Motif ID: NR5A1,2.p2

Z-value: 1.926


Transcription factors associated with NR5A1,2.p2:

Gene SymbolEntrez IDGene Name
NR5A1 2516 nuclear receptor subfamily 5, group A, member 1
NR5A2 2494 nuclear receptor subfamily 5, group A, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR5A2chr1_+_198278339-0.458.1e-02Click!
NR5A1chr9_-_126309510-0.312.5e-01Click!


Activity profile for motif NR5A1,2.p2.

activity profile for motif NR5A1,2.p2


Sorted Z-values histogram for motif NR5A1,2.p2

Sorted Z-values for motif NR5A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR5A1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_144649142 3.129 UTRN
utrophin
chr1_-_206263170 2.718 PLXNA2
plexin A2
chr19_+_54238913 2.691 NM_033043
CGB
CGB5
chorionic gonadotropin, beta polypeptide
chorionic gonadotropin, beta polypeptide 5
chr12_-_13139848 2.630 NM_031289
NM_153823
GSG1

germ cell associated 1

chr6_-_2785682 2.413 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr19_-_54244133 2.335 NM_033183
CGB
CGB5
CGB8
chorionic gonadotropin, beta polypeptide
chorionic gonadotropin, beta polypeptide 5
chorionic gonadotropin, beta polypeptide 8
chr12_+_50104936 2.286 SLC4A8
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr8_-_18585721 2.283 PSD3
pleckstrin and Sec7 domain containing 3
chr19_-_54250808 2.258 NM_033142
CGB7
chorionic gonadotropin, beta polypeptide 7
chr5_+_73145098 2.101 RGNEF
190 kDa guanine nucleotide exchange factor
chr6_+_21701942 1.854 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr19_-_40711034 1.825 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr3_+_14835472 1.823 NM_152536
FGD5
FYVE, RhoGEF and PH domain containing 5
chr11_+_76491532 1.813 NM_006189
OMP
olfactory marker protein
chr1_+_15955719 1.701 FBLIM1
filamin binding LIM protein 1
chr18_-_13905534 1.658 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr19_-_54219039 1.645 NM_000737
CGB
CGB5
chorionic gonadotropin, beta polypeptide
chorionic gonadotropin, beta polypeptide 5
chr7_-_130891861 1.609 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr17_-_45626967 1.606


chr1_+_160618143 1.596 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr7_+_115953582 1.551 NM_001172896
NM_001172897
CAV1

caveolin 1, caveolae protein, 22kDa

chr1_+_31823097 1.523 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr2_-_175578156 1.488 NM_001025201
NM_001822
CHN1

chimerin (chimaerin) 1

chr20_+_57199469 1.459 NM_178457
ZNF831
zinc finger protein 831
chr1_-_158091296 1.458 C1orf204
chromosome 1 open reading frame 204
chr22_+_19239221 1.456 MED15
mediator complex subunit 15
chr22_+_21370394 1.440 IGL@
immunoglobulin lambda locus
chr5_-_112798436 1.434 NM_032028
TSSK1B
testis-specific serine kinase 1B
chrX_-_107112244 1.393 NM_031273
TEX13B
testis expressed 13B
chr12_-_109842736 1.324 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr9_+_132961723 1.319 AIF1L
allograft inflammatory factor 1-like
chr5_+_52320660 1.304 NM_002203
ITGA2
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
chr16_-_66007650 1.296 NM_013304
ZDHHC1
zinc finger, DHHC-type containing 1
chr3_+_3056307 1.291 NM_175612
CNTN4
contactin 4
chr22_+_19458378 1.285 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr1_+_199884152 1.282 NAV1
neuron navigator 1
chr8_+_143758875 1.267 NM_005672
PSCA
prostate stem cell antigen
chr2_+_219354948 1.216 CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr12_+_118100977 1.204 NM_014365
HSPB8
heat shock 22kDa protein 8
chr5_+_67558217 1.190 NM_181523
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr3_-_38666122 1.181 NM_000335
NM_001099404
NM_001099405
NM_198056
NM_001160160
NM_001160161
SCN5A





