Motif ID: NKX3-1.p2

Z-value: 1.305


Transcription factors associated with NKX3-1.p2:

Gene SymbolEntrez IDGene Name
NKX3-1 4824 NK3 homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX3-1chr8_-_23596346-0.165.4e-01Click!


Activity profile for motif NKX3-1.p2.

activity profile for motif NKX3-1.p2


Sorted Z-values histogram for motif NKX3-1.p2

Sorted Z-values for motif NKX3-1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_21399132 3.008 NM_002170
IFNA8
interferon, alpha 8
chr3_+_174598937 2.875 NM_014932
NLGN1
neuroligin 1
chr7_+_94377145 2.742 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr6_+_132000134 2.638 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr22_+_38652555 2.533 GRAP2
GRB2-related adaptor protein 2
chr18_-_29273979 2.370 NM_001105528
C18orf34
chromosome 18 open reading frame 34
chrX_+_99726445 1.864 NM_022144
TNMD
tenomodulin
chr7_+_45899621 1.767


chr3_-_121445831 1.670 NM_001168271
NM_153002
GPR156

G protein-coupled receptor 156

chr4_+_119174947 1.667 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr1_-_3556420 1.525 NM_017818
WDR8
WD repeat domain 8
chr11_-_13474101 1.502 NM_000315
PTH
parathyroid hormone
chr5_+_147238466 1.466 NM_054023
SCGB3A2
secretoglobin, family 3A, member 2
chr11_+_89507465 1.446 NM_005467
NAALAD2
N-acetylated alpha-linked acidic dipeptidase 2
chr9_-_21177529 1.433 NM_021068
IFNA4
interferon, alpha 4
chr3_-_99236520 1.425 NM_001105580
GABRR3
gamma-aminobutyric acid (GABA) receptor, rho 3
chr11_-_100505667 1.419 NM_000926
PGR
progesterone receptor
chr12_-_5925658 1.341 NM_020373
ANO2
anoctamin 2
chr3_+_129124591 1.333 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr1_-_60312013 1.323 NM_152377
C1orf87
chromosome 1 open reading frame 87
chr7_+_86111155 1.319 NM_000840
GRM3
glutamate receptor, metabotropic 3
chr7_-_123460722 1.275 NM_001136002
TMEM229A
transmembrane protein 229A
chr9_-_21218132 1.257 NM_021268
IFNA17
interferon, alpha 17
chr11_-_56914668 1.243 NM_002728
PRG2
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
chr2_-_104834344 1.229 LOC100506421
hypothetical LOC100506421
chr10_+_90336489 1.213 NM_001010939
LIPJ
lipase, family member J
chr7_+_45899080 1.172 IGFBP1
insulin-like growth factor binding protein 1
chr7_+_141457977 1.116 LOC93432
maltase-glucoamylase-like pseudogene
chr18_-_22696532 1.058 NM_004028
AQP4
aquaporin 4
chr5_+_140215778 1.041 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr11_-_77730573 1.018 NM_012296
GAB2
GRB2-associated binding protein 2
chr5_+_127016605 1.010 NM_001127385
CTXN3
cortexin 3
chr10_+_90552466 1.005 NM_001128215
LIPM
lipase, family member M
chrX_-_131089552 0.999 NM_194277
FRMD7
FERM domain containing 7
chr11_+_123625632 0.997 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr12_-_18134319 0.968 NM_024730
RERGL
RERG/RAS-like
chr15_+_57691382 0.957 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr10_+_90474280 0.939 NM_001080518
LIPK
lipase, family member K
chr9_-_21375258 0.936 NM_000605
IFNA2
interferon, alpha 2
chr12_-_80676562 0.908 PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr1_+_50348052 0.869 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr12_-_83954185 0.863 NM_001100917
TSPAN19
tetraspanin 19
chr5_+_147672181 0.860 NM_032566
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr15_-_60244773 0.857 NM_001007595
C2CD4B
C2 calcium-dependent domain containing 4B
chr6_-_64087806 0.845 NM_001143940
NM_016571
LGSN

lengsin, lens protein with glutamine synthetase domain

chrX_-_131401319 0.844 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr3_-_139333813 0.833 NM_016161
A4GNT
alpha-1,4-N-acetylglucosaminyltransferase
chr14_-_74669864 0.816 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr12_+_63510481 0.811


