Motif ID: POU6F1.p2

Z-value: 0.951


Transcription factors associated with POU6F1.p2:

Gene SymbolEntrez IDGene Name
POU6F1 5463 POU class 6 homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU6F1chr12_-_49897743-0.401.3e-01Click!


Activity profile for motif POU6F1.p2.

activity profile for motif POU6F1.p2


Sorted Z-values histogram for motif POU6F1.p2

Sorted Z-values for motif POU6F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU6F1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_95794416 2.738 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr7_-_96471544 2.261 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr7_-_92693716 1.576 NM_001039372
HEPACAM2
HEPACAM family member 2
chr22_+_38652555 1.426 GRAP2
GRB2-related adaptor protein 2
chr10_+_77212524 1.390 NM_032024
C10orf11
chromosome 10 open reading frame 11
chr14_-_60022487 1.382 NM_174978
C14orf39
chromosome 14 open reading frame 39
chr6_+_105511615 1.212 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr10_+_29617995 1.190 NM_032517
LYZL1
lysozyme-like 1
chr8_-_67253234 1.133 NM_000756
CRH
corticotropin releasing hormone
chr6_+_47857733 1.070 NM_181744
OPN5
opsin 5
chr6_+_7524691 1.052 DSP
desmoplakin
chr3_-_13032130 1.048


chr10_-_30958631 1.043 NM_183058
LYZL2
lysozyme-like 2
chr18_-_55136673 1.037 NM_181654
CPLX4
complexin 4
chr11_-_83071084 1.035 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr3_-_191650291 0.955 NM_207316
TMEM207
transmembrane protein 207
chr9_+_21399132 0.913 NM_002170
IFNA8
interferon, alpha 8
chr15_+_72209973 0.904 ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr6_+_127940011 0.901 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr3_-_114047479 0.891 NM_001008784
CD200R1L
CD200 receptor 1-like
chr13_+_42253685 0.872 NM_182508
C13orf30
chromosome 13 open reading frame 30
chr15_+_72209795 0.871 NM_020851
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr20_-_49747397 0.851 ATP9A
ATPase, class II, type 9A
chr3_+_129682434 0.833


chr6_-_132980901 0.802 NM_014626
TAAR2
trace amine associated receptor 2
chr13_+_112746908 0.783 MCF2L
MCF.2 cell line derived transforming sequence-like
chr7_+_38984133 0.734 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chrX_-_106033202 0.711 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chr17_-_36209672 0.700 NM_181535
KRT28
keratin 28
chr7_+_93373755 0.674 NM_021955
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr7_+_18296569 0.663 HDAC9
histone deacetylase 9
chr8_-_125252884 0.657 C8orf78
chromosome 8 open reading frame 78
chr11_-_26550243 0.628 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr5_-_137502975 0.628 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr10_-_128199986 0.626 NM_001004298
C10orf90
chromosome 10 open reading frame 90
chr1_+_111818111 0.625 NM_174896
C1orf162
chromosome 1 open reading frame 162
chr1_-_195302973 0.616 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr6_-_26216299 0.614 NM_005323
HIST1H1T
histone cluster 1, H1t
chr1_-_116112684 0.607 CASQ2
calsequestrin 2 (cardiac muscle)
chr4_-_145281237 0.606 NM_002099
GYPA
glycophorin A (MNS blood group)
chr15_-_100280784 0.603 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr3_+_99555387 0.600 NM_001005517
OR5K4
olfactory receptor, family 5, subfamily K, member 4
chr8_-_114518194 0.593 NM_052900
NM_198123
CSMD3

CUB and Sushi multiple domains 3

chr14_-_56342097 0.586 NM_172337
OTX2
orthodenticle homeobox 2
chr9_-_34448477 0.581 NM_001184940
NM_001184941
NM_001184942
NM_001184943
NM_001184944
NM_001184945
NM_147202
C9orf25






chromosome 9 open reading frame 25






chr1_-_116112853 0.574 CASQ2
calsequestrin 2 (cardiac muscle)
chr6_+_72653126 0.570 RIMS1
regulating synaptic membrane exocytosis 1
chr10_+_96433240 0.565 NM_000772
NM_001128925
CYP2C18

