Motif ID: PRDM1.p3

Z-value: 1.202


Transcription factors associated with PRDM1.p3:

Gene SymbolEntrez IDGene Name
PRDM1 639 PR domain containing 1, with ZNF domain

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PRDM1chr6_+_1066408810.486.1e-02Click!


Activity profile for motif PRDM1.p3.

activity profile for motif PRDM1.p3


Sorted Z-values histogram for motif PRDM1.p3

Sorted Z-values for motif PRDM1.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of PRDM1.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_142795269 3.798 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr16_+_55580910 2.834 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr21_+_42807052 2.581 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr5_+_73145098 2.331 RGNEF
190 kDa guanine nucleotide exchange factor
chr6_+_167445284 2.270 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr6_+_37081387 2.148 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr4_+_187227302 1.858 NM_003265
TLR3
toll-like receptor 3
chr20_-_5048443 1.733 NM_182649
PCNA
proliferating cell nuclear antigen
chr11_+_28088406 1.496 METTL15
methyltransferase like 15
chr12_+_25096472 1.456 NM_006152
LRMP
lymphoid-restricted membrane protein
chr17_+_53602013 1.422 NM_001004707
OR4D2
olfactory receptor, family 4, subfamily D, member 2
chr17_-_45626364 1.308


chr2_-_230792844 1.303 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr10_+_63478974 1.249 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr11_-_85015961 1.175 NM_001142699
DLG2
discs, large homolog 2 (Drosophila)
chr14_+_23771464 1.163 NM_001002000
NM_001002001
GMPR2

guanosine monophosphate reductase 2

chr1_+_220884257 1.154 MIA3
melanoma inhibitory activity family, member 3
chr3_+_186529376 1.108 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr14_-_23771312 1.097 NEDD8
neural precursor cell expressed, developmentally down-regulated 8
chr10_-_35143900 1.088 NM_001184785
NM_001184786
NM_001184787
NM_001184788
NM_001184789
NM_001184790
NM_001184791
NM_001184792
NM_001184793
NM_001184794
NM_019619
PARD3










par-3 partitioning defective 3 homolog (C. elegans)










chr14_-_23771399 1.082 NEDD8
neural precursor cell expressed, developmentally down-regulated 8
chr14_-_23685629 1.038 NM_002818
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr1_+_110254755 0.996 NM_000757
NM_172210
NM_172211
NM_172212
CSF1



colony stimulating factor 1 (macrophage)



chr8_-_29176490 0.960 NM_015254
KIF13B
kinesin family member 13B
chr14_-_23771401 0.928 NM_006156
NEDD8
neural precursor cell expressed, developmentally down-regulated 8
chr14_+_23675206 0.920 NM_006263
NM_176783
PSME1

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

chr1_-_142536082 0.918


chr14_+_23982017 0.896


chr14_-_68329407 0.888 NM_004926
ZFP36L1
zinc finger protein 36, C3H type-like 1
chr14_+_23675233 0.887 PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr17_+_3326045 0.885 NM_000049
ASPA
aspartoacylase
chr1_-_146398501 0.877 LOC100286793
FLJ39739
hypothetical LOC100286793
hypothetical FLJ39739
chr6_+_32929902 0.859 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr15_+_82945223 0.832 NM_001007072
NM_017894
NM_181877
ZSCAN2


zinc finger and SCAN domain containing 2


chr10_+_92970487 0.802 PCGF5
polycomb group ring finger 5
chr16_-_71650034 0.794 NM_001164766
ZFHX3
zinc finger homeobox 3
chr6_-_112682401 0.782 LAMA4
laminin, alpha 4
chr12_+_6431437 0.766 NM_018009
TAPBPL
TAP binding protein-like
chr11_-_85107569 0.758 NM_206929
SYTL2
synaptotagmin-like 2
chr2_-_19421852 0.741 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr6_-_112682038 0.736 LAMA4
laminin, alpha 4
chr2_+_230900121 0.731 NM_138402
SP140L
SP140 nuclear body protein-like
chr3_-_115825742 0.730 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr4_+_152240182 0.727 NM_001006
RPS3A
ribosomal protein S3A
chr3_-_102888090 0.722 NM_000986
RPL24
ribosomal protein L24
chr10_+_69539255 0.714 NM_032578
MYPN
myopalladin
chr6_-_99904251 0.709 NM_032511
C6orf168
chromosome 6 open reading frame 168
chr5_-_37220702 0.704 C5orf42
chromosome 5 open reading frame 42
chr11_-_104344473 0.704 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr1_-_143232464 0.685


