1.49 4.24e-02 GO:0031966 mitochondrial membrane
1.47 4.56e-02 GO:0005740 mitochondrial envelope
2.15 4.77e-02 GO:0000776 kinetochore

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.44 7.93e-22 GO:0003676 nucleic acid binding
1.23 5.71e-19 GO:0005515 protein binding
1.80 4.22e-14 GO:0003723 RNA binding
1.10 1.76e-12 GO:0005488 binding
1.90 2.24e-09 GO:0016874 ligase activity
2.19 4.20e-09 GO:0016881 acid-amino acid ligase activity
1.35 9.17e-09 GO:0003677 DNA binding
2.10 1.05e-08 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.34 3.66e-08 GO:0000166 nucleotide binding
2.21 4.81e-08 GO:0019787 small conjugating protein ligase activity
2.21 1.84e-07 GO:0004842 ubiquitin-protein ligase activity
1.18 6.70e-07 GO:0003824 catalytic activity
1.45 1.22e-03 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.28 1.38e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.31 1.45e-03 GO:0030554 adenyl nucleotide binding
1.44 1.54e-03 GO:0016817 hydrolase activity, acting on acid anhydrides
1.44 1.56e-03 GO:0016462 pyrophosphatase activity
1.31 1.66e-03 GO:0005524 ATP binding
1.27 1.86e-03 GO:0017076 purine nucleotide binding
1.30 1.91e-03 GO:0032559 adenyl ribonucleotide binding
1.27 2.18e-03 GO:0032553 ribonucleotide binding
1.27 2.18e-03 GO:0032555 purine ribonucleotide binding
1.61 6.51e-03 GO:0003712 transcription cofactor activity
1.60 7.24e-03 GO:0000988 protein binding transcription factor activity
1.60 7.24e-03 GO:0000989 transcription factor binding transcription factor activity
1.85 1.24e-02 GO:0003682 chromatin binding
1.40 1.32e-02 GO:0017111 nucleoside-triphosphatase activity
1.83 2.03e-02 GO:0043566 structure-specific DNA binding
2.07 3.32e-02 GO:0016779 nucleotidyltransferase activity