Motif ID: FOXP3.p2

Z-value: 1.148


Transcription factors associated with FOXP3.p2:

Gene SymbolEntrez IDGene Name
FOXP3 50943 forkhead box P3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXP3chrX_-_490081150.322.3e-01Click!


Activity profile for motif FOXP3.p2.

activity profile for motif FOXP3.p2


Sorted Z-values histogram for motif FOXP3.p2

Sorted Z-values for motif FOXP3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXP3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_127012611 1.655 NM_001048252
CTXN3
cortexin 3
chr1_-_151333624 1.368 NM_001024209
SPRR2E
small proline-rich protein 2E
chr13_+_112746908 1.261 MCF2L
MCF.2 cell line derived transforming sequence-like
chr6_-_154719560 1.157 NM_001130700
NM_015553
IPCEF1

interaction protein for cytohesin exchange factors 1

chrX_-_109570113 1.082 NM_001171689
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr1_-_109201228 1.058 NM_152763
AKNAD1
AKNA domain containing 1
chr10_-_91092410 1.041 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr5_+_137447479 0.939 NM_058244
WNT8A
wingless-type MMTV integration site family, member 8A
chr10_-_72215116 0.919 NM_152710
C10orf27
chromosome 10 open reading frame 27
chr15_+_41672543 0.869 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr12_+_10054492 0.854 NM_001129998
NM_205852
CLEC12B

C-type lectin domain family 12, member B

chr2_-_21081694 0.847 APOB
apolipoprotein B (including Ag(x) antigen)
chr9_-_103237851 0.833 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr22_-_35829402 0.829 NM_153609
TMPRSS6
transmembrane protease, serine 6
chr16_+_70646008 0.783 NM_001126102
NM_005143
HP

haptoglobin

chr21_-_32879617 0.782 NM_144659
TCP10L
t-complex 10 (mouse)-like
chrX_-_100527799 0.762 NM_000061
BTK
Bruton agammaglobulinemia tyrosine kinase
chr1_+_66570683 0.750 PDE4B
phosphodiesterase 4B, cAMP-specific
chr1_-_94359266 0.740 NM_000350
ABCA4
ATP-binding cassette, sub-family A (ABC1), member 4
chr11_-_56166490 0.733 NM_001002925
OR5AP2
olfactory receptor, family 5, subfamily AP, member 2
chr6_+_144227265 0.721 NM_001013623
C6orf94
chromosome 6 open reading frame 94
chr11_+_58668827 0.713 NM_022074
NM_198847
FAM111A

family with sequence similarity 111, member A

chr6_-_25982418 0.711 NM_001098486
NM_006632
SLC17A3

solute carrier family 17 (sodium phosphate), member 3

chr3_-_57288019 0.705 NM_130387
ASB14
ankyrin repeat and SOCS box containing 14
chr1_-_151614681 0.702 NM_005621
S100A12
S100 calcium binding protein A12
chr3_+_125586241 0.693 KALRN
kalirin, RhoGEF kinase
chr2_-_158008763 0.685 NM_004288
CYTIP
cytohesin 1 interacting protein
chr11_-_56914668 0.682 NM_002728
PRG2
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
chr11_-_62218759 0.661 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr11_+_123945102 0.657 NM_001005194
OR8A1
olfactory receptor, family 8, subfamily A, member 1
chr17_-_59825221 0.647


chr8_-_7718769 0.634 NM_152250
NM_001040703
DEFB105A
DEFB105B
defensin, beta 105A
defensin, beta 105B
chr3_-_71860958 0.626 NM_001134650
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr3_-_49204294 0.597 NM_001080528
LOC646498
hypothetical protein LOC646498
chr7_+_94953148 0.588 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr3_-_19950675 0.587 NM_144715
EFHB
EF-hand domain family, member B
chr12_-_10215942 0.586 NM_001172632
NM_001172633
NM_002543
OLR1


