Motif ID: EN1,2.p2

Z-value: 2.181


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EN2chr7_+_1549434660.342.0e-01Click!
EN1chr2_-_1193222280.146.0e-01Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_30188845 3.764 NM_007028
TRIM31
tripartite motif containing 31
chr12_+_10351683 2.896 NM_002262
NM_007334
KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr10_+_114144512 2.878 ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_+_157526127 2.492 NM_002001
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr11_-_123182266 2.266 NM_001005325
OR6M1
olfactory receptor, family 6, subfamily M, member 1
chr1_+_31823097 2.170 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr2_+_96355661 2.048 NM_178495
NM_001163524
ITPRIPL1

inositol 1,4,5-triphosphate receptor interacting protein-like 1

chr5_-_77880731 2.030 LHFPL2
lipoma HMGIC fusion partner-like 2
chr6_-_119512035 2.005 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr9_-_110658030 1.891 NM_006686
ACTL7B
actin-like 7B
chr12_+_63510481 1.808


chr22_+_19660361 1.796 AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr1_-_202726068 1.690 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr3_+_120375053 1.671 NM_006952
UPK1B
uroplakin 1B
chr1_+_200775864 1.656 NM_001197131
PPP1R12B
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr12_-_103846186 1.615 NM_032148
SLC41A2
solute carrier family 41, member 2
chr11_-_58947001 1.589 NM_001001954
OR5A2
olfactory receptor, family 5, subfamily A, member 2
chr12_+_54316910 1.583 NM_206899
OR10P1
olfactory receptor, family 10, subfamily P, member 1
chr8_+_128497038 1.577 NM_001159542
POU5F1B
POU class 5 homeobox 1B
chr1_+_160618143 1.566 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr3_-_38967055 1.563 NM_014139
SCN11A
sodium channel, voltage-gated, type XI, alpha subunit
chr6_+_30212488 1.540 NM_138700
TRIM40
tripartite motif containing 40
chr4_+_157044296 1.540 NM_005651
TDO2
tryptophan 2,3-dioxygenase
chr12_+_10054492 1.527 NM_001129998
NM_205852
CLEC12B

C-type lectin domain family 12, member B

chr1_+_169421011 1.512 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr10_+_95362334 1.494 NM_006204
PDE6C
phosphodiesterase 6C, cGMP-specific, cone, alpha prime
chr6_-_132980901 1.474 NM_014626
TAAR2
trace amine associated receptor 2
chr2_-_158008763 1.466 NM_004288
CYTIP
cytohesin 1 interacting protein
chr11_-_123918759 1.447 NM_001005195
OR8B12
olfactory receptor, family 8, subfamily B, member 12
chr2_-_87102453 1.438 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr11_+_123625632 1.426 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr1_-_154484341 1.413 NM_198406
NM_024897
PAQR6

progestin and adipoQ receptor family member VI

chr1_-_157950898 1.401 NM_000567
CRP
C-reactive protein, pentraxin-related
chr1_+_54786394 1.388 NM_015547
NM_147161
ACOT11

acyl-CoA thioesterase 11

chr1_-_150328153 1.373 NM_001008536
TCHHL1
trichohyalin-like 1
chr3_+_52788976 1.373 NM_001166435
NM_001166436
ITIH1

inter-alpha (globulin) inhibitor H1

chr19_-_46048033 1.372 NM_000762
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr3_+_188197029 1.280


chr2_-_162717159 1.261 NM_002054
GCG
glucagon
chr15_+_37330176 1.254 NM_207445
C15orf54
chromosome 15 open reading frame 54
chr3_-_188903038 1.252 NM_001004312
RTP2
receptor (chemosensory) transporter protein 2
chr3_-_125192888 1.243 NM_017578
ROPN1
rhophilin associated tail protein 1
chr11_-_123685871 1.236 NM_001002917
OR8D1
olfactory receptor, family 8, subfamily D, member 1
chr4_-_77147625 1.234 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr5_+_67558217 1.228 NM_181523
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr18_-_56190980 1.210 NM_005912
MC4R
melanocortin 4 receptor
chr10_+_105027431 1.189 INA
internexin neuronal intermediate filament protein, alpha
chr17_-_4589911 1.185 NM_001100812
NM_022059
CXCL16

chemokine (C-X-C motif) ligand 16

chr8_+_22900863 1.164 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr1_-_156784518 1.163 NM_001005189
OR6Y1
olfactory receptor, family 6, subfamily Y, member 1
chr22_+_23921072 1.143 KIAA1671
KIAA1671
chr19_+_46286207 1.123 NM_000766
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr6_-_25834733 1.121 NM_170745
HIST1H2AA
histone cluster 1, H2aa
chr11_-_26700121 1.090 NM_178498
SLC5A12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr11_+_123315459 1.086 NM_001001965
OR4D5
olfactory receptor, family 4, subfamily D, member 5
chr10_-_28611020 1.084 NM_173496
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr10_-_104587069 1.080 NM_000102
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr15_+_84021271 1.072 NM_144767
AKAP13
A kinase (PRKA) anchor protein 13
chr1_+_169484256 1.070 NM_002021
FMO1
flavin containing monooxygenase 1
chr6_+_146390474 1.062 NM_000838
NM_001114329
GRM1

