Motif ID: SPZ1.p2

Z-value: 1.656


Transcription factors associated with SPZ1.p2:

Gene SymbolEntrez IDGene Name
SPZ1 84654 spermatogenic leucine zipper 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SPZ1chr5_+_79651545-0.214.3e-01Click!


Activity profile for motif SPZ1.p2.

activity profile for motif SPZ1.p2


Sorted Z-values histogram for motif SPZ1.p2

Sorted Z-values for motif SPZ1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPZ1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_37586716 2.025 NM_012285
KCNH4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr12_+_50686990 1.797 NM_181711
GRASP
GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
chr3_+_214668 1.597


chr12_-_48017223 1.571 NM_001008223
C1QL4
complement component 1, q subcomponent-like 4
chr6_+_96570565 1.521 NM_006581
FUT9
fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
chrX_-_139414890 1.384 NM_005634
SOX3
SRY (sex determining region Y)-box 3
chr5_+_129268352 1.271 NM_175856
CHSY3
chondroitin sulfate synthase 3
chr14_+_36196523 1.244 NM_006194
PAX9
paired box 9
chr15_-_81113676 1.192 NM_030594
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr18_-_55091596 1.072 NM_013435
RAX
retina and anterior neural fold homeobox
chr9_-_121171400 1.014 NM_014618
DBC1
deleted in bladder cancer 1
chr19_+_45794895 0.996 NM_001042544
LTBP4
latent transforming growth factor beta binding protein 4
chr14_+_23908141 0.981 NM_001198966
NFATC4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
chr2_+_119905812 0.977 NM_183240
TMEM37
transmembrane protein 37
chr6_-_119712596 0.959 NM_005907
MAN1A1
mannosidase, alpha, class 1A, member 1
chr14_+_22581215 0.956 NM_001099780
PSMB11
proteasome (prosome, macropain) subunit, beta type, 11
chr14_-_22596522 0.953 NM_022478
NM_144985
CDH24

cadherin 24, type 2

chr20_-_9767406 0.946 NM_020341
NM_177990
PAK7

p21 protein (Cdc42/Rac)-activated kinase 7

chr20_-_3013335 0.904 NM_000490
AVP
arginine vasopressin
chr19_+_45799060 0.897 NM_001042545
LTBP4
latent transforming growth factor beta binding protein 4
chr20_+_20296744 0.889 NM_002196
INSM1
insulinoma-associated 1
chr14_-_64416307 0.885 SPTB
spectrin, beta, erythrocytic
chr2_+_219532590 0.870 NM_003936
CDK5R2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr1_+_229365296 0.859 NM_001004342
TRIM67
tripartite motif containing 67
chr17_-_35017650 0.838 NEUROD2
neurogenic differentiation 2
chr14_+_23937766 0.828 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr5_+_115326035 0.813 NM_173800
AQPEP
laeverin
chr7_+_94374862 0.812 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr1_+_155097230 0.812 NM_001012331
NM_002529
NTRK1

neurotrophic tyrosine kinase, receptor, type 1

chr13_-_71338558 0.812 DACH1
dachshund homolog 1 (Drosophila)
chr22_+_49333327 0.807 NM_138433
KLHDC7B
kelch domain containing 7B
chr17_+_71095733 0.801 MYO15B
myosin XVB pseudogene
chr17_-_35017691 0.797 NM_006160
NEUROD2
neurogenic differentiation 2
chr10_-_28074752 0.774 NM_173576
MKX
mohawk homeobox
chr3_+_125786195 0.773 NM_007064
KALRN
kalirin, RhoGEF kinase
chr17_+_44429748 0.773 NM_001160423
NM_006546
IGF2BP1

insulin-like growth factor 2 mRNA binding protein 1

chr2_-_47650973 0.766 NM_022055
KCNK12
potassium channel, subfamily K, member 12
chr2_-_219633481 0.765 NM_002181
IHH
Indian hedgehog
chr19_+_56319948 0.755 NM_001198558
NM_014441
SIGLEC9

