Motif ID: SOX17.p2

Z-value: 1.072


Transcription factors associated with SOX17.p2:

Gene SymbolEntrez IDGene Name
SOX17 64321 SRY (sex determining region Y)-box 17

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX17chr8_+_55533047-0.155.9e-01Click!


Activity profile for motif SOX17.p2.

activity profile for motif SOX17.p2


Sorted Z-values histogram for motif SOX17.p2

Sorted Z-values for motif SOX17.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX17.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_37752272 1.004 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr3_-_11736946 0.925 NM_014667
VGLL4
vestigial like 4 (Drosophila)
chr16_-_30841938 0.908 NCRNA00095
non-protein coding RNA 95
chr1_-_202730135 0.865 PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr6_-_139654807 0.838 NM_153235
TXLNB
taxilin beta
chr2_+_159533329 0.779 NM_001145909
NM_033394
TANC1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr14_-_34001164 0.773 NM_138288
C14orf147
chromosome 14 open reading frame 147
chr7_+_128802719 0.766 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr12_-_24606616 0.749 NM_152989
SOX5
SRY (sex determining region Y)-box 5
chr2_+_232281470 0.716 NM_001099285
NM_002823
PTMA

prothymosin, alpha

chr6_+_114285209 0.699 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr15_-_73719546 0.673 NM_018285
IMP3
IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr2_+_152900076 0.664 FMNL2
formin-like 2
chr5_-_111782637 0.621 NM_022140
EPB41L4A
erythrocyte membrane protein band 4.1 like 4A
chr13_-_107317460 0.621 NM_001080396
FAM155A
family with sequence similarity 155, member A
chr2_-_37752731 0.613 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr2_+_149118791 0.613 EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr15_-_53822468 0.607 NM_173814
PRTG
protogenin
chr12_-_120389419 0.601 KDM2B
lysine (K)-specific demethylase 2B
chr2_-_175578156 0.589 NM_001025201
NM_001822
CHN1

chimerin (chimaerin) 1

chr13_-_29938029 0.587 NM_002128
HMGB1
high-mobility group box 1
chr2_+_232281491 0.575 PTMA
prothymosin, alpha
chr7_-_111633428 0.563 DOCK4
dedicator of cytokinesis 4
chr15_+_83724743 0.561 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr2_-_174538675 0.553 NM_001172712
NM_003111
SP3

Sp3 transcription factor

chr11_+_36274300 0.550 NM_001160167
PRR5L
proline rich 5 like
chr9_+_80101810 0.544 NM_021154
NM_058179
PSAT1

phosphoserine aminotransferase 1

chr14_+_23008742 0.536 NGDN
neuroguidin, EIF4E binding protein
chr4_-_185963859 0.527 ACSL1
acyl-CoA synthetase long-chain family member 1
chr1_+_12757570 0.515 NM_001080830
PRAMEF12
PRAME family member 12
chr9_-_128910132 0.513 ANGPTL2
angiopoietin-like 2
chr5_-_137099602 0.507 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr6_+_52637116 0.505 LOC730101
hypothetical LOC730101
chr1_+_34997928 0.498 NM_153212
GJB4
gap junction protein, beta 4, 30.3kDa
chr17_-_36981830 0.497 NM_000226
KRT9
keratin 9
chr7_-_135083906 0.495 NM_205855
FAM180A
family with sequence similarity 180, member A
chr1_+_1104939 0.493 NM_153254
TTLL10
tubulin tyrosine ligase-like family, member 10
chr2_+_149119029 0.487 NM_015630
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr15_+_82945223 0.481 NM_001007072
NM_017894
NM_181877
ZSCAN2


zinc finger and SCAN domain containing 2


chr1_+_2927905 0.479 NM_080431
ACTRT2
actin-related protein T2
chr21_+_40161216 0.472 NM_006198
PCP4
Purkinje cell protein 4
chr14_+_23008723 0.472 NM_001042635
NM_015514
NGDN

neuroguidin, EIF4E binding protein

chr6_+_21701942 0.470 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr9_-_126945536 0.460 NM_001144877
NM_173690
SCAI

