Motif ID: GLI1..3.p2

Z-value: 1.422


Transcription factors associated with GLI1..3.p2:

Gene SymbolEntrez IDGene Name
GLI1 2735 glioma-associated oncogene homolog 1 (zinc finger protein)
GLI2 2736 GLI-Kruppel family member GLI2
GLI3 2737 GLI-Kruppel family member GLI3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GLI2chr2_+_1212713360.136.3e-01Click!
GLI3chr7_-_422431420.087.6e-01Click!
GLI1chr12_+_561401840.039.0e-01Click!


Activity profile for motif GLI1..3.p2.

activity profile for motif GLI1..3.p2


Sorted Z-values histogram for motif GLI1..3.p2

Sorted Z-values for motif GLI1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GLI1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_19691397 1.499 NM_145117
NM_182964
NAV2

neuron navigator 2

chr7_-_107883929 1.295 NM_001193582
NM_001193583
NM_001193584
NM_005010
NRCAM



neuronal cell adhesion molecule



chr16_+_85169615 1.243 NM_005250
FOXL1
forkhead box L1
chr22_+_18090118 1.235 SEPT5-GP1BB
SEPT5-GP1BB read-through transcript
chr5_+_71438796 1.199 NM_005909
MAP1B
microtubule-associated protein 1B
chr14_+_76297885 1.037 NM_014909
VASH1
vasohibin 1
chr14_+_76298693 1.018 VASH1
vasohibin 1
chr4_+_134289893 0.853 NM_020815
NM_032961
PCDH10

protocadherin 10

chr2_+_109112428 0.836 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr19_+_10404110 0.821 NM_001111309
PDE4A
phosphodiesterase 4A, cAMP-specific
chr4_-_140696740 0.811 NM_030648
SETD7
SET domain containing (lysine methyltransferase) 7
chr5_+_92946348 0.798 NR2F1
nuclear receptor subfamily 2, group F, member 1
chr1_-_75854281 0.798 SLC44A5
solute carrier family 44, member 5
chr11_+_56705796 0.776 NM_001005210
LRRC55
leucine rich repeat containing 55
chr9_+_130909926 0.769


chr22_-_17892001 0.720 CLDN5
claudin 5
chr17_-_3321782 0.719 NM_032598
NM_001170699
NM_001170698
NM_001170697
NM_001170695
NM_001170696
SPATA22





spermatogenesis associated 22





chr5_+_175725050 0.719 NM_173664
ARL10
ADP-ribosylation factor-like 10
chr10_+_31650069 0.715 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr5_-_168204430 0.694


chr2_+_128119908 0.688 NM_001161415
NM_001161416
NM_001161417
NM_005291
GPR17



G protein-coupled receptor 17



chr11_-_118693021 0.671 NM_006500
MCAM
melanoma cell adhesion molecule
chr1_-_24307514 0.670 MYOM3
myomesin family, member 3
chr11_+_76491532 0.655 NM_006189
OMP
olfactory marker protein
chr11_+_1897374 0.646 NM_001042780
NM_001042781
NM_001042782
NM_006757
TNNT3



troponin T type 3 (skeletal, fast)



chr1_+_3597092 0.641 NM_001126240
NM_001126241
NM_001126242
TP73


tumor protein p73


chr12_-_3732478 0.641 EFCAB4B
EF-hand calcium binding domain 4B
chr22_-_35835548 0.634 TMPRSS6
transmembrane protease, serine 6
chr12_-_3732614 0.632 NM_001144958
NM_001144959
NM_032680
EFCAB4B


EF-hand calcium binding domain 4B


chr19_+_16296632 0.620 NM_016270
KLF2
Kruppel-like factor 2 (lung)
chr11_-_404975 0.611 NM_001135054
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr22_-_17891777 0.602 CLDN5
claudin 5
chr18_+_58143499 0.598 NM_003839
TNFRSF11A
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
chr12_+_79625538 0.590 NM_002469
MYF6
myogenic factor 6 (herculin)
chr14_+_99181232 0.587 NM_001127258
NM_032425
HHIPL1