chr12_+_83954229 0.803 NM_001079910
NM_032165
LRRIQ1

leucine-rich repeats and IQ motif containing 1

chr8_-_15140162 0.799 NM_139167
SGCZ
sarcoglycan, zeta
chr8_-_17787342 0.789 FGL1
fibrinogen-like 1
chr4_-_157006827 0.784 NM_017419
ACCN5
amiloride-sensitive cation channel 5, intestinal
chr9_-_205892 0.778 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr1_-_177378801 0.763 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr14_-_20098929 0.761 NM_001001673
NM_001110356
NM_001110357
NM_001110358
NM_001110359
NM_001110360
NM_001110361
RNASE9






ribonuclease, RNase A family, 9 (non-active)






chr9_+_89302574 0.759 NM_004938
DAPK1
death-associated protein kinase 1
chr1_-_103269356 0.746 COL11A1
collagen, type XI, alpha 1
chr10_+_118340460 0.737 NM_006229
PNLIPRP1
pancreatic lipase-related protein 1
chr1_+_66230977 0.728 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr4_+_114190233 0.726 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr11_-_30558495 0.715 NM_001584
MPPED2
metallophosphoesterase domain containing 2
chr9_-_21192201 0.715 NM_021057
IFNA7
interferon, alpha 7
chr11_+_120478584 0.711 NM_005422
TECTA
tectorin alpha
chr1_-_150353179 0.698 NM_007113
TCHH
trichohyalin
chr3_+_120799411 0.693 NM_015900
PLA1A
phospholipase A1 member A
chr3_+_192413015 0.689 NM_198184
OSTN
osteocrin
chr3_-_115380539 0.679 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr15_+_57691272 0.669 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr15_+_92700167 0.660 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr6_+_49575629 0.660 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr6_-_49712483 0.659 NM_000324
RHAG
Rh-associated glycoprotein
chr8_+_24207524 0.657 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr12_+_52696908 0.648 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chrX_+_107569671 0.645 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr5_+_76470829 0.638


chr8_+_24354387 0.633 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr7_+_80069439 0.624 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr12_+_61645361 0.621 RPL14
ribosomal protein L14
chr9_-_21358005 0.616 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chrX_+_100241453 0.609 NM_006733
CENPI
centromere protein I
chr5_-_177140071 0.602 NM_173663
FAM153A
FAM153C
family with sequence similarity 153, member A
family with sequence similarity 153, member C
chr4_+_74520796 0.601 NM_001134
AFP
alpha-fetoprotein
chr1_-_118123033 0.593


chr9_-_21207303 0.592 NM_002173
IFNA16
interferon, alpha 16
chr18_-_50776276 0.589 NM_001143829
CCDC68
coiled-coil domain containing 68
chr5_+_32824701 0.588 NM_024563
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr4_+_88748704 0.588 NM_014208
DSPP
dentin sialophosphoprotein
chr3_-_57209319 0.582 NM_003865
HESX1
HESX homeobox 1
chr12_-_242255 0.581 NM_001190997
NM_016615
SLC6A13

solute carrier family 6 (neurotransmitter transporter, GABA), member 13

chr9_+_99303282 0.563 NM_001166116
TMOD1
tropomodulin 1
chr4_-_10295412 0.561 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr18_-_21184824 0.559


chr4_-_155531898 0.553 NM_017639
DCHS2
dachsous 2 (Drosophila)
chr4_-_163304567 0.551 NM_001128427
NM_001128428
NM_020116
FSTL5


follistatin-like 5


chr1_-_68688219 0.548 NM_000329
RPE65
retinal pigment epithelium-specific protein 65kDa
chrX_-_21686079 0.547 NM_014332
SMPX
small muscle protein, X-linked
chr2_+_234490781 0.537 NM_024080
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chrX_-_107569256 0.531 NM_001847
COL4A6
collagen, type IV, alpha 6
chr11_-_57883117 0.530 NM_001005489
OR5B17
olfactory receptor, family 5, subfamily B, member 17
chr11_-_30910074 0.520 NM_020869
DCDC5
doublecortin domain containing 5
chr17_-_7434113 0.517 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr12_+_40117751 0.517 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr4_-_100575313 0.515 NM_001166504
NM_000673
ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr4_+_141484046 0.507 NM_001153446
NM_001153635
NM_001153585
NM_001153690
SCOC



