Motif ID: HES1.p2

Z-value: 1.115


Transcription factors associated with HES1.p2:

Gene SymbolEntrez IDGene Name
HES1 3280 hairy and enhancer of split 1, (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HES1chr3_+_1953366310.165.6e-01Click!


Activity profile for motif HES1.p2.

activity profile for motif HES1.p2


Sorted Z-values histogram for motif HES1.p2

Sorted Z-values for motif HES1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HES1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_149895274 0.985 NM_194317
 LYPD6
LY6/PLAUR domain containing 6
chr7_+_116099648 0.865 NM_000245
NM_001127500
 MET

met proto-oncogene (hepatocyte growth factor receptor)

chr2_-_204108151 0.812 NM_203365
NM_213589
 RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

chr20_+_36810510 0.695 NM_024855
 ACTR5
ARP5 actin-related protein 5 homolog (yeast)
chr12_+_8741746 0.684 NM_020734
 RIMKLB
ribosomal modification protein rimK-like family member B
chr1_-_45924770 0.636 NM_021639
 GPBP1L1
GC-rich promoter binding protein 1-like 1
chr16_+_55199978 0.630 NM_005953
 MT2A
metallothionein 2A
chr1_-_223907283 0.628 NM_001008493
NM_018212
 ENAH

enabled homolog (Drosophila)

chr11_-_2907169 0.603 NM_003311
 PHLDA2
pleckstrin homology-like domain, family A, member 2
chr15_+_94674849 0.597 NM_021005
 NR2F2
nuclear receptor subfamily 2, group F, member 2
chr20_+_11819364 0.585 NM_181443
 BTBD3
BTB (POZ) domain containing 3
chr1_+_234372454 0.579 NM_003272
 GPR137B
G protein-coupled receptor 137B
chr2_-_127580975 0.575 NM_004305
NM_139343
NM_139344
NM_139345
NM_139346
NM_139347
NM_139348
NM_139349
NM_139350
NM_139351
 BIN1









bridging integrator 1









chr20_+_254205 0.565 NM_006943
 SOX12
SRY (sex determining region Y)-box 12
chr8_+_120955080 0.560 NM_022783
 DEPTOR
DEP domain containing MTOR-interacting protein
chr5_+_14196287 0.557 NM_007118
 TRIO
triple functional domain (PTPRF interacting)
chr2_-_172458970 0.544 NM_003705
 SLC25A12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr6_-_86445138 0.544 SNHG5
small nucleolar RNA host gene 5 (non-protein coding)
chr2_+_101680594 0.535 NM_004834
NM_145686
NM_145687
 MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr15_-_53667800 0.517 PYGO1
pygopus homolog 1 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 58 entries
enrichment   p-value GO term description
2.30 2.92e-02 GO:0007173 epidermal growth factor receptor signaling pathway
1.68 1.01e-02 GO:0010608 posttranscriptional regulation of gene expression
1.65 2.33e-02 GO:0032446 protein modification by small protein conjugation
1.65 4.89e-02 GO:0016567 protein ubiquitination
1.60 6.16e-03 GO:0016568 chromatin modification
1.58 3.64e-02 GO:0070647 protein modification by small protein conjugation or removal
1.54 1.24e-02 GO:0072521 purine-containing compound metabolic process
1.51 4.16e-02 GO:0040008 regulation of growth
1.49 1.45e-04 GO:0006468 protein phosphorylation
1.49 7.58e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.46 2.99e-06 GO:0006793 phosphorus metabolic process
1.46 2.99e-06 GO:0006796 phosphate metabolic process
1.45 1.07e-02 GO:0051276 chromosome organization
1.45 3.11e-02 GO:0055086 nucleobase, nucleoside and nucleotide metabolic process
1.44 4.34e-04 GO:0016310 phosphorylation
1.43 8.24e-12 GO:0006464 protein modification process
1.43 6.66e-03 GO:0019220 regulation of phosphate metabolic process
1.43 6.66e-03 GO:0051174 regulation of phosphorus metabolic process
1.43 2.58e-02 GO:0001932 regulation of protein phosphorylation
1.42 2.09e-02 GO:0042325 regulation of phosphorylation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
1.70 4.05e-08 GO:0005730 nucleolus
1.44 2.36e-13 GO:0031981 nuclear lumen
1.43 1.43e-02 GO:0030529 ribonucleoprotein complex
1.41 1.83e-13 GO:0005829 cytosol
1.41 4.58e-08 GO:0005654 nucleoplasm
1.39 6.23e-14 GO:0043233 organelle lumen
1.39 9.54e-14 GO:0070013 intracellular organelle lumen
1.39 2.88e-13 GO:0044428 nuclear part
1.38 2.30e-13 GO:0031974 membrane-enclosed lumen
1.34 3.24e-02 GO:0044451 nucleoplasm part
1.33 5.94e-05 GO:0005739 mitochondrion
1.28 1.70e-08 GO:0043228 non-membrane-bounded organelle
1.28 1.70e-08 GO:0043232 intracellular non-membrane-bounded organelle
1.24 1.29e-17 GO:0005634 nucleus
1.23 1.65e-17 GO:0044444 cytoplasmic part
1.22 3.44e-29 GO:0005737 cytoplasm
1.22 6.40e-14 GO:0044446 intracellular organelle part
1.21 2.89e-13 GO:0044422 organelle part
1.19 4.64e-24 GO:0043227 membrane-bounded organelle
1.19 5.81e-24 GO:0043231 intracellular membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
5.33 4.57e-03 GO:0008139 nuclear localization sequence binding
1.95 5.30e-04 GO:0000287 magnesium ion binding
1.76 2.02e-04 GO:0016881 acid-amino acid ligase activity
1.75 1.72e-03 GO:0019787 small conjugating protein ligase activity
1.73 1.37e-04 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.71 8.14e-03 GO:0004842 ubiquitin-protein ligase activity
1.60 5.12e-05 GO:0016874 ligase activity
1.56 2.71e-02 GO:0016564 transcription repressor activity
1.53 2.94e-03 GO:0004674 protein serine/threonine kinase activity
1.51 2.55e-06 GO:0019899 enzyme binding
1.44 9.01e-06 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.42 6.94e-03 GO:0004672 protein kinase activity
1.38 7.35e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.37 1.36e-08 GO:0016740 transferase activity
1.36 8.18e-07 GO:0030554 adenyl nucleotide binding
1.36 5.12e-03 GO:0003723 RNA binding
1.35 9.94e-07 GO:0032559 adenyl ribonucleotide binding
1.35 3.17e-06 GO:0005524 ATP binding
1.34 2.70e-02 GO:0016301 kinase activity
1.33 2.05e-09 GO:0000166 nucleotide binding