Motif ID: ATF4.p2

Z-value: 1.076


Transcription factors associated with ATF4.p2:

Gene SymbolEntrez IDGene Name
ATF4 468 activating transcription factor 4 (tax-responsive enhancer element B67)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ATF4chr22_+_382465090.058.6e-01Click!


Activity profile for motif ATF4.p2.

activity profile for motif ATF4.p2


Sorted Z-values histogram for motif ATF4.p2

Sorted Z-values for motif ATF4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF4.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_586997 2.211 NM_014410
 CLUL1
clusterin-like 1 (retinal)
chr6_+_139497933 1.230 NM_016217
 HECA
headcase homolog (Drosophila)
chr11_-_76862197 1.044 NM_001128620
NM_002576
 PAK1

p21 protein (Cdc42/Rac)-activated kinase 1

chr1_+_1994943 0.974 NM_001033581
 PRKCZ
protein kinase C, zeta
chr4_+_85723080 0.894 NM_001263
 CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr5_-_176760242 0.863 NM_001029886
 PFN3
profilin 3
chr2_+_219453487 0.843 NM_025216
 WNT10A
wingless-type MMTV integration site family, member 10A
chr7_-_44992729 0.807 C7orf40
chromosome 7 open reading frame 40
chr9_-_126573349 0.725 NM_001489
NM_033334
 NR6A1

nuclear receptor subfamily 6, group A, member 1

chr5_+_112877251 0.706 NM_022828
 YTHDC2
YTH domain containing 2
chr19_+_10388448 0.690 PDE4A
phosphodiesterase 4A, cAMP-specific
chr17_-_4589387 0.687 CXCL16
chemokine (C-X-C motif) ligand 16
chr16_+_22732982 0.683 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr1_+_29435534 0.655 NM_001195001
NM_005704
NM_133177
NM_133178
 PTPRU



protein tyrosine phosphatase, receptor type, U



chr21_-_42060334 0.645 RIPK4
receptor-interacting serine-threonine kinase 4
chr7_-_140270749 0.627 NM_004333
 BRAF
v-raf murine sarcoma viral oncogene homolog B1
chr21_-_42060266 0.599 NM_020639
 RIPK4
receptor-interacting serine-threonine kinase 4
chr1_-_226670928 0.562 TRIM17
tripartite motif containing 17
chr8_+_128875902 0.560 PVT1
Pvt1 oncogene (non-protein coding)
chr6_-_34772565 0.556 NM_022758
NM_024294
 C6orf106

chromosome 6 open reading frame 106


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 34 entries
enrichment   p-value GO term description
3.67 1.01e-02 GO:0006986 response to unfolded protein
2.99 7.32e-03 GO:0016197 endosome transport
2.87 5.93e-03 GO:0051789 response to protein stimulus
2.86 9.71e-03 GO:0050657 nucleic acid transport
2.86 9.71e-03 GO:0050658 RNA transport
2.86 9.71e-03 GO:0051236 establishment of RNA localization
2.77 1.74e-02 GO:0006403 RNA localization
1.91 1.41e-02 GO:0000279 M phase
1.83 3.49e-04 GO:0022403 cell cycle phase
1.81 1.96e-02 GO:0006974 response to DNA damage stimulus
1.78 1.83e-04 GO:0022402 cell cycle process
1.77 3.87e-04 GO:0046907 intracellular transport
1.75 2.71e-02 GO:0000278 mitotic cell cycle
1.72 9.34e-04 GO:0033554 cellular response to stress
1.71 5.99e-05 GO:0007049 cell cycle
1.49 8.98e-06 GO:0090304 nucleic acid metabolic process
1.49 1.27e-03 GO:0006996 organelle organization
1.48 1.29e-07 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.47 3.78e-02 GO:0051641 cellular localization
1.44 2.34e-05 GO:0044267 cellular protein metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 26 entries
enrichment   p-value GO term description
5.71 4.38e-02 GO:0000159 protein phosphatase type 2A complex
4.30 4.76e-03 GO:0008287 protein serine/threonine phosphatase complex
1.97 5.28e-03 GO:0005815 microtubule organizing center
1.92 5.56e-05 GO:0005694 chromosome
1.92 5.21e-04 GO:0044427 chromosomal part
1.66 5.67e-03 GO:0015630 microtubule cytoskeleton
1.54 2.14e-04 GO:0005654 nucleoplasm
1.53 3.06e-08 GO:0044428 nuclear part
1.53 1.80e-06 GO:0031981 nuclear lumen
1.48 8.16e-07 GO:0070013 intracellular organelle lumen
1.46 1.49e-06 GO:0031974 membrane-enclosed lumen
1.46 1.63e-06 GO:0043233 organelle lumen
1.37 5.54e-05 GO:0043228 non-membrane-bounded organelle
1.37 5.54e-05 GO:0043232 intracellular non-membrane-bounded organelle
1.36 3.87e-13 GO:0044446 intracellular organelle part
1.34 2.27e-12 GO:0044422 organelle part
1.29 1.02e-08 GO:0005634 nucleus
1.28 1.18e-03 GO:0032991 macromolecular complex
1.25 7.96e-15 GO:0043231 intracellular membrane-bounded organelle
1.25 1.09e-14 GO:0043227 membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
1.60 1.90e-02 GO:0019899 enzyme binding
1.49 4.79e-04 GO:0005524 ATP binding
1.47 5.98e-04 GO:0030554 adenyl nucleotide binding
1.47 7.07e-04 GO:0032559 adenyl ribonucleotide binding
1.43 5.35e-04 GO:0035639 purine ribonucleoside triphosphate binding
1.41 5.18e-05 GO:0000166 nucleotide binding
1.41 8.80e-04 GO:0017076 purine nucleotide binding
1.41 9.62e-04 GO:0032553 ribonucleotide binding
1.41 9.62e-04 GO:0032555 purine ribonucleotide binding
1.27 5.06e-03 GO:0003676 nucleic acid binding
1.22 2.05e-07 GO:0005515 protein binding
1.18 4.00e-02 GO:0003824 catalytic activity
1.12 7.82e-07 GO:0005488 binding