glutamate receptor, metabotropic 1

chr19_-_14030970 1.062 NM_001145028
PALM3
paralemmin 3
chr2_-_113310796 1.049 NM_000576
IL1B
interleukin 1, beta
chr10_+_5228756 1.042 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr14_+_75907442 1.026 NM_004452
ESRRB
estrogen-related receptor beta
chr14_-_94053933 1.021 NM_173850
SERPINA12
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
chr19_+_45973139 1.021 NM_006533
MIA
melanoma inhibitory activity
chr11_+_59979857 1.018 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr14_-_99911409 0.980 WARS
tryptophanyl-tRNA synthetase
chr17_-_60439764 0.973 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr12_+_119617060 0.973


chr11_+_7574992 0.963 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr11_-_62508946 0.953 NM_004790
NM_153276
NM_153277
NM_153278
SLC22A6



solute carrier family 22 (organic anion transporter), member 6



chr11_+_55776251 0.951 NM_001004747
OR5T3
olfactory receptor, family 5, subfamily T, member 3
chr10_-_98021144 0.951 NM_001114094
NM_013314
BLNK

B-cell linker

chr12_-_7172641 0.944 NM_031491
RBP5
retinol binding protein 5, cellular
chr17_-_36209672 0.944 NM_181535
KRT28
keratin 28
chr17_-_40843530 0.944 ARHGAP27
Rho GTPase activating protein 27
chrX_+_49480643 0.937 NM_007003
PAGE4
P antigen family, member 4 (prostate associated)
chr2_+_231569082 0.931 NM_139073
SPATA3
spermatogenesis associated 3
chrX_-_50403412 0.931 SHROOM4
shroom family member 4
chr3_+_38238080 0.913 OXSR1
oxidative-stress responsive 1
chr14_+_69993969 0.911 NM_003813
ADAM21
ADAM metallopeptidase domain 21
chr5_+_79651545 0.910 NM_032567
SPZ1
spermatogenic leucine zipper 1
chr17_-_36594652 0.907 NM_033060
KRTAP4-1
keratin associated protein 4-1
chr1_-_203657803 0.905 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr19_+_46201665 0.900 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr3_-_188935363 0.896 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr12_+_84792203 0.889 NM_006183
NTS
neurotensin
chr3_+_45902999 0.889 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr7_+_94377145 0.880 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr4_-_647974 0.879 PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr22_+_20929199 0.875 NM_007128
VPREB1
pre-B lymphocyte 1
chr1_+_144124547 0.868 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr6_+_132901119 0.868 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr12_+_108452117 0.866 UBE3B
ubiquitin protein ligase E3B
chrX_-_100015783 0.865 NM_007052
NM_013955
NOX1

NADPH oxidase 1

chrX_+_55666557 0.864 NM_198451
FOXR2
forkhead box R2
chr8_+_86538307 0.861 NM_005181
CA3
carbonic anhydrase III, muscle specific
chr20_+_58004811 0.856 NM_021810
CDH26
cadherin 26
chrX_+_38305634 0.852 NM_004615
TSPAN7
tetraspanin 7
chr11_+_54891935 0.849 NM_001005275
OR4A15
olfactory receptor, family 4, subfamily A, member 15
chr17_-_29507663 0.848 NM_001094
ACCN1
amiloride-sensitive cation channel 1, neuronal
chrX_+_41433169 0.847 NM_001097579
NM_005300
GPR34