HHIP-like 1

chr3_-_38666122 0.585 NM_000335
NM_001099404
NM_001099405
NM_198056
NM_001160160
NM_001160161
SCN5A





sodium channel, voltage-gated, type V, alpha subunit





chr2_+_242460553 0.584 NM_173821
C2orf85
chromosome 2 open reading frame 85
chr2_-_26058831 0.581 KIF3C
kinesin family member 3C
chr5_+_176170041 0.581 NM_133369
UNC5A
unc-5 homolog A (C. elegans)
chr17_-_3740785 0.580 NM_172206
CAMKK1
calcium/calmodulin-dependent protein kinase kinase 1, alpha
chr11_+_122806196 0.578 LOC100128242
hypothetical LOC100128242
chr1_+_43837096 0.574 PTPRF
protein tyrosine phosphatase, receptor type, F
chr3_+_50272648 0.572


chr3_+_155321826 0.569 NM_015595
ARHGEF26
Rho guanine nucleotide exchange factor (GEF) 26
chr5_-_1165106 0.566 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr6_-_168222645 0.552 NM_024919
FRMD1
FERM domain containing 1
chr1_+_9275542 0.549 SPSB1
splA/ryanodine receptor domain and SOCS box containing 1
chr13_+_112789669 0.549 MCF2L
MCF.2 cell line derived transforming sequence-like
chr20_-_44612619 0.549 NM_080721
C20orf123
chromosome 20 open reading frame 123
chr7_+_129918408 0.548 NM_177525
MEST
mesoderm specific transcript homolog (mouse)
chr19_+_14405216 0.542 PKN1
protein kinase N1
chr9_+_130056513 0.537


chr22_+_43442987 0.526 NM_001017528
NM_001017529
PRR5

proline rich 5 (renal)

chr14_-_51605515 0.525 NID2
nidogen 2 (osteonidogen)
chr21_-_31175722 0.521 NM_175858
KRTAP11-1
keratin associated protein 11-1
chr14_-_51605487 0.517 NID2
nidogen 2 (osteonidogen)
chr22_+_18388633 0.515 C22orf25
chromosome 22 open reading frame 25
chr1_-_32036802 0.513 SPOCD1
SPOC domain containing 1
chr1_-_152202574 0.512 SLC39A1
solute carrier family 39 (zinc transporter), member 1
chr22_+_18388656 0.511 C22orf25
chromosome 22 open reading frame 25
chr17_-_17340219 0.510 NM_016084
RASD1
RAS, dexamethasone-induced 1
chr2_-_175578156 0.506 NM_001025201
NM_001822
CHN1

chimerin (chimaerin) 1

chr7_-_130891861 0.505 NM_001018111
NM_005397
PODXL

podocalyxin-like

chrX_+_100361588 0.503 NM_001171184
NM_001939
DRP2

dystrophin related protein 2

chr3_+_39826032 0.502 NM_015460
MYRIP
myosin VIIA and Rab interacting protein
chr10_+_685887 0.498 C10orf108
chromosome 10 open reading frame 108
chr5_-_132189762 0.495 NM_133456
SHROOM1
shroom family member 1
chr16_+_85158357 0.494 NM_005251
FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr14_-_51605461 0.493 NID2
nidogen 2 (osteonidogen)
chr11_-_1007140 0.486 MUC6
mucin 6, oligomeric mucus/gel-forming
chr14_-_51605695 0.485 NM_007361
NID2
nidogen 2 (osteonidogen)
chr11_+_1848674 0.484 NM_001013254
NM_001013255
LSP1

lymphocyte-specific protein 1

chr8_+_21972804 0.479 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr17_+_42686248 0.478


chr16_+_55456619 0.476 NM_000339
NM_001126107
NM_001126108
SLC12A3


solute carrier family 12 (sodium/chloride transporters), member 3


chr1_-_45081190 0.470 NM_001166292
NM_003738
PTCH2

patched 2

chr7_-_150515851 0.466 NM_080871
ASB10
ankyrin repeat and SOCS box containing 10
chr18_-_42810446 0.463 NM_145653
TCEB3C
transcription elongation factor B polypeptide 3C (elongin A3)
chr7_+_27191534 0.463 HOXA11-AS1
HOXA11 antisense RNA 1 (non-protein coding)
chr17_+_42686153 0.460 NM_000212
ITGB3
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
chr2_+_42129440 0.449