cytochrome P450, family 2, subfamily C, polypeptide 18

chr4_+_78651929 0.555 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr22_-_38619739 0.546 NM_152512
ENTHD1
ENTH domain containing 1
chr14_-_57030227 0.544 NM_018168
C14orf105
chromosome 14 open reading frame 105
chr1_-_116112921 0.543 NM_001232
CASQ2
calsequestrin 2 (cardiac muscle)
chr9_+_34448810 0.540 NM_012144
DNAI1
dynein, axonemal, intermediate chain 1
chr8_+_17440664 0.539 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr4_-_145159889 0.527 NM_002100
GYPB
glycophorin B (MNS blood group)
chr10_+_68355797 0.513 NM_178011
LRRTM3
leucine rich repeat transmembrane neuronal 3
chr3_-_18455207 0.510 NM_001131010
SATB1
SATB homeobox 1
chr1_+_58899 0.504 NM_001005484
OR4F4
OR4F5
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 5
chr4_+_42590038 0.499 NM_001080476
GRXCR1
glutaredoxin, cysteine rich 1
chr3_+_129124591 0.498 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr6_+_72983183 0.492 NM_001168410
RIMS1
regulating synaptic membrane exocytosis 1
chr11_+_69176391 0.491 CCND1
cyclin D1
chr19_+_61624 0.486 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr4_-_122304925 0.485 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr22_+_21116283 0.484


chr8_-_13018123 0.477 NM_001164271
DLC1
deleted in liver cancer 1
chr6_+_72982865 0.468 NM_001168409
RIMS1
regulating synaptic membrane exocytosis 1
chr1_-_67366807 0.459 NM_001013674
C1orf141
chromosome 1 open reading frame 141
chr7_+_94135384 0.457 PEG10
paternally expressed 10
chr12_+_108310906 0.454 NM_001101421
MYO1H
myosin IH
chr10_+_90474280 0.437 NM_001080518
LIPK
lipase, family member K
chr7_-_93027057 0.436 NM_001164738
CALCR
calcitonin receptor
chrX_+_48572226 0.435 NM_181532
ERAS
ES cell expressed Ras
chr11_-_123758448 0.435 NM_001005468
OR8B2
olfactory receptor, family 8, subfamily B, member 2
chr5_+_139485703 0.424 NM_001007189
C5orf53
chromosome 5 open reading frame 53
chr1_+_151270301 0.419 NM_003125
SPRR1B
small proline-rich protein 1B
chr8_-_93181091 0.412 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr8_-_30826074 0.406 NM_031271
TEX15
testis expressed 15
chr11_-_57927457 0.401 NM_001005469
OR5B3
olfactory receptor, family 5, subfamily B, member 3
chr11_+_58467297 0.393 NM_080661
GLYATL1
glycine-N-acyltransferase-like 1
chr1_-_120189301 0.391 NM_001047980
NBPF7
neuroblastoma breakpoint family, member 7
chr13_+_77007809 0.388 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr11_-_111636792 0.388 NM_001145024
C11orf34
chromosome 11 open reading frame 34
chrX_-_55074125 0.385 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr2_+_38009405 0.382 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chr4_-_152368492 0.379 SH3D19
SH3 domain containing 19
chr7_-_50596238 0.376 NM_000790
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr5_-_145232723 0.376 NM_001080516
GRXCR2
glutaredoxin, cysteine rich 2
chr12_+_54172413 0.372 NM_001005519
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chr4_+_41309668 0.366 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr1_+_100776280 0.365 NM_022049
GPR88
G protein-coupled receptor 88
chr3_-_112796855 0.360 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr12_+_50271283 0.359 NM_014191
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chrX_+_46938215 0.356 UBA1
ubiquitin-like modifier activating enzyme 1
chr4_+_41309482 0.341 LIMCH1
LIM and calponin homology domains 1
chr8_-_59575249 0.338 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr2_-_72224696 0.332 CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chrX_+_28515479 0.331 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr9_+_19280748 0.331 NM_017925
DENND4C
DENN/MADD domain containing 4C
chr9_-_124981125 0.328 STRBP
spermatid perinuclear RNA binding protein
chr2_+_27652892 0.325 NM_032266
C2orf16
chromosome 2 open reading frame 16
chr1_+_178466064 0.320 NM_033343
LHX4
LIM homeobox 4
chr12_+_20854904 0.318 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr5_-_75954807 0.317 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr10_-_17211795 0.311 NM_001081
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr11_-_11331411 0.307 CSNK2A1P
casein kinase 2, alpha 1 polypeptide pseudogene
chr3_+_143858428 0.306 NM_001172312
PLS1
plastin 1
chr7_+_133862883 0.306 NM_020299
AKR1B10
aldo-keto reductase family 1, member B10 (aldose reductase)
chrX_+_46938136 0.305 NM_003334
UBA1
ubiquitin-like modifier activating enzyme 1
chr1_-_229071957 0.305 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr4_+_41309690 0.303 LIMCH1
LIM and calponin homology domains 1
chr7_+_72034735 0.301 POM121
POM121 membrane glycoprotein
chr7_-_83116414 0.298 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr3_-_152641248 0.295 NM_001178145
NM_001178146
IGSF10

