Motif ID: RFX1..5_RFXANK_RFXAP.p2

Z-value: 1.555


Transcription factors associated with RFX1..5_RFXANK_RFXAP.p2:

Gene SymbolEntrez IDGene Name
RFX1 5989 regulatory factor X, 1 (influences HLA class II expression)
RFX2 5990 regulatory factor X, 2 (influences HLA class II expression)
RFX3 5991 regulatory factor X, 3 (influences HLA class II expression)
RFX4 5992 regulatory factor X, 4 (influences HLA class II expression)
RFX5 5993 regulatory factor X, 5 (influences HLA class II expression)
RFXANK 8625 regulatory factor X-associated ankyrin-containing protein
RFXAP 5994 regulatory factor X-associated protein

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RFX2chr19_-_60614910.775.1e-04Click!
RFX4chr12_+_1055190490.533.5e-02Click!
RFX3chr9_-_3515973-0.467.2e-02Click!
RFXANKchr19_+_191646490.342.0e-01Click!
RFX5chr1_-_1495863410.253.5e-01Click!
RFXAPchr13_+_36291306-0.233.9e-01Click!
RFX1chr19_-_139778750.204.7e-01Click!


Activity profile for motif RFX1..5_RFXANK_RFXAP.p2.

activity profile for motif RFX1..5_RFXANK_RFXAP.p2


Sorted Z-values histogram for motif RFX1..5_RFXANK_RFXAP.p2

Sorted Z-values for motif RFX1..5_RFXANK_RFXAP.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RFX1..5_RFXANK_RFXAP.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_61618276 2.369 NM_145036
CCDC46
coiled-coil domain containing 46
chr2_-_187422141 2.226 NM_182521
ZSWIM2
zinc finger, SWIM-type containing 2
chr17_-_58239382 2.104 NM_152598
MARCH10
membrane-associated ring finger (C3HC4) 10
chr11_+_93885342 1.812 NM_001190462
LOC643037
hypothetical protein LOC643037
chr2_+_27046952 1.651 NM_012326
MAPRE3
microtubule-associated protein, RP/EB family, member 3
chr1_-_33669190 1.430 PHC2
polyhomeotic homolog 2 (Drosophila)
chr14_-_88087575 1.395 PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr13_-_95092283 1.381 DZIP1
DAZ interacting protein 1
chr5_-_149649593 1.349 NM_015981
NM_171825
CAMK2A

calcium/calmodulin-dependent protein kinase II alpha

chr5_+_92944680 1.332 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr3_-_139315011 1.307 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr11_+_110890719 1.283 NM_001100388
NM_207430
C11orf88

chromosome 11 open reading frame 88

chr6_+_109276280 1.277 NM_032131
ARMC2
armadillo repeat containing 2
chrX_-_48578878 1.246 NM_013271
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr1_+_42701460 1.191 CCDC30
coiled-coil domain containing 30
chr19_-_51666503 1.142 PNMAL1
PNMA-like 1
chr10_-_116382089 1.129 ABLIM1
actin binding LIM protein 1
chr5_-_54565181 1.121 NM_021147
CCNO
cyclin O
chr16_-_65984836 1.077 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr19_-_51690989 1.071 NM_020709
PNMAL2
PNMA-like 2
chr16_-_56393871 1.060 KIFC3
kinesin family member C3
chr11_+_101423378 1.040 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr13_-_43259032 1.019 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr19_-_51666629 1.012 NM_001103149
NM_018215
PNMAL1

PNMA-like 1

chr5_-_149649380 1.005 CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr1_-_202647526 0.981 NM_032833
PPP1R15B
protein phosphatase 1, regulatory (inhibitor) subunit 15B
chr16_+_3002457 0.973 NM_020982
CLDN9
claudin 9
chr14_+_99329198 0.962 NM_001008707
NM_004434
EML1

echinoderm microtubule associated protein like 1

chr17_+_75625025 0.962 NM_017950
CCDC40
coiled-coil domain containing 40
chr2_-_175578156 0.962 NM_001025201
NM_001822
CHN1

chimerin (chimaerin) 1

chr2_+_228444570 0.955 NM_178821
WDR69
WD repeat domain 69
chr16_-_56393881 0.936 NM_001130100
NM_005550
KIFC3

