Motif ID: EN1,2.p2

Z-value: 2.181


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EN2chr7_+_1549434660.342.0e-01Click!
EN1chr2_-_1193222280.146.0e-01Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_30188845 3.764 NM_007028
 TRIM31
tripartite motif containing 31
chr12_+_10351683 2.896 NM_002262
NM_007334
 KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr10_+_114144512 2.878 ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_+_157526127 2.492 NM_002001
 FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr11_-_123182266 2.266 NM_001005325
 OR6M1
olfactory receptor, family 6, subfamily M, member 1
chr1_+_31823097 2.170 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr2_+_96355661 2.048 NM_178495
NM_001163524
 ITPRIPL1

inositol 1,4,5-triphosphate receptor interacting protein-like 1

chr5_-_77880731 2.030 LHFPL2
lipoma HMGIC fusion partner-like 2
chr6_-_119512035 2.005 NM_001100411
 FAM184A
family with sequence similarity 184, member A
chr9_-_110658030 1.891 NM_006686
 ACTL7B
actin-like 7B
chr12_+_63510481 1.808


chr22_+_19660361 1.796 AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr1_-_202726068 1.690 NM_002646
 PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr3_+_120375053 1.671 NM_006952
 UPK1B
uroplakin 1B
chr1_+_200775864 1.656 NM_001197131
 PPP1R12B
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr12_-_103846186 1.615 NM_032148
 SLC41A2
solute carrier family 41, member 2
chr11_-_58947001 1.589 NM_001001954
 OR5A2
olfactory receptor, family 5, subfamily A, member 2
chr12_+_54316910 1.583 NM_206899
 OR10P1
olfactory receptor, family 10, subfamily P, member 1
chr8_+_128497038 1.577 NM_001159542
 POU5F1B
POU class 5 homeobox 1B
chr1_+_160618143 1.566 NM_001085375
 C1orf226
chromosome 1 open reading frame 226

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
3.63 1.50e-30 GO:0007608 sensory perception of smell
3.60 6.40e-34 GO:0007606 sensory perception of chemical stimulus
2.64 8.81e-27 GO:0007600 sensory perception
2.64 9.61e-03 GO:0006814 sodium ion transport
2.05 6.57e-20 GO:0050877 neurological system process
1.90 2.80e-19 GO:0003008 system process
1.76 1.32e-04 GO:0006955 immune response
1.48 8.36e-03 GO:0002376 immune system process
1.29 4.82e-11 GO:0050896 response to stimulus
1.29 4.22e-08 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
1.64 3.26e-04 GO:0005615 extracellular space
1.55 4.31e-04 GO:0044421 extracellular region part
1.46 7.72e-17 GO:0005886 plasma membrane
1.45 1.28e-16 GO:0071944 cell periphery
1.42 1.25e-05 GO:0005576 extracellular region
1.24 2.08e-06 GO:0031224 intrinsic to membrane
1.24 3.00e-06 GO:0016021 integral to membrane
1.21 3.59e-06 GO:0044425 membrane part
1.17 2.56e-05 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
6.07 3.45e-02 GO:0008527 taste receptor activity
3.73 9.14e-32 GO:0004984 olfactory receptor activity
2.56 4.32e-26 GO:0004930 G-protein coupled receptor activity
2.16 1.25e-02 GO:0005125 cytokine activity
2.14 4.43e-23 GO:0004888 transmembrane receptor activity
2.11 4.46e-02 GO:0005126 cytokine receptor binding
1.86 7.36e-19 GO:0004872 receptor activity
1.75 4.92e-18 GO:0004871 signal transducer activity
1.75 4.92e-18 GO:0060089 molecular transducer activity
1.44 4.80e-02 GO:0005102 receptor binding