immunoglobulin superfamily, member 10

chr2_-_138762909 0.295


chr1_-_161380562 0.294 RGS5
regulator of G-protein signaling 5
chr3_+_187813553 0.293 AHSG
alpha-2-HS-glycoprotein
chr13_-_45577144 0.291 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr2_+_158666627 0.290 NM_173355
UPP2
uridine phosphorylase 2
chr9_+_80134302 0.289 PSAT1
phosphoserine aminotransferase 1
chrX_+_46938171 0.283 UBA1
ubiquitin-like modifier activating enzyme 1
chr1_-_158815895 0.282 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr18_+_59295123 0.280 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr9_-_21177529 0.279 NM_021068
IFNA4
interferon, alpha 4
chr1_+_61642287 0.276 NFIA
nuclear factor I/A
chr7_-_38279757 0.274 NM_001003799
NM_001003806
TARP

TRGV9
TCR gamma alternate reading frame protein

T cell receptor gamma variable 9
chr3_+_131761867 0.272 NM_001102608
COL6A6
collagen, type VI, alpha 6
chr8_-_91164100 0.270 NM_004929
CALB1
calbindin 1, 28kDa
chr13_-_25687062 0.266 RNF6
ring finger protein (C3H2C3 type) 6
chr8_-_124818754 0.264 NM_001003954
NM_004306
ANXA13

annexin A13

chr2_-_21081694 0.264 APOB
apolipoprotein B (including Ag(x) antigen)
chr16_-_3291378 0.260 NM_033208
TIGD7
tigger transposable element derived 7
chr1_+_158603480 0.260 NM_005598
NHLH1
nescient helix loop helix 1
chr1_-_76170563 0.259 NM_080868
ASB17
ankyrin repeat and SOCS box containing 17
chr2_-_180319013 0.258 NM_001113397
ZNF385B
zinc finger protein 385B
chr21_-_26269298 0.258 APP
amyloid beta (A4) precursor protein
chr12_+_52126131 0.256 PRR13
proline rich 13
chr1_+_160599396 0.248 NM_001126060
NOS1AP
nitric oxide synthase 1 (neuronal) adaptor protein
chr3_+_46717826 0.245 NM_147196
TMIE
transmembrane inner ear
chr1_+_67545634 0.244 NM_001559
IL12RB2
interleukin 12 receptor, beta 2
chrX_+_41433169 0.241 NM_001097579
NM_005300
GPR34

G protein-coupled receptor 34

chr4_+_22303645 0.240 NM_001128432
NM_020973
GBA3

glucosidase, beta, acid 3 (cytosolic)

chr6_+_132933153 0.239 NM_175067
TAAR6
trace amine associated receptor 6
chrX_+_46938157 0.237 UBA1
ubiquitin-like modifier activating enzyme 1
chr11_-_58736897 0.236 NM_001039396
MPEG1
macrophage expressed 1
chr3_+_35658852 0.235 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr14_-_20098929 0.233 NM_001001673
NM_001110356
NM_001110357
NM_001110358
NM_001110359
NM_001110360
NM_001110361
RNASE9






ribonuclease, RNase A family, 9 (non-active)






chr5_+_92944680 0.230 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr19_+_24061717 0.227 NM_203282
ZNF254
zinc finger protein 254
chr11_+_22646229 0.221 NM_177553
GAS2
growth arrest-specific 2
chr12_+_21175394 0.221 NM_006446
SLCO1B1
solute carrier organic anion transporter family, member 1B1
chr5_-_145503190 0.218 LARS
leucyl-tRNA synthetase
chr7_+_120490054 0.218 C7orf58
chromosome 7 open reading frame 58
chr10_+_83627422 0.217 NM_001165973
NRG3
neuregulin 3
chr5_+_125786717 0.215 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr3_+_99350859 0.214 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr1_-_116184846 0.214 NM_001111061
NHLH2
nescient helix loop helix 2
chr3_+_162697289 0.213 NM_001080440
OTOL1
otolin 1 homolog (zebrafish)
chr18_-_58946858 0.213 BCL2
B-cell CLL/lymphoma 2
chr17_+_46176105 0.210 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr19_-_22171592 0.209 NM_001001411
ZNF676
zinc finger protein 676
chrX_+_46938178 0.209 UBA1
ubiquitin-like modifier activating enzyme 1
chr17_+_17548888 0.208