sialic acid binding Ig-like lectin 9

chr7_-_11838260 0.752 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr13_+_34414390 0.751 NM_015678
NBEA
neurobeachin
chr15_-_75711785 0.749 LINGO1
leucine rich repeat and Ig domain containing 1
chr20_-_21326046 0.738 NM_033176
NKX2-4
NK2 homeobox 4
chr11_-_110087982 0.733 ARHGAP20
Rho GTPase activating protein 20
chr15_-_32875040 0.732 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr15_-_71448194 0.726 HCN4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr13_+_27264779 0.725 NM_145657
GSX1
GS homeobox 1
chrX_-_106033202 0.720 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chr17_-_44022595 0.720 HOXB3
homeobox B3
chr17_+_35075124 0.719 NM_003673
TCAP
titin-cap (telethonin)
chr13_+_95541093 0.709 NM_153456
HS6ST3
heparan sulfate 6-O-sulfotransferase 3
chr14_-_22974707 0.706 NM_000257
MYH7
myosin, heavy chain 7, cardiac muscle, beta
chr15_+_58083798 0.703 FOXB1
forkhead box B1
chr14_+_89597860 0.698 NM_022054
KCNK13
potassium channel, subfamily K, member 13
chr1_-_21868380 0.694 NM_001145657
NM_002885
RAP1GAP

RAP1 GTPase activating protein

chr17_+_71582486 0.690 NM_003857
GALR2
galanin receptor 2
chr9_-_85342868 0.679 NM_174938
FRMD3
FERM domain containing 3
chr11_-_110088097 0.674 ARHGAP20
Rho GTPase activating protein 20
chr14_-_59407103 0.665 NM_021136
RTN1
reticulon 1
chr20_+_19141364 0.665 SLC24A3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr22_+_38075703 0.665 NM_004711
NM_145731
SYNGR1

synaptogyrin 1

chr6_-_84475211 0.660 SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr1_+_151917674 0.658 NM_000906
NPR1
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
chr2_+_33025872 0.650 NM_206943
LTBP1
latent transforming growth factor beta binding protein 1
chr16_-_87535106 0.648 NM_175931
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr7_-_103417198 0.646 NM_005045
NM_173054
RELN

reelin

chr1_-_3517918 0.636 NM_001409
MEGF6
multiple EGF-like-domains 6
chr2_+_185171480 0.629 ZNF804A
zinc finger protein 804A
chr15_+_39008822 0.616 NM_019074
DLL4
delta-like 4 (Drosophila)
chr3_-_62835601 0.610


chr2_-_24995402 0.608 NM_004036
ADCY3
adenylate cyclase 3
chr2_-_222871577 0.605 NM_000438
NM_001127366
NM_013942
NM_181457
NM_181458
NM_181459
NM_181460
NM_181461
PAX3







paired box 3







chr11_-_32413486 0.603 WT1
Wilms tumor 1
chr16_-_65984836 0.599 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr15_-_71448657 0.597 NM_005477
HCN4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr17_+_35853177 0.591 NM_001552
IGFBP4
insulin-like growth factor binding protein 4
chr11_+_43920385 0.584 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr8_+_65656164 0.584 BHLHE22
basic helix-loop-helix family, member e22
chr4_-_73653331 0.581 NM_014243
ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr18_-_50777634 0.581 NM_025214
CCDC68
coiled-coil domain containing 68
chr11_+_17714070 0.577 NM_001112741
NM_004976
KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chr20_+_24397834 0.573 NM_024893
TMEM90B
transmembrane protein 90B
chr20_+_3661316 0.569 NM_001197327
NM_052970
HSPA12B

heat shock 70kD protein 12B

chr11_-_27677755 0.569 NM_170734
BDNF
brain-derived neurotrophic factor
chr17_+_29931880 0.567 NM_207313
TMEM132E
transmembrane protein 132E
chr11_+_19691397 0.563 NM_145117
NM_182964
NAV2

neuron navigator 2

chr7_-_20791907 0.563


chr10_-_103525646 0.560 NM_006119
NM_033163
NM_033164
NM_033165
FGF8



fibroblast growth factor 8 (androgen-induced)



chr9_-_34512972 0.559 NM_198573
ENHO
energy homeostasis associated
chr14_+_95412481 0.558


chr17_+_33761234 0.557 NM_014598
SOCS7
suppressor of cytokine signaling 7
chr16_-_60627536 0.553 NM_001796
CDH8
cadherin 8, type 2
chr8_+_142471290 0.551