kinesin family member C3

chr6_-_32227695 0.934 NM_030651
PRRT1
proline-rich transmembrane protein 1
chr17_+_39437439 0.934 NM_153006
NAGS
N-acetylglutamate synthase
chr17_+_52026058 0.926 NM_005450
NOG
noggin
chr3_-_139531417 0.891 NM_178130
TXNDC6
thioredoxin domain containing 6
chr16_+_56230707 0.886 NM_001145774
GPR56
G protein-coupled receptor 56
chrX_+_53095230 0.866 NM_018969
GPR173
G protein-coupled receptor 173
chr2_+_48521411 0.854 NM_001135629
NM_001193475
NM_152994
KLRAQ1


KLRAQ motif containing 1


chr4_+_87734489 0.854 NM_006264
NM_080683
NM_080684
NM_080685
PTPN13



protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)



chr1_-_158182006 0.845 NM_001135050
NM_020789
IGSF9

immunoglobulin superfamily, member 9

chr14_+_105063975 0.829 NM_025268
TMEM121
transmembrane protein 121
chr4_+_128773529 0.827 NM_015693
INTU
inturned planar cell polarity effector homolog (Drosophila)
chr13_-_51601214 0.817 NM_199289
NEK5
NIMA (never in mitosis gene a)-related kinase 5
chr11_-_6998041 0.815 NM_013249
ZNF214
zinc finger protein 214
chr9_+_123501186 0.814 DAB2IP
DAB2 interacting protein
chr16_-_66007650 0.803 NM_013304
ZDHHC1
zinc finger, DHHC-type containing 1
chr11_+_6998275 0.794 NM_176822
NLRP14
NLR family, pyrin domain containing 14
chr9_-_109291866 0.790 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr5_-_14064846 0.773 DNAH5
dynein, axonemal, heavy chain 5
chr5_-_114533448 0.761 TRIM36
tripartite motif containing 36
chr16_+_56219802 0.753 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr6_-_46728188 0.752 NM_016593
CYP39A1
cytochrome P450, family 39, subfamily A, polypeptide 1
chr11_-_114880275 0.750 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr6_-_32227645 0.741 PRRT1
proline-rich transmembrane protein 1
chr1_-_6480058 0.728 NM_001042663
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr13_+_35904408 0.728 NM_001111045
NM_003914
CCNA1

cyclin A1

chr11_+_7997366 0.697 TUB
tubby homolog (mouse)
chr6_+_46728590 0.687 NM_004277
SLC25A27
solute carrier family 25, member 27
chr1_-_24612742 0.680 NM_001199013
NM_001199014
NM_178122
C1orf201


chromosome 1 open reading frame 201


chr10_+_124020810 0.674 NM_144587
BTBD16
BTB (POZ) domain containing 16
chr11_-_118757574 0.657 NM_004205
USP2
ubiquitin specific peptidase 2
chr3_-_41978464 0.655 NM_017886
ULK4
unc-51-like kinase 4 (C. elegans)
chr15_+_94674849 0.655 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr1_-_48710378 0.655 NM_019073
SPATA6
spermatogenesis associated 6
chr12_-_88270369 0.653 DUSP6
dual specificity phosphatase 6
chr17_-_39437362 0.650 NM_004160
PYY
peptide YY
chrX_-_99778340 0.645 NM_003270
TSPAN6
tetraspanin 6
chr22_-_16887151 0.644 NM_001122731
NM_001136004
NM_015241
MICAL3


microtubule associated monoxygenase, calponin and LIM domain containing 3


chr1_-_6480035 0.644 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr12_-_88270375 0.642 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr19_+_44308224 0.635 NM_001014831
NM_001014832
NM_001014834
NM_001014835
NM_005884
PAK4




p21 protein (Cdc42/Rac)-activated kinase 4




chr3_+_159771646 0.627 NM_001130156
NM_001130157
NM_001195432
NM_001195433
NM_001195434
NM_022443
MLF1





myeloid leukemia factor 1





chr1_+_153413675 0.626 TRIM46
tripartite motif containing 46
chr11_-_118757477 0.621 USP2
ubiquitin specific peptidase 2
chr11_+_85763425 0.619 NM_001156474
NM_021827
CCDC81