suppressor of cancer cell invasion

chr4_-_2233606 0.458 MXD4
MAX dimerization protein 4
chr6_-_27222556 0.458 NM_080593
HIST1H2BK
histone cluster 1, H2bk
chr17_-_69869552 0.454 NM_001080466
BTBD17
BTB (POZ) domain containing 17
chr1_+_13784553 0.452 NM_001006624
NM_001006625
PDPN

podoplanin

chr6_+_29249289 0.448 NM_030905
OR2J2
olfactory receptor, family 2, subfamily J, member 2
chr5_+_66160359 0.448 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr3_-_150422474 0.447 NM_000096
CP
ceruloplasmin (ferroxidase)
chr1_+_1994943 0.437 NM_001033581
PRKCZ
protein kinase C, zeta
chr2_-_136005238 0.436 NM_032143
ZRANB3
zinc finger, RAN-binding domain containing 3
chr7_+_148613304 0.433 LOC155060
AI894139 pseudogene
chr7_+_116447527 0.433 ST7
suppression of tumorigenicity 7
chr20_-_48980858 0.431 NM_015339
NM_181442
ADNP

activity-dependent neuroprotector homeobox

chr17_-_8054587 0.430 NM_004217
AURKB
aurora kinase B
chr5_+_79651545 0.429 NM_032567
SPZ1
spermatogenic leucine zipper 1
chr2_-_234317362 0.428 NM_001001394
DNAJB3
DnaJ (Hsp40) homolog, subfamily B, member 3
chr4_-_2233504 0.428 NM_006454
MXD4
MAX dimerization protein 4
chr11_+_4564596 0.428 NM_001005170
OR52I2
olfactory receptor, family 52, subfamily I, member 2
chr6_+_36752244 0.424 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr1_+_207668787 0.424 NM_001104548
LOC642587
NPC-A-5
chr17_-_39191658 0.416 NM_025237
SOST
sclerostin
chr1_+_116455898 0.407 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr10_+_31650069 0.405 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr19_+_63482118 0.402 NM_021089
ZNF8
zinc finger protein 8
chr16_-_8964751 0.399 NM_003470
USP7
ubiquitin specific peptidase 7 (herpes virus-associated)
chr7_+_134114957 0.398 CALD1
caldesmon 1
chr1_-_26105230 0.396 NM_203401
STMN1
stathmin 1
chr2_-_207739815 0.391 KLF7
Kruppel-like factor 7 (ubiquitous)
chr3_+_195336625 0.391 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr20_-_41788975 0.386 NM_001008901
NM_176791
GTSF1L

gametocyte specific factor 1-like

chr7_-_130891861 0.386 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr9_-_98220360 0.385 ZNF367
zinc finger protein 367
chr2_-_9688552 0.385 NM_006826
YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chr6_-_42527760 0.384 NM_033502
TRERF1
transcriptional regulating factor 1
chr2_-_1905508 0.383 MYT1L
myelin transcription factor 1-like
chr2_-_201536425 0.382 NM_006190
ORC2
origin recognition complex, subunit 2
chr7_+_143683365 0.380 NM_005435
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr13_-_29937966 0.379 HMGB1
HMGB1P6
high-mobility group box 1
high-mobility group box 1 pseudogene 6
chr14_-_20975241 0.379 NM_020920
CHD8
chromodomain helicase DNA binding protein 8
chr2_-_70329067 0.374 NM_022037
NM_022173
TIA1