chr22_+_38720881 0.546 NM_138435
FAM83F
family with sequence similarity 83, member F
chr1_+_12108542 0.546 NM_152942
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr3_-_13436802 0.542 NM_024923
NUP210
nucleoporin 210kDa
chr1_+_153317887 0.542 NM_004952
EFNA3
ephrin-A3
chr1_+_16242833 0.535 NM_000085
CLCNKB
chloride channel Kb
chr16_+_31132842 0.533 NM_001008274
TRIM72
tripartite motif containing 72
chr1_+_179148935 0.533 NM_020950
KIAA1614
KIAA1614
chr14_+_60858151 0.531 NM_006255
PRKCH
protein kinase C, eta
chr5_-_63293301 0.526 NM_000524
HTR1A
5-hydroxytryptamine (serotonin) receptor 1A
chr5_-_134899537 0.525 NM_006161
NEUROG1
neurogenin 1
chr19_+_40223249 0.524 NM_002151
NM_182983
HPN

hepsin

chr13_-_71338144 0.524 DACH1
dachshund homolog 1 (Drosophila)
chr4_+_184257337 0.522 NM_024949
WWC2
WW and C2 domain containing 2
chr6_-_85529884 0.521 TBX18
T-box 18
chr3_-_13436725 0.520 NUP210
nucleoporin 210kDa
chr15_-_20666684 0.512 LOC283683
hypothetical LOC283683
chr19_+_12810258 0.506 NM_014975
MAST1
microtubule associated serine/threonine kinase 1
chr20_+_19141282 0.504 NM_020689
SLC24A3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr2_-_213111525 0.504 NM_001042599
NM_005235
ERBB4

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

chr9_+_70107602 0.504 NM_199135
FOXD4L3
FOXD4L6
forkhead box D4-like 3
forkhead box D4-like 6
chr17_+_42641426 0.503 NM_001002841
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr17_+_26742767 0.503 NM_032932
RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr11_+_66939720 0.503 NM_001166222
NM_020811
CARNS1

carnosine synthase 1

chr17_+_4348877 0.501 NM_001124758
SPNS2
spinster homolog 2 (Drosophila)
chr9_-_93750916 0.500 ROR2
receptor tyrosine kinase-like orphan receptor 2
chr1_-_149385556 0.495 NM_001178061
NM_001178062
NM_030913
SEMA6C


sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C


chr11_-_2116775 0.494 NM_000612
IGF2
insulin-like growth factor 2 (somatomedin A)
chr10_+_94439658 0.493 NM_002729
HHEX
hematopoietically expressed homeobox
chr19_+_11510578 0.492 NM_001299
CNN1
calponin 1, basic, smooth muscle
chr3_-_187562470 0.488 NM_001080744
NM_001080745
NM_001346
DGKG


diacylglycerol kinase, gamma 90kDa


chr7_+_49783774 0.488 NM_198570
VWC2
von Willebrand factor C domain containing 2
chr1_-_215377718 0.484 NM_001134285
ESRRG
estrogen-related receptor gamma
chr10_-_101180191 0.484 NM_002079
GOT1
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
chr22_+_29122932 0.481 NM_012429
NM_033382
SEC14L2

SEC14-like 2 (S. cerevisiae)

chr11_-_57039721 0.480 NM_003627
SLC43A1
solute carrier family 43, member 1
chr8_+_31616809 0.477 NM_013962
NRG1
neuregulin 1
chr5_+_113726203 0.476 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr9_+_70509925 0.472 NM_003558
PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr9_+_8848130 0.470


chr13_+_32488477 0.470 NM_004795
KL
klotho
chr11_-_61441536 0.470 NM_013401
RAB3IL1
RAB3A interacting protein (rabin3)-like 1
chr19_+_56420181 0.469 CD33
CD33 molecule
chr11_-_33847937 0.469 NM_001142316
LMO2
LIM domain only 2 (rhombotin-like 1)
chr2_-_133144094 0.467 LYPD1
LY6/PLAUR domain containing 1
chr11_+_63627816 0.467 NM_013280
FLRT1
fibronectin leucine rich transmembrane protein 1
chr11_-_124127295 0.466 NM_014312
VSIG2
V-set and immunoglobulin domain containing 2
chr6_-_117193505 0.465 NM_001085480
FAM162B
family with sequence similarity 162, member B
chr3_-_159306532 0.463 NM_001163678
NM_003030
NM_006884
SHOX2