G protein-coupled receptor 34

chr12_-_119249938 0.847 NM_000928
PLA2G1B
phospholipase A2, group IB (pancreas)
chr3_+_185233312 0.844 NM_001163646
HTR3D
5-hydroxytryptamine (serotonin) receptor 3 family member D
chr1_-_229627412 0.835 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr19_+_61624 0.833 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr15_+_41672543 0.832 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr12_-_55790355 0.825 NM_001178079
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr13_+_52114565 0.818 HNRNPA1L2
heterogeneous nuclear ribonucleoprotein A1-like 2
chr11_+_123391491 0.805 NM_001004462
OR10G4
olfactory receptor, family 10, subfamily G, member 4
chr1_+_33710818 0.803 NM_145238
ZSCAN20
zinc finger and SCAN domain containing 20
chr3_-_18455207 0.802 NM_001131010
SATB1
SATB homeobox 1
chr1_+_151015471 0.797 NM_178354
LCE1F
late cornified envelope 1F
chr1_-_220788048 0.779 NM_024746
HHIPL2
HHIP-like 2
chr12_-_66933492 0.778 NM_020525
IL22
interleukin 22
chr4_+_74500748 0.775 ALB
albumin
chr11_+_57123927 0.771 SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr3_+_185253528 0.767 NM_130770
HTR3C
5-hydroxytryptamine (serotonin) receptor 3, family member C
chr9_-_70345549 0.767 NM_153237
C9orf71
chromosome 9 open reading frame 71
chr11_-_6870306 0.763 NM_003700
OR2D2
olfactory receptor, family 2, subfamily D, member 2
chr15_-_50375143 0.761 NM_018728
MYO5C
myosin VC
chr17_+_29670171 0.760 NM_005623
CCL8
chemokine (C-C motif) ligand 8
chr21_-_38792173 0.749 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr11_-_123758448 0.743 NM_001005468
OR8B2
olfactory receptor, family 8, subfamily B, member 2
chr12_+_6424293 0.743 NM_001242
CD27
CD27 molecule
chr11_+_6762823 0.732 NM_001004489
OR2AG1
olfactory receptor, family 2, subfamily AG, member 1
chr12_+_49922592 0.727 DAZAP2
DAZ associated protein 2
chr18_+_70352779 0.719 CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chrX_-_109570113 0.715 NM_001171689
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr3_+_42702014 0.714 NM_152393
KBTBD5
kelch repeat and BTB (POZ) domain containing 5
chr10_+_105026773 0.709 NM_032727
INA
internexin neuronal intermediate filament protein, alpha
chr7_+_117651947 0.704 NM_019644
ANKRD7
ankyrin repeat domain 7
chr1_-_164402575 0.699 NM_001017961
FAM78B
family with sequence similarity 78, member B
chr7_-_86433139 0.698 NM_152748
KIAA1324L
KIAA1324-like
chr11_+_7463175 0.688 NM_198474
OLFML1
olfactomedin-like 1
chr15_-_88150823 0.680 ANPEP
alanyl (membrane) aminopeptidase
chr1_+_224083047 0.679 EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr8_-_7275279 0.678 NM_001081551
DEFB103A
DEFB103B
defensin, beta 103A
defensin, beta 103B
chr1_-_180908639 0.677 NM_001102450
NM_033345
RGS8

regulator of G-protein signaling 8

chr4_-_107508040 0.675 NM_001195138
LOC100507096
GTPase IMAP family member-like
chr1_-_148854503 0.675


chr17_-_31441390 0.675 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr19_+_51535801 0.670 HIF3A
hypoxia inducible factor 3, alpha subunit
chr22_+_19651446 0.670 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr1_+_210864411 0.668 NM_153606
FAM71A
family with sequence similarity 71, member A
chr3_+_142253432 0.664 NM_080862
SPSB4
splA/ryanodine receptor domain and SOCS box containing 4
chr1_-_150065176 0.661 NM_001001523
RORC
RAR-related orphan receptor C
chr6_+_42231121 0.654 NM_000409
GUCA1A
guanylate cyclase activator 1A (retina)
chr1_-_7998265 0.651 ERRFI1
ERBB receptor feedback inhibitor 1
chr1_-_156056456 0.647 NM_001159397
NM_001159398
NM_052938
FCRL1


Fc receptor-like 1


chr15_-_40173949 0.645 NM_178034
PLA2G4D
phospholipase A2, group IVD (cytosolic)
chr1_-_120737466 0.645 NM_001004340
NM_001017986
FCGR1A
FCGR1B

Fc fragment of IgG, high affinity Ia, receptor (CD64)
Fc fragment of IgG, high affinity Ib, receptor (CD64)

chr6_+_155453114 0.645 NM_012454
TIAM2
T-cell lymphoma invasion and metastasis 2
chr20_+_34019942 0.641 NM_080834
C20orf152
chromosome 20 open reading frame 152
chrX_+_50670474 0.638 NM_005448
BMP15
bone morphogenetic protein 15
chr15_+_40484249 0.633 NM_173089
NM_173090
CAPN3

calpain 3, (p94)