chr4_+_142777172 0.678 NM_000585
NM_172174
IL15

interleukin 15

chr19_+_35555158 0.658 NM_014717
ZNF536
zinc finger protein 536
chr1_-_203867402 0.653 ELK4
ELK4, ETS-domain protein (SRF accessory protein 1)
chr1_-_181540631 0.645 NM_170706
NMNAT2
nicotinamide nucleotide adenylyltransferase 2
chr4_+_146623405 0.594 NM_001003688
SMAD1
SMAD family member 1
chr1_-_166171838 0.592 NM_015415
BRP44
brain protein 44
chr17_+_6600080 0.590 XAF1
XIAP associated factor 1
chr6_-_33389768 0.567 TAPBP
TAP binding protein (tapasin)
chr1_-_146543016 0.566


chr6_+_3204133 0.566 NM_001128591
NM_001128592
NM_001135750
PSMG4


proteasome (prosome, macropain) assembly chaperone 4


chr1_+_166172420 0.559 NM_001017977
NM_001198956
NM_001198957
NM_018442
DCAF6



DDB1 and CUL4 associated factor 6



chr16_-_83703496 0.556 NM_198491
FAM92B
family with sequence similarity 92, member B
chr6_-_10520592 0.553 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr6_-_10520264 0.548 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr1_+_149638633 0.548 NM_002796
PSMB4
proteasome (prosome, macropain) subunit, beta type, 4
chr20_+_13924263 0.540 MACROD2
MACRO domain containing 2
chr6_-_112682573 0.522 LAMA4
laminin, alpha 4
chr12_-_56111054 0.519 R3HDM2
R3H domain containing 2
chr9_-_14858974 0.508 FREM1
FRAS1 related extracellular matrix 1
chr2_+_205118801 0.508 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr1_+_166172545 0.505 DCAF6
DDB1 and CUL4 associated factor 6
chr1_-_166171702 0.505 BRP44
brain protein 44
chr21_-_34820916 0.500 NM_203418
RCAN1
regulator of calcineurin 1
chr7_-_42938255 0.476 PSMA2
proteasome (prosome, macropain) subunit, alpha type, 2
chr7_-_42938304 0.476 NM_002787
PSMA2
proteasome (prosome, macropain) subunit, alpha type, 2
chr6_+_126282078 0.472 NCOA7
nuclear receptor coactivator 7
chr1_-_146543102 0.471


chr15_+_67393795 0.463 NM_001104554
PAQR5
progestin and adipoQ receptor family member V
chr1_-_143232526 0.462 FAM91A2
family with sequence similarity 91, member A2
chr16_-_46738061 0.456 NM_033226
ABCC12
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
chr7_+_42938463 0.455 NM_031903
MRPL32
mitochondrial ribosomal protein L32
chr11_+_32069183 0.450 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr11_+_63060848 0.441 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr5_+_49998528 0.439 NM_001178056
NM_024615
PARP8

poly (ADP-ribose) polymerase family, member 8

chr2_+_234191029 0.434 NM_019076
UGT1A8
UDP glucuronosyltransferase 1 family, polypeptide A8
chr4_+_88075176 0.426 NM_001166693
AFF1
AF4/FMR2 family, member 1
chr10_-_13789628 0.424 FRMD4A
FERM domain containing 4A
chr6_+_3204184 0.417 PSMG4
proteasome (prosome, macropain) assembly chaperone 4
chr2_+_234209838 0.406 NM_019075
UGT1A10
UDP glucuronosyltransferase 1 family, polypeptide A10
chr6_-_33389825 0.403 TAPBP
TAP binding protein (tapasin)
chr2_-_202216451 0.403 NM_001044385
ALS2CR4
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4
chr11_+_5602782 0.400 NM_021616
TRIM34
tripartite motif containing 34
chr2_+_205118710 0.397 NM_057177
NM_152526
NM_205863
PARD3B