short stature homeobox 2


chr22_-_42589543 0.463 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr4_-_44145266 0.463 KCTD8
potassium channel tetramerisation domain containing 8
chrX_+_14457340 0.461 NM_001118885
NM_001118886
NM_001171942
NM_002063
GLRA2



glycine receptor, alpha 2



chr9_-_129557373 0.461 NM_001142534
NM_001142533
SH2D3C

SH2 domain containing 3C

chr17_-_53964386 0.458 NM_080415
NM_080416
SEPT4

septin 4

chr6_-_128883125 0.456 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr6_-_84475424 0.454 SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr9_-_138757175 0.452 NM_001001712
LCN10
lipocalin 10
chr12_+_102982365 0.450 NM_013320
HCFC2
host cell factor C2
chr2_-_50428395 0.449 NM_138735
NRXN1
neurexin 1
chr11_-_124127343 0.449 VSIG2
V-set and immunoglobulin domain containing 2
chr1_-_149955415 0.449 NM_001172648
NM_001172649
CELF3

CUGBP, Elav-like family member 3

chr20_-_42872295 0.448 NM_182970
RIMS4
regulating synaptic membrane exocytosis 4
chr4_+_93444572 0.447 NM_001510
GRID2
glutamate receptor, ionotropic, delta 2
chr12_+_119456538 0.446 RNF10
ring finger protein 10
chr11_+_20647692 0.446 NM_006157
NM_201551
NELL1

NEL-like 1 (chicken)

chrX_+_74410774 0.444


chr17_-_53964360 0.443 SEPT4
septin 4
chr15_+_77511912 0.442 NM_015206
KIAA1024
KIAA1024
chr10_-_104587069 0.442 NM_000102
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr3_+_85090721 0.442 NM_001167674
NM_001167675
CADM2

cell adhesion molecule 2

chr22_-_28041650 0.440 NM_001007279
NM_006477
RASL10A

RAS-like, family 10, member A

chr7_-_45095017 0.439 NM_001146334
NACAD
NAC alpha domain containing
chrX_+_117364444 0.438 WDR44
WD repeat domain 44
chr16_+_162845 0.437 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr2_-_165186603 0.435 NM_004490
GRB14
growth factor receptor-bound protein 14
chr11_-_124127244 0.434 VSIG2
V-set and immunoglobulin domain containing 2
chr11_+_45900731 0.433 GYLTL1B
glycosyltransferase-like 1B
chr2_+_171280944 0.432 SP5
Sp5 transcription factor
chr16_+_1324505 0.429 NM_003933
BAIAP3
BAI1-associated protein 3
chr17_+_40581704 0.427 HEXIM1
hexamethylene bis-acetamide inducible 1
chrX_+_117992603 0.426 LONRF3
LON peptidase N-terminal domain and ring finger 3
chr17_+_7495436 0.425 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr20_-_581844 0.425 NM_080725
SRXN1
sulfiredoxin 1
chr2_+_242400702 0.424 NM_001167599
NM_001167602
NM_080741
NEU4


sialidase 4


chr19_-_18198234 0.423 NM_001098818
PDE4C
phosphodiesterase 4C, cAMP-specific
chrX_-_74062005 0.423 NM_001008537
KIAA2022
KIAA2022
chr11_-_74914514 0.423 GDPD5
glycerophosphodiester phosphodiesterase domain containing 5
chr11_-_8982107 0.421 NM_020645
NRIP3
nuclear receptor interacting protein 3
chr15_+_58083737 0.421


chr15_+_58083712 0.421 NM_012182
FOXB1
forkhead box B1
chr2_+_223625105 0.419 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr1_-_31154023 0.413 NM_014654
SDC3
syndecan 3
chr5_-_63293715 0.412 HTR1A
5-hydroxytryptamine (serotonin) receptor 1A
chr2_-_192767844 0.411 NM_016192
TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr17_+_42641712 0.410 NM_002476
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr20_-_581808 0.410 SRXN1
sulfiredoxin 1
chr22_-_28041474 0.409 RASL10A
RAS-like, family 10, member A
chr20_-_22513050 0.407 NM_021784
FOXA2
forkhead box A2
chr5_+_170779664 0.407 FGF18
fibroblast growth factor 18
chr4_-_672915 0.407 MFSD7
major facilitator superfamily domain containing 7
chrX_-_99551926 0.406 NM_001105243
NM_001184880
NM_020766
PCDH19