sodium channel, voltage-gated, type V, alpha subunit





chr1_-_23376860 1.172 LUZP1
leucine zipper protein 1
chr17_-_45621312 1.171 COL1A1
collagen, type I, alpha 1
chr2_-_110665188 1.162 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr8_-_37576515 1.160 LOC157860
hypothetical protein LOC157860
chr1_+_221168388 1.156 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr6_-_108252200 1.142 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr5_+_140848905 1.137 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr1_+_165330710 1.130 NM_001080426
DUSP27
dual specificity phosphatase 27 (putative)
chr11_+_1897374 1.114 NM_001042780
NM_001042781
NM_001042782
NM_006757
TNNT3



troponin T type 3 (skeletal, fast)



chr17_-_45619038 1.113 COL1A1
collagen, type I, alpha 1
chr11_-_6298284 1.101 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr4_-_5881271 1.099 CRMP1
collapsin response mediator protein 1
chr9_-_135334003 1.099 NM_001145099
NM_017585
SLC2A6

solute carrier family 2 (facilitated glucose transporter), member 6

chr12_+_50104859 1.092 NM_001039960
NM_004858
SLC4A8

solute carrier family 4, sodium bicarbonate cotransporter, member 8

chr11_-_86060812 1.069 NM_001014811
ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr1_+_17817397 1.068 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr17_+_45940911 1.063 MYCBPAP
MYCBP associated protein
chr11_+_61005160 1.061 NM_001170753
NM_145017
C11orf66

chromosome 11 open reading frame 66

chr2_-_161058550 1.056 NM_002897
NM_016836
RBMS1

RNA binding motif, single stranded interacting protein 1

chr19_+_59796858 1.023 NM_006863
LILRA1
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
chr17_-_36996611 1.021 NM_000526
KRT14
keratin 14
chr7_+_157339985 1.010 LOC100506585
hypothetical LOC100506585
chr11_-_1006736 1.002 MUC6
mucin 6, oligomeric mucus/gel-forming
chr8_-_107851593 0.996 NM_139166
ABRA
actin-binding Rho activating protein
chr2_-_128149112 0.991 NM_001136037
NM_001161403
LIMS2

LIM and senescent cell antigen-like domains 2

chr12_-_47464143 0.982 NM_015270
ADCY6
adenylate cyclase 6
chr1_+_200018380 0.976 NAV1
neuron navigator 1
chr7_+_142459538 0.952 NM_001001667
OR6V1
olfactory receptor, family 6, subfamily V, member 1
chr1_+_22176004 0.943 NM_007352
CELA3A
CELA3B
chymotrypsin-like elastase family, member 3A
chymotrypsin-like elastase family, member 3B
chr5_+_72452131 0.941 NM_001161342
NM_173490
TMEM171

transmembrane protein 171

chr16_-_65781499 0.939 NM_178516
EXOC3L1
exocyst complex component 3-like 1
chr1_+_63832067 0.926 NM_001172819
PGM1
phosphoglucomutase 1
chr11_-_8788765 0.925 NM_213618
ST5
suppression of tumorigenicity 5
chr17_-_45621571 0.923 COL1A1
collagen, type I, alpha 1
chr12_+_50592379 0.919 NM_001077401
ACVRL1
activin A receptor type II-like 1
chr22_-_16887151 0.913 NM_001122731
NM_001136004
NM_015241
MICAL3