par-3 partitioning defective 3 homolog B (C. elegans)


chr11_-_4371463 0.396 NM_003141
TRIM21
tripartite motif containing 21
chr4_-_100359353 0.387 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr12_+_25096755 0.387 LRMP
lymphoid-restricted membrane protein
chr10_+_92970302 0.381 NM_032373
PCGF5
polycomb group ring finger 5
chr1_-_44269719 0.379 NM_001024845
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr2_-_224611568 0.373 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr14_-_23981493 0.371 NM_020195
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr18_+_18989786 0.368 NM_138375
CABLES1
Cdk5 and Abl enzyme substrate 1
chr2_+_178893216 0.367 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr12_+_27511009 0.359 NM_001145010
C12orf70
chromosome 12 open reading frame 70
chr14_-_22549168 0.355 NM_001130706
NM_001130708
NM_021944
C14orf93


chromosome 14 open reading frame 93


chr6_-_130072971 0.354 NM_033515
ARHGAP18
Rho GTPase activating protein 18
chr6_-_112682459 0.353 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr7_+_128367961 0.344 NM_001098627
IRF5
interferon regulatory factor 5
chr17_+_6599879 0.340 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr11_+_28086373 0.331 NM_001113528
NM_152636
METTL15

methyltransferase like 15

chr8_-_38324809 0.331 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr3_+_120495906 0.324 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr8_-_42184350 0.313 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr2_+_205118961 0.310 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr3_+_115099007 0.310 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr1_-_242073094 0.306 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr22_+_37766554 0.302 NM_001006666
NM_145298
APOBEC3F

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F

chr1_-_142535878 0.302 LOC100286793
FLJ39739
hypothetical LOC100286793
hypothetical FLJ39739
chr20_+_18396030 0.296 NM_006466
POLR3F
polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
chr5_+_139869819 0.293


chr4_-_48477021 0.292 FRYL
FRY-like
chr20_-_34102250 0.292 LOC647979
hypothetical LOC647979
chr4_+_14985272 0.290 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr20_+_44070946 0.282 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr6_-_32919751 0.274 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr10_-_82039158 0.273 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr6_-_105691675 0.272 BVES
blood vessel epicardial substance
chr21_-_42219849 0.271 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr12_-_54995923 0.259 CNPY2
canopy 2 homolog (zebrafish)
chr11_-_85108030 0.252 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr7_-_92301147 0.252 NM_001259
CDK6
cyclin-dependent kinase 6
chr19_-_23370066 0.252 NM_003430
ZNF91
zinc finger protein 91
chr2_+_17585287 0.250 NM_003385
VSNL1
visinin-like 1
chr4_-_185632610 0.248 NM_002199
IRF2
interferon regulatory factor 2
chr1_-_44269615 0.245 SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr1_-_143232275 0.241 LOC728855
hypothetical LOC728855
chr16_-_28425632 0.231 NM_145659
IL27
interleukin 27
chr5_-_75044001 0.231 NM_152408
POC5
POC5 centriolar protein homolog (Chlamydomonas)
chr8_-_145132551 0.228 PARP10
poly (ADP-ribose) polymerase family, member 10
chr16_-_10696285 0.228 NM_144674
TEKT5
tektin 5
chr1_-_7998265 0.227 ERRFI1
ERBB receptor feedback inhibitor 1
chr8_+_39890484 0.226 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr17_+_75851984 0.225


chr16_+_49333513 0.224 NM_001042412
CYLD
cylindromatosis (turban tumor syndrome)
chr2_-_151854619 0.217 NM_004688
NMI
N-myc (and STAT) interactor
chr22_+_20880112 0.216