protocadherin 19


chr10_+_89409332 0.406 NM_001015880
NM_004670
PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

chr2_-_230287442 0.406 NM_139072
DNER
delta/notch-like EGF repeat containing
chr1_+_151967164 0.403 NM_023015
INTS3
integrator complex subunit 3
chr5_-_83716346 0.403 NM_005711
EDIL3
EGF-like repeats and discoidin I-like domains 3
chr1_-_39929654 0.402 NM_016257
HPCAL4
hippocalcin like 4
chr13_-_49597776 0.402 DLEU2
deleted in lymphocytic leukemia 2 (non-protein coding)
chr1_+_1557419 0.401 NM_006983
MMP23B
matrix metallopeptidase 23B

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.41 2.73e-12 GO:0007399 nervous system development
1.13 1.01e-11 GO:0065007 biological regulation
1.23 1.48e-11 GO:0023052 signaling
1.14 6.61e-11 GO:0050794 regulation of cellular process
1.31 1.48e-10 GO:0048869 cellular developmental process
1.32 1.84e-10 GO:0030154 cell differentiation
1.13 3.10e-10 GO:0050789 regulation of biological process
1.48 9.30e-10 GO:0022008 neurogenesis
1.25 3.68e-09 GO:0048731 system development
1.25 1.54e-08 GO:0048518 positive regulation of biological process
1.46 2.75e-08 GO:0048699 generation of neurons
1.21 2.94e-08 GO:0007165 signal transduction
1.21 3.04e-08 GO:0007275 multicellular organismal development
1.20 3.67e-08 GO:0032502 developmental process
1.51 5.42e-08 GO:0030182 neuron differentiation
1.08 7.99e-08 GO:0009987 cellular process
1.25 1.04e-07 GO:0048522 positive regulation of cellular process
1.20 1.23e-06 GO:0048856 anatomical structure development
1.35 1.29e-06 GO:0031325 positive regulation of cellular metabolic process
1.34 1.73e-06 GO:0009893 positive regulation of metabolic process
1.36 1.82e-06 GO:0010604 positive regulation of macromolecule metabolic process
1.17 2.57e-06 GO:0051716 cellular response to stimulus
1.30 5.67e-06 GO:0009653 anatomical structure morphogenesis
1.33 5.68e-06 GO:0051239 regulation of multicellular organismal process
1.26 2.05e-05 GO:0007166 cell surface receptor linked signaling pathway
1.48 2.45e-05 GO:0048666 neuron development
1.51 3.11e-05 GO:0000904 cell morphogenesis involved in differentiation
1.37 3.92e-05 GO:0048468 cell development
1.18 4.64e-05 GO:0060255 regulation of macromolecule metabolic process
1.40 5.27e-05 GO:0051173 positive regulation of nitrogen compound metabolic process
1.40 1.00e-04 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.17 1.09e-04 GO:0031323 regulation of cellular metabolic process
1.34 1.24e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.15 1.41e-04 GO:0019222 regulation of metabolic process
1.17 1.51e-04 GO:0080090 regulation of primary metabolic process
1.52 1.58e-04 GO:0032583 regulation of gene-specific transcription
1.52 1.58e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.37 1.93e-04 GO:0031328 positive regulation of cellular biosynthetic process
1.41 2.24e-04 GO:0010628 positive regulation of gene expression
1.43 2.32e-04 GO:0032989 cellular component morphogenesis
1.42 2.56e-04 GO:0030030 cell projection organization
1.51 2.88e-04 GO:0048812 neuron projection morphogenesis
1.25 3.25e-04 GO:0023051 regulation of signaling
1.42 5.82e-04 GO:0000902 cell morphogenesis
1.38 6.04e-04 GO:0010557 positive regulation of macromolecule biosynthetic process
1.41 6.74e-04 GO:0045893 positive regulation of transcription, DNA-dependent
1.40 7.24e-04 GO:0051254 positive regulation of RNA metabolic process
1.46 8.05e-04 GO:0031175 neuron projection development
1.35 9.03e-04 GO:0009891 positive regulation of biosynthetic process
1.50 9.86e-04 GO:0007409 axonogenesis
1.45 1.06e-03 GO:0048858 cell projection morphogenesis
1.45 1.12e-03 GO:0032990 cell part morphogenesis
1.21 1.14e-03 GO:0048523 negative regulation of cellular process
1.19 1.39e-03 GO:0048519 negative regulation of biological process
1.18 1.42e-03 GO:0031326 regulation of cellular biosynthetic process
1.32 1.74e-03 GO:0042127 regulation of cell proliferation
1.19 1.88e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.46 1.90e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.19 2.05e-03 GO:0010556 regulation of macromolecule biosynthetic process
1.30 2.11e-03 GO:0010646 regulation of cell communication
1.52 2.30e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.17 2.82e-03 GO:0009889 regulation of biosynthetic process
1.32 2.82e-03 GO:0050793 regulation of developmental process
1.20 3.06e-03 GO:0065008 regulation of biological quality
1.24 4.79e-03 GO:0065009 regulation of molecular function
1.10 5.16e-03 GO:0050896 response to stimulus
1.32 5.39e-03 GO:0006351 transcription, DNA-dependent
1.11 5.74e-03 GO:0032501 multicellular organismal process
1.34 6.55e-03 GO:2000026 regulation of multicellular organismal development
1.21 6.67e-03 GO:0048583 regulation of response to stimulus
1.24 8.02e-03 GO:0009966 regulation of signal transduction
1.28 9.95e-03 GO:0032268 regulation of cellular protein metabolic process
1.51 1.04e-02 GO:0007411 axon guidance
1.35 1.10e-02 GO:0009890 negative regulation of biosynthetic process
1.16 1.32e-02 GO:0051171 regulation of nitrogen compound metabolic process
1.27 1.41e-02 GO:0051246 regulation of protein metabolic process
1.48 1.48e-02 GO:0007420 brain development
1.35 1.62e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
1.40 1.71e-02 GO:0007417 central nervous system development
1.17 1.87e-02 GO:0010468 regulation of gene expression
1.39 2.03e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.33 3.26e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.34 3.42e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.19 3.50e-02 GO:0048513 organ development
1.16 3.53e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.33 3.64e-02 GO:0045595 regulation of cell differentiation
1.41 3.88e-02 GO:0008283 cell proliferation
1.62 4.39e-02 GO:0032582 negative regulation of gene-specific transcription

