Motif ID: SOX5.p2

Z-value: 1.695


Transcription factors associated with SOX5.p2:

Gene SymbolEntrez IDGene Name
SOX5 6660 SRY (sex determining region Y)-box 5

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX5chr12_-_246066160.485.9e-02Click!


Activity profile for motif SOX5.p2.

activity profile for motif SOX5.p2


Sorted Z-values histogram for motif SOX5.p2

Sorted Z-values for motif SOX5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_16380967 3.708 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr12_-_24606616 2.601 NM_152989
SOX5
SRY (sex determining region Y)-box 5
chr6_+_12398514 2.188 NM_001168319
NM_001955
EDN1

endothelin 1

chr21_+_42492867 1.979 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr6_+_21774624 1.949 FLJ22536
hypothetical locus LOC401237
chr3_+_174598937 1.921 NM_014932
NLGN1
neuroligin 1
chr7_+_128802719 1.781 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr11_+_20005704 1.776 NAV2
neuron navigator 2
chr1_+_50344550 1.743 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr7_-_111633428 1.738 DOCK4
dedicator of cytokinesis 4
chr7_-_11838260 1.676 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr11_-_119104463 1.618 NM_002855
NM_203285
NM_203286
PVRL1


poliovirus receptor-related 1 (herpesvirus entry mediator C)


chr1_+_183970093 1.565 NM_031935
HMCN1
hemicentin 1
chr5_-_125956996 1.534 ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr17_-_10393664 1.345 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr16_+_65938753 1.331 NM_001161575
LRRC36
leucine rich repeat containing 36
chr21_-_38792173 1.329 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr12_-_66905802 1.313 NM_018402
IL26
interleukin 26
chr11_+_5925152 1.300 NM_001003443
OR56A3
olfactory receptor, family 56, subfamily A, member 3
chr2_-_128138435 1.264 NM_017980
LIMS2
LIM and senescent cell antigen-like domains 2
chr7_-_27108826 1.249 NM_006735
HOXA2
homeobox A2
chr4_+_42590038 1.216 NM_001080476
GRXCR1
glutaredoxin, cysteine rich 1
chr6_+_155579788 1.210 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr1_+_8928508 1.190 NM_001215
CA6
carbonic anhydrase VI
chr7_+_134226690 1.177 NM_033139
NM_033140
CALD1

caldesmon 1

chr20_-_29457650 1.177 NM_001011878
DEFB121
defensin, beta 121
chr7_-_111633620 1.166 NM_014705
DOCK4
dedicator of cytokinesis 4
chr20_-_49612574 1.151 NM_001136021
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr10_+_118295417 1.112 NM_000936
PNLIP
pancreatic lipase
chrX_-_99778340 1.109 NM_003270
TSPAN6
tetraspanin 6
chr1_+_12757570 1.106 NM_001080830
PRAMEF12
PRAME family member 12
chr1_-_7998265 1.095 ERRFI1
ERBB receptor feedback inhibitor 1
chrX_+_107174855 1.086 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr3_-_150533948 1.073 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chrX_-_10548458 1.069 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr20_-_49612745 1.066 NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr3_+_189425886 1.063 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr5_+_38439399 1.061 NM_182798
NM_182799
EGFLAM

EGF-like, fibronectin type III and laminin G domains

chr11_+_113280727 1.032 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr2_-_21084077 1.031 APOB
apolipoprotein B (including Ag(x) antigen)
chr10_-_61819493 1.030 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr1_+_2927905 1.020 NM_080431
ACTRT2
actin-related protein T2
chr3_+_173954940 1.020 NM_018098
ECT2
epithelial cell transforming sequence 2 oncogene
chr2_+_38009405 1.009 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chr6_+_31190505 0.998 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr1_-_229627412 0.997 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr7_+_134226727 0.994 CALD1
caldesmon 1
chr16_+_85169615 0.993 NM_005250
FOXL1
forkhead box L1
chr15_+_100175888 0.977 NM_001001674
OR4F15
olfactory receptor, family 4, subfamily F, member 15
chr1_+_184532027 0.965 NM_001127708
NM_001127709
NM_001127710
NM_005807
PRG4



