Motif ID: NKX6-1,2.p2

Z-value: 0.982


Transcription factors associated with NKX6-1,2.p2:

Gene SymbolEntrez IDGene Name
NKX6-1 4825 NK6 homeobox 1
NKX6-2 84504 NK6 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX6-2chr10_-_1344494670.107.1e-01Click!
NKX6-1chr4_-_856384100.039.1e-01Click!


Activity profile for motif NKX6-1,2.p2.

activity profile for motif NKX6-1,2.p2


Sorted Z-values histogram for motif NKX6-1,2.p2

Sorted Z-values for motif NKX6-1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX6-1,2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_52696908 1.820 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr9_-_21375258 1.690 NM_000605
IFNA2
interferon, alpha 2
chr12_-_28016182 1.342 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr4_-_90978469 1.078 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr12_+_52697160 1.064 HOXC5
HOXC6
homeobox C5
homeobox C6
chr8_-_82769761 1.026 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr13_+_23042722 1.006 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr3_-_171070314 1.002 NM_024727
LRRC31
leucine rich repeat containing 31
chr1_-_116184846 0.988 NM_001111061
NHLH2
nescient helix loop helix 2
chr22_-_34892170 0.919 NM_145641
NM_145642
APOL3

apolipoprotein L, 3

chr3_-_148607096 0.878 NM_032153
ZIC4
Zic family member 4
chr20_+_19985289 0.849 NM_001167816
C20orf26
chromosome 20 open reading frame 26
chr10_-_100985548 0.842 NM_001166244
NM_001166245
NM_001166246
NM_021828
HPSE2



heparanase 2



chr20_-_19984685 0.819 NM_016652
CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr17_-_53849888 0.816 RNF43
ring finger protein 43
chr5_+_140709907 0.813 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr6_-_46811388 0.796 NM_001168357
PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr10_-_14412813 0.754 NM_018027
FRMD4A
FERM domain containing 4A
chr11_-_7684516 0.750 NM_198185
OVCH2
ovochymase 2 (gene/pseudogene)
chr18_-_55136673 0.740 NM_181654
CPLX4
complexin 4
chr17_-_36074812 0.733 NM_152349
KRT222
keratin 222
chr2_+_68815416 0.723 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr8_-_37916803 0.693 NM_152413
GOT1L1
glutamic-oxaloacetic transaminase 1-like 1
chr12_-_56422120 0.683 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr2_+_218698980 0.636 NM_001557
CXCR2
chemokine (C-X-C motif) receptor 2
chr4_-_77147625 0.632 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr2_+_169465995 0.626 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr19_-_47623340 0.606 NM_005357
LIPE
lipase, hormone-sensitive
chr14_-_56342097 0.594 NM_172337
OTX2
orthodenticle homeobox 2
chr5_+_49997489 0.592 NM_001178055
PARP8
poly (ADP-ribose) polymerase family, member 8
chr20_+_16676997 0.577 NM_020157
OTOR
otoraplin
chr4_+_75393053 0.571 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr20_-_18425811 0.568 NM_006606
RBBP9
retinoblastoma binding protein 9
chr15_-_74091817 0.552 NM_138573
NRG4
neuregulin 4
chr17_-_53849929 0.546 NM_017763
RNF43
ring finger protein 43
chr5_+_166644420 0.545 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr6_+_132901119 0.542 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr6_-_128263868 0.536 NM_001010923
NM_001164685
THEMIS

thymocyte selection associated

chr7_+_120752656 0.535 NM_016087
WNT16
wingless-type MMTV integration site family, member 16
chr15_+_46271158 0.526 NM_001145668
CTXN2
SLC12A1
cortexin 2
solute carrier family 12 (sodium/potassium/chloride transporters), member 1
chr15_-_40089736 0.523 NM_001080490
PLA2G4E
phospholipase A2, group IVE
chr3_+_2117246 0.523 NM_175607
CNTN4
contactin 4
chr10_-_69661860 0.519 NM_145178
ATOH7
atonal homolog 7 (Drosophila)
chr3_-_139531417 0.516 NM_178130
TXNDC6
thioredoxin domain containing 6
chr2_+_218698242 0.511 NM_001168298
CXCR2
chemokine (C-X-C motif) receptor 2
chr7_+_94135384 0.505 PEG10
paternally expressed 10
chr8_-_109868945 0.503 NM_153015
TMEM74
transmembrane protein 74
chr3_+_150065732 0.498 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr8_-_114518194 0.495 NM_052900
NM_198123
CSMD3