TIA1 cytotoxic granule-associated RNA binding protein

chr1_-_223907283 0.374 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr1_+_32777556 0.373 ZBTB8A
zinc finger and BTB domain containing 8A
chr6_-_20320607 0.372 NM_001080480
MBOAT1
membrane bound O-acyltransferase domain containing 1
chr6_-_26767892 0.369 NM_024639
ZNF322A
zinc finger protein 322A
chrX_+_49013243 0.367 NM_001184745
NM_033215
PPP1R3F

protein phosphatase 1, regulatory (inhibitor) subunit 3F

chr1_-_203557379 0.365 NM_030952
NUAK2
NUAK family, SNF1-like kinase, 2
chr6_-_24985432 0.364 NM_015864
FAM65B
family with sequence similarity 65, member B
chr14_-_92284626 0.364 NM_001008530
NM_005606
LGMN

legumain

chr4_+_154345039 0.363 NM_015271
TRIM2
tripartite motif containing 2
chr1_+_24158898 0.362 PNRC2
proline-rich nuclear receptor coactivator 2
chr2_+_178893216 0.360 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr1_+_199975674 0.358 NAV1
neuron navigator 1
chr20_-_10602139 0.355 JAG1
jagged 1
chr20_+_42644633 0.354 PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chrX_+_49013270 0.354 PPP1R3F
protein phosphatase 1, regulatory (inhibitor) subunit 3F
chr2_+_26862416 0.349 CENPA
centromere protein A
chr1_+_234372454 0.348 NM_003272
GPR137B
G protein-coupled receptor 137B
chr20_+_17628592 0.345 NM_001014977
NM_178477
BANF2

barrier to autointegration factor 2

chr1_+_43945804 0.344 NM_006279
NM_174963
NM_174964
NM_174965
NM_174966
NM_174967
NM_174968
NM_174969
NM_174970
NM_174971
ST3GAL3









ST3 beta-galactoside alpha-2,3-sialyltransferase 3









chr17_-_70662088 0.343 HN1
hematological and neurological expressed 1
chr2_+_54536780 0.342 NM_003128
SPTBN1
spectrin, beta, non-erythrocytic 1
chr3_+_44571600 0.341 NM_018651
NM_025169
ZNF167

zinc finger protein 167

chr20_+_58004811 0.341 NM_021810
CDH26
cadherin 26
chr18_-_13905534 0.338 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr9_+_124742932 0.337 NM_012197
RABGAP1
RAB GTPase activating protein 1
chr2_+_85676347 0.333 NM_016494
RNF181
ring finger protein 181
chr1_+_183970093 0.333 NM_031935
HMCN1
hemicentin 1
chr6_-_29752909 0.332 NM_001109809
ZFP57
zinc finger protein 57 homolog (mouse)
chr3_+_100840129 0.332 NM_001850
NM_020351
COL8A1

collagen, type VIII, alpha 1

chr15_-_32446537 0.329 NM_153613
LPCAT4
lysophosphatidylcholine acyltransferase 4
chr14_-_89155078 0.329 NM_001085471
FOXN3
forkhead box N3
chr6_-_150388292 0.327 NM_130900
RAET1L
retinoic acid early transcript 1L
chr16_+_8675904 0.326 NM_020686
ABAT
4-aminobutyrate aminotransferase
chr9_-_98220482 0.325 NM_153695
ZNF367
zinc finger protein 367
chr3_+_195336631 0.324 HES1
hairy and enhancer of split 1, (Drosophila)
chr2_-_20413838 0.324 PUM2
pumilio homolog 2 (Drosophila)
chr9_+_132990834 0.322 NUP214
nucleoporin 214kDa
chr2_-_96769502 0.322 LMAN2L
lectin, mannose-binding 2-like
chr7_+_134114912 0.320 CALD1
caldesmon 1
chr22_-_37481857 0.319 NM_015374
SUN2
Sad1 and UNC84 domain containing 2
chr5_+_148186348 0.318 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr17_-_36996611 0.316 NM_000526
KRT14
keratin 14
chr2_+_62786290 0.314 NM_001142616
NM_015252
EHBP1

EH domain binding protein 1

chr10_+_170423 0.311 NM_001161482
NM_006624
NM_212479
ZMYND11


zinc finger, MYND-type containing 11


chr3_-_107070400 0.311 NM_170662
CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr12_+_62524778 0.310 NM_020762
SRGAP1
SLIT-ROBO Rho GTPase activating protein 1
chr3_-_139315011 0.310 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr12_-_67012303 0.310 NM_017440
NM_020128
MDM1