proteoglycan 4



chr11_+_4799126 0.957 NM_001004753
OR51F2
olfactory receptor, family 51, subfamily F, member 2
chr2_+_69093641 0.943 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr2_+_169631777 0.934 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr1_-_204455269 0.931 NM_001007544
C1orf186
chromosome 1 open reading frame 186
chr3_-_194118321 0.922 MB21D2
Mab-21 domain containing 2
chr6_-_160599779 0.922 NM_003058
SLC22A2
solute carrier family 22 (organic cation transporter), member 2
chr6_-_138935359 0.908 NM_020464
NHSL1
NHS-like 1
chr6_+_148705421 0.906 NM_015278
SASH1
SAM and SH3 domain containing 1
chr6_+_148705817 0.895 SASH1
SAM and SH3 domain containing 1
chr6_-_116973465 0.895 NM_001139444
BET3L
BET3 like (S. cerevisiae)
chr5_-_168204430 0.895


chr2_-_1905508 0.885 MYT1L
myelin transcription factor 1-like
chr8_-_18585721 0.865 PSD3
pleckstrin and Sec7 domain containing 3
chr10_+_18280773 0.864 NM_001145195
NM_152725
SLC39A12

solute carrier family 39 (zinc transporter), member 12

chr5_-_71838875 0.862 NM_152625
ZNF366
zinc finger protein 366
chr9_-_128910132 0.853 ANGPTL2
angiopoietin-like 2
chr11_-_4555625 0.845 NM_144663
C11orf40
chromosome 11 open reading frame 40
chrX_+_135079461 0.844 NM_001167819
FHL1
four and a half LIM domains 1
chr6_-_29752909 0.837 NM_001109809
ZFP57
zinc finger protein 57 homolog (mouse)
chr8_+_7731402 0.834 NM_080389
NM_001040702
DEFB104A
DEFB104B
defensin, beta 104A
defensin, beta 104B
chr4_-_152316105 0.829 NM_001128924
SH3D19
SH3 domain containing 19
chrX_-_15312390 0.827 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr3_+_88270951 0.822 NM_018293
ZNF654
zinc finger protein 654
chr7_+_93373755 0.815 NM_021955
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr1_+_559129 0.806


chr20_+_58004811 0.806 NM_021810
CDH26
cadherin 26
chr17_+_3047559 0.805 NM_012352
OR1A2
olfactory receptor, family 1, subfamily A, member 2
chrX_+_123062143 0.796 STAG2
stromal antigen 2
chr9_+_116943917 0.795 NM_017418
DEC1
deleted in esophageal cancer 1
chr1_-_230717850 0.794 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr15_+_37330176 0.783 NM_207445
C15orf54
chromosome 15 open reading frame 54
chr4_+_124537334 0.777 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr4_+_37655385 0.773 TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr8_-_108579270 0.770 NM_001146
ANGPT1
angiopoietin 1
chr3_+_3056307 0.770 NM_175612
CNTN4
contactin 4
chr7_+_116238309 0.767 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr4_-_170314382 0.761 SH3RF1
SH3 domain containing ring finger 1
chr15_+_69220841 0.759 NM_024817
THSD4
thrombospondin, type I, domain containing 4
chr12_-_103846186 0.756 NM_032148
SLC41A2
solute carrier family 41, member 2
chr12_+_54172413 0.756 NM_001005519
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chr7_-_16811131 0.753 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr2_+_27573206 0.750 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr1_+_33494745 0.749 NM_152493
ZNF362
zinc finger protein 362
chrX_-_50573759 0.730 NM_020717
SHROOM4
shroom family member 4
chr3_-_194118627 0.730 NM_178496
MB21D2
Mab-21 domain containing 2
chr6_-_138581319 0.729 NM_021635
PBOV1
prostate and breast cancer overexpressed 1
chr7_-_27171673 0.721 NM_152739
HOXA9
homeobox A9
chr3_+_182900081 0.716 SOX2OT
SOX2 overlapping transcript (non-protein coding)
chr12_-_109842736 0.716 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr9_+_27099138 0.715 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr7_+_153633127 0.714 NM_001936
DPP6
dipeptidyl-peptidase 6
chr7_-_139948780 0.714 NM_015689
DENND2A
DENN/MADD domain containing 2A
chrX_+_130019896 0.713 NM_144967
ARHGAP36
Rho GTPase activating protein 36
chr1_-_154484341 0.708 NM_198406
NM_024897
PAQR6