CUB and Sushi multiple domains 3

chr12_+_52680143 0.492 NM_006897
HOXC9
homeobox C9
chr2_+_135312655 0.488 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr5_+_140719773 0.469 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr16_+_20682812 0.468 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr22_+_38903825 0.465 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr11_-_123695302 0.460 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr2_-_131073329 0.457 NM_032545
NM_001079530
CFC1
CFC1B
cripto, FRL-1, cryptic family 1
cripto, FRL-1, cryptic family 1B
chr2_+_73864823 0.451 NM_001080474
C2orf78
chromosome 2 open reading frame 78
chr20_+_41569727 0.443 NM_032107
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr17_-_36403910 0.441 NM_033185
KRTAP3-3
keratin associated protein 3-3
chr3_+_68136056 0.431 NM_213609
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr11_-_40271086 0.428 LRRC4C
leucine rich repeat containing 4C
chr7_-_92693716 0.425 NM_001039372
HEPACAM2
HEPACAM family member 2
chr1_-_234511917 0.423 NM_019891
ERO1LB
ERO1-like beta (S. cerevisiae)
chr12_+_53178834 0.421 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr14_-_60185659 0.417 NM_005982
SIX1
SIX homeobox 1
chr1_+_78858675 0.415 NM_006820
IFI44L
interferon-induced protein 44-like
chr2_-_219614481 0.415 NM_152389
NM_194302
CCDC108

coiled-coil domain containing 108

chr3_-_15814678 0.415 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr12_+_106692291 0.412 NM_203436
ASCL4
achaete-scute complex homolog 4 (Drosophila)
chr3_-_74652952 0.412 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr14_+_61532293 0.411 NM_031914
SYT16
synaptotagmin XVI
chr12_-_16652202 0.410 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chr6_-_64087806 0.409 NM_001143940
NM_016571
LGSN

lengsin, lens protein with glutamine synthetase domain

chr5_-_13997588 0.405 NM_001369
DNAH5
dynein, axonemal, heavy chain 5
chr12_+_52708460 0.405 NM_004503
HOXC6
homeobox C6
chr15_+_92700167 0.398 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr7_+_23252945 0.398 GPNMB
glycoprotein (transmembrane) nmb
chr2_+_130995136 0.397 NM_032545
NM_001079530
CFC1
CFC1B
cripto, FRL-1, cryptic family 1
cripto, FRL-1, cryptic family 1B
chr11_-_117552355 0.396 SCN2B
sodium channel, voltage-gated, type II, beta
chr8_+_79591074 0.394 PKIA
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr12_+_70618892 0.391 NM_173353
TPH2
tryptophan hydroxylase 2
chr20_+_51235228 0.391 NM_001193421
TSHZ2
teashirt zinc finger homeobox 2
chr7_+_23252909 0.388 GPNMB
glycoprotein (transmembrane) nmb
chr11_-_117552545 0.383 NM_004588
SCN2B
sodium channel, voltage-gated, type II, beta
chr4_+_155703581 0.380 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr6_-_26151863 0.380 NM_021062
HIST1H2BB
histone cluster 1, H2bb
chr14_-_59167284 0.376 RTN1
reticulon 1
chr13_-_45323757 0.375 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr14_+_30098079 0.373 NM_017769
G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chr13_+_22653059 0.373 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr14_+_38772870 0.368 NM_054024
MIA2
melanoma inhibitory activity 2
chr8_-_28403652 0.366 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr12_+_28301399 0.358 NM_018318
CCDC91
coiled-coil domain containing 91
chr4_-_10295412 0.348 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr4_-_40212670 0.348 NM_019027
RBM47
RNA binding motif protein 47
chr6_+_114285209 0.347 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr10_-_90601655 0.344 NM_144590
ANKRD22
ankyrin repeat domain 22
chr6_+_26359805 0.341 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr2_-_74424041 0.341 NM_133478
SLC4A5
solute carrier family 4, sodium bicarbonate cotransporter, member 5
chr13_+_27392136 0.339 NM_000209
PDX1
pancreatic and duodenal homeobox 1
chr8_-_15140162 0.338 NM_139167
SGCZ
sarcoglycan, zeta
chr2_-_165768798 0.335 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr7_+_23252926 0.335 GPNMB
glycoprotein (transmembrane) nmb
chr22_+_38627129 0.334 GRAP2
GRB2-related adaptor protein 2
chr18_-_3209986 0.333 NM_003803
NM_019856
MYOM1