oxidized low density lipoprotein (lectin-like) receptor 1


chr11_+_124294355 0.579 NM_001037558
HEPN1
hepatocellular carcinoma, down-regulated 1
chr6_+_132901119 0.577 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr1_+_171871283 0.576 NM_001195190
LOC730159
hypothetical protein LOC730159
chr15_+_83467295 0.563 PDE8A
phosphodiesterase 8A
chr5_-_37220702 0.561 C5orf42
chromosome 5 open reading frame 42
chr1_-_151296611 0.559 NM_005988
SPRR2A
small proline-rich protein 2A
chr14_+_20568184 0.555 NM_173846
TPPP2
tubulin polymerization-promoting protein family member 2
chr16_+_70654625 0.552 NM_020995
HPR
haptoglobin-related protein
chr6_+_132915522 0.540 NM_053278
TAAR8
trace amine associated receptor 8
chr6_+_31838751 0.535 NM_001039651
C6orf26
chromosome 6 open reading frame 26
chr4_+_39874921 0.533 NM_004310
RHOH
ras homolog gene family, member H
chr1_-_151310707 0.525 NM_001017418
SPRR2B
small proline-rich protein 2B
chr17_-_8215577 0.524 NM_213597
KRBA2
KRAB-A domain containing 2
chr7_+_29840865 0.501 NM_001080529
WIPF3
WAS/WASL interacting protein family, member 3
chr6_-_32605898 0.500 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr17_+_38306339 0.487 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr9_-_70780574 0.480


chr10_+_96943946 0.476 NM_207321
C10orf129
chromosome 10 open reading frame 129
chr5_+_140723939 0.449 NM_018918
NM_032054
PCDHGA5

protocadherin gamma subfamily A, 5

chr1_-_205161821 0.441 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr19_-_14813688 0.439 NM_001005190
OR7A10
olfactory receptor, family 7, subfamily A, member 10
chr12_-_10850845 0.438 NM_023918
TAS2R8
taste receptor, type 2, member 8
chr22_-_37966852 0.434 NM_033016
PDGFB
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
chr3_+_187917791 0.430 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr9_-_99740243 0.428 NM_197978
HEMGN
hemogen
chr18_+_30427279 0.427 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr11_-_51269023 0.427 NM_001005272
OR4A5
olfactory receptor, family 4, subfamily A, member 5
chr4_-_107508040 0.426 NM_001195138
LOC100507096
GTPase IMAP family member-like
chr5_-_135318420 0.421 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr6_+_88111289 0.421 NM_001010868
C6orf163
chromosome 6 open reading frame 163
chr5_+_34723420 0.420 NM_001145523
RAI14
retinoic acid induced 14
chr6_-_11490487 0.401 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr11_-_72057755 0.401 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr12_+_108452117 0.398 UBE3B
ubiquitin protein ligase E3B
chr12_-_10453409 0.393 NM_013431
KLRC4-KLRK1
KLRC4
KLRC4-KLRK1 read-through transcript
killer cell lectin-like receptor subfamily C, member 4
chr15_+_19869841 0.388 NM_001004719
OR4M2
olfactory receptor, family 4, subfamily M, member 2
chr3_-_15773061 0.384 NM_001195099
ANKRD28
ankyrin repeat domain 28
chr6_-_11887265 0.383 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr8_-_110724594 0.379 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr2_+_102136833 0.369 NM_000877
IL1R1
interleukin 1 receptor, type I
chr4_+_114433551 0.367 ANK2
ankyrin 2, neuronal
chr11_+_123315459 0.366 NM_001001965
OR4D5
olfactory receptor, family 4, subfamily D, member 5
chr1_-_150070849 0.360 NM_005060
RORC
RAR-related orphan receptor C
chr11_-_123414917 0.360 NM_001004463
OR10G7
olfactory receptor, family 10, subfamily G, member 7
chr11_-_123758448 0.356 NM_001005468
OR8B2
olfactory receptor, family 8, subfamily B, member 2
chr5_+_156540425 0.352 NM_005546
ITK
IL2-inducible T-cell kinase
chr2_+_165860528 0.352 NM_001040143
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr1_+_46418786 0.349 TSPAN1
tetraspanin 1
chr3_-_58538110 0.343 FAM107A
family with sequence similarity 107, member A
chr11_+_124329222 0.342 NM_025004
CCDC15
coiled-coil domain containing 15
chr22_+_20316968 0.341 NM_152612
CCDC116
coiled-coil domain containing 116
chr12_-_55929189 0.336