progestin and adipoQ receptor family member VI

chr1_+_161305188 0.704 NM_005613
RGS4
regulator of G-protein signaling 4
chr17_+_63252704 0.704 BPTF
bromodomain PHD finger transcription factor
chr4_+_120029426 0.703 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr9_-_4142182 0.703 NM_152629
GLIS3
GLIS family zinc finger 3
chr2_-_133144094 0.701 LYPD1
LY6/PLAUR domain containing 1
chr12_+_32546243 0.699 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr6_-_42527760 0.695 NM_033502
TRERF1
transcriptional regulating factor 1
chr12_-_69289889 0.681 NM_002837
PTPRB
protein tyrosine phosphatase, receptor type, B
chr3_-_47909001 0.678 MAP4
microtubule-associated protein 4
chr11_+_19328846 0.677 NM_001111018
NAV2
neuron navigator 2
chr7_+_29486010 0.664 NM_001039936
CHN2
chimerin (chimaerin) 2
chr9_+_129066576 0.659 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr4_-_185376012 0.657 NM_153343
ENPP6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr14_-_88953059 0.648 NM_005197
FOXN3
forkhead box N3
chr6_-_139654807 0.646 NM_153235
TXLNB
taxilin beta
chr3_-_51976428 0.643 NM_020418
NM_001174100
NM_033008
PCBP4


poly(rC) binding protein 4


chr5_+_55182963 0.640 NM_139017
IL31RA
interleukin 31 receptor A
chr5_-_148738980 0.640 NM_014443
IL17B
interleukin 17B
chr9_-_72673753 0.640 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr12_+_26096757 0.638 NM_001164746
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr8_+_42671718 0.627 NM_000749
CHRNB3
cholinergic receptor, nicotinic, beta 3
chr7_+_142850667 0.625 NM_177437
TAS2R60
taste receptor, type 2, member 60
chrX_-_19727828 0.615 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr13_+_23742846 0.615 SPATA13
spermatogenesis associated 13
chr10_-_116434364 0.611 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr1_+_151442542 0.604 NM_001010857
LELP1
late cornified envelope-like proline-rich 1
chrX_+_135079120 0.602 NM_001159704
FHL1
four and a half LIM domains 1
chr3_-_58627509 0.598 NM_138805
FAM3D
family with sequence similarity 3, member D
chr4_+_141397889 0.591 NM_032547
SCOC
short coiled-coil protein
chr7_-_26198673 0.589 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chrX_+_15435351 0.588 NM_001721
BMX
BMX non-receptor tyrosine kinase
chr15_+_57286313 0.588 NM_033195
LDHAL6B
lactate dehydrogenase A-like 6B
chr10_+_86121526 0.587 FAM190B
family with sequence similarity 190, member B
chr10_-_108914277 0.586 NM_001013031
NM_052918
SORCS1

sortilin-related VPS10 domain containing receptor 1

chrX_-_110541029 0.586 NM_000555
DCX
doublecortin
chr2_-_160181206 0.583 NM_013450
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr2_-_56266408 0.583 LOC100129434
hypothetical LOC100129434
chr1_+_61697209 0.581 NFIA
nuclear factor I/A
chr7_+_111633878 0.580 NM_021994
ZNF277
zinc finger protein 277
chr18_-_27594696 0.580 NM_001034172
MCART2
mitochondrial carrier triple repeat 2
chr1_+_199975674 0.580 NAV1
neuron navigator 1
chr15_+_60146467 0.579 NM_207322
C2CD4A
C2 calcium-dependent domain containing 4A
chrX_+_107569671 0.575 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr1_-_202730135 0.575 PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr6_-_29120930 0.573 NM_030903
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chr19_-_14800275 0.570 NM_017506
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr9_-_129557373 0.570 NM_001142534
NM_001142533
SH2D3C

