Motif ID: GTF2I.p2

Z-value: 2.382


Transcription factors associated with GTF2I.p2:

Gene SymbolEntrez IDGene Name
GTF2I 2969 general transcription factor II, i

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GTF2Ichr7_+_737099430.136.3e-01Click!


Activity profile for motif GTF2I.p2.

activity profile for motif GTF2I.p2


Sorted Z-values histogram for motif GTF2I.p2

Sorted Z-values for motif GTF2I.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2I.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_17714070 5.038 NM_001112741
NM_004976
 KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chrX_+_144707022 3.650 NM_001144003
NM_001144004
NM_001144005
NM_032539
 SLITRK2



SLIT and NTRK-like family, member 2



chr15_-_86600658 3.473 NM_001007156
NM_001012338
NM_002530
 NTRK3


neurotrophic tyrosine kinase, receptor, type 3


chr12_+_6800950 3.168 NM_014449
NM_019858
 GPR162

G protein-coupled receptor 162

chr2_+_45022540 3.035 NM_005413
 SIX3
SIX homeobox 3
chr18_-_21184824 2.943


chr14_-_60185659 2.904 NM_005982
 SIX1
SIX homeobox 1
chr18_-_28606839 2.890 NM_020805
 KLHL14
kelch-like 14 (Drosophila)
chr13_+_99431417 2.854


chr2_-_200030944 2.845 NM_001172509
 SATB2
SATB homeobox 2
chrX_+_136476353 2.834 ZIC3
Zic family member 3 (odd-paired homolog, Drosophila)
chr17_-_44047299 2.816 NM_024016
 HOXB8
homeobox B8
chr13_+_57103944 2.645 PCDH17
protocadherin 17
chr13_+_57103789 2.604 NM_001040429
 PCDH17
protocadherin 17
chr8_+_104582151 2.528 NM_001100117
 RIMS2
regulating synaptic membrane exocytosis 2
chr14_-_36058648 2.496 NM_003317
 NKX2-1
NK2 homeobox 1
chr1_+_26609893 2.449 LIN28A
lin-28 homolog A (C. elegans)
chr14_-_23117614 2.434 JPH4
junctophilin 4
chr12_+_93066370 2.426 NM_005761
 PLXNC1
plexin C1
chr10_+_102495327 2.421 NM_000278
NM_003987
NM_003988
NM_003989
NM_003990
 PAX2




paired box 2





Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 175 entries
enrichment   p-value GO term description
2.38 1.32e-03 GO:0021987 cerebral cortex development
2.02 2.04e-05 GO:0021537 telencephalon development
2.02 1.68e-02 GO:0021543 pallium development
1.99 2.87e-03 GO:0050770 regulation of axonogenesis
1.91 3.97e-09 GO:0030900 forebrain development
1.91 1.55e-02 GO:0031346 positive regulation of cell projection organization
1.91 1.55e-02 GO:0048638 regulation of developmental growth
1.90 3.64e-02 GO:0009953 dorsal/ventral pattern formation
1.90 4.41e-02 GO:0030902 hindbrain development
1.89 5.95e-03 GO:0055123 digestive system development
1.89 2.47e-02 GO:0048565 digestive tract development
1.85 6.53e-07 GO:0006813 potassium ion transport
1.84 1.32e-03 GO:0010720 positive regulation of cell development
1.81 1.52e-04 GO:0022604 regulation of cell morphogenesis
1.80 2.79e-04 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.77 9.20e-04 GO:0010975 regulation of neuron projection development
1.75 1.82e-13 GO:0007420 brain development
1.72 5.53e-06 GO:0045664 regulation of neuron differentiation
1.72 5.50e-04 GO:0031344 regulation of cell projection organization
1.65 5.01e-08 GO:0022603 regulation of anatomical structure morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 35 entries
enrichment   p-value GO term description
2.91 3.87e-02 GO:0008328 ionotropic glutamate receptor complex
2.51 3.23e-05 GO:0042734 presynaptic membrane
1.99 1.19e-04 GO:0033267 axon part
1.91 5.34e-04 GO:0014069 postsynaptic density
1.89 2.49e-04 GO:0008076 voltage-gated potassium channel complex
1.89 2.49e-04 GO:0034705 potassium channel complex
1.86 8.27e-07 GO:0034703 cation channel complex
1.76 1.81e-12 GO:0044456 synapse part
1.72 1.27e-15 GO:0045202 synapse
1.72 1.31e-07 GO:0034702 ion channel complex
1.69 3.35e-06 GO:0030425 dendrite
1.69 1.29e-04 GO:0045211 postsynaptic membrane
1.67 4.80e-05 GO:0043025 neuronal cell body
1.64 1.02e-04 GO:0044297 cell body
1.63 1.40e-04 GO:0030424 axon
1.61 3.52e-02 GO:0044420 extracellular matrix part
1.60 1.66e-10 GO:0043005 neuron projection
1.48 3.77e-02 GO:0031252 cell leading edge
1.46 1.86e-05 GO:0031012 extracellular matrix
1.46 2.34e-04 GO:0005578 proteinaceous extracellular matrix

Gene overrepresentation in function category:

Showing 1 to 20 of 36 entries
enrichment   p-value GO term description
3.15 1.53e-02 GO:0043548 phosphatidylinositol 3-kinase binding
2.86 3.94e-03 GO:0005234 extracellular-glutamate-gated ion channel activity
2.83 1.13e-02 GO:0004970 ionotropic glutamate receptor activity
2.58 9.35e-04 GO:0008066 glutamate receptor activity
1.93 1.60e-08 GO:0022843 voltage-gated cation channel activity
1.89 9.40e-05 GO:0005249 voltage-gated potassium channel activity
1.88 2.15e-06 GO:0005267 potassium channel activity
1.84 3.45e-09 GO:0005244 voltage-gated ion channel activity
1.84 3.45e-09 GO:0022832 voltage-gated channel activity
1.76 5.50e-11 GO:0005261 cation channel activity
1.72 1.40e-11 GO:0022836 gated channel activity
1.70 1.56e-03 GO:0015276 ligand-gated ion channel activity
1.70 1.56e-03 GO:0022834 ligand-gated channel activity
1.64 3.90e-09 GO:0016563 transcription activator activity
1.62 5.82e-11 GO:0005216 ion channel activity
1.60 3.44e-10 GO:0022838 substrate-specific channel activity
1.58 1.45e-17 GO:0043565 sequence-specific DNA binding
1.58 4.92e-10 GO:0015267 channel activity
1.58 6.51e-10 GO:0022803 passive transmembrane transporter activity
1.46 1.87e-08 GO:0008324 cation transmembrane transporter activity