myomesin 1, 185kDa

chr9_+_115303527 0.332 NM_130795
RGS3
regulator of G-protein signaling 3
chr6_+_41128917 0.330 NM_006789
APOBEC2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr10_-_115413630 0.329 NM_006175
NM_198060
NRAP

nebulin-related anchoring protein

chr3_+_99555387 0.328 NM_001005517
OR5K4
olfactory receptor, family 5, subfamily K, member 4
chr7_+_23252911 0.326 GPNMB
glycoprotein (transmembrane) nmb
chr6_+_26071255 0.324 TRIM38
tripartite motif containing 38
chr14_-_59167139 0.324 RTN1
reticulon 1
chr2_+_234490781 0.323 NM_024080
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr2_+_204509698 0.322 NM_012092
ICOS
inducible T-cell co-stimulator
chr14_-_98807574 0.321 NM_022898
NM_138576
BCL11B

B-cell CLL/lymphoma 11B (zinc finger protein)

chr7_+_23252915 0.319 GPNMB
glycoprotein (transmembrane) nmb
chr2_-_225519974 0.319 DOCK10
dedicator of cytokinesis 10
chr10_-_96819064 0.317 NM_000770
NM_001198853
NM_001198854
NM_001198855
CYP2C8



cytochrome P450, family 2, subfamily C, polypeptide 8



chr8_+_24354387 0.316 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr4_+_100714995 0.312 MTTP
microsomal triglyceride transfer protein
chr5_-_88004891 0.311 LOC645323
hypothetical LOC645323
chr3_+_133518900 0.310 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr2_-_156894927 0.310 NR4A2
nuclear receptor subfamily 4, group A, member 2
chr1_+_67404756 0.309 NM_144701
IL23R
interleukin 23 receptor
chr1_-_154665807 0.309 NM_006365
C1orf61
chromosome 1 open reading frame 61
chr14_-_59167067 0.306 RTN1
reticulon 1
chr7_+_28305464 0.305 NM_182899
CREB5
cAMP responsive element binding protein 5
chr6_+_72979234 0.302 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chr9_-_21340885 0.302 NM_021002
IFNA6
interferon, alpha 6
chr1_-_67366807 0.300 NM_001013674
C1orf141
chromosome 1 open reading frame 141
chr6_+_26070957 0.299 NM_006355
TRIM38
tripartite motif containing 38
chr8_-_122722674 0.299 NM_005328
HAS2
hyaluronan synthase 2
chr20_+_23293020 0.298 NM_022482
GZF1
GDNF-inducible zinc finger protein 1
chr5_+_140780797 0.298 PCDHGA11
protocadherin gamma subfamily A, 11
chr12_+_69148120 0.298


chr12_+_56230110 0.297 NM_004984
KIF5A
kinesin family member 5A
chr11_+_17289030 0.296


chr7_-_93027057 0.293 NM_001164738
CALCR
calcitonin receptor
chr5_+_140762551 0.293 NM_018921
NM_032089
PCDHGA9

protocadherin gamma subfamily A, 9

chr4_+_151722526 0.292 NM_006439
MAB21L2
mab-21-like 2 (C. elegans)
chr12_-_10464308 0.289 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr7_-_22828922 0.289 NM_019059
TOMM7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr14_-_98807307 0.288 BCL11B
B-cell CLL/lymphoma 11B (zinc finger protein)
chr4_+_54790020 0.287 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr2_+_158666627 0.285 NM_173355
UPP2
uridine phosphorylase 2
chr17_+_57801309 0.285 NM_001144933
EFCAB3
EF-hand calcium binding domain 3
chr1_+_207944807 0.284 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr4_+_54790190 0.283 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr12_-_86947276 0.280 NM_152589
C12orf50
chromosome 12 open reading frame 50
chr3_+_149930656 0.280 NM_032049
AGTR1
angiotensin II receptor, type 1
chr3_-_45812916 0.278 SLC6A20
solute carrier family 6 (proline IMINO transporter), member 20
chr6_+_26548678 0.278 NM_006994
NM_197974
BTN3A3

