Motif ID: NFE2.p2

Z-value: 0.919


Transcription factors associated with NFE2.p2:

Gene SymbolEntrez IDGene Name
NFE2 4778 nuclear factor (erythroid-derived 2), 45kDa

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFE2chr12_-_529758230.656.5e-03Click!


Activity profile for motif NFE2.p2.

activity profile for motif NFE2.p2


Sorted Z-values histogram for motif NFE2.p2

Sorted Z-values for motif NFE2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_19706979 1.236 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr16_+_56219802 1.194 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr12_-_56445653 1.081 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr22_+_19699441 0.936 NM_001159554
NM_005446
P2RX6

purinergic receptor P2X, ligand-gated ion channel, 6

chr16_-_3025542 0.929 NM_001103175
CCDC64B
coiled-coil domain containing 64B
chr4_-_77163609 0.918 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr21_+_29439768 0.891 C21orf7
chromosome 21 open reading frame 7
chr1_-_119333701 0.865 NM_152380
TBX15
T-box 15
chr2_-_113752957 0.860 NM_003466
NM_013952
NM_013953
NM_013992
PAX8



paired box 8



chr6_-_41781655 0.828 TFEB
transcription factor EB
chr10_-_31328426 0.806 NM_001143769
ZNF438
zinc finger protein 438
chr12_+_54361685 0.783 METTL7B
methyltransferase like 7B
chr18_+_19947314 0.759 TTC39C
tetratricopeptide repeat domain 39C
chr1_-_24311212 0.759 NM_152372
MYOM3
myomesin family, member 3
chr19_-_4510713 0.747 SEMA6B
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr22_+_21042091 0.746 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr17_-_36834183 0.737 NM_003770
KRT37
keratin 37
chr4_+_120276386 0.731 NM_016599
MYOZ2
myozenin 2
chrX_-_15593074 0.716 NM_020665
TMEM27
transmembrane protein 27
chr8_-_26778832 0.710 NM_000680
NM_033302
NM_033303
NM_033304
ADRA1A



adrenergic, alpha-1A-, receptor



chr9_+_102231616 0.707 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr19_-_40673185 0.703 NM_207392
KRTDAP
keratinocyte differentiation-associated protein
chr22_+_20899155 0.697


chr16_-_70763849 0.695 NM_001160213
PMFBP1
polyamine modulated factor 1 binding protein 1
chr17_+_45965076 0.677 EPN3
epsin 3
chr4_+_154397975 0.665 TRIM2
tripartite motif containing 2
chr1_+_24522116 0.621 NM_021180
GRHL3
grainyhead-like 3 (Drosophila)
chr5_+_176807931 0.617 NM_001174102
PRR7
proline rich 7 (synaptic)
chr6_-_149847718 0.615 ZC3H12D
zinc finger CCCH-type containing 12D
chr5_+_145297490 0.608 SH3RF2
SH3 domain containing ring finger 2
chr5_-_141041982 0.602 NM_022481
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr3_+_185377341 0.600 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr22_+_21495273 0.593


chr6_+_31190505 0.589 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr1_+_12698704 0.588 NM_001103169
NM_001103170
AADACL3

arylacetamide deacetylase-like 3

chr1_-_6474346 0.576 NM_020631
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr13_+_51334117 0.576 NM_031290
CCDC70
coiled-coil domain containing 70
chr16_-_27806978 0.564 NM_144675
GSG1L
GSG1-like
chr22_+_21011653 0.564


chr15_+_84021271 0.557 NM_144767
AKAP13
A kinase (PRKA) anchor protein 13
chr22_+_21393107 0.556 IGLJ3
immunoglobulin lambda joining 3
chr3_+_57069508 0.555 NM_181727
SPATA12
spermatogenesis associated 12
chrX_+_133198742 0.554 NM_001101357
CCDC160
coiled-coil domain containing 160
chr17_-_202557 0.553 RPH3AL
rabphilin 3A-like (without C2 domains)
chr8_-_143820825 0.550 NM_020427
SLURP1
secreted LY6/PLAUR domain containing 1
chr9_-_96442377 0.547 FBP1
fructose-1,6-bisphosphatase 1
chr22_+_18388656 0.545 C22orf25
chromosome 22 open reading frame 25
chr9_-_96442351 0.544 NM_001127628
FBP1
fructose-1,6-bisphosphatase 1
chr1_+_181421984 0.538 LAMC2
laminin, gamma 2
chr21_-_36774257 0.532 NM_001146079
NM_144492
CLDN14