microtubule associated monoxygenase, calponin and LIM domain containing 3


chr1_-_19998955 0.910 NM_181719
TMCO4
transmembrane and coiled-coil domains 4
chr1_+_64983312 0.907 NM_018211
RAVER2
ribonucleoprotein, PTB-binding 2
chr7_+_116238309 0.906 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr12_-_105056577 0.905 NUAK1
NUAK family, SNF1-like kinase, 1
chr6_+_167658563 0.905 NM_031949
TTLL2
tubulin tyrosine ligase-like family, member 2
chr3_-_46850588 0.905 NM_182702
PRSS42
protease, serine, 42
chr4_+_110991934 0.894 NM_198506
LRIT3
leucine-rich repeat, immunoglobulin-like and transmembrane domains 3
chr1_+_22200735 0.891 NM_005747
CELA3A
chymotrypsin-like elastase family, member 3A
chr1_-_202726068 0.890 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr18_-_3870068 0.885 NM_004746
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr1_+_18680010 0.877 NM_152375
KLHDC7A
kelch domain containing 7A
chr19_+_53801811 0.865 NM_133498
SPACA4
sperm acrosome associated 4
chr1_+_46413335 0.862 NM_005727
TSPAN1
tetraspanin 1
chr6_+_36773605 0.855 RAB44
RAB44, member RAS oncogene family
chr7_-_27153892 0.850 NM_024014
HOXA6
homeobox A6
chr17_-_38421363 0.849 VAT1
vesicle amine transport protein 1 homolog (T. californica)
chr8_-_20156971 0.843 NM_021020
LZTS1
leucine zipper, putative tumor suppressor 1
chr7_+_2409731 0.837 NM_018641
CHST12
carbohydrate (chondroitin 4) sulfotransferase 12
chr7_-_27186400 0.834 NM_153715
HOXA10
homeobox A10
chr2_+_149119029 0.819 NM_015630
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr2_+_17861266 0.819 NM_001105569
MSGN1
mesogenin 1
chr10_+_75427853 0.817 NM_003373
NM_014000
VCL

vinculin

chr5_+_145296313 0.817 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr8_-_124622434 0.811 NM_058229
FBXO32
F-box protein 32
chr20_-_49612574 0.806 NM_001136021
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr15_+_71522551 0.805 NM_001042367
C15orf60
chromosome 15 open reading frame 60
chr15_-_73719546 0.802 NM_018285
IMP3
IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr11_+_122031549 0.788 NM_032873
UBASH3B
ubiquitin associated and SH3 domain containing B
chr1_+_156229686 0.786 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr9_+_115970599 0.785 COL27A1
collagen, type XXVII, alpha 1
chr1_+_2026014 0.784 NM_001033582
PRKCZ
protein kinase C, zeta
chr14_+_92049396 0.782 NM_024832
RIN3
Ras and Rab interactor 3
chr20_-_49612745 0.772 NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr4_-_152316105 0.767 NM_001128924
SH3D19
SH3 domain containing 19
chr4_+_77829634 0.765 SHROOM3
shroom family member 3
chr16_-_47201588 0.764 NM_153029
N4BP1
NEDD4 binding protein 1
chr11_-_101906640 0.762 NM_002423
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr22_+_21006814 0.758


chrX_+_47752113 0.755 NM_001079900
SPACA5
SPACA5B
sperm acrosome associated 5
sperm acrosome associated 5B
chr4_+_169989680 0.755 NM_001166110
PALLD
palladin, cytoskeletal associated protein
chr19_-_51168396 0.751 NM_002516
NOVA2
neuro-oncological ventral antigen 2
chr3_+_16901455 0.749 NM_001144382
PLCL2
phospholipase C-like 2
chr5_+_159589014 0.748 NM_001445
FABP6
fatty acid binding protein 6, ileal
chr12_-_121753795 0.743 NM_177551
GPR109A
G protein-coupled receptor 109A
chr7_-_139948780 0.736 NM_015689
DENND2A
DENN/MADD domain containing 2A
chr17_+_37122138 0.734 NM_000805
GAST
gastrin
chr22_+_29122932 0.729 NM_012429
NM_033382
SEC14L2

SEC14-like 2 (S. cerevisiae)

chr7_-_98643024 0.728 NM_001145715
KPNA7
karyopherin alpha 7 (importin alpha 8)
chr22_-_35835548 0.723 TMPRSS6
transmembrane protease, serine 6
chr11_-_123414917 0.723 NM_001004463
OR10G7
olfactory receptor, family 10, subfamily G, member 7
chr11_-_8789457 0.716 NM_139157
ST5
suppression of tumorigenicity 5
chrX_+_152608159 0.706 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr15_-_42274529 0.706 NM_032892
FRMD5
FERM domain containing 5
chr11_+_60858611 0.705 DAK
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chr16_-_29781842 0.704 NM_006319
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr2_+_33213111 0.703 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr9_-_131555111 0.703 NM_004878
PTGES
prostaglandin E synthase
chr1_-_169888373 0.702 NM_000261
MYOC
myocilin, trabecular meshwork inducible glucocorticoid response
chr2_+_96790298 0.701 NM_020184
CNNM4
cyclin M4
chr7_-_21951946 0.700 NM_001127370
NM_001127371
NM_018719
CDCA7L