chr10_+_49563520 0.334 NM_020945
WDFY4
WDFY family member 4
chr13_+_107753764 0.330


chr15_+_40484249 0.313 NM_173089
NM_173090
CAPN3

calpain 3, (p94)

chr8_+_9990471 0.313 NM_001135671
MSRA
methionine sulfoxide reductase A
chr7_+_102176561 0.307 NM_001145268
NM_001145269
FAM185A

family with sequence similarity 185, member A

chr15_+_46285789 0.307 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr2_-_75650355 0.300 NM_032181
FAM176A
family with sequence similarity 176, member A
chr21_+_42946719 0.300 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
PDE9A



















phosphodiesterase 9A



















chr1_+_156416360 0.299 NM_001766
CD1D
CD1d molecule
chr15_+_39918302 0.297 NM_001114633
PLA2G4B
phospholipase A2, group IVB (cytosolic)
chr1_+_66570363 0.296 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chr11_+_71578249 0.296 NM_016724
NM_016725
FOLR1

folate receptor 1 (adult)

chr1_-_93172119 0.295


chr16_+_14976422 0.295 PDXDC1
pyridoxal-dependent decarboxylase domain containing 1
chr15_-_77994652 0.294 NM_001100879
ST20
suppressor of tumorigenicity 20
chr1_+_15862887 0.292


chr6_+_30212488 0.292 NM_138700
TRIM40
tripartite motif containing 40
chr11_+_123282307 0.292 NM_001005197
OR8D4
olfactory receptor, family 8, subfamily D, member 4
chr6_-_32665409 0.291 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr4_+_41234944 0.289 LIMCH1
LIM and calponin homology domains 1
chr12_+_49522967 0.281 NM_182559
TMPRSS12
transmembrane (C-terminal) protease, serine 12
chr8_-_30826074 0.280 NM_031271
TEX15
testis expressed 15
chr4_+_41235077 0.277 LIMCH1
LIM and calponin homology domains 1
chr19_+_17723285 0.276 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chr14_-_106352471 0.275


chr10_-_50012058 0.272 NM_001164484
FAM170B
family with sequence similarity 170, member B
chr1_-_172153087 0.271 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr17_-_3283884 0.267 NM_003554
OR1E2
olfactory receptor, family 1, subfamily E, member 2
chr3_+_133518966 0.267 ACPP
acid phosphatase, prostate
chr3_+_12367993 0.266 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr21_-_33107813 0.262 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chrX_-_8099307 0.262 NM_016378
VCX2
variable charge, X-linked 2
chr1_+_24518398 0.260 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr9_+_106306275 0.258 NM_001004485
OR13F1
olfactory receptor, family 13, subfamily F, member 1
chr2_+_44356100 0.251 NM_000341
SLC3A1
solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1
chr3_-_46761248 0.249 NM_199183
PRSS45
protease, serine, 45
chr3_-_42892195 0.249 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr17_+_57801309 0.248 NM_001144933
EFCAB3
EF-hand calcium binding domain 3
chr12_-_10498481 0.247 NM_213657
NM_213658
KLRC1

killer cell lectin-like receptor subfamily C, member 1

chr1_+_156490550 0.246 NM_001763
CD1A
CD1a molecule
chr1_+_24518501 0.245 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr4_-_123596921 0.244 NM_000586
IL2
interleukin 2
chr7_+_21434818 0.244


chr1_-_172153024 0.243 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr18_+_59374372 0.240 NM_080474
SERPINB12
serpin peptidase inhibitor, clade B (ovalbumin), member 12
chr5_+_140762551 0.239 NM_018921
NM_032089
PCDHGA9