coiled-coil domain containing 81

chr16_+_2016807 0.618 NM_001130012
NM_004785
SLC9A3R2

solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2

chr7_-_44195405 0.615 NM_000162
GCK
glucokinase (hexokinase 4)
chr5_+_34875025 0.613 NM_144725
TTC23L
tetratricopeptide repeat domain 23-like
chr6_-_35216981 0.609 NM_001093728
NM_018679
TCP11

t-complex 11 homolog (mouse)

chr9_-_109291575 0.599 KLF4
Kruppel-like factor 4 (gut)
chr12_-_88270128 0.582 DUSP6
dual specificity phosphatase 6
chr19_+_60857227 0.578 NM_001012478
NM_007279
U2AF2

U2 small nuclear RNA auxiliary factor 2

chr1_-_48710263 0.572 SPATA6
spermatogenesis associated 6
chr9_+_134275431 0.570 NM_207417
C9orf171
chromosome 9 open reading frame 171
chr14_+_105012106 0.567 NM_001312
CRIP2
cysteine-rich protein 2
chr5_-_159730196 0.562 NM_031908
C1QTNF2
C1q and tumor necrosis factor related protein 2
chr1_-_167663278 0.553 NM_021179
C1orf114
chromosome 1 open reading frame 114
chr5_+_157031138 0.549 NM_001145132
C5orf52
chromosome 5 open reading frame 52
chr3_+_184648089 0.542 LOC100505687
hypothetical LOC100505687
chr10_+_105243724 0.541 NM_004210
NEURL
neuralized homolog (Drosophila)
chr11_+_102485293 0.535 NM_001080463
NM_001377
DYNC2H1

dynein, cytoplasmic 2, heavy chain 1

chr18_+_30544193 0.534 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr20_+_9963696 0.523 NM_022096
NM_198798
ANKRD5

ankyrin repeat domain 5

chr19_-_15421761 0.520 NM_021241
WIZ
widely interspaced zinc finger motifs
chr12_+_8958397 0.515 NM_004426
PHC1
polyhomeotic homolog 1 (Drosophila)
chr17_-_40339919 0.511 GFAP
glial fibrillary acidic protein
chr11_+_131285747 0.511 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr1_+_34098662 0.509 NM_145205
HMGB4
high-mobility group box 4
chr11_+_133444175 0.506 JAM3
junctional adhesion molecule 3
chr20_-_49612745 0.503 NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr5_-_142046175 0.501 NM_033136
FGF1
fibroblast growth factor 1 (acidic)
chr5_+_172000793 0.499 NM_001142651
NEURL1B
neuralized homolog 1B (Drosophila)
chr11_-_75056761 0.489 MAP6
microtubule-associated protein 6
chr12_+_124377114 0.488 NM_052907
TMEM132B
transmembrane protein 132B
chr22_-_36679479 0.478 NM_032561
C22orf23
chromosome 22 open reading frame 23
chr8_-_49810270 0.475 NM_001142857
NM_024593
EFCAB1

EF-hand calcium binding domain 1

chr11_+_66499323 0.469 NM_001136485
C11orf86
chromosome 11 open reading frame 86
chr6_-_2787111 0.461 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr5_-_16795336 0.459 MYO10
myosin X
chr10_+_63092724 0.456 NM_173554
C10orf107
chromosome 10 open reading frame 107
chr5_-_157031022 0.453 SOX30
SRY (sex determining region Y)-box 30
chr17_-_6675731 0.449 NM_053285
TEKT1
tektin 1
chr11_-_5916424 0.445 TRIM5
tripartite motif containing 5
chr6_-_43585958 0.445 C6orf154
chromosome 6 open reading frame 154
chr20_-_49612574 0.424 NM_001136021
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr16_+_29731058 0.423 PRRT2
proline-rich transmembrane protein 2
chr11_-_75057299 0.423 MAP6
microtubule-associated protein 6
chr1_-_6468108 0.420 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr21_+_45532377 0.418 LOC642852
hypothetical LOC642852
chr7_+_129919157 0.416 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr12_-_25597444 0.416 NM_152590
NM_001145728
NM_001145729
IFLTD1