chr3_+_160964574 0.447 SCHIP1
schwannomin interacting protein 1
chr19_-_44158130 0.446 NM_024907
FBXO17
F-box protein 17
chrX_+_115481848 0.445 SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr22_+_45401321 0.445 NM_015124
GRAMD4
GRAM domain containing 4
chr16_+_56259657 0.443 NM_170776
GPR97
G protein-coupled receptor 97
chr15_+_67378326 0.441 NM_017705
PAQR5
progestin and adipoQ receptor family member V
chr2_+_54537842 0.440 SPTBN1
spectrin, beta, non-erythrocytic 1
chr19_+_14405100 0.440 NM_002741
PKN1
protein kinase N1
chr22_+_18388602 0.439 NM_152906
C22orf25
chromosome 22 open reading frame 25
chr3_+_44601457 0.438 NM_173658
ZNF660
zinc finger protein 660
chrX_-_114374860 0.437 NM_020871
LRCH2
leucine-rich repeats and calponin homology (CH) domain containing 2
chr2_-_20075929 0.437 NM_002381
MATN3
matrilin 3
chr17_-_74432671 0.437 TIMP2
TIMP metallopeptidase inhibitor 2
chr19_-_59676153 0.436 NM_145057
CDC42EP5
CDC42 effector protein (Rho GTPase binding) 5
chr13_+_112808102 0.433 NM_000131
NM_019616
F7

coagulation factor VII (serum prothrombin conversion accelerator)

chr5_+_122452739 0.432 NM_001136239
PRDM6
PR domain containing 6
chr12_+_50586958 0.429 ACVRL1
activin A receptor type II-like 1
chr16_+_87021379 0.428 NM_001127464
ZNF469
zinc finger protein 469
chr19_+_16296734 0.423 KLF2
Kruppel-like factor 2 (lung)
chr20_+_60558104 0.421 NM_178463
C20orf166
chromosome 20 open reading frame 166
chrX_+_13581145 0.419 NM_152634
TCEANC
transcription elongation factor A (SII) N-terminal and central domain containing
chr2_-_133144094 0.419 LYPD1
LY6/PLAUR domain containing 1
chr12_-_111304138 0.414 NM_001109662
C12orf51
chromosome 12 open reading frame 51
chr17_-_74432800 0.414 TIMP2
TIMP metallopeptidase inhibitor 2
chrX_-_16798363 0.413 RBBP7
retinoblastoma binding protein 7
chr14_+_105012106 0.412 NM_001312
CRIP2
cysteine-rich protein 2
chr18_-_42810206 0.407 NM_001100817
TCEB3C
TCEB3CL
transcription elongation factor B polypeptide 3C (elongin A3)
transcription elongation factor B polypeptide 3C-like
chr17_+_42686217 0.405 ITGB3
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
chr11_-_60880799 0.405 NM_001161452
CYBASC3
cytochrome b, ascorbate dependent 3
chr9_-_138757175 0.398 NM_001001712
LCN10
lipocalin 10
chr15_+_65217412 0.396 NM_001145103
SMAD3
SMAD family member 3
chr3_-_130761967 0.395 PLXND1
plexin D1
chrX_-_52700674 0.393 NM_173358
SSX7
synovial sarcoma, X breakpoint 7
chr5_+_161427225 0.388 NM_000816
NM_198903
NM_198904
GABRG2


gamma-aminobutyric acid (GABA) A receptor, gamma 2


chr17_+_7264366 0.386 NM_199339
SPEM1
spermatid maturation 1
chr18_-_42798364 0.386 NM_001100817
TCEB3C
TCEB3CL
transcription elongation factor B polypeptide 3C (elongin A3)
transcription elongation factor B polypeptide 3C-like
chr11_-_1006736 0.384 MUC6
mucin 6, oligomeric mucus/gel-forming
chr6_+_136214495 0.382 NM_018945
PDE7B
phosphodiesterase 7B
chr20_-_36191623 0.382 TGM2
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr18_-_42804531 0.381 NM_145653
TCEB3C
transcription elongation factor B polypeptide 3C (elongin A3)
chr7_-_100262971 0.381 NM_004444
EPHB4
EPH receptor B4
chr16_-_16224791 0.378 NM_001079528
NM_001171
ABCC6