short coiled-coil protein



chr7_-_93027057 0.506 NM_001164738
CALCR
calcitonin receptor
chr12_+_130004404 0.505 NM_198827
GPR133
G protein-coupled receptor 133
chr1_+_115373937 0.504 NM_000549
TSHB
thyroid stimulating hormone, beta
chr2_-_131073329 0.500 NM_032545
NM_001079530
CFC1
CFC1B
cripto, FRL-1, cryptic family 1
cripto, FRL-1, cryptic family 1B
chr4_-_70861301 0.496 NM_001891
CSN2
casein beta
chrX_-_131989963 0.492 NM_031907
USP26
ubiquitin specific peptidase 26
chr14_+_87541220 0.492 NM_003608
GPR65
G protein-coupled receptor 65
chrX_+_56772391 0.492 LOC550643
hypothetical LOC550643
chr3_-_152541129 0.491 NM_176876
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr8_+_23157094 0.487 NM_152272
CHMP7
CHMP family, member 7
chr15_-_100280784 0.487 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr1_+_58899 0.482 NM_001005484
OR4F4
OR4F5
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 5
chr9_-_103237851 0.481 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr9_+_89302239 0.476 DAPK1
death-associated protein kinase 1
chr4_+_74498042 0.467 ALB
albumin
chr11_+_58888460 0.466 NM_001004729
OR5AN1
olfactory receptor, family 5, subfamily AN, member 1
chr9_-_23811808 0.460 ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr12_-_10850845 0.459 NM_023918
TAS2R8
taste receptor, type 2, member 8
chr2_-_73350103 0.459 NM_001080410
FBXO41
F-box protein 41
chr9_-_23811842 0.458 NM_001171195
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr20_-_52120710 0.458 NM_003657
BCAS1
breast carcinoma amplified sequence 1
chr6_+_55147029 0.456 NM_001526
HCRTR2
hypocretin (orexin) receptor 2
chr4_+_47403107 0.456


chr3_+_152934393 0.456 NM_207365
AADACL2
arylacetamide deacetylase-like 2
chr11_-_40271086 0.454 LRRC4C
leucine rich repeat containing 4C
chr4_+_9055357 0.452 NM_001040448
DEFB131
defensin, beta 131
chr17_+_23818922 0.451


chr13_+_52500830 0.446 NM_006418
OLFM4
olfactomedin 4
chr7_-_27133163 0.431 NM_153631
HOXA3
homeobox A3
chr6_+_32003180 0.430 NM_000063
NM_001145903
C2

complement component 2

chr18_+_59571256 0.427 NM_001040147
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr4_+_74493918 0.426 ALB
albumin
chr15_+_60146467 0.426 NM_207322
C2CD4A
C2 calcium-dependent domain containing 4A
chr15_+_46285789 0.425 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr8_+_120148604 0.423 NM_006438
COLEC10
collectin sub-family member 10 (C-type lectin)
chr12_-_29828958 0.420 NM_175861
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chrX_+_66705407 0.419 NM_001011645
AR
androgen receptor
chr11_-_5099422 0.419 NM_001005222
OR52A4
olfactory receptor, family 52, subfamily A, member 4
chr4_+_157044296 0.416 NM_005651
TDO2
tryptophan 2,3-dioxygenase
chr17_+_50698169 0.414 HLF
hepatic leukemia factor
chr9_-_25668855 0.411 NM_001004125
TUSC1
tumor suppressor candidate 1
chr4_+_186587537 0.409 NM_001114357
C4orf47
chromosome 4 open reading frame 47
chr1_-_158815850 0.409 CD84
CD84 molecule
chr14_+_31868229 0.408 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr12_-_86947276 0.406 NM_152589
C12orf50
chromosome 12 open reading frame 50
chr18_+_59733724 0.406 NM_005024
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr11_+_56512922 0.406 NM_001005323
OR5AK2
olfactory receptor, family 5, subfamily AK, member 2
chr15_-_74091817 0.405 NM_138573
NRG4
neuregulin 4
chr1_-_245902965 0.404 NM_001005487
OR13G1
olfactory receptor, family 13, subfamily G, member 1
chr4_-_138673078 0.402 NM_019035
PCDH18
protocadherin 18
chr13_+_51334117 0.401 NM_031290
CCDC70
coiled-coil domain containing 70
chr3_-_168853982 0.397 NM_178824
WDR49
WD repeat domain 49
chr2_-_18634257 0.390 NM_001002006
NM_033253
NT5C1B-RDH14
NT5C1B