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.06 3.37e-06 GO:0044424 intracellular part
1.06 3.81e-06 GO:0005622 intracellular
1.09 4.16e-06 GO:0005737 cytoplasm
1.04 5.74e-06 GO:0044464 cell part
1.03 6.14e-06 GO:0005623 cell
1.20 1.54e-04 GO:0044459 plasma membrane part
1.19 9.88e-04 GO:0005829 cytosol
1.22 1.51e-03 GO:0005856 cytoskeleton
1.36 2.20e-03 GO:0030054 cell junction
1.43 3.08e-03 GO:0045202 synapse
1.43 3.37e-03 GO:0043005 neuron projection
1.15 3.79e-03 GO:0043234 protein complex
1.48 1.05e-02 GO:0044456 synapse part
1.67 1.18e-02 GO:0005912 adherens junction
1.24 1.22e-02 GO:0044430 cytoskeletal part
1.73 2.60e-02 GO:0030016 myofibril
1.74 2.77e-02 GO:0044449 contractile fiber part
1.71 2.90e-02 GO:0043292 contractile fiber
3.36 3.68e-02 GO:0001772 immunological synapse
1.77 4.93e-02 GO:0005925 focal adhesion

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 3.50e-15 GO:0005515 protein binding
1.36 4.08e-06 GO:0001071 nucleic acid binding transcription factor activity
1.36 4.08e-06 GO:0003700 sequence-specific DNA binding transcription factor activity
1.33 3.22e-05 GO:0030528 transcription regulator activity
1.40 4.14e-05 GO:0043565 sequence-specific DNA binding
1.44 1.27e-04 GO:0008092 cytoskeletal protein binding
1.05 1.37e-04 GO:0005488 binding
1.56 1.97e-04 GO:0016563 transcription activator activity
1.31 9.24e-03 GO:0019899 enzyme binding
1.54 1.62e-02 GO:0019900 kinase binding
1.45 2.01e-02 GO:0003779 actin binding
2.23 4.14e-02 GO:0008013 beta-catenin binding