Motif ID: KLF12.p2

Z-value: 3.102


Transcription factors associated with KLF12.p2:

Gene SymbolEntrez IDGene Name
KLF12 11278 Kruppel-like factor 12

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
KLF12chr13_-_73605914-0.155.8e-01Click!


Activity profile for motif KLF12.p2.

activity profile for motif KLF12.p2


Sorted Z-values histogram for motif KLF12.p2

Sorted Z-values for motif KLF12.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF12.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_27180398 2.731 NM_018951
 HOXA10
homeobox A10
chr10_+_94439658 2.505 NM_002729
 HHEX
hematopoietically expressed homeobox
chr2_+_176702667 2.387 NM_019558
 HOXD8
homeobox D8
chr13_-_27967215 2.215 NM_001159920
NM_001160030
NM_001160031
NM_002019
 FLT1



fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)



chr3_-_193609531 2.164 NM_021032
 FGF12
fibroblast growth factor 12
chrX_+_67965517 2.149 NM_004429
 EFNB1
ephrin-B1
chr3_-_173648896 2.148 NM_004122
NM_198407
 GHSR

growth hormone secretagogue receptor

chr10_+_106390848 2.065 NM_014978
 SORCS3
sortilin-related VPS10 domain containing receptor 3
chr1_-_90955365 1.997 NM_020063
 BARHL2
BarH-like homeobox 2
chr17_+_23723220 1.884 SARM1
sterile alpha and TIR motif containing 1
chrX_-_71268475 1.882 NM_001024455
 RGAG4
retrotransposon gag domain containing 4
chr1_+_63561632 1.870 FOXD3
forkhead box D3
chr12_+_79625538 1.783 NM_002469
 MYF6
myogenic factor 6 (herculin)
chr16_-_47873183 1.780 NM_004352
 CBLN1
cerebellin 1 precursor
chr1_+_152741318 1.763 NM_001098475
NM_182499
 TDRD10

tudor domain containing 10

chrX_-_111953009 1.748 NM_001113490
 AMOT
angiomotin
chr6_-_33268177 1.684 NM_001163771
NM_080679
NM_080680
NM_080681
 COL11A2



collagen, type XI, alpha 2



chr12_+_52665196 1.684 NM_017409
 HOXC10
homeobox C10
chr1_+_16247870 1.651 NM_001165945
 CLCNKB
chloride channel Kb
chr8_-_140784416 1.626 NM_016601
 KCNK9
potassium channel, subfamily K, member 9

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 73 entries
enrichment   p-value GO term description
2.74 9.39e-04 GO:0003014 renal system process
2.32 2.54e-02 GO:0048167 regulation of synaptic plasticity
1.77 2.05e-02 GO:0048705 skeletal system morphogenesis
1.67 3.48e-02 GO:0006813 potassium ion transport
1.62 4.91e-09 GO:0019226 transmission of nerve impulse
1.62 4.91e-09 GO:0035637 multicellular organismal signaling
1.60 5.08e-05 GO:0007411 axon guidance
1.58 1.40e-06 GO:0007268 synaptic transmission
1.56 6.60e-06 GO:0048667 cell morphogenesis involved in neuron differentiation
1.56 1.10e-05 GO:0007409 axonogenesis
1.56 3.75e-04 GO:0044057 regulation of system process
1.55 7.11e-06 GO:0048812 neuron projection morphogenesis
1.55 2.28e-04 GO:0007420 brain development
1.55 2.01e-02 GO:0030036 actin cytoskeleton organization
1.52 3.26e-06 GO:0007417 central nervous system development
1.52 1.13e-02 GO:0030029 actin filament-based process
1.51 7.90e-09 GO:0030182 neuron differentiation
1.50 1.15e-10 GO:0048699 generation of neurons
1.50 1.55e-05 GO:0048858 cell projection morphogenesis
1.50 2.54e-05 GO:0000904 cell morphogenesis involved in differentiation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 29 entries
enrichment   p-value GO term description
2.26 4.34e-03 GO:0043197 dendritic spine
2.18 4.35e-02 GO:0044306 neuron projection terminus
2.17 1.15e-02 GO:0044309 neuron spine
2.03 1.66e-03 GO:0033267 axon part
1.95 5.21e-03 GO:0014069 postsynaptic density
1.81 5.79e-06 GO:0030424 axon
1.77 2.67e-02 GO:0005925 focal adhesion
1.63 1.86e-02 GO:0045211 postsynaptic membrane
1.61 1.30e-05 GO:0044456 synapse part
1.61 3.43e-03 GO:0030425 dendrite
1.58 3.06e-07 GO:0045202 synapse
1.53 8.92e-06 GO:0043005 neuron projection
1.47 4.61e-02 GO:0016323 basolateral plasma membrane
1.44 2.12e-02 GO:0015629 actin cytoskeleton
1.38 1.72e-02 GO:0044463 cell projection part
1.37 5.33e-04 GO:0030054 cell junction
1.32 3.39e-04 GO:0005626 insoluble fraction
1.31 3.33e-04 GO:0042995 cell projection
1.29 2.61e-03 GO:0005624 membrane fraction
1.24 2.24e-07 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

Showing 1 to 17 of 17 entries
enrichment   p-value GO term description
2.83 1.42e-03 GO:0008066 glutamate receptor activity
1.72 1.71e-02 GO:0005267 potassium channel activity
1.58 1.76e-02 GO:0005244 voltage-gated ion channel activity
1.58 1.76e-02 GO:0022832 voltage-gated channel activity
1.56 6.14e-12 GO:0043565 sequence-specific DNA binding
1.52 5.43e-03 GO:0005261 cation channel activity
1.51 1.59e-03 GO:0022836 gated channel activity
1.45 1.16e-02 GO:0003779 actin binding
1.43 2.32e-03 GO:0015267 channel activity
1.43 2.70e-03 GO:0022803 passive transmembrane transporter activity
1.43 3.08e-03 GO:0022838 substrate-specific channel activity
1.43 3.56e-03 GO:0005216 ion channel activity
1.37 3.19e-07 GO:0001071 nucleic acid binding transcription factor activity
1.37 3.19e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.33 2.88e-02 GO:0008092 cytoskeletal protein binding
1.29 3.00e-04 GO:0030528 transcription regulator activity
1.27 4.63e-02 GO:0015075 ion transmembrane transporter activity