chr22_+_20880159 0.214 IGLV6-57
immunoglobulin lambda variable 6-57
chr1_-_219982049 0.211 DUSP10
dual specificity phosphatase 10
chr4_+_76868850 0.210 NM_003715
USO1
USO1 vesicle docking protein homolog (yeast)
chr6_-_25044156 0.202 FAM65B
family with sequence similarity 65, member B
chr15_-_39195701 0.201 INO80
INO80 homolog (S. cerevisiae)
chr7_-_86686754 0.195 NM_024315
C7orf23
chromosome 7 open reading frame 23
chr12_-_54996044 0.195 CNPY2
canopy 2 homolog (zebrafish)
chr8_+_97575196 0.194 SDC2
syndecan 2
chr8_+_144711619 0.191 NM_024736
GSDMD
gasdermin D
chr1_-_219982081 0.191 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr16_+_49333461 0.191 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr17_+_38412267 0.190 NM_005533
IFI35
interferon-induced protein 35
chr8_-_79880095 0.189 NM_000880
IL7
interleukin 7
chr9_+_33785558 0.186 NM_002771
PRSS3
protease, serine, 3
chr20_-_18395622 0.185 NM_001099407
C20orf12
chromosome 20 open reading frame 12
chr20_+_9963696 0.185 NM_022096
NM_198798
ANKRD5

ankyrin repeat domain 5

chr2_+_121271336 0.185 NM_005270
GLI2
GLI family zinc finger 2
chr14_+_72594985 0.184 RBM25
RNA binding motif protein 25
chr20_+_56397695 0.180 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr1_+_110254979 0.178 CSF1
colony stimulating factor 1 (macrophage)
chr16_-_66528235 0.176 NM_002801
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr9_-_16717887 0.175 BNC2
basonuclin 2
chr20_+_337346 0.174 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr6_+_26070957 0.173 NM_006355
TRIM38
tripartite motif containing 38
chr8_-_42184194 0.173 PLAT
plasminogen activator, tissue
chr1_-_116185215 0.170 NM_005599
NHLH2
nescient helix loop helix 2
chr1_-_2486313 0.169 NM_003820
TNFRSF14
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
chr9_+_108665168 0.167 NM_021224
ZNF462
zinc finger protein 462
chr2_+_17585462 0.166 VSNL1
visinin-like 1
chr14_+_72595020 0.166 RBM25
RNA binding motif protein 25
chr8_-_143864933 0.165 NM_003695
LY6D
lymphocyte antigen 6 complex, locus D
chr10_+_122600843 0.163 WDR11
WD repeat domain 11
chr11_+_59001421 0.160 NM_001004705
OR4D10
olfactory receptor, family 4, subfamily D, member 10
chr12_+_68923043 0.158 NM_014515
CNOT2
CCR4-NOT transcription complex, subunit 2
chr22_+_38903825 0.157 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr19_+_61202902 0.157 NM_153447
NLRP5
NLR family, pyrin domain containing 5
chr11_-_786175 0.156 NM_024698
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr9_+_136673464 0.155 NM_000093
COL5A1
collagen, type V, alpha 1
chr15_+_94677572 0.153 NM_001145157
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr19_-_11500912 0.149 NM_001142464
NM_001142465
NM_016581
ECSIT


ECSIT homolog (Drosophila)


chr3_-_44527083 0.146 ZNF852
zinc finger protein 852
chr3_-_69212192 0.144 NM_003968
NM_198195
UBA3

ubiquitin-like modifier activating enzyme 3

chr18_+_46659424 0.144 NM_001168335
NM_002396
ME2

malic enzyme 2, NAD(+)-dependent, mitochondrial

chr1_-_152847301 0.142 NM_001111
NM_015840
NM_015841
ADAR


adenosine deaminase, RNA-specific


chr8_-_145132582 0.139 NM_032789
PARP10
poly (ADP-ribose) polymerase family, member 10
chr6_+_32919873 0.139


chr8_+_97575244 0.139 SDC2
syndecan 2
chr10_-_73167586 0.138 NM_001168390
C10orf105
chromosome 10 open reading frame 105
chr4_-_48477038 0.137 NM_015030
FRYL
FRY-like
chr20_+_336693 0.135 NM_006462
NM_031229
RBCK1

RanBP-type and C3HC4-type zinc finger containing 1

chr15_+_72620570 0.134 NM_006465
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr15_-_29181198 0.133 NM_002420
TRPM1
transient receptor potential cation channel, subfamily M, member 1
chr1_+_17779528 0.130 NM_001011722
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr10_-_27569269 0.130 NM_145698
ACBD5
acyl-CoA binding domain containing 5
chr2_+_148495043 0.129 NM_018328
MBD5
methyl-CpG binding domain protein 5