claudin 14

chr6_-_149847809 0.521 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr1_-_925332 0.519 NM_001142467
NM_021170
HES4

hairy and enhancer of split 4 (Drosophila)

chr2_+_74595073 0.518 NM_016170
TLX2
T-cell leukemia homeobox 2
chr22_+_21340757 0.510


chr10_+_47867667 0.510 NM_001137556
NM_001137549
NM_001137548
FAM25B
FAM25G
FAM25C
family with sequence similarity 25, member B
family with sequence similarity 25, member G
family with sequence similarity 25, member C
chr19_-_53935648 0.508 NM_017805
RASIP1
Ras interacting protein 1
chr6_+_41712907 0.500 MDFI
MyoD family inhibitor
chr5_-_35083996 0.498 NM_031900
AGXT2
alanine--glyoxylate aminotransferase 2
chr19_+_43971689 0.496 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr6_-_29563657 0.492 NM_052967
MAS1L
MAS1 oncogene-like
chr1_+_17404206 0.490 NM_013358
PADI1
peptidyl arginine deiminase, type I
chr3_+_185377430 0.488 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr8_-_131483395 0.486 NM_018482
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr5_-_141041933 0.486 ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr8_+_22900863 0.485 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr1_+_229365296 0.483 NM_001004342
TRIM67
tripartite motif containing 67
chr12_+_54361596 0.477 NM_152637
METTL7B
methyltransferase like 7B
chr2_-_169596078 0.477 NM_003742
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chrX_-_2896285 0.467 ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr1_-_925215 0.467 HES4
hairy and enhancer of split 4 (Drosophila)
chr17_-_202617 0.455 NM_001190411
NM_001190412
NM_001190413
NM_006987
RPH3AL



rabphilin 3A-like (without C2 domains)



chr16_-_70763524 0.454 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chrX_+_99786044 0.451 SRPX2
sushi-repeat containing protein, X-linked 2
chr8_+_24827173 0.449 NM_005382
NEFM
neurofilament, medium polypeptide
chrX_-_10761729 0.447 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr1_-_11841476 0.445 NM_002521
NPPB
natriuretic peptide B
chr15_+_57691382 0.441 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr9_-_115880281 0.440 AMBP
alpha-1-microglobulin/bikunin precursor
chr11_+_67107641 0.439 NM_000852
GSTP1
glutathione S-transferase pi 1
chr13_+_77007809 0.436 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr12_-_51153788 0.436 NM_173086
KRT6C
keratin 6C
chr4_+_152549776 0.435 NM_001109977
FAM160A1
family with sequence similarity 160, member A1
chr9_-_115880494 0.434 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr8_+_24827181 0.431 NEFM
neurofilament, medium polypeptide
chr7_-_98305599 0.428 NM_001134450
NM_001134451
NM_152913
TMEM130


transmembrane protein 130


chr1_+_31855873 0.425 NM_001525
HCRTR1
hypocretin (orexin) receptor 1
chr15_+_57691272 0.424 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr16_-_1369613 0.423 NM_001193389
NM_023076
UNKL

unkempt homolog (Drosophila)-like

chr7_+_142768916 0.414 ZYX
zyxin
chr16_-_2848106 0.413 NM_022119
PRSS22
protease, serine, 22
chr2_-_89400935 0.413 IGKC
immunoglobulin kappa constant
chrX_-_16640590 0.412 NM_175859
NM_019857
CTPS2

CTP synthase II

chr3_+_134976965 0.407 TF
transferrin
chr10_-_46601687 0.401 NM_001137556
NM_001137549
NM_001137548
FAM25B
FAM25G
FAM25C
family with sequence similarity 25, member B
family with sequence similarity 25, member G
family with sequence similarity 25, member C
chr22_+_21065202 0.401


chr16_+_30903963 0.401 NM_001142777
NM_001142778
NM_025193
HSD3B7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr1_+_17507276 0.401 NM_012387
PADI4
peptidyl arginine deiminase, type IV
chr17_+_22823151 0.400 NM_014238
KSR1
kinase suppressor of ras 1
chr22_+_21053972 0.399