SH2 domain containing 3C

chr6_-_132064233 0.569 NM_030908
OR2A4
olfactory receptor, family 2, subfamily A, member 4
chr1_+_61642287 0.569 NFIA
nuclear factor I/A
chr2_-_73170290 0.569 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr5_-_38631263 0.568 NM_002310
LIFR
leukemia inhibitory factor receptor alpha
chr9_+_115265827 0.564 NM_017790
RGS3
regulator of G-protein signaling 3
chr17_-_31332568 0.564 NM_004590
CCL16
chemokine (C-C motif) ligand 16
chr3_+_25444753 0.559 NM_016152
RARB
retinoic acid receptor, beta
chr3_+_44571600 0.558 NM_018651
NM_025169
ZNF167

zinc finger protein 167

chr1_+_68070573 0.556


chr12_-_98072602 0.555 NM_020140
NM_181670
ANKS1B

ankyrin repeat and sterile alpha motif domain containing 1B

chr7_+_111633972 0.555 ZNF277
zinc finger protein 277
chr6_-_24985432 0.555 NM_015864
FAM65B
family with sequence similarity 65, member B
chr4_-_24523605 0.553 NM_001130726
CCDC149
coiled-coil domain containing 149
chr1_-_85703198 0.551 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr2_-_160838397 0.550 RBMS1
RNA binding motif, single stranded interacting protein 1
chr11_+_5862076 0.549 NM_001005165
OR52E4
olfactory receptor, family 52, subfamily E, member 4
chr10_+_69539255 0.546 NM_032578
MYPN
myopalladin
chr7_-_130891861 0.545 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr2_+_178893216 0.545 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr12_+_47498778 0.538 NM_000725
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr9_+_123501186 0.536 DAB2IP
DAB2 interacting protein
chr3_-_11585264 0.531 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr16_-_30705707 0.531 NM_001080417
ZNF629
zinc finger protein 629
chr19_+_3958690 0.529 NM_015897
PIAS4
protein inhibitor of activated STAT, 4
chr18_-_13905534 0.529 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr16_-_20271530 0.524 NM_001008389
NM_003361
UMOD

uromodulin

chr1_+_198975227 0.523 NM_203459
CAMSAP1L1
calmodulin regulated spectrin-associated protein 1-like 1
chr19_-_56164628 0.522 NM_002774
KLK6
kallikrein-related peptidase 6
chr6_-_24491498 0.521 NM_001195610
DCDC2
doublecortin domain containing 2
chr1_-_68470585 0.520 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr4_-_184478920 0.520 NM_001111319
CLDN22
claudin 22
chr6_-_138862271 0.518 NM_001144060
NHSL1
NHS-like 1
chr12_+_54132264 0.516 NM_054105
OR6C2
olfactory receptor, family 6, subfamily C, member 2
chr7_-_143587653 0.516 NM_001005328
OR2A7
OR2A4
olfactory receptor, family 2, subfamily A, member 7
olfactory receptor, family 2, subfamily A, member 4
chr16_+_54072969 0.514 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr8_-_6783193 0.514 NM_001925
DEFA4
defensin, alpha 4, corticostatin
chr16_+_31105579 0.513


chr1_+_116727514 0.512 NM_001160234
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr5_-_16989371 0.511 NM_012334
MYO10
myosin X
chr16_+_55373241 0.509 NUP93
nucleoporin 93kDa
chr9_-_96442377 0.508 FBP1
fructose-1,6-bisphosphatase 1
chr3_-_126215069 0.505 HEG1
HEG homolog 1 (zebrafish)
chr13_-_93929719 0.505 NM_001129889
NM_001922
DCT

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)

chr6_-_18095672 0.500 NM_001105566
NM_001105567
NM_001105568
NM_022113
KIF13A



kinesin family member 13A



chr3_+_25444837 0.499 NM_000965
RARB
retinoic acid receptor, beta
chr5_-_121842680 0.499


chr1_-_40140126 0.498 NM_001033081
NM_001033082
NM_005376
MYCL1


v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)


chr7_-_150555153 0.498 NM_005692
NM_007189
ABCF2

ATP-binding cassette, sub-family F (GCN20), member 2

chr1_-_224993498 0.493 NM_002221
ITPKB
inositol 1,4,5-trisphosphate 3-kinase B

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.19 5.17e-05 GO:0050896 response to stimulus
1.71 1.17e-02 GO:0007606 sensory perception of chemical stimulus
1.17 1.20e-02 GO:0032501 multicellular organismal process
1.75 1.28e-02 GO:0007608 sensory perception of smell

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.53 2.11e-02 GO:0030054 cell junction
1.16 4.99e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.78 2.54e-03 GO:0004984 olfactory receptor activity