Motif ID: NFKB1_REL_RELA.p2

Z-value: 1.391


Transcription factors associated with NFKB1_REL_RELA.p2:

Gene SymbolEntrez IDGene Name
NFKB1 4790 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
REL 5966 v-rel reticuloendotheliosis viral oncogene homolog (avian)
RELA 5970 v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFKB1chr4_+_1036415850.562.5e-02Click!
RELchr2_+_609622060.458.3e-02Click!
RELAchr11_-_651870030.302.5e-01Click!


Activity profile for motif NFKB1_REL_RELA.p2.

activity profile for motif NFKB1_REL_RELA.p2


Sorted Z-values histogram for motif NFKB1_REL_RELA.p2

Sorted Z-values for motif NFKB1_REL_RELA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB1_REL_RELA.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_219453487 2.357 NM_025216
 WNT10A
wingless-type MMTV integration site family, member 10A
chr14_-_34943574 2.158 NM_020529
 NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr20_-_4743768 1.465 NM_170774
 RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr6_+_116798791 1.300 NM_013352
 DSE
dermatan sulfate epimerase
chr14_-_34253473 1.270 NM_138638
 CFL2
cofilin 2 (muscle)
chr17_+_37694007 1.256 STAT5A
signal transducer and activator of transcription 5A
chr6_+_30958672 1.094 DDR1
discoidin domain receptor tyrosine kinase 1
chr2_+_170363573 1.093 NM_003142
 SSB
Sjogren syndrome antigen B (autoantigen La)
chr17_+_43328514 1.066 NM_003110
 SP2
Sp2 transcription factor
chr19_+_40632456 0.996 NM_005306
 FFAR2
free fatty acid receptor 2
chr1_+_45046740 0.922 NM_001136537
 BTBD19
BTB (POZ) domain containing 19
chr6_-_143307976 0.915 NM_006734
 HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr14_-_22825072 0.899 HOMEZ
homeobox and leucine zipper encoding
chr10_+_104145421 0.892 NM_002502
 NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr2_-_231498184 0.892 NM_005683
 GPR55
G protein-coupled receptor 55
chr16_-_73798539 0.878 NM_001025200
 CTRB1
CTRB2
chymotrypsinogen B1
chymotrypsinogen B2
chr7_-_104440707 0.872 LOC100216545
hypothetical LOC100216545
chr8_-_95343716 0.853 NM_005261
NM_181702
 GEM

GTP binding protein overexpressed in skeletal muscle

chr18_+_3584056 0.848 FLJ35776
hypothetical LOC649446
chr16_+_84490267 0.846 NM_002163
 IRF8
interferon regulatory factor 8

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 39 entries
enrichment   p-value GO term description
4.84 2.70e-02 GO:0060330 regulation of response to interferon-gamma
4.84 2.70e-02 GO:0060334 regulation of interferon-gamma-mediated signaling pathway
2.13 1.62e-02 GO:0051251 positive regulation of lymphocyte activation
2.04 5.98e-03 GO:0051249 regulation of lymphocyte activation
1.94 1.78e-02 GO:0002694 regulation of leukocyte activation
1.57 4.53e-03 GO:0002682 regulation of immune system process
1.54 3.75e-03 GO:0031399 regulation of protein modification process
1.53 1.42e-04 GO:0032268 regulation of cellular protein metabolic process
1.49 1.13e-03 GO:0042981 regulation of apoptosis
1.48 4.39e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.48 9.57e-04 GO:0051246 regulation of protein metabolic process
1.48 1.16e-03 GO:0043067 regulation of programmed cell death
1.47 1.87e-03 GO:0010941 regulation of cell death
1.46 2.67e-03 GO:0022607 cellular component assembly
1.43 1.28e-03 GO:0009893 positive regulation of metabolic process
1.43 1.88e-03 GO:0002376 immune system process
1.43 2.99e-03 GO:0031325 positive regulation of cellular metabolic process
1.39 2.39e-02 GO:0044085 cellular component biogenesis
1.34 2.50e-05 GO:0048522 positive regulation of cellular process
1.33 4.60e-04 GO:0048523 negative regulation of cellular process

Gene overrepresentation in compartment category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
9.20 7.70e-03 GO:0033256 I-kappaB/NF-kappaB complex
1.74 2.03e-02 GO:0015629 actin cytoskeleton
1.34 6.61e-05 GO:0005829 cytosol
1.20 2.89e-06 GO:0005634 nucleus
1.15 2.52e-03 GO:0044444 cytoplasmic part
1.13 1.06e-04 GO:0005737 cytoplasm
1.12 4.38e-05 GO:0043227 membrane-bounded organelle
1.12 5.75e-05 GO:0043231 intracellular membrane-bounded organelle
1.10 3.82e-07 GO:0044424 intracellular part
1.10 2.03e-06 GO:0005622 intracellular
1.10 1.90e-04 GO:0043226 organelle
1.10 2.62e-04 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
1.19 3.14e-09 GO:0005515 protein binding
1.08 3.69e-04 GO:0005488 binding