chr6_-_41811916 0.632 NM_001167827
TFEB
transcription factor EB
chr4_+_77575276 0.631 NM_020859
SHROOM3
shroom family member 3
chr9_-_111230926 0.629 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr8_-_125649926 0.625 MTSS1
metastasis suppressor 1
chr12_+_111829191 0.622 OAS1
2',5'-oligoadenylate synthetase 1, 40/46kDa
chr5_+_57823017 0.621 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr12_-_119172339 0.616 NM_025157
PXN
paxillin
chr1_+_242281175 0.611 NM_205768
ZNF238
zinc finger protein 238
chr12_-_94469357 0.610 NM_032147
USP44
ubiquitin specific peptidase 44
chr6_+_116889248 0.608 NM_001010919
FAM26F
family with sequence similarity 26, member F
chr7_+_123083096 0.603 NM_207163
LMOD2
leiomodin 2 (cardiac)
chr7_-_75876830 0.602 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr17_+_70244553 0.602 NM_001163989
RAB37
RAB37, member RAS oncogene family
chr6_-_30236667 0.601 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr6_-_41114905 0.598 NM_173561
UNC5CL
unc-5 homolog C (C. elegans)-like
chr5_+_60969392 0.595 NM_173667
FLJ37543
hypothetical protein FLJ37543
chr11_-_64403712 0.593 EHD1
EH-domain containing 1
chr1_-_161439248 0.593 NM_001195303
RGS5
regulator of G-protein signaling 5
chr4_+_72321113 0.592 SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr15_+_57286313 0.592 NM_033195
LDHAL6B
lactate dehydrogenase A-like 6B
chr18_+_70352649 0.592 NM_032649
CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr10_-_43383912 0.592 NM_005674
ZNF239
zinc finger protein 239
chrX_+_106057984 0.589 CLDN2
claudin 2
chr8_+_133948384 0.588 NM_003235
TG
thyroglobulin
chr3_+_46594079 0.584 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr18_-_29273979 0.581 NM_001105528
C18orf34
chromosome 18 open reading frame 34
chr8_-_38577891 0.578


chr3_+_189353502 0.577 LPP
LIM domain containing preferred translocation partner in lipoma
chr11_+_20577521 0.576 NM_004211
SLC6A5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
chr2_+_38031099 0.575 NM_001170793
NM_144713
FAM82A1

family with sequence similarity 82, member A1

chr14_-_76958984 0.574 NM_138791
NM_001113475
C14orf148

chromosome 14 open reading frame 148

chr18_+_30652223 0.573 NM_001198942
NM_001198944
NM_032980
NM_032981
DTNA



dystrobrevin, alpha



chr7_+_141136485 0.569 NM_018980
TAS2R5
taste receptor, type 2, member 5
chr11_+_20027185 0.568 NAV2
neuron navigator 2
chr1_-_120737416 0.568 FCGR1B
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr1_-_156567835 0.568 NM_001764
CD1B
CD1b molecule
chr8_-_67253234 0.567 NM_000756
CRH
corticotropin releasing hormone
chr3_-_184756101 0.567 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr7_+_143378393 0.566 NM_012365
OR2A5
olfactory receptor, family 2, subfamily A, member 5
chr5_-_169749215 0.566 NM_004137
KCNMB1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr7_+_111908143 0.563 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr1_-_142559339 0.561 NM_001123068
PPIAL4G
peptidylprolyl isomerase A (cyclophilin A)-like 4G
chr6_+_25834983 0.560 NM_170610
HIST1H2BA
histone cluster 1, H2ba

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.60 6.40e-34 GO:0007606 sensory perception of chemical stimulus
3.63 1.50e-30 GO:0007608 sensory perception of smell
2.64 8.81e-27 GO:0007600 sensory perception
2.05 6.57e-20 GO:0050877 neurological system process
1.90 2.80e-19 GO:0003008 system process
1.29 4.82e-11 GO:0050896 response to stimulus
1.29 4.22e-08 GO:0032501 multicellular organismal process
1.76 1.32e-04 GO:0006955 immune response
1.48 8.36e-03 GO:0002376 immune system process
2.64 9.61e-03 GO:0006814 sodium ion transport

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.46 7.72e-17 GO:0005886 plasma membrane
1.45 1.28e-16 GO:0071944 cell periphery
1.24 2.08e-06 GO:0031224 intrinsic to membrane
1.24 3.00e-06 GO:0016021 integral to membrane
1.21 3.59e-06 GO:0044425 membrane part
1.42 1.25e-05 GO:0005576 extracellular region
1.17 2.56e-05 GO:0016020 membrane
1.64 3.26e-04 GO:0005615 extracellular space
1.55 4.31e-04 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.73 9.14e-32 GO:0004984 olfactory receptor activity
2.56 4.32e-26 GO:0004930 G-protein coupled receptor activity
2.14 4.43e-23 GO:0004888 transmembrane receptor activity
1.86 7.36e-19 GO:0004872 receptor activity
1.75 4.92e-18 GO:0004871 signal transducer activity
1.75 4.92e-18 GO:0060089 molecular transducer activity
2.16 1.25e-02 GO:0005125 cytokine activity
6.07 3.45e-02 GO:0008527 taste receptor activity
2.11 4.46e-02 GO:0005126 cytokine receptor binding
1.44 4.80e-02 GO:0005102 receptor binding