Mdm1 nuclear protein homolog (mouse)

chr11_+_34029764 0.309 NM_005898
NM_203364
CAPRIN1

cell cycle associated protein 1

chr21_+_17807167 0.309 NM_001338
CXADR
coxsackie virus and adenovirus receptor
chr10_-_14686243 0.308 FAM107B
family with sequence similarity 107, member B
chr5_-_125956996 0.307 ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr2_+_149895274 0.307 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr7_+_123083096 0.307 NM_207163
LMOD2
leiomodin 2 (cardiac)
chr21_-_15358996 0.306 NM_003489
NRIP1
nuclear receptor interacting protein 1
chr9_-_132759045 0.306 NM_198180
QRFP
pyroglutamylated RFamide peptide
chr9_+_132990760 0.306 NM_005085
NUP214
nucleoporin 214kDa
chr3_-_194118627 0.304 NM_178496
MB21D2
Mab-21 domain containing 2
chr2_-_171631728 0.304 NM_001136555
TLK1
tousled-like kinase 1
chr5_+_108112537 0.303 FER
fer (fps/fes related) tyrosine kinase
chr16_-_8870343 0.303 NM_014316
CARHSP1
calcium regulated heat stable protein 1, 24kDa
chr1_+_6767968 0.302 NM_001195563
NM_015215
CAMTA1

calmodulin binding transcription activator 1

chr10_+_70418482 0.302 NM_015634
KIAA1279
KIAA1279
chr12_+_56374004 0.300 NM_001017956
NM_001017957
NM_001017958
NM_006812
OS9



osteosarcoma amplified 9, endoplasmic reticulum lectin



chr2_-_61618898 0.300 NM_003400
XPO1
exportin 1 (CRM1 homolog, yeast)
chr1_-_234096793 0.300


chr2_-_9688450 0.299 YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chr7_+_116238309 0.299 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr19_-_17275083 0.298 NM_024527
ABHD8
abhydrolase domain containing 8
chr17_-_45617899 0.297 COL1A1
collagen, type I, alpha 1
chr5_+_14493905 0.294 TRIO
triple functional domain (PTPRF interacting)
chr12_-_102413875 0.292 NM_198521
NM_001099336
C12orf42

chromosome 12 open reading frame 42

chr6_-_53321545 0.292 ELOVL5
ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
chr4_+_87734489 0.292 NM_006264
NM_080683
NM_080684
NM_080685
PTPN13



protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)



chr7_-_27171600 0.289 HOXA9
homeobox A9
chr22_+_20316968 0.287 NM_152612
CCDC116
coiled-coil domain containing 116
chr5_-_141318810 0.287 NM_016580
PCDH12
protocadherin 12
chr1_-_21373816 0.286 NM_001198803
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr15_-_42274529 0.285 NM_032892
FRMD5
FERM domain containing 5
chr3_+_113200696 0.284 NM_001008273
TAGLN3
transgelin 3
chr20_+_54541672 0.284 NM_001013646
C20orf107
chromosome 20 open reading frame 107
chrX_-_76928334 0.283 NM_000489
NM_138270
ATRX

alpha thalassemia/mental retardation syndrome X-linked

chr2_+_85619802 0.282 MAT2A
methionine adenosyltransferase II, alpha
chr6_-_152664906 0.282 SYNE1
spectrin repeat containing, nuclear envelope 1
chr3_+_123817151 0.282 NM_152615
PARP15
poly (ADP-ribose) polymerase family, member 15
chr16_-_10696285 0.280 NM_144674
TEKT5
tektin 5
chr15_+_75010997 0.280 NM_002902
RCN2
reticulocalbin 2, EF-hand calcium binding domain
chr1_-_6468108 0.280 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr6_+_31190505 0.279 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr16_-_78192111 0.279 NM_001031804
NM_005360
MAF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

chr6_+_27222839 0.278 NM_080596
HIST1H2AH
histone cluster 1, H2ah
chr2_+_206255376 0.277 NM_003872
NM_018534
NM_201264
NM_201266
NM_201267
NM_201279
NRP2