chr22_+_21065207 0.398 IGLJ3
immunoglobulin lambda joining 3
chrX_+_69314060 0.397 NM_198512
DGAT2L6
diacylglycerol O-acyltransferase 2-like 6
chr22_+_21065134 0.394 LOC100290481
immunoglobulin lambda light chain-like
chr3_-_48607596 0.391 NM_000094
COL7A1
collagen, type VII, alpha 1
chr20_+_34206070 0.390 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr1_-_117554999 0.389 NM_024626
VTCN1
V-set domain containing T cell activation inhibitor 1
chr19_+_46640902 0.389 NM_001130514
C19orf69
chromosome 19 open reading frame 69
chrX_-_24575375 0.388 NM_001163265
NM_004845
PCYT1B

phosphate cytidylyltransferase 1, choline, beta

chr11_+_118463906 0.387 NM_001024382
HMBS
hydroxymethylbilane synthase
chr3_-_197549588 0.385 TM4SF19
transmembrane 4 L six family member 19
chr11_+_1812115 0.379 NM_138567
SYT8
synaptotagmin VIII
chrX_-_19727828 0.377 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr16_-_30032330 0.375 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr9_-_115880366 0.374 AMBP
alpha-1-microglobulin/bikunin precursor
chr15_+_72315719 0.374 NM_025055
CCDC33
coiled-coil domain containing 33
chr1_-_244647333 0.373 NM_022743
SMYD3
SET and MYND domain containing 3
chr2_-_73170290 0.373 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr1_-_151614681 0.372 NM_005621
S100A12
S100 calcium binding protein A12
chr5_+_150000394 0.370 NM_001109974
NM_007286
SYNPO

synaptopodin

chr19_-_55914837 0.370


chr9_-_115880425 0.370 AMBP
alpha-1-microglobulin/bikunin precursor
chr9_-_103237851 0.369 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr1_+_148747110 0.366 NM_004425
NM_022664
ECM1

extracellular matrix protein 1

chrX_-_53327473 0.365 NM_015075
IQSEC2
IQ motif and Sec7 domain 2
chr1_+_81544432 0.363 LPHN2
latrophilin 2
chrX_-_19727775 0.363 SH3KBP1
SH3-domain kinase binding protein 1
chr8_+_22266256 0.363 PIWIL2
piwi-like 2 (Drosophila)
chr17_-_36850978 0.360 NM_006771
KRT38
keratin 38
chr1_-_67039518 0.359 NM_005478
INSL5
insulin-like 5
chr11_-_6298284 0.356 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr10_-_81698840 0.356 NM_003019
SFTPD
surfactant protein D
chr7_-_98305551 0.354 TMEM130
transmembrane protein 130
chr19_+_12810258 0.351 NM_014975
MAST1
microtubule associated serine/threonine kinase 1
chr1_+_207668787 0.350 NM_001104548
LOC642587
NPC-A-5
chr10_+_77212524 0.350 NM_032024
C10orf11
chromosome 10 open reading frame 11
chr17_+_77910411 0.346 NM_207459
TEX19
testis expressed 19
chr11_+_35640918 0.345 NM_017583
TRIM44
tripartite motif containing 44
chr8_-_81949570 0.345 NM_001033723
ZNF704
zinc finger protein 704
chr4_+_183302105 0.344 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr7_+_154493478 0.341 NM_024012
HTR5A
5-hydroxytryptamine (serotonin) receptor 5A
chr1_+_151025376 0.340 NM_178353
LCE1E
late cornified envelope 1E
chrX_+_153423652 0.337 NM_001099856
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr9_-_139068269 0.336 NM_001246
NM_203468
ENTPD2

ectonucleoside triphosphate diphosphohydrolase 2

chr7_-_33047042 0.334 NM_001166118
NM_016489
NT5C3

5'-nucleotidase, cytosolic III

chr4_+_74825138 0.333 NM_000584
IL8
interleukin 8
chr13_-_98757634 0.332 NM_004951
GPR183
G protein-coupled receptor 183
chr18_+_29573152 0.331 ASXL3
additional sex combs like 3 (Drosophila)
chr7_+_116099648 0.330 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr3_-_58175437 0.330 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chrX_-_24575146 0.329 PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr16_+_30326386 0.327 ZNF771
zinc finger protein 771
chr18_+_59405513 0.327 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr7_-_5533621 0.326 ACTB
actin, beta
chr7_+_95239753 0.325 NM_001135556
NM_001135557
NM_004411
DYNC1I1