intermediate filament tail domain containing 1


chr6_+_143423656 0.413 NM_016108
AIG1
androgen-induced 1
chr6_-_2787068 0.409 NM_030666
SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr7_+_129919134 0.408 MEST
mesoderm specific transcript homolog (mouse)
chrX_-_13957879 0.404 NM_001042479
NM_001042480
NM_017856
GEMIN8


gem (nuclear organelle) associated protein 8


chr17_-_71648965 0.399 NM_001454
FOXJ1
forkhead box J1
chr8_-_133756943 0.398 NM_012472
LRRC6
leucine rich repeat containing 6
chr20_-_3710060 0.397 NM_015417
SPEF1
sperm flagellar 1
chr3_-_171013000 0.393 LRRC34
leucine rich repeat containing 34
chr4_-_177353707 0.387 NM_144644
SPATA4
spermatogenesis associated 4
chr1_+_33319287 0.386 NM_052998
ADC
arginine decarboxylase
chr20_+_42593849 0.384 NM_007066
NM_181804
NM_181805
PKIG


protein kinase (cAMP-dependent, catalytic) inhibitor gamma


chr22_+_21742364 0.384 NM_002073
GNAZ
guanine nucleotide binding protein (G protein), alpha z polypeptide
chr6_+_117044334 0.383 NM_001010892
NM_001161664
RSPH4A

radial spoke head 4 homolog A (Chlamydomonas)

chrX_-_71268475 0.380 NM_001024455
RGAG4
retrotransposon gag domain containing 4
chr4_+_3264509 0.379 RGS12
regulator of G-protein signaling 12
chr1_-_176273680 0.378 LOC730102
quinone oxidoreductase-like protein 2 pseudogene
chr1_-_43509187 0.377 EBNA1BP2
EBNA1 binding protein 2
chr2_-_201930311 0.376 NM_001127391
NM_139163
ALS2CR12

amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12

chr9_-_35818728 0.376 NM_001012446
C9orf128
chromosome 9 open reading frame 128
chr3_+_38055699 0.374 NM_007335
NM_007337
DLEC1

deleted in lung and esophageal cancer 1

chr7_-_157054403 0.373 PTPRN2
protein tyrosine phosphatase, receptor type, N polypeptide 2
chr11_+_45899747 0.370 NM_152312
GYLTL1B
glycosyltransferase-like 1B
chr15_+_73803351 0.363 NM_175881
ODF3L1
outer dense fiber of sperm tails 3-like 1
chr1_-_171905593 0.362 NM_198493
ANKRD45
ankyrin repeat domain 45
chr3_+_156280129 0.362 NM_000902
MME
membrane metallo-endopeptidase
chr7_+_30777512 0.355 NM_032222
FAM188B
family with sequence similarity 188, member B
chr10_-_123343320 0.351 NM_001144913
NM_001144914
FGFR2

fibroblast growth factor receptor 2

chr6_+_143423738 0.350 AIG1
androgen-induced 1
chr1_-_158136521 0.349 NM_012337
CCDC19
coiled-coil domain containing 19
chr5_-_142045770 0.349 NM_000800
FGF1
fibroblast growth factor 1 (acidic)
chr17_-_39211706 0.347 NM_004090
DUSP3
dual specificity phosphatase 3
chr6_+_143423723 0.343 AIG1
androgen-induced 1
chr1_+_15608974 0.343 NM_024329
EFHD2
EF-hand domain family, member D2
chr22_+_21742727 0.343 GNAZ
guanine nucleotide binding protein (G protein), alpha z polypeptide
chr2_-_26717713 0.343 NM_001029881
CIB4
calcium and integrin binding family member 4
chrX_-_150893752 0.342 NM_004961
GABRE
gamma-aminobutyric acid (GABA) A receptor, epsilon
chr7_+_129919330 0.341 MEST
mesoderm specific transcript homolog (mouse)
chr4_-_171161486 0.341 NM_001009554
MFAP3L
microfibrillar-associated protein 3-like
chr1_+_201862845 0.337 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr3_-_71860958 0.335 NM_001134650
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr11_-_10519265 0.331 NM_016422
RNF141
ring finger protein 141
chr22_-_41815277 0.327 NM_012263
TTLL1
tubulin tyrosine ligase-like family, member 1
chr12_+_50104859 0.326 NM_001039960
NM_004858
SLC4A8