neuropilin 2





chr11_+_6854431 0.276 NM_207186
OR10A4
olfactory receptor, family 10, subfamily A, member 4
chr17_-_46298671 0.276 TOB1
transducer of ERBB2, 1
chr2_+_152899837 0.276 NM_052905
FMNL2
formin-like 2
chr8_+_128497038 0.274 NM_001159542
POU5F1B
POU class 5 homeobox 1B
chr7_-_27171673 0.273 NM_152739
HOXA9
homeobox A9
chr7_+_134114701 0.273 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr11_+_60448487 0.273 NM_017870
NM_178031
TMEM132A

transmembrane protein 132A

chr22_-_37481925 0.273 SUN2
Sad1 and UNC84 domain containing 2
chr6_+_7671267 0.273 BMP6
bone morphogenetic protein 6
chr11_+_33520348 0.273 NM_012194
C11orf41
chromosome 11 open reading frame 41
chr9_-_130980359 0.271 NM_203434
IER5L
immediate early response 5-like
chr18_+_7936885 0.271 PTPRM
protein tyrosine phosphatase, receptor type, M
chr3_+_113200275 0.271 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr21_-_30460841 0.270 NM_012131
CLDN17
claudin 17
chr3_+_158637273 0.269 NM_002852
PTX3
pentraxin 3, long
chr7_+_27102508 0.268


chr6_+_46728590 0.268 NM_004277
SLC25A27
solute carrier family 25, member 27
chr1_+_110683586 0.267 RBM15
RNA binding motif protein 15
chr7_-_27171648 0.267 HOXA9
homeobox A9
chr16_-_20323533 0.267 NM_174924
PDILT
protein disulfide isomerase-like, testis expressed
chr2_+_149894744 0.266 NM_001195685
LYPD6
LY6/PLAUR domain containing 6
chr9_+_102275310 0.265 NM_003692
TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr2_-_73151894 0.264 SFXN5
sideroflexin 5
chr16_+_55373241 0.263 NUP93
nucleoporin 93kDa
chr11_+_6823458 0.262 NM_178168
OR10A5
olfactory receptor, family 10, subfamily A, member 5

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.34 1.23e-03 GO:0006996 organelle organization
1.76 1.63e-02 GO:0030029 actin filament-based process
1.57 3.56e-02 GO:0006325 chromatin organization
1.37 4.06e-02 GO:0007049 cell cycle
1.44 4.35e-02 GO:0071844 cellular component assembly at cellular level

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.21 8.99e-09 GO:0005634 nucleus
1.09 9.09e-07 GO:0005622 intracellular
1.09 3.97e-06 GO:0044424 intracellular part
1.10 3.83e-05 GO:0043226 organelle
1.39 4.43e-05 GO:0005654 nucleoplasm
1.28 5.73e-05 GO:0043233 organelle lumen
1.10 6.23e-05 GO:0043229 intracellular organelle
1.32 7.11e-05 GO:0031981 nuclear lumen
1.29 7.77e-05 GO:0044428 nuclear part
1.29 7.87e-05 GO:0070013 intracellular organelle lumen
1.27 1.16e-04 GO:0031974 membrane-enclosed lumen
1.23 5.83e-04 GO:0043228 non-membrane-bounded organelle
1.23 5.83e-04 GO:0043232 intracellular non-membrane-bounded organelle
1.53 2.27e-03 GO:0005694 chromosome
1.14 2.66e-03 GO:0044422 organelle part
1.57 4.51e-03 GO:0044427 chromosomal part
1.13 5.05e-03 GO:0044446 intracellular organelle part
1.79 6.84e-03 GO:0000785 chromatin
1.79 1.16e-02 GO:0016604 nuclear body
1.67 1.50e-02 GO:0015629 actin cytoskeleton
2.49 3.50e-02 GO:0000786 nucleosome
1.26 3.76e-02 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 1.64e-03 GO:0005515 protein binding
1.68 6.97e-03 GO:0003779 actin binding
1.06 3.95e-02 GO:0005488 binding