protocadherin gamma subfamily A, 9

chr4_+_151722526 0.238 NM_006439
MAB21L2
mab-21-like 2 (C. elegans)
chr19_+_16691786 0.237 NM_001007525
NWD1
NACHT and WD repeat domain containing 1
chr1_+_40631603 0.236 NM_001198979
SMAP2
small ArfGAP2
chr5_-_160044844 0.231 ATP10B
ATPase, class V, type 10B
chr17_-_25685175 0.230 NM_206832
TMIGD1
transmembrane and immunoglobulin domain containing 1
chr7_+_143331954 0.230 NM_001005281
OR6B1
olfactory receptor, family 6, subfamily B, member 1
chr9_-_36365965 0.230 RNF38
ring finger protein 38
chr6_-_38671741 0.224 NM_001172418
NM_152733
BTBD9

BTB (POZ) domain containing 9

chr1_-_51560469 0.222 NM_001080494
TTC39A
tetratricopeptide repeat domain 39A
chr13_+_77213295 0.220 NM_144595
SLAIN1
SLAIN motif family, member 1
chr11_+_54867202 0.218 NM_001005274
OR4A16
olfactory receptor, family 4, subfamily A, member 16
chr1_+_67404756 0.218 NM_144701
IL23R
interleukin 23 receptor
chr7_-_133652042 0.217 SLC35B4
solute carrier family 35, member B4
chr17_+_57811645 0.215 NM_173503
EFCAB3
EF-hand calcium binding domain 3
chr21_-_30893063 0.212 NM_181604
KRTAP6-2
keratin associated protein 6-2
chrX_-_135166306 0.211 NM_001173516
MAP7D3
MAP7 domain containing 3
chr12_-_10479810 0.208 NM_002260
KLRC2
KLRC3
killer cell lectin-like receptor subfamily C, member 2
killer cell lectin-like receptor subfamily C, member 3
chr9_-_21295311 0.205 NM_002169
IFNA5
interferon, alpha 5
chr19_-_44427446 0.205 NM_172139
IL28B
interleukin 28B (interferon, lambda 3)
chr12_+_48310593 0.205 NM_001031698
PRPF40B
PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
chr6_+_160462852 0.205 NM_003057
NM_153187
SLC22A1

solute carrier family 22 (organic cation transporter), member 1

chr3_-_158695832 0.204 NM_001167917
VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr12_+_99391870 0.203 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr15_-_48198697 0.203 NM_024837
ATP8B4
ATPase, class I, type 8B, member 4
chr1_+_226937424 0.201 NM_021205
RHOU
ras homolog gene family, member U
chr2_-_157892391 0.195 NM_001009959
ERMN
ermin, ERM-like protein
chr11_+_55189189 0.195 NM_001004704
OR4C6
olfactory receptor, family 4, subfamily C, member 6
chr3_+_133518900 0.193 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr1_+_116727514 0.191 NM_001160234
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr7_+_141124710 0.190 NM_016944
TAS2R4
taste receptor, type 2, member 4
chr12_-_10433852 0.189 NM_007360
KLRK1
killer cell lectin-like receptor subfamily K, member 1
chr8_+_7332600 0.189 NM_152250
NM_001040703
DEFB105A
DEFB105B
defensin, beta 105A
defensin, beta 105B
chr1_-_245988330 0.188 NM_012353
OR1C1
olfactory receptor, family 1, subfamily C, member 1
chr8_-_25338472 0.187 NM_000825
NM_001083111
GNRH1

gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)

chr18_-_58946858 0.187 BCL2
B-cell CLL/lymphoma 2
chr11_+_5714253 0.186 NM_001005180
OR56B1
olfactory receptor, family 56, subfamily B, member 1
chr11_-_112851051 0.185 NM_000795
NM_016574
DRD2

dopamine receptor D2

chr16_-_3783475 0.183 CREBBP
CREB binding protein
chr13_+_45174446 0.183 NM_152719
SPERT
spermatid associated
chr6_-_6632197 0.182