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
10.86 2.31e-05 GO:0060337 type I interferon-mediated signaling pathway
10.86 2.31e-05 GO:0071357 cellular response to type I interferon
10.69 2.71e-05 GO:0034340 response to type I interferon
8.53 9.84e-04 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
10.16 1.02e-03 GO:0006521 regulation of cellular amino acid metabolic process
7.87 1.97e-03 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
7.77 2.20e-03 GO:0031575 mitotic cell cycle G1/S transition checkpoint
7.77 2.20e-03 GO:0051443 positive regulation of ubiquitin-protein ligase activity
7.77 2.20e-03 GO:0071779 G1/S transition checkpoint
7.57 2.73e-03 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
3.10 2.75e-03 GO:0044092 negative regulation of molecular function
8.83 3.06e-03 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
8.83 3.06e-03 GO:0072395 signal transduction involved in cell cycle checkpoint
8.83 3.06e-03 GO:0072401 signal transduction involved in DNA integrity checkpoint
8.83 3.06e-03 GO:0072404 signal transduction involved in G1/S transition checkpoint
8.83 3.06e-03 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
8.83 3.06e-03 GO:0072422 signal transduction involved in DNA damage checkpoint
8.83 3.06e-03 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
8.83 3.06e-03 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
7.39 3.36e-03 GO:0051351 positive regulation of ligase activity
7.39 3.36e-03 GO:2000045 regulation of G1/S transition of mitotic cell cycle
4.76 3.69e-03 GO:0019221 cytokine-mediated signaling pathway
3.50 4.29e-03 GO:0045087 innate immune response
8.42 4.43e-03 GO:0033238 regulation of cellular amine metabolic process
8.42 4.43e-03 GO:0071158 positive regulation of cell cycle arrest
2.47 4.72e-03 GO:0010605 negative regulation of macromolecule metabolic process
7.05 5.01e-03 GO:0030330 DNA damage response, signal transduction by p53 class mediator
2.54 5.77e-03 GO:0006952 defense response
8.04 6.28e-03 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
7.92 7.02e-03 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
6.73 7.31e-03 GO:0051438 regulation of ubiquitin-protein ligase activity
2.36 8.14e-03 GO:0009892 negative regulation of metabolic process
7.69 8.74e-03 GO:0051352 negative regulation of ligase activity
7.69 8.74e-03 GO:0051444 negative regulation of ubiquitin-protein ligase activity
2.16 1.04e-02 GO:0002376 immune system process
6.45 1.05e-02 GO:0051340 regulation of ligase activity
4.29 1.13e-02 GO:0071345 cellular response to cytokine stimulus
4.81 1.87e-02 GO:0009615 response to virus
4.81 1.87e-02 GO:0010498 proteasomal protein catabolic process
4.81 1.87e-02 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
6.91 1.96e-02 GO:0000216 M/G1 transition of mitotic cell cycle
5.94 2.03e-02 GO:0051100 negative regulation of binding
1.59 2.71e-02 GO:0060255 regulation of macromolecule metabolic process
2.33 2.80e-02 GO:0031324 negative regulation of cellular metabolic process
5.06 2.88e-02 GO:0010565 regulation of cellular ketone metabolic process
5.66 2.98e-02 GO:0042770 signal transduction in response to DNA damage
6.49 3.10e-02 GO:0043392 negative regulation of DNA binding
5.61 3.21e-02 GO:0000084 S phase of mitotic cell cycle
5.61 3.21e-02 GO:0031398 positive regulation of protein ubiquitination
5.51 3.71e-02 GO:0051320 S phase
4.85 4.21e-02 GO:0000082 G1/S transition of mitotic cell cycle
6.19 4.36e-02 GO:0031397 negative regulation of protein ubiquitination
2.23 4.38e-02 GO:0032774 RNA biosynthetic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
20.19 5.35e-05 GO:0005839 proteasome core complex
8.55 6.58e-04 GO:0000502 proteasome complex
67.30 3.58e-02 GO:0071797 LUBAC complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
19.23 1.01e-04 GO:0004298 threonine-type endopeptidase activity
19.23 1.01e-04 GO:0070003 threonine-type peptidase activity
2.09 3.14e-02 GO:0001071 nucleic acid binding transcription factor activity
2.09 3.14e-02 GO:0003700 sequence-specific DNA binding transcription factor activity