ATP-binding cassette, sub-family C (CFTR/MRP), member 6

chr19_+_48610874 0.378 NM_001130011
TEX101
testis expressed 101
chr19_+_3490154 0.373 NM_001135580
C19orf71
chromosome 19 open reading frame 71
chrX_-_16798383 0.373 NM_002893
RBBP7
retinoblastoma binding protein 7
chr2_-_192767844 0.372 NM_016192
TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr15_+_72253940 0.371 NM_201526
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr2_-_20075889 0.371 MATN3
matrilin 3
chr13_+_56613052 0.369 NM_198441
NM_001130404
NM_001130405
NM_001130406
NM_001130407
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
proline rich 20A
proline rich 20B
proline rich 20C
proline rich 20D
proline rich 20E
chr14_+_95222506 0.361 NM_004918
NM_199206
TCL1B

T-cell leukemia/lymphoma 1B

chr12_+_50587468 0.361 NM_000020
ACVRL1
activin A receptor type II-like 1
chr1_-_45862225 0.358 NM_001114938
NM_001190182
CCDC17

coiled-coil domain containing 17

chrX_-_34585287 0.357 NM_031442
TMEM47
transmembrane protein 47
chr15_+_37660568 0.355 NM_003246
THBS1
thrombospondin 1
chr12_-_4425040 0.354 NM_020996
FGF6
fibroblast growth factor 6
chr6_-_3697244 0.354 NM_183373
C6orf145
chromosome 6 open reading frame 145
chrX_-_43717864 0.354 NM_000266
NDP
Norrie disease (pseudoglioma)
chr19_+_659766 0.354 NM_001040134
NM_002579
PALM

paralemmin

chr12_-_6668880 0.353 NM_001039917
NM_001039919
NM_001039920
NM_001135734
ZNF384



zinc finger protein 384



chrX_-_135941498 0.353 NM_054021
GPR101
G protein-coupled receptor 101
chr6_+_3697328 0.348


chr3_+_138020550 0.345 NM_001097599
NM_001097600
NM_025246
TMEM22


transmembrane protein 22


chr7_-_100009205 0.344 NM_001168682
SAP25
sin3A-binding protein 25
chrX_+_115481774 0.342 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr8_+_21972631 0.340 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr12_-_117026038 0.340 NM_019086
VSIG10
V-set and immunoglobulin domain containing 10
chr2_-_144991556 0.339 ZEB2
zinc finger E-box binding homeobox 2
chr1_-_159099090 0.338 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr9_+_89302239 0.338 DAPK1
death-associated protein kinase 1
chr17_+_15788955 0.337 NM_000676
ADORA2B
adenosine A2b receptor
chr4_-_164614335 0.332 NM_032136
TKTL2
transketolase-like 2
chr1_+_1256585 0.329 NM_152228
TAS1R3
taste receptor, type 1, member 3
chr19_-_53516962 0.329 CCDC114
coiled-coil domain containing 114
chr7_-_4889772 0.326 NM_018059
RADIL
Ras association and DIL domains
chrX_-_47394808 0.325 ELK1
ELK1, member of ETS oncogene family
chr1_+_22224571 0.325 HSPC157
hypothetical LOC29092
chrX_+_111212908 0.323 NM_001004308
ZCCHC16
zinc finger, CCHC domain containing 16
chrX_+_52797004 0.321 NM_003147
NM_175698
NM_001164417
SSX2