NT5C1B-RDH14 readthrough
5'-nucleotidase, cytosolic IB

chr15_-_48345453 0.390 NM_002112
HDC
histidine decarboxylase
chr8_-_30826074 0.384 NM_031271
TEX15
testis expressed 15
chr12_+_52697160 0.382 HOXC5
HOXC6
homeobox C5
homeobox C6
chr4_+_74497998 0.381 ALB
albumin
chr3_-_120761092 0.380 NM_005191
CD80
CD80 molecule
chr4_+_78651929 0.379 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr2_-_21106291 0.379 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_-_102234959 0.378 OLFM3
olfactomedin 3
chr7_+_48041632 0.378 NM_001100159
C7orf57
chromosome 7 open reading frame 57
chr6_-_76259976 0.377 NM_015687
FILIP1
filamin A interacting protein 1
chr7_-_92693716 0.377 NM_001039372
HEPACAM2
HEPACAM family member 2
chr5_+_147529488 0.373 NM_001001325
SPINK14
serine peptidase inhibitor, Kazal type 14 (putative)
chr11_-_128399218 0.373 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr12_+_119617060 0.372


chr10_-_99084417 0.372 NM_012083
FRAT2
frequently rearranged in advanced T-cell lymphomas 2
chr1_+_205329206 0.371 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr19_-_14853166 0.369 NM_030901
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr1_-_195302973 0.369 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr16_-_23632008 0.369 ERN2
endoplasmic reticulum to nucleus signaling 2
chr18_+_28023984 0.367 NM_005925
MEP1B
meprin A, beta
chr3_+_99288706 0.367 NM_054106
OR5AC2
olfactory receptor, family 5, subfamily AC, member 2
chr12_+_53178834 0.367 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr3_+_35697432 0.367 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr13_+_51496679 0.364 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr3_+_68136056 0.363 NM_213609
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chrX_+_114734074 0.361 NM_001136025
NM_001172335
PLS3

plastin 3

chr11_-_16953135 0.360 RPL36A
ribosomal protein L36a
chr6_-_76838944 0.359 NM_001563
IMPG1
interphotoreceptor matrix proteoglycan 1
chr4_+_71283383 0.357 NM_006685
SMR3B
submaxillary gland androgen regulated protein 3B
chr3_+_99350859 0.352 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr3_-_198784590 0.351 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr10_+_101078784 0.347 NM_020348
CNNM1
cyclin M1
chr14_+_28311740 0.347 C14orf23
chromosome 14 open reading frame 23
chr8_-_110762409 0.347 NM_001099745
NM_001099746
SYBU

syntabulin (syntaxin-interacting)

chr5_+_140757787 0.347 NM_018925
NM_032099
PCDHGB5

protocadherin gamma subfamily B, 5

chr1_+_220977180 0.347 NM_207468
FAM177B
family with sequence similarity 177, member B
chr20_-_33580861 0.346 NM_001145350
C20orf173
chromosome 20 open reading frame 173
chr11_+_55335418 0.345 NM_001004738
OR5L1
olfactory receptor, family 5, subfamily L, member 1
chr9_-_72673753 0.345 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr21_-_31041390 0.341 NM_181617
KRTAP21-2
keratin associated protein 21-2
chr1_-_26571812 0.340 NM_001114759
NM_173574
ZNF683

zinc finger protein 683

chr6_+_50894397 0.340 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.07 1.45e-13 GO:0007606 sensory perception of chemical stimulus
3.18 3.75e-13 GO:0007608 sensory perception of smell
2.16 3.88e-08 GO:0007600 sensory perception
1.65 1.26e-05 GO:0003008 system process
1.29 6.58e-05 GO:0032501 multicellular organismal process
1.69 9.45e-05 GO:0050877 neurological system process
1.22 4.00e-03 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.63 5.15e-08 GO:0005576 extracellular region
1.39 1.10e-07 GO:0005886 plasma membrane
1.39 1.20e-07 GO:0071944 cell periphery
1.22 3.31e-04 GO:0044425 membrane part
1.24 9.10e-04 GO:0016021 integral to membrane
1.23 9.93e-04 GO:0031224 intrinsic to membrane
1.58 1.06e-02 GO:0044421 extracellular region part
1.15 2.40e-02 GO:0016020 membrane
1.63 2.95e-02 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.28 3.49e-14 GO:0004984 olfactory receptor activity
2.38 6.67e-13 GO:0004930 G-protein coupled receptor activity
1.95 3.62e-10 GO:0004888 transmembrane receptor activity
1.74 1.13e-08 GO:0004872 receptor activity
17.26 2.98e-06 GO:0005132 interferon-alpha/beta receptor binding
1.53 2.15e-05 GO:0004871 signal transducer activity
1.53 2.15e-05 GO:0060089 molecular transducer activity
13.15 4.24e-02 GO:0030021 extracellular matrix structural constituent conferring compression resistance
13.15 4.24e-02 GO:0030345 structural constituent of tooth enamel