cell division cycle associated 7-like


chr5_-_122400219 0.700 PPIC
peptidylprolyl isomerase C (cyclophilin C)
chr1_+_17738863 0.700 NM_018125
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr1_+_63861474 0.697 NM_001172818
PGM1
phosphoglucomutase 1
chr6_+_12622286 0.697


chr6_+_43846735 0.693 VEGFA
vascular endothelial growth factor A
chr11_-_7941617 0.693 NM_176821
NLRP10
NLR family, pyrin domain containing 10
chr3_-_188936941 0.687 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr1_+_204390905 0.685 NM_000707
AVPR1B
arginine vasopressin receptor 1B
chr9_+_132990760 0.682 NM_005085
NUP214
nucleoporin 214kDa
chr19_+_8814268 0.681 NM_145208
MBD3L1
methyl-CpG binding domain protein 3-like 1
chr19_+_11211282 0.678 NM_018687
LOC55908
hepatocellular carcinoma-associated gene TD26
chr22_+_19651446 0.677 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr20_+_19818209 0.673 NM_018993
RIN2
Ras and Rab interactor 2
chr11_+_5925152 0.673 NM_001003443
OR56A3
olfactory receptor, family 56, subfamily A, member 3
chr12_+_27511009 0.671 NM_001145010
C12orf70
chromosome 12 open reading frame 70
chr1_-_42978320 0.671 NM_001123395
NM_001185117
NM_148960
CLDN19


claudin 19


chr15_-_81412354 0.668 NM_004839
NM_199330
NM_199331
NM_199332
HOMER2



homer homolog 2 (Drosophila)



chr16_-_73798539 0.668 NM_001025200
CTRB1
CTRB2
chymotrypsinogen B1
chymotrypsinogen B2
chr1_+_36160375 0.667 EIF2C1
eukaryotic translation initiation factor 2C, 1
chr16_+_10878539 0.666 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr11_-_1007140 0.665 MUC6
mucin 6, oligomeric mucus/gel-forming
chr7_+_116099648 0.662 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr5_-_122400312 0.660 NM_000943
PPIC
peptidylprolyl isomerase C (cyclophilin C)
chr6_-_112147946 0.656 NM_153047
FYN
FYN oncogene related to SRC, FGR, YES
chrX_+_100361588 0.651 NM_001171184
NM_001939
DRP2

dystrophin related protein 2

chr18_+_606671 0.650 NM_199167
CLUL1
clusterin-like 1 (retinal)
chr3_-_42719322 0.648 NM_020707
HHATL
hedgehog acyltransferase-like
chr12_+_5473558 0.645 NM_002527
NTF3
neurotrophin 3
chr3_-_3127057 0.644 NM_000564
NM_175724
NM_175725
NM_175726
NM_175727
NM_175728
IL5RA