SSX2B
synovial sarcoma, X breakpoint 2

synovial sarcoma, X breakpoint 2B
chr7_-_27180398 0.320 NM_018951
HOXA10
homeobox A10
chr17_+_4348877 0.319 NM_001124758
SPNS2
spinster homolog 2 (Drosophila)
chr5_-_149515331 0.319 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr17_-_44641741 0.319 NM_031498
NM_001198755
NM_001198756
GNGT2


guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2


chr17_+_4795128 0.317 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr1_+_152566899 0.315 NM_020452
ATP8B2
ATPase, class I, type 8B, member 2
chr18_+_2896178 0.314 EMILIN2
elastin microfibril interfacer 2
chr18_+_2896956 0.314 EMILIN2
elastin microfibril interfacer 2
chr7_+_94130752 0.314 PEG10
paternally expressed 10
chr11_-_3035172 0.314 NM_001014437
NM_001194997
NM_001751
NM_139273
CARS



cysteinyl-tRNA synthetase



chr15_-_76720598 0.313 NM_000750
CHRNB4
cholinergic receptor, nicotinic, beta 4
chr12_-_131256525 0.313 NM_021808
GALNT9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
chr10_+_5556923 0.313 NM_005185
CALML3
calmodulin-like 3
chr5_+_175017705 0.312 HRH2
histamine receptor H2
chr2_-_80384454 0.311 LRRTM1
leucine rich repeat transmembrane neuronal 1
chr5_+_176449156 0.310 NM_022963
FGFR4
fibroblast growth factor receptor 4
chrX_-_52752935 0.309 NM_003147
NM_175698
NM_001164417
SSX2

SSX2B
synovial sarcoma, X breakpoint 2

synovial sarcoma, X breakpoint 2B
chr21_+_44534575 0.309 NM_000658
AIRE
autoimmune regulator
chr3_+_47004457 0.308 NBEAL2
neurobeachin-like 2
chr7_-_27191287 0.308 NM_005523
HOXA11
homeobox A11
chr8_-_86762977 0.307 NM_172239
REXO1L1
REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 1
chr1_+_148090804 0.305 NM_021059
NM_001005464
HIST2H3C
HIST2H3A
histone cluster 2, H3c
histone cluster 2, H3a
chr16_+_87232501 0.303 NM_013278
IL17C
interleukin 17C
chr19_-_15436333 0.303 NM_022904
RASAL3
RAS protein activator like 3
chr7_+_68702252 0.302 AUTS2
autism susceptibility candidate 2
chrX_+_151837064 0.300 NM_001178113
ZNF185
zinc finger protein 185 (LIM domain)
chr1_+_1104939 0.299 NM_153254
TTLL10
tubulin tyrosine ligase-like family, member 10
chr1_-_151784889 0.298 NM_002961
NM_019554
S100A4

S100 calcium binding protein A4

chr5_-_37285160 0.297 NM_023073
C5orf42
chromosome 5 open reading frame 42
chr2_+_131692393 0.297 NM_001083538
POTEE
POTE ankyrin domain family, member E
chrX_-_53367246 0.295 NM_001111125
IQSEC2
IQ motif and Sec7 domain 2
chr11_-_45643711 0.295 NM_003654
CHST1
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
chr22_+_38090120 0.294 NM_145738
SYNGR1
synaptogyrin 1
chrX_+_51944658 0.292 NM_001098800
NM_030801
NM_177535
NM_177537
MAGED4
MAGED4B


melanoma antigen family D, 4
melanoma antigen family D, 4B


chrX_+_101792949 0.292 NM_001099410
NM_001099411
NM_014710
NM_001184727
GPRASP1



G protein-coupled receptor associated sorting protein 1



chr9_-_114692782 0.288 NM_033051
SLC46A2
solute carrier family 46, member 2
chr15_+_67393795 0.287 NM_001104554
PAQR5
progestin and adipoQ receptor family member V
chr3_-_46481346 0.285 NM_002343
LTF
lactotransferrin
chr17_+_45008473 0.283 NXPH3
neurexophilin 3
chr1_+_43539239 0.282 NM_005424
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr14_+_92049396 0.282 NM_024832
RIN3
Ras and Rab interactor 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.30 7.87e-03 GO:0023051 regulation of signaling

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.64 1.22e-02 GO:0015629 actin cytoskeleton
1.42 3.39e-02 GO:0030054 cell junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 3.86e-04 GO:0005515 protein binding