solute carrier family 4, sodium bicarbonate cotransporter, member 8

chr5_-_1165106 0.325 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr11_+_31347947 0.324 NM_181706
DNAJC24
DnaJ (Hsp40) homolog, subfamily C, member 24
chr2_-_130619038 0.322 NM_207310
CCDC74B
coiled-coil domain containing 74B
chr1_+_207926172 0.319 NM_181755
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr6_-_76051351 0.319 NM_001143958
NM_018247
TMEM30A

transmembrane protein 30A

chr2_-_182229977 0.319 NM_001030311
NM_001030312
NM_001030313
NM_001160277
NM_201548
CERKL




ceramide kinase-like




chr12_-_62348506 0.318 NM_173812
DPY19L2
dpy-19-like 2 (C. elegans)
chr19_-_63775901 0.316 MZF1
myeloid zinc finger 1
chr3_+_151171755 0.315 LOC646903
hypothetical LOC646903
chr17_-_959007 0.313 NM_001092
ABR
active BCR-related gene
chr1_+_15609009 0.311 EFHD2
EF-hand domain family, member D2
chr1_+_201711578 0.310 PRELP
proline/arginine-rich end leucine-rich repeat protein
chr10_-_25344871 0.308 NM_145010
ENKUR
enkurin, TRPC channel interacting protein
chr7_+_156126157 0.308 NM_030936
NM_001184996
RNF32

ring finger protein 32

chr15_+_96304911 0.308 NM_183376
ARRDC4
arrestin domain containing 4
chr6_+_125346208 0.306 NM_152553
RNF217
ring finger protein 217
chr10_-_127361583 0.305 NM_001128202
C10orf122
chromosome 10 open reading frame 122
chr11_+_93394025 0.300 NM_001098672
HEPHL1
hephaestin-like 1
chr17_+_65612589 0.300 NM_170742
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr20_-_36322587 0.299 NM_001029864
KIAA1755
KIAA1755
chr1_+_227473458 0.299 NM_004578
RAB4A
RAB4A, member RAS oncogene family
chr7_+_48041632 0.298 NM_001100159
C7orf57
chromosome 7 open reading frame 57
chr18_-_45630154 0.297 MYO5B
myosin VB
chr19_-_63776442 0.290 MZF1
myeloid zinc finger 1
chr21_+_17807167 0.289 NM_001338
CXADR
coxsackie virus and adenovirus receptor
chr17_+_4683280 0.289 NM_001024937
NM_015716
NM_153827
NM_170663
MINK1



misshapen-like kinase 1



chr1_+_201711505 0.286 NM_002725
NM_201348
PRELP

proline/arginine-rich end leucine-rich repeat protein

chr12_+_32546243 0.285 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr21_-_42789369 0.283 NM_080860
RSPH1
radial spoke head 1 homolog (Chlamydomonas)
chr9_+_115970599 0.283 COL27A1
collagen, type XXVII, alpha 1
chr22_+_19651446 0.281 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr11_-_31347896 0.280 NM_181807
DCDC1
doublecortin domain containing 1
chr11_-_75057062 0.278 NM_033063
NM_207577
MAP6

microtubule-associated protein 6

chrX_+_117841761 0.277 NM_173798
ZCCHC12
zinc finger, CCHC domain containing 12
chr7_+_101861007 0.276 ORAI2
ORAI calcium release-activated calcium modulator 2

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.63 1.44e-05 GO:0005929 cilium
1.20 1.70e-04 GO:0005737 cytoplasm
5.38 1.86e-04 GO:0005930 axoneme
6.31 2.49e-04 GO:0035085 cilium axoneme
4.90 5.76e-04 GO:0044441 cilium part
2.40 7.97e-03 GO:0005874 microtubule

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.55 7.88e-04 GO:0017076 purine nucleotide binding
1.53 1.78e-03 GO:0032553 ribonucleotide binding
1.53 1.78e-03 GO:0032555 purine ribonucleotide binding
1.52 4.13e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.44 8.20e-03 GO:0000166 nucleotide binding
1.53 1.82e-02 GO:0030554 adenyl nucleotide binding
1.52 2.49e-02 GO:0032559 adenyl ribonucleotide binding