chr15_-_48626193 0.205 NM_203494
USP50
ubiquitin specific peptidase 50
chr4_-_24641404 0.203 NM_018176
LGI2
leucine-rich repeat LGI family, member 2
chr4_+_35962038 0.201 NM_001170700
DTHD1
death domain containing 1
chr14_-_105623358 0.198 IGHA1
IGHD
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
chr18_-_28606839 0.197 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr11_-_56166490 0.196 NM_001002925
OR5AP2
olfactory receptor, family 5, subfamily AP, member 2
chr1_+_234748187 0.195 NM_201545
LGALS8
lectin, galactoside-binding, soluble, 8
chr6_+_30238961 0.195 NM_033229
TRIM15
tripartite motif containing 15
chr4_+_74497998 0.194 ALB
albumin
chr1_-_150044365 0.194 NM_001004432
LINGO4
leucine rich repeat and Ig domain containing 4
chr1_-_214963279 0.193 NM_001438
ESRRG
estrogen-related receptor gamma
chr3_+_192413015 0.192 NM_198184
OSTN
osteocrin
chr2_+_161701711 0.192 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr19_-_51236113 0.191 NM_001002923
IGFL4
IGF-like family member 4
chr20_+_71230 0.190 NM_030931
DEFB126
defensin, beta 126
chr7_+_142539291 0.190 NM_002652
PIP
prolactin-induced protein
chr2_-_121964373 0.189 CLASP1
cytoplasmic linker associated protein 1
chr16_+_4842077 0.189 NM_016936
UBN1
ubinuclein 1
chr5_+_161207262 0.186 NM_001127643
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr12_-_4358968 0.186 NM_020638
FGF23
fibroblast growth factor 23
chrX_+_150635162 0.186 NM_033085
FATE1
fetal and adult testis expressed 1
chr8_+_80685927 0.186 STMN2
stathmin-like 2
chr11_+_122214415 0.185 NM_019604
CRTAM
cytotoxic and regulatory T cell molecule
chr8_+_80685931 0.183 NM_007029
STMN2
stathmin-like 2
chr9_+_35031101 0.182 NM_001040411
NM_001040412
C9orf131

chromosome 9 open reading frame 131

chr7_-_27125738 0.182 NM_030661
HOXA3
homeobox A3
chr1_+_66230977 0.181 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr12_-_11106159 0.180 NM_176887
TAS2R46
taste receptor, type 2, member 46
chr2_+_88966170 0.177


chr1_-_34404029 0.176 NM_052896
CSMD2
CUB and Sushi multiple domains 2
chr11_-_59390518 0.176 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr5_+_176449156 0.175 NM_022963
FGFR4
fibroblast growth factor receptor 4
chrX_+_135106578 0.172 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr4_+_74498042 0.169 ALB
albumin
chr11_+_5466490 0.169 NM_001005163
OR52D1
olfactory receptor, family 52, subfamily D, member 1
chr11_-_123772456 0.168 NM_001005467
OR8B3
olfactory receptor, family 8, subfamily B, member 3
chr17_-_44400952 0.167 NM_004123
GIP
gastric inhibitory polypeptide

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.01 2.46e-14 GO:0007606 sensory perception of chemical stimulus
3.69 3.46e-10 GO:0007608 sensory perception of smell
2.76 6.48e-10 GO:0007600 sensory perception
2.06 1.04e-08 GO:0003008 system process
2.19 3.19e-08 GO:0050877 neurological system process
1.49 3.69e-08 GO:0032501 multicellular organismal process
1.27 2.25e-02 GO:0050896 response to stimulus
19.62 3.21e-02 GO:0007635 chemosensory behavior
6.39 3.96e-02 GO:0050909 sensory perception of taste

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.58 2.99e-09 GO:0005886 plasma membrane
1.56 5.45e-09 GO:0071944 cell periphery
1.66 1.28e-04 GO:0005576 extracellular region
1.30 1.41e-04 GO:0044425 membrane part
1.21 5.13e-03 GO:0016020 membrane
1.28 6.02e-03 GO:0031224 intrinsic to membrane
1.28 8.89e-03 GO:0016021 integral to membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.97 1.54e-13 GO:0004930 G-protein coupled receptor activity
3.77 7.11e-11 GO:0004984 olfactory receptor activity
2.10 2.57e-10 GO:0004872 receptor activity
2.28 1.00e-09 GO:0004888 transmembrane receptor activity
1.90 8.19e-09 GO:0004871 signal transducer activity
1.90 8.19e-09 GO:0060089 molecular transducer activity
6.01 4.28e-02 GO:0003823 antigen binding