dynein, cytoplasmic 1, intermediate chain 1


chr9_+_35528890 0.324 RUSC2
RUN and SH3 domain containing 2
chr16_+_2023279 0.323 SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr19_-_61039939 0.322 NM_145007
NLRP11
NLR family, pyrin domain containing 11
chr19_+_61039755 0.320 NM_134444
NLRP4
NLR family, pyrin domain containing 4
chr19_+_12996830 0.317 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr16_+_30326864 0.317 ZNF771
zinc finger protein 771
chr2_-_215967442 0.313 FN1
fibronectin 1
chr22_+_21006814 0.310


chr2_-_85494664 0.309 CAPG
capping protein (actin filament), gelsolin-like
chrX_+_51091822 0.308 NM_153183
NUDT10
nudix (nucleoside diphosphate linked moiety X)-type motif 10
chr14_+_76362467 0.307 NM_194287
C14orf166B
chromosome 14 open reading frame 166B
chr17_+_1592879 0.307 NM_000934
NM_001165921
SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr2_-_85494639 0.307 CAPG
capping protein (actin filament), gelsolin-like
chr17_+_71229151 0.305 ITGB4
integrin, beta 4
chr9_-_26937435 0.305 NM_001031689
PLAA
phospholipase A2-activating protein
chr1_+_148747208 0.304 ECM1
extracellular matrix protein 1
chr19_-_43926953 0.304 NM_144691
CAPN12
calpain 12
chr3_-_13089547 0.304 NM_001134382
IQSEC1
IQ motif and Sec7 domain 1
chr19_-_54350457 0.303 NM_002152
HRC
histidine rich calcium binding protein
chr22_+_21359175 0.303 IGLV3-25
immunoglobulin lambda variable 3-25
chr8_-_145097031 0.301 NM_201380
PLEC
plectin
chr1_-_181826086 0.301 NCF2
neutrophil cytosolic factor 2
chr19_+_41119861 0.299 NM_024509
LRFN3
leucine rich repeat and fibronectin type III domain containing 3
chr1_-_159257567 0.299 F11R
F11 receptor
chr3_+_156280129 0.298 NM_000902
MME
membrane metallo-endopeptidase
chr11_-_47502115 0.298 NM_001172639
CELF1
CUGBP, Elav-like family member 1
chr9_-_99974994 0.295 NM_003389
CORO2A
coronin, actin binding protein, 2A
chr1_-_151296611 0.294 NM_005988
SPRR2A
small proline-rich protein 2A
chr3_+_187840842 0.292 NM_014375
FETUB
fetuin B
chr12_+_47205681 0.291 NM_001005203
OR8S1
olfactory receptor, family 8, subfamily S, member 1
chr22_+_21116283 0.291


chr1_-_159257486 0.290 F11R
F11 receptor
chr1_+_17571277 0.290 NM_207421
PADI6
peptidyl arginine deiminase, type VI
chr3_+_185386664 0.290 ABCF3
ATP-binding cassette, sub-family F (GCN20), member 3
chr22_-_43986896 0.289 KIAA0930
KIAA0930
chr6_+_74462226 0.288 NM_001159587
NM_001159588
NM_133493
CD109


CD109 molecule


chr19_+_12996368 0.287 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr5_-_59100091 0.286 PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_+_71229191 0.285 ITGB4
integrin, beta 4
chr19_+_12996745 0.285 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr1_+_15128882 0.285 NM_001018001
KAZN
kazrin, periplakin interacting protein
chr18_-_45630154 0.284 MYO5B
myosin VB
chr1_+_181422016 0.284 LAMC2
laminin, gamma 2
chr19_+_40895669 0.282 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr17_+_29606408 0.282 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chrX_-_39921525 0.281 NM_001123383
NM_001123384
BCOR

BCL6 corepressor

chr1_-_17180659 0.281 NM_001135247
NM_017459
MFAP2

microfibrillar-associated protein 2


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.21 1.10e-02 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.75 3.58e-03 GO:0001533 cornified envelope
1.24 1.01e-02 GO:0005886 plasma membrane
1.74 1.30e-02 GO:0030054 cell junction
1.24 1.58e-02 GO:0071944 cell periphery
1.35 2.32e-02 GO:0044459 plasma membrane part

Nothing significant found in function category.