interleukin 5 receptor, alpha





chr20_+_34937928 0.643 NM_080628
C20orf118
chromosome 20 open reading frame 118
chr2_-_88208650 0.641 NM_001443
FABP1
fatty acid binding protein 1, liver
chr12_-_26169074 0.641 NM_030762
BHLHE41
basic helix-loop-helix family, member e41
chr8_+_38877909 0.639 NM_021623
PLEKHA2
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
chr19_-_17217022 0.638 NM_005234
NR2F6
nuclear receptor subfamily 2, group F, member 6
chr17_+_40580466 0.637 NM_006460
HEXIM1
hexamethylene bis-acetamide inducible 1
chr2_+_39000007 0.636 NM_001145451
ARHGEF33
Rho guanine nucleotide exchange factor (GEF) 33
chr11_+_119586879 0.635 NM_178507
OAF
OAF homolog (Drosophila)
chr1_+_156229934 0.632 KIRREL
kin of IRRE like (Drosophila)
chr20_+_43764068 0.625 NM_172005
WFDC13
WAP four-disulfide core domain 13
chr20_+_30061905 0.624 NM_080625
C20orf160
chromosome 20 open reading frame 160
chr5_+_125828685 0.623 NM_001146322
GRAMD3
GRAM domain containing 3
chr17_-_24972471 0.620 NM_032854
CORO6
coronin 6
chr20_+_29492071 0.620 NM_153324
DEFB123
defensin, beta 123
chr2_-_25418819 0.617 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr11_-_59237893 0.616 NM_001005324
OR10V1
olfactory receptor, family 10, subfamily V, member 1
chr6_-_26343139 0.616 NM_005320
HIST1H1D
histone cluster 1, H1d
chr7_+_48095464 0.613 UPP1
uridine phosphorylase 1
chr17_+_21249040 0.613 NM_001194958
KCNJ18
potassium inwardly-rectifying channel, subfamily J, member 18
chr20_+_30329096 0.613 NM_004798
KIF3B
kinesin family member 3B
chr17_-_52248248 0.611 NM_001085430
C17orf67
chromosome 17 open reading frame 67
chr2_-_25418856 0.611 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr6_-_27222556 0.609 NM_080593
HIST1H2BK
histone cluster 1, H2bk
chr1_-_180621272 0.605 GLUL
glutamate-ammonia ligase
chr10_+_80942362 0.605 NM_001099692
EIF5AL1
eukaryotic translation initiation factor 5A-like 1
chr9_+_132990834 0.602 NUP214
nucleoporin 214kDa
chr19_-_14771947 0.602 NM_198944
OR7C1
olfactory receptor, family 7, subfamily C, member 1
chr12_+_107797985 0.601 NM_001917
DAO
D-amino-acid oxidase
chrX_-_43717864 0.600 NM_000266
NDP
Norrie disease (pseudoglioma)
chr4_-_164614335 0.596 NM_032136
TKTL2
transketolase-like 2
chrX_-_119913274 0.592 NM_173571
NM_001080137
NM_001080138
NM_001080139
NM_001080141
NM_001080142
NM_001080143
NM_001080144
NM_001080145
NM_001080146
CT47A11
CT47A10
CT47A9
CT47A8
CT47A6
CT47A5
CT47A4
CT47A3
CT47A2
CT47A1
cancer/testis antigen family 47, member A11
cancer/testis antigen family 47, member A10
cancer/testis antigen family 47, member A9
cancer/testis antigen family 47, member A8
cancer/testis antigen family 47, member A6
cancer/testis antigen family 47, member A5
cancer/testis antigen family 47, member A4
cancer/testis antigen family 47, member A3
cancer/testis antigen family 47, member A2
cancer/testis antigen family 47, member A1
chr17_+_75625025 0.588 NM_017950
CCDC40
coiled-coil domain containing 40
chr3_-_33675484 0.587 CLASP2
cytoplasmic linker associated protein 2
chr1_+_22224571 0.587 HSPC157
hypothetical LOC29092

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.70 1.09e-03 GO:0006091 generation of precursor metabolites and energy
1.82 2.22e-03 GO:0015980 energy derivation by oxidation of organic compounds
2.33 1.38e-02 GO:0022904 respiratory electron transport chain

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.18 3.58e-03 GO:0030055 cell-substrate junction
1.78 3.63e-03 GO:0016323 basolateral plasma membrane
2.24 3.86e-03 GO:0005925 focal adhesion
2.20 4.17e-03 GO:0005924 cell-substrate adherens junction
1.54 4.75e-03 GO:0031966 mitochondrial membrane
1.97 5.44e-03 GO:0005912 adherens junction
1.52 5.61e-03 GO:0005740 mitochondrial envelope
1.91 6.31e-03 GO:0070161 anchoring junction
2.32 9.89e-03 GO:0045095 keratin filament
1.65 1.05e-02 GO:0015629 actin cytoskeleton
2.03 1.08e-02 GO:0043292 contractile fiber
1.62 1.37e-02 GO:0005743 mitochondrial inner membrane
2.03 1.85e-02 GO:0030016 myofibril
2.02 2.66e-02 GO:0044449 contractile fiber part
1.38 3.81e-02 GO:0044429 mitochondrial part
1.55 3.96e-02 GO:0019866 organelle inner membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.10 7.14e-03 GO:0005515 protein binding