chr9_+_124463665 0.182 NM_001005236
OR1L1
olfactory receptor, family 1, subfamily L, member 1
chr8_+_92184022 0.181 NM_001129890
LRRC69
leucine rich repeat containing 69
chr8_+_120148604 0.179 NM_006438
COLEC10
collectin sub-family member 10 (C-type lectin)
chr16_+_14976333 0.178 NM_015027
PDXDC1
pyridoxal-dependent decarboxylase domain containing 1
chr13_+_42253685 0.177 NM_182508
C13orf30
chromosome 13 open reading frame 30
chr4_-_100575313 0.176 NM_001166504
NM_000673
ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr11_-_55757236 0.175 NM_001004746
OR5T2
olfactory receptor, family 5, subfamily T, member 2
chr19_-_49523747 0.174 ZFP112
zinc finger protein 112 homolog (mouse)
chr9_+_831689 0.170 NM_021951
DMRT1
doublesex and mab-3 related transcription factor 1
chr4_+_74505710 0.168


chr1_-_159604287 0.168 NM_001013625
C1orf192
chromosome 1 open reading frame 192
chrX_-_76824726 0.166 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr1_-_68688219 0.164 NM_000329
RPE65
retinal pigment epithelium-specific protein 65kDa
chr4_-_186934059 0.164 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr4_-_145281237 0.164 NM_002099
GYPA
glycophorin A (MNS blood group)
chr6_+_47774247 0.162 NM_153838
GPR115
G protein-coupled receptor 115
chr5_-_41249270 0.161 NM_000065
C6
complement component 6
chr2_-_113310796 0.161 NM_000576
IL1B
interleukin 1, beta
chr2_-_113752957 0.161 NM_003466
NM_013952
NM_013953
NM_013992
PAX8



paired box 8



chr9_-_21132143 0.159 NM_002177
IFNW1
interferon, omega 1
chr8_+_7731402 0.159 NM_080389
NM_001040702
DEFB104A
DEFB104B
defensin, beta 104A
defensin, beta 104B
chr21_+_37495641 0.158 TTC3
tetratricopeptide repeat domain 3
chr10_+_104580420 0.155


chr18_-_72857951 0.154 MBP
myelin basic protein
chr1_-_100416358 0.154 NM_144620
LRRC39
leucine rich repeat containing 39

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.64 1.62e-11 GO:0007606 sensory perception of chemical stimulus
3.64 4.73e-10 GO:0007608 sensory perception of smell
1.35 2.58e-05 GO:0050896 response to stimulus
2.28 4.03e-05 GO:0007600 sensory perception
2.19 3.45e-04 GO:0006952 defense response
1.75 4.87e-04 GO:0003008 system process
1.75 8.99e-03 GO:0050877 neurological system process
1.95 1.10e-02 GO:0009611 response to wounding
2.79 1.93e-02 GO:0006954 inflammatory response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.61 4.20e-11 GO:0071944 cell periphery
1.61 9.12e-11 GO:0005886 plasma membrane
1.34 1.10e-04 GO:0016021 integral to membrane
1.32 2.96e-04 GO:0031224 intrinsic to membrane
1.24 3.49e-04 GO:0016020 membrane
1.28 4.12e-04 GO:0044425 membrane part
1.53 5.51e-03 GO:0005576 extracellular region
3.53 3.01e-02 GO:0005765 lysosomal membrane
1.80 4.51e-02 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.72 9.61e-11 GO:0004984 olfactory receptor activity
2.67 3.29e-10 GO:0004930 G-protein coupled receptor activity
2.22 4.15e-09 GO:0004888 transmembrane receptor activity
1.92 1.79e-07 GO:0004872 receptor activity
1.71 1.14e-05 GO:0004871 signal transducer activity
1.71 1.14e-05 GO:0060089 molecular transducer activity
8.46 1.72e-02 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
8.13 2.20e-02 GO:0004112 cyclic-nucleotide phosphodiesterase activity
10.58 2.30e-02 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity