Motif ID: SOX2.p2

Z-value: 1.406


Transcription factors associated with SOX2.p2:

Gene SymbolEntrez IDGene Name
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX2chr3_+_182912769-0.543.1e-02Click!


Activity profile for motif SOX2.p2.

activity profile for motif SOX2.p2


Sorted Z-values histogram for motif SOX2.p2

Sorted Z-values for motif SOX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_114285209 2.217 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr7_-_27186400 2.083 NM_153715
HOXA10
homeobox A10
chr6_-_139654807 2.079 NM_153235
TXLNB
taxilin beta
chr6_+_12398514 1.986 NM_001168319
NM_001955
EDN1

endothelin 1

chr17_+_34114924 1.601 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr1_-_224993498 1.563 NM_002221
ITPKB
inositol 1,4,5-trisphosphate 3-kinase B
chr17_-_44006808 1.413 NM_002146
HOXB3
homeobox B3
chr6_-_33028790 1.249 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr17_+_63252704 1.246 BPTF
bromodomain PHD finger transcription factor
chr7_+_128802719 1.223 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr11_-_85108030 1.212 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr1_-_115039614 1.169 NM_000036
NM_001172626
AMPD1

adenosine monophosphate deaminase 1

chr12_-_24606616 1.131 NM_152989
SOX5
SRY (sex determining region Y)-box 5
chr7_+_153633127 1.126 NM_001936
DPP6
dipeptidyl-peptidase 6
chr1_-_7923464 1.080 NM_001561
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr6_+_21701942 1.068 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr5_-_125956996 1.058 ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr11_-_85107569 1.044 NM_206929
SYTL2
synaptotagmin-like 2
chr3_-_150422474 1.034 NM_000096
CP
ceruloplasmin (ferroxidase)
chr2_+_33213111 1.017 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr7_+_20336849 0.996 ITGB8
integrin, beta 8
chr17_+_63252668 0.973 BPTF
bromodomain PHD finger transcription factor
chr18_-_27594696 0.973 NM_001034172
MCART2
mitochondrial carrier triple repeat 2
chr6_+_130381408 0.951 NM_001007102
NM_032438
L3MBTL3

l(3)mbt-like 3 (Drosophila)

chr12_+_14429499 0.933 ATF7IP
activating transcription factor 7 interacting protein
chr10_-_13789628 0.930 FRMD4A
FERM domain containing 4A
chr12_-_68369322 0.925 NM_152439
BEST3
bestrophin 3
chr15_-_32398220 0.924 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr10_-_62002672 0.918 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr2_-_110665188 0.911 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr4_+_146623405 0.897 NM_001003688
SMAD1
SMAD family member 1
chr3_-_150993299 0.896 NM_001144960
C3orf16
chromosome 3 open reading frame 16
chr5_-_71838875 0.884 NM_152625
ZNF366
zinc finger protein 366
chr1_+_12757570 0.868 NM_001080830
PRAMEF12
PRAME family member 12
chr2_-_1905508 0.859 MYT1L
myelin transcription factor 1-like
chr16_-_71639670 0.858 NM_006885
ZFHX3
zinc finger homeobox 3
chr3_-_3127057 0.822 NM_000564
NM_175724
NM_175725
NM_175726
NM_175727
NM_175728
IL5RA





interleukin 5 receptor, alpha





chr2_-_37752272 0.801 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr20_-_45418818 0.785 NM_012408
NM_183047
NM_183048
ZMYND8


zinc finger, MYND-type containing 8


chr11_-_14342627 0.780 NM_001177314
RRAS2
related RAS viral (r-ras) oncogene homolog 2
chr17_+_55269974 0.771


chr7_+_27190688 0.763


chr2_-_70329067 0.760 NM_022037
NM_022173
TIA1

TIA1 cytotoxic granule-associated RNA binding protein

chr4_+_37655385 0.752 TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr8_-_81155564 0.744 NM_001025252
TPD52
tumor protein D52
chr4_-_186969041 0.725 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr6_+_155579788 0.713 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr12_+_47498778 0.709 NM_000725
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr14_+_76298693 0.708 VASH1
vasohibin 1
chr1_-_223907283 0.699 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr6_+_36752244 0.696 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr1_-_177106702 0.688 NM_004673
ANGPTL1
angiopoietin-like 1
chr9_-_35640852 0.676 NM_014450
SIT1
signaling threshold regulating transmembrane adaptor 1
chr1_-_26105954 0.674 NM_203399
STMN1
stathmin 1
chr5_-_111119846 0.673 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr13_+_92677012 0.669 NM_005708
GPC6
glypican 6
chr10_-_32707549 0.669 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr4_-_186969202 0.667 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr3_-_194118321 0.665 MB21D2
Mab-21 domain containing 2
chr1_+_144152864 0.657 TXNIP
thioredoxin interacting protein
chr6_-_134680888 0.654 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr2_-_218551786 0.654 TNS1
tensin 1
chr5_-_160211623 0.653 NM_025153
ATP10B
ATPase, class V, type 10B
chr1_-_32574185 0.653 NM_023009
MARCKSL1
MARCKS-like 1
chr6_-_29752909 0.642 NM_001109809
ZFP57
zinc finger protein 57 homolog (mouse)
chr21_+_36429079 0.640 NM_001236
CBR3
carbonyl reductase 3
chr7_+_134114912 0.632 CALD1
caldesmon 1
chr18_+_27281729 0.632 NM_001944
DSG3
desmoglein 3
chr17_+_74542066 0.625 NM_198593
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr5_+_143171918 0.623 NM_021182
HMHB1
histocompatibility (minor) HB-1
chr7_+_139175420 0.613 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr16_-_83703496 0.600 NM_198491
FAM92B
family with sequence similarity 92, member B
chr4_+_120029426 0.600 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr6_+_121798443 0.595 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr17_-_30783631 0.594 NM_018042
SLFN12
schlafen family member 12
chr6_-_116973465 0.592 NM_001139444
BET3L
BET3 like (S. cerevisiae)
chr3_-_194118627 0.592 NM_178496
MB21D2
Mab-21 domain containing 2
chr3_-_150533948 0.586 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr7_-_7541974 0.581 NM_001037763
COL28A1
collagen, type XXVIII, alpha 1
chr2_+_120233676 0.572 NM_002830
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr8_-_28403652 0.567 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr15_+_50098730 0.564 MAPK6
mitogen-activated protein kinase 6
chr2_+_101874809 0.562 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr16_+_21518633 0.561 METTL9
methyltransferase like 9
chr6_-_56816403 0.560 DST
dystonin
chr12_-_109842736 0.558 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr17_-_39094787 0.555 NM_001040002
MEOX1
mesenchyme homeobox 1
chr7_+_134114957 0.551 CALD1
caldesmon 1
chr2_-_207738858 0.547 NM_003709
KLF7
Kruppel-like factor 7 (ubiquitous)
chr22_-_20419975 0.542 NM_013313
YPEL1
yippee-like 1 (Drosophila)
chr17_-_10393664 0.534 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr16_-_15742883 0.531 MYH11
myosin, heavy chain 11, smooth muscle
chr5_+_138706029 0.526 NM_001033112
PAIP2
poly(A) binding protein interacting protein 2
chr11_+_61005160 0.524 NM_001170753
NM_145017
C11orf66

chromosome 11 open reading frame 66

chr16_-_69876262 0.523 FTSJD1
FtsJ methyltransferase domain containing 1
chr1_+_242281199 0.522 ZNF238
zinc finger protein 238
chr8_-_18710575 0.521 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr8_-_93144039 0.516


chr1_+_66570363 0.513 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chrX_-_76928334 0.513 NM_000489
NM_138270
ATRX

alpha thalassemia/mental retardation syndrome X-linked

chr2_+_169631777 0.509 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr7_-_111633428 0.508 DOCK4
dedicator of cytokinesis 4
chr11_+_36274300 0.507 NM_001160167
PRR5L
proline rich 5 like
chr1_+_154120170 0.506 SYT11
synaptotagmin XI
chr7_-_130891861 0.505 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr7_+_20337249 0.503 NM_002214
ITGB8
integrin, beta 8
chr15_+_50098724 0.500 MAPK6
mitogen-activated protein kinase 6
chr3_-_69254226 0.499 NM_198271
LMOD3
leiomodin 3 (fetal)
chr12_+_50633430 0.498 NM_020327
ACVR1B
activin A receptor, type IB
chr2_-_37752731 0.497 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr6_-_159386007 0.496 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr8_-_38444398 0.493 NM_001174065
NM_001174066
NM_001174067
FGFR1


fibroblast growth factor receptor 1


chr13_-_22905822 0.491 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr22_+_38903825 0.488 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr14_-_91483757 0.485 NM_006329
FBLN5
fibulin 5
chr2_-_207739815 0.484 KLF7
Kruppel-like factor 7 (ubiquitous)
chr6_-_134415311 0.478 NM_145176
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chr4_-_187114407 0.477 SORBS2
sorbin and SH3 domain containing 2
chr1_+_183970093 0.474 NM_031935
HMCN1
hemicentin 1
chr7_+_116099648 0.473 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr7_-_27190882 0.470 HOXA11
homeobox A11
chr6_-_11340886 0.470 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr10_+_18280773 0.467 NM_001145195
NM_152725
SLC39A12

solute carrier family 39 (zinc transporter), member 12

chr12_-_10173947 0.461 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr6_-_11340869 0.459 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr10_-_61819493 0.456 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr7_-_142293382 0.452 NM_018646
TRPV6
transient receptor potential cation channel, subfamily V, member 6
chr17_-_36915329 0.448 NM_002274
NM_153490
KRT13

keratin 13

chr18_+_7936885 0.447 PTPRM
protein tyrosine phosphatase, receptor type, M
chr12_-_68379331 0.447 NM_032735
BEST3
bestrophin 3
chr2_-_39201631 0.446 SOS1
son of sevenless homolog 1 (Drosophila)
chr6_-_42527760 0.446 NM_033502
TRERF1
transcriptional regulating factor 1
chr4_-_72868598 0.446 NM_000583
GC
group-specific component (vitamin D binding protein)
chr15_-_31147376 0.441 NM_001103184
FMN1
formin 1
chr3_+_3056307 0.441 NM_175612
CNTN4
contactin 4
chr1_-_114215768 0.441 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr15_+_69220841 0.440 NM_024817
THSD4
thrombospondin, type I, domain containing 4
chr17_-_1195096 0.438 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr9_+_4480193 0.435 NM_004170
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr4_+_146622154 0.434 NM_005900
SMAD1
SMAD family member 1
chr14_-_88953059 0.434 NM_005197
FOXN3
forkhead box N3
chr8_-_124622434 0.432 NM_058229
FBXO32
F-box protein 32
chr15_-_68128924 0.430 TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr9_+_115678365 0.430 NM_133374
ZNF618
zinc finger protein 618
chr1_-_202730135 0.429 PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr1_+_203106600 0.428 NFASC
neurofascin
chr4_-_74307637 0.428 ANKRD17
ankyrin repeat domain 17
chr1_+_116455898 0.427 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr15_-_29734833 0.426 NM_130901
OTUD7A
OTU domain containing 7A
chr7_-_26202626 0.426 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr7_+_93388951 0.425 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr6_+_21774624 0.424 FLJ22536
hypothetical locus LOC401237
chr6_+_168161401 0.423 NM_005355
NM_030615
KIF25

kinesin family member 25

chr4_-_140696740 0.421 NM_030648
SETD7
SET domain containing (lysine methyltransferase) 7
chr1_-_180624380 0.421 GLUL
glutamate-ammonia ligase
chr16_+_55373241 0.421 NUP93
nucleoporin 93kDa
chr11_+_101693403 0.420 NM_001165
NM_182962
BIRC3

baculoviral IAP repeat containing 3

chr2_-_198248828 0.417 NM_144629
RFTN2
raftlin family member 2
chr2_+_138438277 0.416 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr1_+_8928508 0.415 NM_001215
CA6
carbonic anhydrase VI
chr2_+_203207912 0.415 FAM117B
family with sequence similarity 117, member B
chr5_-_88235624 0.415 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr2_-_20413838 0.414 PUM2
pumilio homolog 2 (Drosophila)
chr14_-_88090641 0.413 NM_007039
PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr17_+_64922420 0.412 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr21_+_34112456 0.411 ITSN1
intersectin 1 (SH3 domain protein)
chr6_+_144649142 0.411 UTRN
utrophin
chr2_+_110013297 0.409 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr3_-_121883647 0.409 HGD
homogentisate 1,2-dioxygenase
chr20_+_17622319 0.407 NM_001159495
BANF2
barrier to autointegration factor 2
chr4_-_52578542 0.406 NM_001024611
LRRC66
leucine rich repeat containing 66
chr2_-_56266408 0.405 LOC100129434
hypothetical LOC100129434
chr1_+_33494745 0.403 NM_152493
ZNF362
zinc finger protein 362
chr20_+_30831298 0.402 NM_175850
DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta
chr17_+_34115383 0.401 NM_005937
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr12_+_91620749 0.400 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr10_+_24795465 0.399 KIAA1217
KIAA1217
chr10_-_14686243 0.399 FAM107B
family with sequence similarity 107, member B
chrX_+_135079461 0.398 NM_001167819
FHL1
four and a half LIM domains 1
chr20_+_54541672 0.397 NM_001013646
C20orf107
chromosome 20 open reading frame 107
chr6_-_138935359 0.397 NM_020464
NHSL1
NHS-like 1
chr7_-_111633620 0.397 NM_014705
DOCK4
dedicator of cytokinesis 4
chr9_+_102275310 0.396 NM_003692
TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chrX_-_76928142 0.395 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr2_+_232281470 0.395 NM_001099285
NM_002823
PTMA