butyrophilin, subfamily 3, member A3

chr4_-_100575313 0.278 NM_001166504
NM_000673
ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr11_+_65026382 0.274


chr11_+_123600553 0.274 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr11_+_122258600 0.273 NM_024806
NM_199124
C11orf63

chromosome 11 open reading frame 63

chr12_-_23993830 0.273 NM_006940
SOX5
SRY (sex determining region Y)-box 5
chr2_-_227952249 0.272 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr6_+_49626071 0.269 NM_001145652
C6orf141
chromosome 6 open reading frame 141
chr9_-_72926333 0.268 NM_001007471
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr2_-_80385227 0.267 LRRTM1
leucine rich repeat transmembrane neuronal 1
chr12_-_92489652 0.267 LOC144481
hypothetical protein LOC144481
chr3_-_198784590 0.266 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr6_+_50789215 0.266 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr1_-_89261021 0.264 NM_018284
GBP3
guanylate binding protein 3
chr4_+_84175262 0.263 NM_016129
COPS4
COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
chr9_+_92629525 0.263 NM_001174167
SYK
spleen tyrosine kinase
chr12_+_49522967 0.262 NM_182559
TMPRSS12
transmembrane (C-terminal) protease, serine 12
chr22_-_35733784 0.262 NM_001163857
NM_178552
C22orf33

chromosome 22 open reading frame 33

chr13_-_35327798 0.261 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr3_+_99592199 0.261 NM_001005516
OR5K3
olfactory receptor, family 5, subfamily K, member 3
chr4_-_23500706 0.260 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr16_+_31178778 0.260 NM_000632
NM_001145808
ITGAM

integrin, alpha M (complement component 3 receptor 3 subunit)

chr12_-_53664722 0.254 NM_001136030
KIAA0748
KIAA0748
chr14_-_57030227 0.253 NM_018168
C14orf105
chromosome 14 open reading frame 105
chr14_-_59167193 0.252 NM_206852
RTN1
reticulon 1
chr17_+_55269974 0.248


chr4_-_187114407 0.246 SORBS2
sorbin and SH3 domain containing 2
chr12_-_93921586 0.245 NDUFA12
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
chr5_+_31229549 0.245 NM_004932
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr9_+_76302071 0.244 NM_006914
RORB
RAR-related orphan receptor B
chr18_-_3864252 0.242 DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr2_-_104834344 0.241 LOC100506421
hypothetical LOC100506421
chr8_-_134184491 0.240 NM_001045556
NM_001045557
SLA

Src-like-adaptor

chr2_+_220017617 0.240 SPEG
SPEG complex locus
chr11_+_26310253 0.239 NM_031418
ANO3
anoctamin 3
chr8_+_79590890 0.239 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr7_+_23252802 0.239 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr14_-_20636909 0.237 NM_001101672
ZNF219
zinc finger protein 219
chr6_-_32892705 0.237 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr5_+_108111421 0.235 NM_005246
FER
fer (fps/fes related) tyrosine kinase
chr18_+_59405513 0.234 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr4_+_40953652 0.233 NM_004181
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr3_-_45813030 0.233 NM_020208
NM_022405
SLC6A20

solute carrier family 6 (proline IMINO transporter), member 20

chr7_+_5609416 0.232 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr9_-_21156609 0.231 NM_002175
IFNA21
interferon, alpha 21
chr16_+_31178828 0.231 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr17_-_10217046 0.230 NM_003802
MYH13
myosin, heavy chain 13, skeletal muscle
chr3_+_133518966 0.228 ACPP
acid phosphatase, prostate
chr1_-_20374273 0.227 NM_001105572
PLA2G2C
phospholipase A2, group IIC

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.37 1.87e-04 GO:0007156 homophilic cell adhesion
1.44 4.47e-02 GO:0003008 system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.20 7.58e-03 GO:0031224 intrinsic to membrane
1.20 1.07e-02 GO:0016021 integral to membrane
1.16 3.97e-02 GO:0044425 membrane part

Nothing significant found in function category.