prothymosin, alpha

chr1_+_176577228 0.394 NM_004841
RASAL2
RAS protein activator like 2
chr5_-_14924555 0.394 NM_054027
ANKH
ankylosis, progressive homolog (mouse)
chr8_+_32623792 0.393 NM_013959
NRG1
neuregulin 1
chr10_-_74863303 0.391 NM_001024593
ZMYND17
zinc finger, MYND-type containing 17
chr9_+_132700462 0.390 ABL1
c-abl oncogene 1, non-receptor tyrosine kinase
chr17_+_72958920 0.390 SEPT9
septin 9
chr3_+_153469421 0.389 MBNL1
muscleblind-like (Drosophila)
chr10_+_71232281 0.388 COL13A1
collagen, type XIII, alpha 1
chr1_+_24158887 0.388 NM_017761
PNRC2
proline-rich nuclear receptor coactivator 2
chr2_+_152900076 0.386 FMNL2
formin-like 2
chr5_-_171643399 0.386 NM_152277
UBTD2
ubiquitin domain containing 2
chr15_-_43280664 0.386 NM_138356
SHF
Src homology 2 domain containing F
chr2_-_217248967 0.386 IGFBP5
insulin-like growth factor binding protein 5
chr18_+_27210737 0.386 NM_001134453
NM_177986
DSG4

desmoglein 4

chr6_+_144654565 0.385 NM_007124
UTRN
utrophin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.21 3.44e-04 GO:0007275 multicellular organismal development
1.19 1.60e-03 GO:0032502 developmental process
1.19 3.77e-03 GO:0016043 cellular component organization
1.14 4.19e-03 GO:0032501 multicellular organismal process
1.56 4.98e-03 GO:0007010 cytoskeleton organization
1.19 5.08e-03 GO:0071840 cellular component organization or biogenesis
1.25 5.76e-03 GO:0048869 cellular developmental process
1.44 6.97e-03 GO:2000026 regulation of multicellular organismal development
1.30 7.73e-03 GO:0007399 nervous system development
1.72 9.38e-03 GO:0030029 actin filament-based process
1.25 1.20e-02 GO:0030154 cell differentiation
1.28 1.20e-02 GO:0006996 organelle organization
1.11 1.31e-02 GO:0050794 regulation of cellular process
1.21 1.39e-02 GO:0071842 cellular component organization at cellular level
1.20 2.53e-02 GO:0071841 cellular component organization or biogenesis at cellular level
1.39 3.36e-02 GO:0051128 regulation of cellular component organization
2.17 3.61e-02 GO:0040029 regulation of gene expression, epigenetic

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.08 4.49e-07 GO:0005622 intracellular
1.17 4.63e-07 GO:0005634 nucleus
1.08 9.88e-06 GO:0044424 intracellular part
1.31 2.80e-04 GO:0005856 cytoskeleton
1.08 9.52e-04 GO:0043226 organelle
1.08 1.64e-03 GO:0043229 intracellular organelle
1.20 1.69e-03 GO:0043228 non-membrane-bounded organelle
1.20 1.69e-03 GO:0043232 intracellular non-membrane-bounded organelle
1.82 8.04e-03 GO:0031252 cell leading edge
2.03 1.81e-02 GO:0030055 cell-substrate junction
1.41 2.05e-02 GO:0030054 cell junction
1.83 3.38e-02 GO:0005912 adherens junction
2.14 3.45e-02 GO:0030027 lamellipodium
1.77 4.19e-02 GO:0070161 anchoring junction
1.03 4.48e-02 GO:0044464 cell part
1.03 4.64e-02 GO:0005623 cell

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.63 6.50e-06 GO:0008092 cytoskeletal protein binding
1.77 6.37e-05 GO:0003779 actin binding
1.12 7.18e-05 GO:0005515 protein binding
1.20 2.89e-04 GO:0003676 nucleic acid binding
1.22 3.16e-03 GO:0003677 DNA binding
2.05 1.82e-02 GO:0017124 SH3 domain binding